Structure-Activity Study of Tripeptide Thrombin Inhibitors Using .alpha.-Alkyl Amino Acids and Other Conformationally Constrained Amino Acid Substitutions von Shuman, Robert T, Rothenberger, Robert B, Campbell, Charles S, Smith, Gerald F, Gifford-Moore, Donetta S, Paschal, Jonathan W, Gesellchen, Paul D

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Diamino Benzo[b]thiophene Derivatives as a Novel Class of Active Site Directed Thrombin Inhibitors. 5. Potency, Efficacy, and Pharmacokinetic Properties of Modified C-3 Side Chain... von Sall, Daniel J, Bailey, Dianna L, Bastian, Jolie A, Buben, John A, Chirgadze, Nickolay Y, Clemens-Smith, Amy C, Denney, Michael L, Fisher, Matthew J, Giera, Deborah D, Gifford-Moore, Donetta S, Harper, Richard W, Johnson, Lea M, Klimkowski, Valentine J, Kohn, Todd J, Lin, Ho-Shen, McCowan, Jefferson R, Palkowitz, Alan D, Richett, Michael E, Smith, Gerald F, Snyder, David W, Takeuchi, Kumiko, Toth, John E, Zhang, Minsheng

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Investigation of the terminal P4 domain in a series of d-phenylglycinamide-based factor Xa inhibitors von Franciskovich, Jeffry B., Masters, John J., Weber, Wayne W., Klimkowski, Valentine J., Chouinard, Michael, Sipes, Philip R., Johnson, Lea M., Snyder, David W., Chastain, Marcia K., Craft, Trelia J., Towner, Richard D., Gifford-Moore, Donetta S., Froelich, Larry L., Smallwood, Jeffrey K., Foster, Ronald S., Smith, Gerald F., Liebeschuetz, John W., Murray, Christopher W., Young, Stephen C.

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Inhibition of thrombin activatable fibrinolysis inhibitor by cysteine derivatives von Do, Yee H., Gifford-Moore, Donetta S., Beight, Douglas W., Rathnachalam, Radhakrishnan, Klimkowski, Valentine J., Warshawsky, Alan M., Lu, Deshun

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Investigation of factor Xa inhibitors containing non-amidine S1 elements von Franciskovich, Jeffry B., Masters, John J., Tinsley, Jennifer M., Craft, Trelia J., Froelich, Larry L., Gifford-Moore, Donetta S., Klimkowski, Valentine J., Smallwood, Jeffrey K., Smith, Gerald F., Smith, Tommy, Towner, Richard R., Weir, Leonard C., Wiley, Michael R.

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1,2-disubstituted indole, azaindole and benzimidazole derivatives possessing amine moiety: a novel series of thrombin inhibitors von Takeuchi, Kumiko, Bastian, Jolie A, Gifford-Moore, Donetta S, Harper, Richard W, Miller, Shawn C, Mullaney, Jeffrey T, Sall, Daniel J, Smith, Gerald F, Zhang, Minsheng, Fisher, Matthew J

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Dibasic benzo[ b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 2. Exploring interactions at the proximal (S 2) binding site von Sall, Daniel J., Briggs, Stephen L., Chirgadze, Nickolay Y., Clawson, David K., Gifford-Moore, Donetta S., Klimkowski, Valentine J., McCowan, Jefferson R., Smith, Gerald F., Wikel, James H.

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Highly selective tripeptide thrombin inhibitors von Shuman, Robert T, Rothenberger, Robert B, Campbell, Charles S, Smith, Gerald F, Gifford-Moore, Donetta S, Gesellchen, Paul D

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The crystal structure of human α‐thrombin complexed with LY178550, a nonpeptidyl, active site‐directed inhibitor von Chirgadze, Nickolay Y., Sall, Daniel J., Klimkowski, Valentine J., Clawson, David K., Briggs, Steve L., Hermann, Robert, Smith, Gerald F., Gifford‐Moore, Donetta S., Wery, Jean‐Pierre

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Dibasic benzo[ b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 4. SAR studies on the conformationally restricted C3-side chain of hydroxybenzo... von Takeuchi, Kumiko, Kohn, Todd J., Sall, Daniel J., Denney, Michael L., McCowan, Jefferson R., Smith, Gerry F., Gifford-Moore, Donetta S.

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Structure-Based Design of Potent, Amidine-Derived Inhibitors of Factor Xa:  Evaluation of Selectivity, Anticoagulant Activity, and Antithrombotic Activity von Wiley, Michael R, Weir, Leonard C, Briggs, Steven, Bryan, Nancy A, Buben, John, Campbell, Charles, Chirgadze, Nickolay Y, Conrad, Richard C, Craft, Trelia J, Ficorilli, James V, Franciskovich, Jeffry B, Froelich, Larry L, Gifford-Moore, Donetta S, Goodson, Theodore, Herron, David K, Klimkowski, Valentine J, Kurz, Kenneth D, Kyle, Jeffery A, Masters, John J, Ratz, Andrew M, Milot, Guy, Shuman, Robert T, Smith, Tommy, Smith, Gerald F, Tebbe, Ann Louise, Tinsley, Jennifer M, Towner, Richard D, Wilson, Alexander, Yee, Ying K

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Non-Amidine-Containing 1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa with Potent Anticoagulant and Antithrombotic Activity von Masters, John J, Franciskovich, Jeffry B, Tinsley, Jennifer M, Campbell, Charles, Campbell, Jack B, Craft, Trelia J, Froelich, Larry L, Gifford-Moore, Donetta S, Hay, Lynne A, Herron, David K, Klimkowski, Valentine J, Kurz, Kenneth D, Metz, James T, Ratz, Andrew M, Shuman, Robert T, Smith, Gerald F, Smith, Tommy, Towner, Richard D, Wiley, Michael R, Wilson, Alex, Yee, Ying K

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Dibasic Benzo[b]thiophene Derivatives as a Novel Class of Active Site-Directed Thrombin Inhibitors. 1. Determination of the Serine Protease Selectivity, Structure−Activity Relation... von Sall, Daniel J, Bastian, Jolie A, Briggs, Stephen L, Buben, John A, Chirgadze, Nickolay Y, Clawson, David K, Denney, Michael L, Giera, Deborah D, Gifford-Moore, Donetta S, Harper, Richard W, Hauser, Kenneth L, Klimkowski, Valentine J, Kohn, Todd J, Lin, Ho-Shen, McCowan, Jefferson R, Palkowitz, Alan D, Smith, Gerald F, Takeuchi, Kumiko, Thrasher, Kenneth J, Tinsley, Jennifer M, Utterback, Barbara G, Yan, Sau-Chi B, Zhang, Minsheng

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A Family of Arginal Thrombin Inhibitors Related to Efegatran von Smith, Gerald F., Shuman, Robert T., Craft, Trelia J., Gifford, Donetta S., Kurz, Kenneth D., Jones, Noel D., Chirgadze, Nickolay, Hermann, Robert B., Coffman, William J., Sandusky, George E., Roberts, Eiry, Van Jackson, Charles

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ChemInform Abstract: Dibasic Benzo[b]thiophene Derivatives as a Novel Class of Active Site Directed Thrombin Inhibitors. Part 4. SAR Studies on the Conformationally Restricted C3-S... von Takeuchi, Kumiko, Kohn, Todd J., Sall, Daniel J., Denney, Michael L., McCowan, Jefferson R., Smith, Gerry F., Gifford-Moore, Donetta S.

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ChemInform Abstract: 1,2-Disubstituted Indole, Azaindole, and Benzimidazole Derivatives Possessing Amine Moiety: A Novel Series of Thrombin Inhibitors von Takeuchi, Kumiko, Bastian, Jolie A., Gifford-Moore, Donetta S., Harper, Richard W., Miller, Shawn C., Mullaney, Jeffrey T., Sall, Daniel J., Smith, Gerald F., Zhang, Minsheng, Fisher, Matthew J.

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The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element von Wiley, Michael R., Weir, Leonard C., Briggs, Steven L., Chirgadze, Nickolay Y., Clawson, David, Gifford-Moore, Donetta S., Schacht, Aaron L., Smith, Gerald F., Vasudevan, Vasu, Zornes, Larry L., Klimkowski, Valentine J.

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ChemInform Abstract: Diamino Benzo[b]thiophene Derivatives as a Novel Class of Active Site Directed Thrombin Inhibitors. Part 6. Further Focus on the Contracted C4′-Side Chain Anal... von Takeuchi, Kumiko, Kohn, Todd J., Harper, Richard W., Lin, Ho-Shen, Gifford-Moore, Donetta S., Richett, Michael E., Sall, Daniel J., Smith, Gerald F., Zhang, Minsheng

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D-Phe-Pro- p-Amidinobenzylamine: A potent and highly selective thrombin inhibitor von Wiley, Michael R., Chirgadze, Nickolay Y., Clawson, David K., Craft, Trelia J., Gifford-Moore, Donetta S., Jones, Noel D., Olkowski, Jennifer L., Weir, Leonard C., Smith, Gerald F.

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Solid phase chemistry approach to the SAR development of a novel class of active site-directed thrombin inhibitors von Johnson, Mary George, Bronson, Duane D., Gillespie, Jan E., Gifford-Moore, Donetta S., Kalter, Kyomi, Lynch, Michael P., McCowan, Jefferson R., Redick, Catherine C., Sall, Daniel J., Smith, Gerald F., Foglesong, Robert J.

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