Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma von Yeung, Choh, Gibson, Anna E, Issaq, Sameer H, Oshima, Nobu, Baumgart, Joshua T, Edessa, Leah D, Rai, Ganesha, Urban, Daniel J, Johnson, Michelle S, Benavides, Gloria A, Squadrito, Giuseppe L, Yohe, Marielle E, Lei, Haiyan, Eldridge, Sandy, Hamre, 3rd, John, Dowdy, Tyrone, Ruiz-Rodado, Victor, Lita, Adrian, Mendoza, Arnulfo, Shern, Jack F, Larion, Mioara, Helman, Lee J, Stott, Gordon M, Krishna, Murali C, Hall, Matthew D, Darley-Usmar, Victor, Neckers, Leonard M, Heske, Christine M

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Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma von Gibson, Anna E., Yeung, Choh, Issaq, Sameer H., Collins, Victor J., Gouzoulis, Michael, Zhang, Yiping, Ji, Jiuping, Mendoza, Arnulfo, Heske, Christine M.

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Abstract 5477: Targeting nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 in Ewing sarcoma von Gibson, Anna E., Mendoza, Arnulfo, Korotchkina, Lioubov, Chernova, Olga, Heske, Christine M.

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Abstract PR08: Lactate dehydrogenase A is a pharmacologically tractable EWS-FLI1 transcriptional target that regulates the glycolytic dependence of Ewing sarcoma von Yeung, Choh, Gibson, Anna E., Issaq, Sameer H., Oshima, Nobu, Yohe, Marielle E., Lei, Haiyan, Rai, Ganesha, Urban, Daniel J., Johnson, Michelle S., Benevides, Gloria A., Squadrito, Giuseppe L., Eldridge, Sandy, Hamre, John, Mendoza, Arnulfo, Shern, Jack F., Helman, Lee J., Krishna, Murali C., Hall, Matthew D., Darley-Usmar, Victor M., Neckers, Leonard M., Heske, Christine M.

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Abstract B16: Evaluation of LDH inhibition as a treatment strategy in Ewing sarcoma von Heske, Christine M., Gibson, Anna E., Baumgart, Josh T., Yeung, Choh, Issaq, Sameer H., Mendoza, A, Johnson, Michelle S., Squadrito, Guiseppe L., Culp, Lillian, Darley-Usmar, Victor M., Neckers, Len M.

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Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment von Geraghty, Anna C., Gibson, Erin M., Ghanem, Reem A., Greene, Jacob J., Ocampo, Alfonso, Goldstein, Andrea K., Ni, Lijun, Yang, Tao, Marton, Rebecca M., Paşca, Sergiu P., Greenberg, Michael E., Longo, Frank M., Monje, Michelle

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Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels von Gibson, Spencer, Konzelman, Carmen, Blankstein, Anna R., Villalpando-Rodriguez, Gloria E.

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The characterization of twenty sequenced human genomes von Pelak, Kimberly, Shianna, Kevin V, Ge, Dongliang, Maia, Jessica M, Zhu, Mingfu, Smith, Jason P, Cirulli, Elizabeth T, Fellay, Jacques, Dickson, Samuel P, Gumbs, Curtis E, Heinzen, Erin L, Need, Anna C, Ruzzo, Elizabeth K, Singh, Abanish, Campbell, C Ryan, Hong, Linda K, Lornsen, Katharina A, McKenzie, Alexander M, Sobreira, Nara L M, Hoover-Fong, Julie E, Milner, Joshua D, Ottman, Ruth, Haynes, Barton F, Goedert, James J, Goldstein, David B

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A Proteome-wide Screen for Mammalian SxIP Motif-Containing Microtubule Plus-End Tracking Proteins von Jiang, Kai, Toedt, Grischa, Montenegro Gouveia, Susana, Davey, Norman E., Hua, Shasha, van der Vaart, Babet, Grigoriev, Ilya, Larsen, Jesper, Pedersen, Lotte B., Bezstarosti, Karel, Lince-Faria, Mariana, Demmers, Jeroen, Steinmetz, Michel O., Gibson, Toby J., Akhmanova, Anna

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Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants von Zou, Fanggeng, Chai, High Seng, Younkin, Curtis S, Allen, Mariet, Crook, Julia, Pankratz, V Shane, Carrasquillo, Minerva M, Rowley, Christopher N, Nair, Asha A, Middha, Sumit, Maharjan, Sooraj, Nguyen, Thuy, Ma, Li, Malphrus, Kimberly G, Palusak, Ryan, Lincoln, Sarah, Bisceglio, Gina, Georgescu, Constantin, Kouri, Naomi, Kolbert, Christopher P, Jen, Jin, Haines, Jonathan L, Mayeux, Richard, Pericak-Vance, Margaret A, Farrer, Lindsay A, Schellenberg, Gerard D, Petersen, Ronald C, Graff-Radford, Neill R, Dickson, Dennis W, Younkin, Steven G, Ertekin-Taner, Nilüfer

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A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation von Coviello, Andrea D, Haring, Robin, Wellons, Melissa, Vaidya, Dhananjay, Lehtimäki, Terho, Keildson, Sarah, Lunetta, Kathryn L, He, Chunyan, Fornage, Myriam, Lagou, Vasiliki, Mangino, Massimo, Onland-Moret, N Charlotte, Chen, Brian, Eriksson, Joel, Garcia, Melissa, Liu, Yong Mei, Koster, Annemarie, Lohman, Kurt, Lyytikäinen, Leo-Pekka, Petersen, Ann-Kristin, Prescott, Jennifer, Stolk, Lisette, Vandenput, Liesbeth, Wood, Andrew R, Zhuang, Wei Vivian, Ruokonen, Aimo, Hartikainen, Anna-Liisa, Pouta, Anneli, Bandinelli, Stefania, Biffar, Reiner, Brabant, Georg, Cox, David G, Chen, Yuhui, Cummings, Steven, Ferrucci, Luigi, Gunter, Marc J, Hankinson, Susan E, Martikainen, Hannu, Hofman, Albert, Homuth, Georg, Illig, Thomas, Jansson, John-Olov, Johnson, Andrew D, Karasik, David, Karlsson, Magnus, Kettunen, Johannes, Kiel, Douglas P, Kraft, Peter, Liu, Jingmin, Ljunggren, Östen, Lorentzon, Mattias, Maggio, Marcello, Markus, Marcello R P, Mellström, Dan, Miljkovic, Iva, Mirel, Daniel, Nelson, Sarah, Morin Papunen, Laure, Peeters, Petra H M, Prokopenko, Inga, Raffel, Leslie, Reincke, Martin, Reiner, Alex P, Rexrode, Kathryn, Rivadeneira, Fernando, Schwartz, Stephen M, Siscovick, David, Soranzo, Nicole, Stöckl, Doris, Tworoger, Shelley, Uitterlinden, André G, van Gils, Carla H, Vasan, Ramachandran S, Wichmann, H-Erich, Zhai, Guangju, Bhasin, Shalender, Bidlingmaier, Martin, Chanock, Stephen J, De Vivo, Immaculata, Harris, Tamara B, Hunter, David J, Kähönen, Mika, Liu, Simin, Ouyang, Pamela, Spector, Tim D, van der Schouw, Yvonne T, Viikari, Jorma, Wallaschofski, Henri, McCarthy, Mark I, Frayling, Timothy M, Murray, Anna, Franks, Steve, Järvelin, Marjo-Riitta, de Jong, Frank H, Raitakari, Olli, Teumer, Alexander, Ohlsson, Claes, Murabito, Joanne M, Perry, John R B

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Common genetic determinants of intraocular pressure and primary open-angle glaucoma von van Koolwijk, Leonieke M E, Ramdas, Wishal D, Ikram, M Kamran, Jansonius, Nomdo M, Pasutto, Francesca, Hysi, Pirro G, Macgregor, Stuart, Janssen, Sarah F, Hewitt, Alex W, Viswanathan, Ananth C, ten Brink, Jacoline B, Hosseini, S Mohsen, Amin, Najaf, Despriet, Dominiek D G, Willemse-Assink, Jacqueline J M, Kramer, Rogier, Rivadeneira, Fernando, Struchalin, Maksim, Aulchenko, Yurii S, Weisschuh, Nicole, Zenkel, Matthias, Mardin, Christian Y, Gramer, Eugen, Welge-Lüssen, Ulrich, Montgomery, Grant W, Carbonaro, Francis, Young, Terri L, Bellenguez, Céline, McGuffin, Peter, Foster, Paul J, Topouzis, Fotis, Mitchell, Paul, Wang, Jie Jin, Wong, Tien Y, Czudowska, Monika A, Hofman, Albert, Uitterlinden, Andre G, Wolfs, Roger C W, de Jong, Paulus T V M, Oostra, Ben A, Paterson, Andrew D, Mackey, David A, Bergen, Arthur A B, Reis, André, Hammond, Christopher J, Vingerling, Johannes R, Lemij, Hans G, Klaver, Caroline C W, van Duijn, Cornelia M

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Quantitative genetics of CTCF binding reveal local sequence effects and different modes of X-chromosome association von Ding, Zhihao, Ni, Yunyun, Timmer, Sander W, Lee, Bum-Kyu, Battenhouse, Anna, Louzada, Sandra, Yang, Fengtang, Dunham, Ian, Crawford, Gregory E, Lieb, Jason D, Durbin, Richard, Iyer, Vishwanath R, Birney, Ewan

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Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis von Fingerlin, Tasha E, Murphy, Elissa, Zhang, Weiming, Peljto, Anna L, Brown, Kevin K, Steele, Mark P, Loyd, James E, Cosgrove, Gregory P, Lynch, David, Groshong, Steve, Collard, Harold R, Wolters, Paul J, Bradford, Williamson Z, Kossen, Karl, Seiwert, Scott D, du Bois, Roland M, Garcia, Christine Kim, Devine, Megan S, Gudmundsson, Gunnar, Isaksson, Helgi J, Kaminski, Naftali, Zhang, Yingze, Gibson, Kevin F, Lancaster, Lisa H, Cogan, Joy D, Mason, Wendi R, Maher, Toby M, Molyneaux, Philip L, Wells, Athol U, Moffatt, Miriam F, Selman, Moises, Pardo, Annie, Kim, Dong Soon, Crapo, James D, Make, Barry J, Regan, Elizabeth A, Walek, Dinesha S, Daniel, Jerry J, Kamatani, Yoichiro, Zelenika, Diana, Smith, Keith, McKean, David, Pedersen, Brent S, Talbert, Janet, Kidd, Raven N, Markin, Cheryl R, Beckman, Kenneth B, Lathrop, Mark, Schwarz, Marvin I, Schwartz, David A

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Association Between the MUC5B Promoter Polymorphism and Survival in Patients With Idiopathic Pulmonary Fibrosis von Peljto, Anna L, Zhang, Yingze, Fingerlin, Tasha E, Ma, Shwu-Fan, Garcia, Joe G. N, Richards, Thomas J, Silveira, Lori J, Lindell, Kathleen O, Steele, Mark P, Loyd, James E, Gibson, Kevin F, Seibold, Max A, Brown, Kevin K, Talbert, Janet L, Markin, Cheryl, Kossen, Karl, Seiwert, Scott D, Murphy, Elissa, Noth, Imre, Schwarz, Marvin I, Kaminski, Naftali, Schwartz, David A

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Does genetic diversity protect host populations from parasites? A meta‐analysis across natural and agricultural systems von Gibson, Amanda Kyle, Nguyen, Anna E.

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Lead in drinking water at North Carolina childcare centers: Piloting a citizen science-based testing strategy von Redmon, Jennifer Hoponick, Levine, Keith E., Aceituno, Anna M., Litzenberger, Kristin, Gibson, Jacqueline MacDonald

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MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis von Rosas, Ivan O, Richards, Thomas J, Konishi, Kazuhisa, Zhang, Yingze, Gibson, Kevin, Lokshin, Anna E, Lindell, Kathleen O, Cisneros, Jose, Macdonald, Sandra D, Pardo, Annie, Sciurba, Frank, Dauber, James, Selman, Moises, Gochuico, Bernadette R, Kaminski, Naftali

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The conservation status of the world’s freshwater molluscs von Böhm, Monika, Dewhurst-Richman, Nadia I., Seddon, Mary, Ledger, Sophie E. H., Albrecht, Christian, Allen, David, Bogan, Arthur E., Cordeiro, Jay, Cummings, Kevin S., Cuttelod, Annabelle, Darrigran, Gustavo, Darwall, Will, Fehér, Zoltán, Gibson, Claudine, Graf, Daniel L., Köhler, Frank, Lopes-Lima, Manuel, Pastorino, Guido, Perez, Kathryn E., Smith, Kevin, van Damme, Dirk, Vinarski, Maxim V., von Proschwitz, Ted, von Rintelen, Thomas, Aldridge, David C., Aravind, Neelavar A., Budha, Prem B., Clavijo, Cristhian, Van Tu, Do, Gargominy, Olivier, Ghamizi, Mohamed, Haase, Martin, Hilton-Taylor, Craig, Johnson, Paul D., Kebapçı, Ümit, Lajtner, Jasna, Lange, Charles N., Lepitzki, Dwayne A.W., Martínez-Ortí, Alberto, Moorkens, Evelyn A., Neubert, Eike, Pollock, Caroline M., Prié, Vincent, Radea, Canella, Ramirez, Rina, Ramos, Marian A., Santos, Sonia B., Slapnik, Rajko, Son, Mikhail O., Stensgaard, Anna-Sofie, Collen, Ben

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2017 Cardiovascular and Stroke Endpoint Definitions for Clinical Trials von Hicks, Karen A., Mahaffey, Kenneth W., Mehran, Roxana, Nissen, Steven E., Wiviott, Stephen D., Dunn, Billy, Solomon, Scott D., Marler, John R., Teerlink, John R., Farb, Andrew, Morrow, David A., Targum, Shari L., Sila, Cathy A., Thanh Hai, Mary T., Jaff, Michael R., Joffe, Hylton V., Cutlip, Donald E., Desai, Akshay S., Lewis, Eldrin F., Gibson, C. Michael, Landray, Martin J., Lincoff, A. Michael, White, Christopher J., Brooks, Steven S., Rosenfield, Kenneth, Domanski, Michael J., Lansky, Alexandra J., McMurray, John J.V., Tcheng, James E., Steinhubl, Steven R., Burton, Paul, Mauri, Laura, O’Connor, Christopher M., Pfeffer, Marc A., Hung, H.M. James, Stockbridge, Norman L., Chaitman, Bernard R., Temple, Robert J., Fitter, Heather D., Illoh, Kachikwu, Cavanaugh, Kenneth J., Scirica, Benjamin M., Irony, Ilan, Brown Kichline, Rachel E., Levine, Jonathan G., Park, Anna, Sacks, Leonard, Szarfman, Ana, Unger, Ellis F., Wachter, Lori Ann, Zuckerman, Bram, Mitchel, Yale, Peddicord, Douglas, Shook, Thomas, Kisler, Bron, Jaffe, Charles, Bartley, Rhonda, DeMets, David L., Mencini, MariJo, Janning, Cheri, Bai, Steve, Lawrence, John, D’Agostino, Ralph B., Pocock, Stuart J.

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