Evaluation of Clinically Relevant Drug–Drug Interactions and Population Pharmacokinetics of Darolutamide in Patients with Nonmetastatic Castration-Resistant Prostate Cancer: Result... von Shore, Neal, Zurth, Christian, Fricke, Robert, Gieschen, Hille, Graudenz, Kristina, Koskinen, Mikko, Ploeger, Bart, Moss, Jonathan, Prien, Olaf, Borghesi, Gustavo, Petrenciuc, Oana, Tammela, Teuvo L., Kuss, Iris, Verholen, Frank, Smith, Matthew R., Fizazi, Karim

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Drug–Drug Interaction Potential of Darolutamide: In Vitro and Clinical Studies von Zurth, Christian, Koskinen, Mikko, Fricke, Robert, Prien, Olaf, Korjamo, Timo, Graudenz, Kristina, Denner, Karsten, Bairlein, Michaela, von Bühler, Clemens-Jeremias, Wilkinson, Gary, Gieschen, Hille

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Higher blood–brain barrier penetration of [ 14 C]apalutamide and [ 14 C]enzalutamide compared to [ 14 C]darolutamide in rats using whole-body autoradiography von Zurth, Christian, Sandman, Steffen, Trummel, Dagmar, Seidel, Dietrich, Nubbemeyer, Reinhard, Gieschen, Hille

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Characterization of new estrogen receptor destabilizing compounds: Effects on estrogen-sensitive and tamoxifen-resistant breast cancer von HOFFMANN, Jens, BOHLMANN, Rolf, GIESCHEN, Hille, ULBRICH, Hannes-F, SCHNEIDER, Martin R, HEINRICH, Nikolaus, HOFMEISTER, Helmut, KROLL, Jörg, KÜNZER, Hermann, LICHTNER, Rosemarie B, NISHINO, Yuki, PARCZYK, Karsten, SAUER, Gerhard

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Blood-brain barrier penetration of [14C]darolutamide compared with [14C]enzalutamide in rats using whole body autoradiography von Zurth, Christian, Sandmann, Steffen, Trummel, Dagmar, Seidel, Dietrich, Gieschen, Hille

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Metabolism and Mass Balance of the Novel Nonsteroidal Androgen Receptor Inhibitor Darolutamide in Humans von Taavitsainen, Paivi, Prien, Olaf, Kahkonen, Marja, Niehues, Michael, Korjamo, Timo, Denner, Karsten, Nykanen, Pirjo, Vuorela, Annamari, Jungmann, Natalia A., Von Buhler, Clemens-Jeremias, Koskinen, Mikko, Zurth, Christian, Gieschen, Hille

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Improving the ex vivo stability of drug ester compounds in rat and dog serum: Inhibition of the specific esterases and implications on their identity von Koitka, Matthias, Höchel, Joachim, Gieschen, Hille, Borchert, Hans-Hubert

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Determination of rat serum esterase activities by an HPLC method using S-acetylthiocholine iodide and p-nitrophenyl acetate von Koitka, Matthias, Höchel, Joachim, Obst, Detlev, Rottmann, Antje, Gieschen, Hille, Borchert, Hans-Hubert

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Drug–Drug Interaction Potential of Darolutamide: In Vitro and Clinical Studies von Zurth, Christian, Koskinen, Mikko, Fricke, Robert, Prien, Olaf, Korjamo, Timo, Graudenz, Kristina, Denner, Karsten, Bairlein, Michaela, Clemens-Jeremias Von Bühler, Wilkinson, Gary, Gieschen, Hille

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The bioavailability of oral fludarabine phosphate is unaffected by food von Oscier, D, Orchard, J A, Culligan, D, Cunningham, D, Johnson, S, Parker, A, Klein, M, Gieschen, H

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Development of a V79 cell line expressing human cytochrome P450 2D6 and its application as a metabolic screening tool von Rauschenbach, Reimund, Gieschen, Hille, Salomon, Birgit, Kraus, Christian, Kühne, Gerhard, Hildebrand, Michael

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Stable expression of human cytochrome P450 3A4 in V79 cells and its application for metabolic profiling of ergot derivatives von Rauschenbach, Reimund, Gieschen, Hille, Husemann, Manfred, Salomon, Birgit, Hildebrand, Michael

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