IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment von Karakasheva, Tatiana A, Lin, Eric W, Tang, Qiaosi, Qiao, Edmund, Waldron, Todd J, Soni, Monica, Klein-Szanto, Andres J, Sahu, Varun, Basu, Devraj, Ohashi, Shinya, Baba, Kiichiro, Giaccone, Zachary T, Walker, Sarah R, Frank, David A, Wileyto, E Paul, Long, Qi, Dunagin, Margaret C, Raj, Arjun, Diehl, J Alan, Wong, K K, Bass, Adam J, Rustgi, Anil K

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The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer von Khan, Mohammad W., Saadalla, Abdulrahman, Ewida, Ahmed H., Al-Katranji, Khalid, Al-Saoudi, Ghadier, Giaccone, Zachary T., Gounari, Fotini, Zhang, Ming, Frank, David A., Khazaie, Khashayarsha

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Gene expression–based discovery of atovaquone as a STAT3 inhibitor and anticancer agent von Xiang, Michael, Kim, Haesook, Ho, Vincent T., Walker, Sarah R., Bar-Natan, Michal, Anahtar, Melodi, Liu, Suhu, Toniolo, Patricia A., Kroll, Yasmin, Jones, Nichole, Giaccone, Zachary T., Heppler, Lisa N., Ye, Darwin Q., Marineau, Jason J., Shaw, Daniel, Bradner, James E., Blonquist, Traci, Neuberg, Donna, Hetz, Claudio, Stone, Richard M., Soiffer, Robert J., Frank, David A.

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Mutant KRAS Downregulates the Receptor for Leukemia Inhibitory Factor (LIF) to Enhance a Signature of Glycolysis in Pancreatic Cancer and Lung Cancer von Liu, Suhu, Gandler, Helen I., Tosic, Isidora, Ye, Darwin Q., Giaccone, Zachary T., Frank, David A.

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Targeting constitutively active STAT3 in chronic lymphocytic leukemia: A clinical trial of the STAT3 inhibitor pyrimethamine with pharmacodynamic analyses von Brown, Jennifer R., Walker, Sarah R., Heppler, Lisa N., Tyekucheva, Svitlana, Nelson, Erik A., Klitgaard, Josephine, Nicolais, Maria, Kroll, Yasmin, Xiang, Michael, Yeh, Jennifer E., Chaudhury, Mousumi, Giaccone, Zachary T., Fernandes, Stacey M., Jacobsen, Eric D., Fisher, David C., Freedman, Arnold S., Davids, Matthew S., Supko, Jeffrey G., Wu, Catherine, Frank, David A.

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Coordination of the third step of protein splicing in two cyanobacterial inteins von Ramsoomair, Christian K., Yakely, Anthony E., Urbanski, Laura M., Karanja, Kevin, Giaccone, Zachary T., Siegart, Nicolle M., Wang, Chunyu, Gomez, Alvin V., Reitter, Julie N., Mills, Kenneth V.

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Abstract B01: Gene expression network--based identification of drugs targeting advanced ovarian cancer von Walker, Sarah R., Giaccone, Zachary T., Frank, David A.

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Abstract B16: STAT3 promotes ovarian cancer spheroid growth and metastasis von Walker, David F., Lacroix, Sarah J., Giaccone, Zachary T., Frank, David A., Walker, Sarah R.

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Abstract B32: Mutant KRAS downregulates LIFR to enhance glycolysis in pancreatic cancer von Liu, Suhu, Gandler, Helen I., Walker, Sarah R., Ye, Darwin Q., Giaccone, Zachary T., Nowak, Jonathan A., Aguirre, Andrew J., Wolpin, Brian M., Frank, David A.

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Abstract NTOC-111: TARGETING COMPONENTS OF THE STAT3 SIGNALING PATHWAY FOR OVARIAN CANCER THERAPY: IMPLICATIONS FROM 3D CULTURE SYSTEMS von Walker, Sarah R., Zhang, Yixi, Liu, Suhu, Giaccone, Zachary T., Frank, David A.

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The Tale of Two Inteins: Similar Inteins with Different C‐termini von Ramsoomair, Christian K, Giaccone, Zachary T, Reitter, Julie N, Mills, Kenneth V

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A Clinical Trial of the STAT3 Inhibitor Pyrimethamine in Chronic Lymphocytic Leukemia von Brown, Jennifer R., Walker, Sarah R., Heppler, Lisa N., Tyekucheva, Svitlana, Nelson, Erik, Klitgaard, Josephine L., Nicolais, Maria, Kroll, Yasmin, Xiang, Michael, Yeh, Jennifer E., Chaudhury, Mousumi, Giaccone, Zachary T., Fernandes, Stacey, Supko, Jeffrey G., Wu, Catherine J., Frank, David A.

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Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies von Broce, Iris, Karch, Celeste M, Wen, Natalie, Fan, Chun C, Wang, Yunpeng, Tan, Chin Hong, Kouri, Naomi, Ross, Owen A, Höglinger, Günter U, Muller, Ulrich, Hardy, John, Momeni, Parastoo, Hess, Christopher P, Dillon, William P, Miller, Zachary A, Bonham, Luke W, Rabinovici, Gil D, Rosen, Howard J, Schellenberg, Gerard D, Franke, Andre, Karlsen, Tom H, Veldink, Jan H, Ferrari, Raffaele, Yokoyama, Jennifer S, Miller, Bruce L, Andreassen, Ole A, Dale, Anders M, Desikan, Rahul S, Sugrue, Leo P

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A Biophysical Analysis of Asp Cyclization Coupled to Peptide Bond Cleavage von Koulopoulos, Michael, Giaccone, Zachary, Reitter, Julie, Mills, Kenneth

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Peptide Bond Cleavage through Asparagine Cyclization von Giaccone, Zachary, Reitter, Julie, Steeves, Adam, Kulik, Heather, Mills, Kenneth

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Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia von Bonham, Luke W., Steele, Natasha Z. R., Karch, Celeste M., Broce, Iris, Geier, Ethan G., Wen, Natalie L., Momeni, Parastoo, Hardy, John, Miller, Zachary A., Gorno-Tempini, Maria Luisa, Hess, Christopher P., Lewis, Patrick, Miller, Bruce L., Seeley, William W., Manzoni, Claudia, Desikan, Rahul S., Baranzini, Sergio E., Ferrari, Raffaele, Yokoyama, Jennifer S.

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Peptide bond cleavage through cyclization of asparagine (768.4) von Giaccone, Zachary, Urbanski, Laura, Siegart, Nicolle, Reitter, Julie, Mills, Kenneth

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Protein network analysis reveals selectively vulnerable regions and biological processes in FTD von Bonham, Luke W, Steele, Natasha Z R, Karch, Celeste M, Manzoni, Claudia, Geier, Ethan G, Wen, Natalie, Ofori-Kuragu, Aaron, Momeni, Parastoo, Hardy, John, Miller, Zachary A, Hess, Christopher P, Lewis, Patrick, Miller, Bruce L, Seeley, William W, Baranzini, Sergio E, Desikan, Rahul S, Ferrari, Raffaele, Yokoyama, Jennifer S

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Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia von Bonham, Luke W, Broce, Iris, Geier, Ethan G, Hess, Christopher P, Lewis, Patrick, Miller, Bruce L, Seeley, William W, Manzoni, Claudia, Desikan, Rahul S, Baranzini, Sergio E, Ferrari, Raffaele, Yokoyama, Jennifer S, Hernandez, D. G, Rohrer, J. D, Ramasamy, A, Kwok, J. B. J, Dobson-Stone, C, Schofield, P. R, Piguet, O, Hernández, I, Ruiz, A, Boada, M, Borroni, B, Cairns, N. J, Benussi, L, Binetti, G, Forloni, G, Galimberti, D, Scarpini, E, Clarimón, J, Lleó, A, Blesa, R, Nilsson, K, Nilsson, C, Mann, D. M. A, Pietrini, P, Jaros, E, Tierney, M. C, Ortega-Cubero, S, Alonso, E, Perneczky, R, Alexopoulos, P, Kurz, A, Rainero, I, Rubino, E, Pinessi, L, Rogaeva, E, St George-Hyslop, P, Rossi, G, Giaccone, G, Rowe, J. B, Schlachetzki, J. C. M, Uphill, J, Van Deerlin, V. M, van der Zee, J, Cappa, S. F, Hannequin, D, Vercelletto, M, Brice, A, Sorbi, S, Bagnoli, S, Piaceri, I, Nielsen, J. E, Ibach, B, Gasparoni, G, Gu, W, Fox, N. C, Warren, J. D, Rizzu, P, Heutink, P, Snowden, J. S, Rollinson, S, Gerhard, A, Bruni, A. C, Cupidi, C, Anfossi, M, Rademakers, R, Graff-Radford, N. R, Knopman, D, Boeve, B. F, Parisi, J. E, Rosen, H, van Swieten, J. C, Dopper, E. G. P, Seelaar, H, Pijnenburg, Y. A. L, Capozzo, R, Franceschi, M, Postiglione, A, Milan, G, Kristiansen, M, Chiang, H. -H, Graff, C, Rollin, A, Deramecourt, V, Lebouvier, T, Kapogiannis, D, Ferrucci, L, Pickering-Brown, S, Singleton, A. B

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Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia von Bonham, Luke W, Broce, Iris, Geier, Ethan G, Hess, Christopher P, Lewis, Patrick, Miller, Bruce L, Seeley, William W, Manzoni, Claudia, Desikan, Rahul S, Baranzini, Sergio E, Ferrari, Raffaele, Yokoyama, Jennifer S, Hernandez, D. G, Rohrer, J. D, Ramasamy, A, Kwok, J. B. J, Dobson-Stone, Carol, Schofield, P. R, Piguet, O, Ruiz, A, Boada, Mercè, Cruchaga, Carlos, Cairns, N. J, Benussi, Luisa, Forloni, G, Albani, Diego, Scarpini, E, Lleó, Alberto, Blesa, Rafael, Nilsson, K, Nilsson, C, Mann, D. M. A, Pietrini, P, Jaros, E, Tierney, M. C, Pastor, Pau, Ortega-Cubero, S, Alonso, E, Alexopoulos, Panagiotis, Kurz, A, Rainero, Innocenzo, Rubino, E, Pinessi, L, Rogaeva, Ekaterina, St George-Hyslop, P, Rossi, G, Tagliavini, Fabrizio, Giaccone, G, Rowe, J. B, Schlachetzki, J. C. M, Uphill, J, Danek, Adrian, Van Deerlin, V. M, van der Zee, J, Cruts, Marc, Van Broeckhoven, C, Cappa, S. F, Leber, Isabelle, Hannequin, D, Vercelletto, M, Brice, Alexis, Sorbi, Sandro, Bagnoli, Silvia, Piaceri, I, Nielsen, J. E, Ibach, B, Gasparoni, G, Gu, W, Fox, N. C, Warren, J. D, Rizzu, P, Heutink, Peter, Snowden, J. S, Gerhard, A, Bruni, A. C, Cupidi, C, Conidi, Maria E, Rademakers, Rosa, Dickson, Dennis W, Graff-Radford, N. R, Knopman, D, Boeve, Bradley F, Parisi, J. E, Rosen, H, van Swieten, J. C, Dopper, E. G. P, Seelaar, H, Pijnenburg, Y. A. L, Logroscino, Giancarlo, Capozzo, R, Franceschi, M, Postiglione, A, Milan, G, Kristiansen, M, Graff, C, Deramecourt, Vincent, Lebouvier, T, Kapogiannis, D, Ferrucci, Luigi, Pickering-Brown, S

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