Clinical Pharmacokinetics and Pharmacodynamics of Evolocumab, a PCSK9 Inhibitor von Kasichayanula, Sreeneeranj, Grover, Anita, Emery, Maurice G., Gibbs, Megan A., Somaratne, Ransi, Wasserman, Scott M., Gibbs, John P.

Volltext

Quantitative Model of the Relationship Between Dipeptidyl Peptidase-4 (DPP-4) Inhibition and Response: Meta-Analysis of Alogliptin, Saxagliptin, Sitagliptin, and Vildagliptin Effic... von Gibbs, John P., Fredrickson, Jill, Barbee, Todd, Correa, Itzela, Smith, Brian, Lin, Shao-Lee, Gibbs, Megan A.

Volltext

Multiple-Dose Pharmacokinetics of the Selective Nicotinic Receptor Partial Agonist, Varenicline, in Healthy Smokers von Faessel, Hélène M., Gibbs, Megan A., Clark, David J., Rohrbacher, Kevin, Stolar, Marilyn, Burstein, Aaron H.

Volltext

Clinical Pharmacology of Elagolix: An Oral Gonadotropin-Releasing Hormone Receptor Antagonist for Endometriosis von Shebley, Mohamad, Polepally, Akshanth R., Nader, Ahmed, Ng, Juki W., Winzenborg, Insa, Klein, Cheri E., Noertersheuser, Peter, Gibbs, Megan A., Mostafa, Nael M.

Volltext

Quantitative Prediction of Human Pharmacokinetics for Monoclonal Antibodies: Retrospective Analysis of Monkey as a Single Species for First-in-Human Prediction von Dong, Jennifer Q., Salinger, David H., Endres, Christopher J., Gibbs, John P., Hsu, Cheng-Pang, Stouch, Brian J., Hurh, Eunju, Gibbs, Megan

Volltext

Impact of Target‐Mediated Elimination on the Dose and Regimen of Evolocumab, a Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) von Gibbs, John P., Doshi, Sameer, Kuchimanchi, Mita, Grover, Anita, Emery, Maurice G., Dodds, Michael G., Gibbs, Megan A., Somaratne, Ransi, Wasserman, Scott M., Blom, Dirk

Volltext

A model-based meta-analysis of monoclonal antibody pharmacokinetics to guide optimal first-in-human study design von Davda, Jasmine P, Dodds, Michael G, Gibbs, Megan A, Wisdom, Wendy, Gibbs, John P

Volltext

Quantitative systems modeling approaches towards model-informed drug development: Perspective through case studies von Verma, Meghna, Gall, Louis, Biasetti, Jacopo, Di Veroli, Giovanni Y., Pichardo-Almarza, Cesar, Gibbs, Megan A., Kimko, Holly

Volltext

Population pharmacokinetics of brodalumab in healthy adults and adults with psoriasis from single and multiple dose studies von Endres, Christopher J., Salinger, David H., Köck, Kathleen, Gastonguay, Marc R., Martin, David A., Klekotka, Paul, Nirula, Ajay, Gibbs, Megan A.

Volltext

Population Pharmacokinetic/Pharmacodynamic Model of Subcutaneous Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Activity After Oral Administration of AMG 221, a Selecti... von Gibbs, John P., Emery, Maurice G., McCaffery, Ian, Smith, Brian, Gibbs, Megan A., Akrami, Anna, Rossi, John, Paweletz, Katherine, Gastonguay, Marc R., Bautista, Edgar, Wang, Minghan, Perfetti, Riccardo, Daniels, Oranee

Volltext

Single-Dose Pharmacokinetics of Varenicline, a Selective Nicotinic Receptor Partial Agonist, in Healthy Smokers and Nonsmokers von Faessel, Hélène M., Smith, Bill J., Gibbs, Megan A., Gobey, Jason S., Clark, David J., Burstein, Aaron H.

Volltext

A semi-mechanistic model to characterize the pharmacokinetics and pharmacodynamics of brodalumab in healthy volunteers and subjects with psoriasis in a first-in-human single ascend... von Salinger, David H., Endres, Christopher J., Martin, David A., Gibbs, Megan A.

Volltext

Factors affecting the clinical development of cytochrome P450 3A substrates von GIBBS, Megan A, HOSEA, Natilie A

Volltext

Persistent inhibition of CYP3A4 by ketoconazole in modified Caco-2 cells von GIBBS, M. A, BAILLIE, M. T, SHEN, D. D, KUNZE, K. L, THUMMEL, K. E

Volltext

CYP3A5 polymorphism and alprazolam pharmacokinetics/pharmacodynamics von Venkatakrishnan, Karthik, Gibbs, Megan A.

Volltext

Evaluation of structural models to describe the effect of placebo upon the time course of major depressive disorder von Shang, Elizabeth Y., Gibbs, Megan A., Landen, Jaren W., Krams, Michael, Russell, Tanya, Denman, Nicholas G., Mould, Diane R.

Volltext

Absolute oral bioavailability of traxoprodil in cytochrome P450 2D6 extensive and poor metabolisers von TAYLOR, Timothy J, DIRINGER, Kelly, RUSSELL, Tanya, VENKATAKRISHNAN, Karthik, WILNER, Keith, CROWNOVER, Penelope H, BENINCOSA, Lisa J, GIBBS, Megan A

Volltext

Displacement of Serotonin and Dopamine Transporters by Venlafaxine Extended Release Capsule at Steady State: A [123I]2β-Carbomethoxy-3β-(4-Iodophenyl)-Tropane Single Photon Emissio... von Shang, Yili, Gibbs, Megan A., Marek, Gerard J., Stiger, Thomas, Burstein, Aaron H., Marek, Kenneth, Seibyl, John P., Rogers, Janyce F.

Volltext

Population Pharmacokinetic/Pharmacodynamic Model of Subcutaneous Adipose 11[beta]-Hydroxysteroid Dehydrogenase Type 1 (11[beta]-HSD1) Activity After Oral Administration of AMG 221,... von Gibbs, John P, Emery, Maurice G, McCaffery, Ian, Smith, Brian, Gibbs, Megan A, Akrami, Anna, Rossi, John, Paweletz, Katherine, Gastonguay, Marc R, Bautista, Edgar, Wang, Minghan, Perfetti, Riccardo, Daniels, Oranee

Volltext

Displacement of serotonin and dopamine transporters by venlafaxine extended release capsule at steady state: a [123I]2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane single photon e... von Shang, Yili, Gibbs, Megan A, Marek, Gerard J, Stiger, Thomas, Burstein, Aaron H, Marek, Kenneth, Seibyl, John P, Rogers, Janyce F

Volltext