Human genetics evidence supports two-thirds of the 2021 FDA-approved drugs von Ochoa, David, Karim, Mohd, Ghoussaini, ​​Maya, Hulcoop, David G., McDonagh, Ellen M., Dunham, Ian

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An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci von Mountjoy, Edward, Schmidt, Ellen M., Carmona, Miguel, Schwartzentruber, Jeremy, Peat, Gareth, Miranda, Alfredo, Fumis, Luca, Hayhurst, James, Buniello, Annalisa, Karim, Mohd Anisul, Wright, Daniel, Hercules, Andrew, Papa, Eliseo, Fauman, Eric B., Barrett, Jeffrey C., Todd, John A., Ochoa, David, Dunham, Ian, Ghoussaini, Maya

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Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation von Jerber, Julie, Seaton, Daniel D., Cuomo, Anna S. E., Kumasaka, Natsuhiko, Haldane, James, Steer, Juliette, Patel, Minal, Pearce, Daniel, Andersson, Malin, Bonder, Marc Jan, Mountjoy, Ed, Ghoussaini, Maya, Lancaster, Madeline A., Marioni, John C., Merkle, Florian T., Gaffney, Daniel J., Stegle, Oliver

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A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance von Anisul, Mohd, Shilts, Jarrod, Schwartzentruber, Jeremy, Hayhurst, James, Buniello, Annalisa, Shaikho Elhaj Mohammed, Elmutaz, Zheng, Jie, Holmes, Michael, Ochoa, David, Carmona, Miguel, Maranville, Joseph, Gaunt, Tom R, Emilsson, Valur, Gudnason, Vilmundur, McDonagh, Ellen M, Wright, Gavin J, Ghoussaini, Maya, Dunham, Ian

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A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression von Meyer, Kerstin B, Maia, Ana-Teresa, O'Reilly, Martin, Ghoussaini, Maya, Prathalingam, Radhika, Porter-Gill, Patricia, Ambs, Stefan, Prokunina-Olsson, Ludmila, Carroll, Jason, Ponder, Bruce A J

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Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features von Bonnefond, Amélie, Raimondo, Anne, Stutzmann, Fanny, Ghoussaini, Maya, Ramachandrappa, Shwetha, Bersten, David C, Durand, Emmanuelle, Vatin, Vincent, Balkau, Beverley, Lantieri, Olivier, Raverdy, Violeta, Pattou, François, Van Hul, Wim, Van Gaal, Luc, Peet, Daniel J, Weill, Jacques, Miller, Jennifer L, Horber, Fritz, Goldstone, Anthony P, Driscoll, Daniel J, Bruning, John B, Meyre, David, Whitelaw, Murray L, Froguel, Philippe

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Multi-ancestry Mendelian randomization of omics traits revealing drug targets of COVID-19 severity von Zheng, Jie, Zhang, Yuemiao, Zhao, Huiling, Liu, Yi, Baird, Denis, Karim, Mohd Anisul, Ghoussaini, Maya, Schwartzentruber, Jeremy, Dunham, Ian, Elsworth, Benjamin, Roberts, Katherine, Compton, Hannah, Miller-Molloy, Felix, Liu, Xingzi, Wang, Lin, Zhang, Hong, Smith, George Davey, Gaunt, Tom R

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Inherited Genetic Susceptibility to Breast Cancer von Ghoussaini, Maya, Pharoah, Paul D.P, Easton, Douglas F

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Future prospects for human genetics and genomics in drug discovery von Ghoussaini, Maya, Nelson, Matthew R., Dunham, Ian

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Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics von Ghoussaini, Maya, Mountjoy, Edward, Carmona, Miguel, Peat, Gareth, Schmidt, Ellen M, Hercules, Andrew, Fumis, Luca, Miranda, Alfredo, Carvalho-Silva, Denise, Buniello, Annalisa, Burdett, Tony, Hayhurst, James, Baker, Jarrod, Ferrer, Javier, Gonzalez-Uriarte, Asier, Jupp, Simon, Karim, Mohd Anisul, Koscielny, Gautier, Machlitt-Northen, Sandra, Malangone, Cinzia, Pendlington, Zoe May, Roncaglia, Paola, Suveges, Daniel, Wright, Daniel, Vrousgou, Olga, Papa, Eliseo, Parkinson, Helen, MacArthur, Jacqueline A L, Todd, John A, Barrett, Jeffrey C, Schwartzentruber, Jeremy, Hulcoop, David G, Ochoa, David, McDonagh, Ellen M, Dunham, Ian

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Mapping the human genetic architecture of COVID-19 von Niemi, Mari E. K., Karjalainen, Juha, Daly, Mark, Ganna, Andrea, Mehtonen, Juha, Cordioli, Mattia, Kaunisto, Mari, Pigazzini, Sara, Donner, Kati, Kivinen, Katja, Palotie, Aarno, Daly, Mark J., Liao, Rachel G., Kanai, Masahiro, Veerapen, Kumar, Minica, Camelia, Trankiem, Amy, Balaconis, Mary K., Nguyen, Huy, Solomonson, Matthew, Francioli, Laurent, Wang, Qingbo, Green, Robert C., Bryant, Sam, Finucane, Hilary, Martin, Alicia R., Zhou, Wei, Nkambule, Lindokuhle, Karczewski, Konrad J., Atkinson, Elizabeth G., Tsuo, Kristin, Baya, Nikolas, Turley, Patrick, Gupta, Rahul, Walters, Raymond K., Palmer, Duncan S., Sarma, Gopal, Cheng, Nathan, Lu, Wenhan, Churchhouse, Claire, Goldstein, Jacqueline, King, Daniel, Seed, Cotton, Neale, Benjamin M., Satterstrom, F. Kyle, Pathak, Gita A., Wendt, Frank R., Polimanti, Renato, Andrews, Shea J., Sloofman, Laura, Sealfon, Stuart C., Fernandez-Cadenas, Israel, Schulte, Eva C., Protzer, Ulrike, Striano, Pasquale, Coviello, Domenico A., Zara, Federico, Salpietro, Vincenzo, Iacomino, Michele, Scudieri, Paolo, Bocciardi, Renata, Minetti, Carlo, Vari, Maria Stella, Madia, Francesca, Marouli, Eirini, Kanoni, Stavroula, Moutsianas, Loukas, Karim, Mohd Anisul, Ghoussaini, Maya, Schwartzentruber, Jeremy, Dunham, Ian, Savage, Jeanne, Posthuma, Danielle, Tissink, Elleke, Uffelmann, Emil, Butler-Laporte, Guillaume, Richards, J. Brent, Nakanishi, Tomoko, Morrison, David R., Forgetta, Vincenzo, Ghosh, Biswarup, Laurent, Laetitia, Henry, Danielle, Abdullah, Tala, Adeleye, Olumide, Mamlouk, Noor, Kimchi, Nofar, Afrasiabi, Zaman, Rezk, Nardin, Vulesevic, Branka, Bouab, Meriem, Guzman, Charlotte, Petitjean, Louis, Tselios, Chris, Xue, Xiaoqing, Afilalo, Jonathan, Adra, Darin, Kim, Han-Na, Okada, Yukinori, Byun, Jinyoung

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Open Targets Platform: supporting systematic drug–target identification and prioritisation von Ochoa, David, Hercules, Andrew, Carmona, Miguel, Suveges, Daniel, Gonzalez-Uriarte, Asier, Malangone, Cinzia, Miranda, Alfredo, Fumis, Luca, Carvalho-Silva, Denise, Spitzer, Michaela, Baker, Jarrod, Ferrer, Javier, Raies, Arwa, Razuvayevskaya, Olesya, Faulconbridge, Adam, Petsalaki, Eirini, Mutowo, Prudence, Machlitt-Northen, Sandra, Peat, Gareth, McAuley, Elaine, Ong, Chuang Kee, Mountjoy, Edward, Ghoussaini, Maya, Pierleoni, Andrea, Papa, Eliseo, Pignatelli, Miguel, Koscielny, Gautier, Karim, Mohd, Schwartzentruber, Jeremy, Hulcoop, David G, Dunham, Ian, McDonagh, Ellen M

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Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population von Ghoussaini, Maya, Meyre, David, Lobbens, Stéphane, Charpentier, Guillaume, Clément, Karine, Charles, Marie-Aline, Tauber, Maïté, Weill, Jacques, Froguel, Philippe

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Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms von Gordon, David E., Hiatt, Joseph, Bouhaddou, Mehdi, Rezelj, Veronica V., Ulferts, Svenja, Braberg, Hannes, Jureka, Alexander S., Obernier, Kirsten, Guo, Jeffrey Z., Batra, Jyoti, Kaake, Robyn M., Weckstein, Andrew R., Owens, Tristan W., Gupta, Meghna, Pourmal, Sergei, Titus, Erron W., Cakir, Merve, Soucheray, Margaret, McGregor, Michael, Cakir, Zeynep, Jang, Gwendolyn, O'Meara, Matthew J., Tummino, Tia A., Zhang, Ziyang, Foussard, Helene, Rojc, Ajda, Zhou, Yuan, Kuchenov, Dmitry, Huttenhain, Ruth, Xu, Jiewei, Eckhardt, Manon, Swaney, Danielle L., Fabius, Jacqueline M., Ummadi, Manisha, Tutuncuoglu, Beril, Rathore, Ujjwal, Modak, Maya, Haas, Paige, Haas, Kelsey M., Naing, Zun Zar Chi, Pulido, Ernst H., Shi, Ying, Barrio-Hernandez, Inigo, Memon, Danish, Petsalaki, Eirini, Dunham, Alistair, Marrero, Miguel Correa, Burke, David, Koh, Cassandra, Vallet, Thomas, Silvas, Jesus A., Azumaya, Caleigh M., Billesbolle, Christian, Brilot, Axel F., Campbell, Melody G., Diallo, Amy, Dickinson, Miles Sasha, Diwanji, Devan, Herrera, Nadia, Hoppe, Nick, Kratochvil, Huong T., Liu, Yanxin, Merz, Gregory E., Moritz, Michelle, Nguyen, Henry C., Nowotny, Carlos, Puchades, Cristina, Rizo, Alexandrea N., Schulze-Gahmen, Ursula, Smith, Amber M., Sun, Ming, Young, Iris D., Zhao, Jianhua, Asarnow, Daniel, Biel, Justin, Bowen, Alisa, Braxton, Julian R., Chen, Jen, Chio, Cynthia M., Chio, Un Seng, Deshpande, Ishan, Doan, Loan, Faust, Bryan, Flores, Sebastian, Jin, Mingliang, Kim, Kate, Lam, Victor L., Li, Fei, Li, Junrui, Li, Yen-Li, Li, Yang, Liu, Xi, Lo, Megan, Lopez, Kyle E., Melo, Arthur A., Moss, Frank R., Phuong Nguyen, Paulino, Joana, Pawar, Komal Ishwar, Peters, Jessica K.

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The next-generation Open Targets Platform: reimagined, redesigned, rebuilt von Ochoa, David, Hercules, Andrew, Carmona, Miguel, Suveges, Daniel, Baker, Jarrod, Malangone, Cinzia, Lopez, Irene, Miranda, Alfredo, Cruz-Castillo, Carlos, Fumis, Luca, Bernal-Llinares, Manuel, Tsukanov, Kirill, Cornu, Helena, Tsirigos, Konstantinos, Razuvayevskaya, Olesya, Buniello, Annalisa, Schwartzentruber, Jeremy, Karim, Mohd, Ariano, Bruno, Martinez Osorio, Ricardo Esteban, Ferrer, Javier, Ge, Xiangyu, Machlitt-Northen, Sandra, Gonzalez-Uriarte, Asier, Saha, Shyamasree, Tirunagari, Santosh, Mehta, Chintan, Roldán-Romero, Juan María, Horswell, Stuart, Young, Sarah, Ghoussaini, Maya, Hulcoop, David G, Dunham, Ian, McDonagh, Ellen M

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Network expansion of genetic associations defines a pleiotropy map of human cell biology von Barrio-Hernandez, Inigo, Schwartzentruber, Jeremy, Shrivastava, Anjali, del-Toro, Noemi, Gonzalez, Asier, Zhang, Qian, Mountjoy, Edward, Suveges, Daniel, Ochoa, David, Ghoussaini, Maya, Bradley, Glyn, Hermjakob, Henning, Orchard, Sandra, Dunham, Ian, Anderson, Carl A., Porras, Pablo, Beltrao, Pedro

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A map of transcriptional heterogeneity and regulatory variation in human microglia von Young, Adam M. H., Kumasaka, Natsuhiko, Calvert, Fiona, Hammond, Timothy R., Knights, Andrew, Panousis, Nikolaos, Park, Jun Sung, Schwartzentruber, Jeremy, Liu, Jimmy, Kundu, Kousik, Segel, Michael, Murphy, Natalia A., McMurran, Christopher E., Bulstrode, Harry, Correia, Jason, Budohoski, Karol P., Joannides, Alexis, Guilfoyle, Mathew R., Trivedi, Rikin, Kirollos, Ramez, Morris, Robert, Garnett, Matthew R., Timofeev, Ivan, Jalloh, Ibrahim, Holland, Katherine, Mannion, Richard, Mair, Richard, Watts, Colin, Price, Stephen J., Kirkpatrick, Peter J., Santarius, Thomas, Mountjoy, Edward, Ghoussaini, Maya, Soranzo, Nicole, Bayraktar, Omer A., Stevens, Beth, Hutchinson, Peter J., Franklin, Robin J. M., Gaffney, Daniel J.

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Inherited genetic susceptibility to breast cancer: the beginning of the end or the end of the beginning? von Ghoussaini, Maya, Pharoah, Paul D P, Easton, Douglas F

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Large-scale genotyping identifies 41 new loci associated with breast cancer risk von Hall, Per, Gonzalez-Neira, Anna, Dennis, Joe, Milne, Roger L, Schmidt, Marjanka K, Bojesen, Stig E, Wang, Qin, Dicks, Ed, Lee, Andrew, Turnbull, Clare, Rahman, Nazneen, Gibson, Lorna, Muranen, Taru A, Adank, Muriel, Dahmen, Norbert, Beckman, Lars, Meindl, Alfons, Lichtner, Peter, Southey, Melissa C, Makalic, Enes, Tessier, Daniel C, Canisius, Sander, Brown, Judith, Humphreys, Keith, Li, Jingmei, Couch, Fergus J, Lambrechts, Diether, Rudolph, Anja, Flesch-Janys, Dieter, Johnson, Nichola, Broeks, Annegien, Schneeweiss, Andreas, Burwinkel, Barbara, Zamora, M Pilar, Perez, Jose Ignacio Arias, Alonso, M Rosario, Brock, Ian W, Cross, Simon S, Sawyer, Elinor J, Kerin, Michael J, Henderson, Brian E, Le Marchand, Loic, Andrulis, Irene L, Knight, Julia A, Lindblom, Annika, Margolin, Sara, Hooning, Maartje J, Hollestelle, Antoinette, van den Ouweland, Ans M W, Jager, Agnes, Dite, Gillian S, Apicella, Carmel, Tsimiklis, Helen, Baglietto, Laura, Brenner, Hermann, Arndt, Volker, Stegmaier, Christa, Swerdlow, Anthony, Ashworth, Alan, Jones, Michael, Figueroa, Jonine, Lissowska, Jolanta, Goldberg, Mark S, Labrèche, France, Pylkäs, Katri, Jukkola-Vuorinen, Arja, Brauch, Hiltrud, Hamann, Ute, Brüning, Thomas, Peterlongo, Paolo, Manoukian, Siranoush, van Asperen, Christi J, Jaworska, Katarzyna, Durda, Katarzyna, Mannermaa, Arto, Bogdanova, Natalia V, Antonenkova, Natalia N, Kristensen, Vessela N, Anton-Culver, Hoda, Toland, Amanda E, Edge, Stephen, Fostira, Florentia, Yoo, Keun-Young, Iwata, Hiroji, Wu, Anna H, Stram, Daniel O, Shu, Xiao-Ou, Lu, Wei, Gao, Yu-Tang, Cai, Hui, Yip, Cheng Har, Phuah, Sze Yee, Miao, Hui, Siriwanarangsan, Pornthep, Shen, Chen-Yang, Blot, William J, Cai, Qiuyin, Deming-Halverson, Sandra, Shrubsole, Martha, Benitez, Javier

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A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer von Michailidou, Kyriaki, Lu, Yingchang, Cai, Qiuyin, Rozali, Esdy, Li, Bingshan, Barfield, Richard T., Andrulis, Irene L., Anton-Culver, Hoda, Barrdahl, Myrto, Baynes, Caroline, Beckmann, Matthias W., Benitez, Javier, Brauch, Hiltrud, Brinton, Louise, Broberg, Per, Brucker, Sara Y., Burwinkel, Barbara, Caldés, Trinidad, Canzian, Federico, Christiansen, Hans, Collée, Margriet, Cornelissen, Sten, Couch, Fergus J., Cox, David, Cross, Simon S., Cunningham, Julie M., Dörk, Thilo, dos-Santos-Silva, Isabel, Eccles, Diana M., Engel, Christoph, Eriksson, Mikael, Fachal, Laura, Figueroa, Jonine, Flesch-Janys, Dieter, Fletcher, Olivia, Gabrielson, Marike, Gaudet, Mia M., Giles, Graham G., Goldberg, Mark S., González-Neira, Anna, Guénel, Pascal, Håkansson, Niclas, Hall, Per, Hamann, Ute, Harrington, Patricia, Hein, Alexander, Hicks, Belynda, Hoover, Robert N., Huang, Guanmengqian, Humphreys, Keith, Hunter, David J., Jakubowska, Anna, John, Esther M., Jones, Kristine, Jones, Michael E., Jung, Audrey, Khusnutdinova, Elza, Kristensen, Vessela N., Lambrechts, Diether, Le Marchand, Loic, Li, Jingmei, Lo, Wing-Yee, Loibl, Sibylle, Lubinski, Jan, Luccarini, Craig, Lux, Michael P., Meindl, Alfons, Nevanlinna, Heli, Olopade, Olufunmilayo I., Peterlongo, Paolo, Peto, Julian, Presneau, Nadege, Rennert, Gad, Romero, Atocha, Romm, Jane, Rudolph, Anja, Saloustros, Emmanouil, Sandler, Dale P., Schmidt, Marjanka K., Scott, Rodney J., Scott, Christopher G., Seal, Sheila, Surowy, Harald, Tamimi, Rulla M., Tapper, William, Tessier, Daniel C., Tollenaar, Rob A. E. M., Torres, Diana, Truong, Thérèse, Van Den Berg, David, Vincent, Daniel, Whittemore, Alice S., Wildiers, Hans, Willett, Walter C., Wolk, Alicja, Ziogas, Argyrios, Dunning, Alison M., Simard, Jacques, Easton, Douglas F., Zheng, Wei

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