FRONTOTEMPORAL LOBAR DEGENERATION: CLINICAL PICTURES, NEUROPATHOLOGIES AND GENETICS von Ghetti, Bernardino Francesco

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Single‐nuclei transcriptomic identifies type‐specific neuronal cell vulnerability and non‐neuronal molecular changes in Amnestic and Logopenic Variant Primary Progressive Aphasia A... von Pereira, Felipe Luiz, Lew, Caroline, Li, Song Hua, Soloviev, Alexander, Spina, Salvatore, Seeley, William W., Suemoto, Claudia Kimie, Leite, Renata Elaine Paraizo, Newell, Kathy L, Ghetti, Bernardino Francesco, Murray, Melissa E., Grinberg, Lea T.

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Identification and characterization of novel anti‐tau antibodies that inhibit tau‐seed mediated pathology in a P301S tauopathy mouse model Alzheimer’s Disease and tauopathies von Liu, Wencheng, Kurella, Vinodh, Liu, Li, Kavanagh, Dillon, Paranjpe, Maneesha, Holth, Jerrah, Chung, Charlotte, Powers, Alex, Ren, Xiao‐Qin, Shu, Yanqun, Capili, Allen, Hou, Jay, Ghetti, Bernardino Francesco, Bales, Kelly R., Paul, Steven M., Carter, Todd

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P4‐257: NEURONS WITH TAU AGGREGATES EXPOSE PHOSPHATIDYLSERINE AND ARE PHAGOCYTOSED LIVE BY MICROGLIA von Brelstaff, Jack H., Tolkovsky, Aviva, Ghetti, Bernardino Francesco, Goedert, Michel, Spillantini, Maria Grazia

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NEURONS WITH TAU AGGREGATES EXPOSE PHOSPHATIDYLSERINE AND ARE PHAGOCYTOSED LIVE BY MICROGLIA von Brelstaff, Jack H., Tolkovsky, Aviva, Ghetti, Bernardino Francesco, Goedert, Michel, Spillantini, Maria Grazia

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Structural variants in Lewy body dementia and frontotemporal dementia spectrum von Kaivola, Karri, Chia, Ruth, Ding, Jinhui, Rasheed, Memoona, Fujita, Masashi, Menon, Vilas, Walton, Ronald L., Collins, Ryan, Billingsley, Kimberley, Brand, Harrison, Talkowski, Michael, Zhao, Xuefang, Dewan, Ramita, Ray, Anindita K, Solaiman, Sultana, Jerez, Pilar Alvarez, Malik, Laksh, Dawson, Ted M, Rosenthal, Liana, Albert, Marilyn S., Pletnikova, Olga, Troncoso, Juan C, Masellis, Mario, Keith, Julia, Black, Sandra E., Ferrucci, Luigi, Resnick, Susan M., Tanaka, Toshiko, Topol, Eric, Torkamani, Ali, Tienari, Pentti, Foroud, Tatiana M., Ghetti, Bernardino Francesco, Landers, John E, Ryten, Mina, Morris, Huw R, Hardy, John A., Mazzini, Letizia, D'Alfonso, Sandra, Moglia, Cristina, Calvo, Andrea, Serrano, Geidy E, Beach, Thomas G, Ferman, Tanis J, Graff‐Radford, Neill R, Boeve, Brad F., Wszolek, Zbigniew, Dickson, Dennis W., Chio, Adriano, Bennett, David A. A, De Jager, Philip L, Ross, Owen A., Dalgard, Clifton L., Gibbs, J. Raphael, Traynor, Bryan J, Scholz, Sonja W

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ULTRASENSITIVE AND SELECTIVE DETECTION OF 3-REPEAT TAU SEEDING ACTIVITY IN PICK DISEASE BRAIN AND CEREBROSPINAL FLUID USING TAU RT-QUIC von Saijo, Eri, Ghetti, Bernardino Francesco, Zanusso, Gianluigi, Oblak, Adrian L., Furman, Jennifer L., Diamond, Marc, Caughey, Byron

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RAPID AND ULTRA-SENSITIVE DETECTION OF α-SYNUCLEIN SEEDS IN BRAIN AND CEREBROSPINAL FLUID BY α-SYN RT-QUIC: AN AID TO DIAGNOSIS FOR PD AND DLB von Galasko, Doug R., Groveman, Bradley R., Orru, Christina D., Hughson, Andrew G., Raymond, Lynne D., Zanusso, Gianluigi, Ghetti, Bernardino Francesco, Campbell, Katrina J., Safar, Jiri, Caughey, Byron

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P1‐250: RAPID AND ULTRA‐SENSITIVE DETECTION OF α‐SYNUCLEIN SEEDS IN BRAIN AND CEREBROSPINAL FLUID BY α‐SYN RT‐QUIC: AN AID TO DIAGNOSIS FOR PD AND DLB von Galasko, Doug R., Groveman, Bradley R., Orru, Christina D., Hughson, Andrew G., Raymond, Lynne D., Zanusso, Gianluigi, Ghetti, Bernardino Francesco, Campbell, Katrina J., Safar, Jiri, Caughey, Byron

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Presence of co‐pathology in sporadic early‐onset Alzheimer disease versus dominantly inherited Alzheimer disease von Llibre‐Guerra, Jorge J, Li, Yan, Franklin, Erin E., Miller, Carol A, Teich, Andrew F, Kofler, Julia, Dickson, Dennis W, Ghetti, Bernardino Francesco, Frosch, Matthew P., Halliday, Glenda M, McLean, Catriona, Lashley, Tammaryn, Gordon, Brian A., Schindler, Suzanne E., Chen, Charles D., Fagan, Anne M., Benzinger, Tammie L.S., Wang, Guoqiao, Hassenstab, Jason, Morris, John C., Bateman, Randall J., Perrin, Richard J., McDade, Eric

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NEURODEGENERATION-ASSOCIATED PROTEINS IN HUMAN OLFACTORY NEURONS von Zanusso, Gianluigi, Sacchetto, Luca, Brozzetti, Lorenzo, Olivieri, Dario, Ferrari, Sergio, Faccioli, Luca, Bongianni, Matilde, Pedrazzoli, Matteo, Buffelli, Mario, Monaco, Salvatore, Pocchiari, Maurizio, Caughey, Byron, Ghetti, Bernardino Francesco

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CRYO-EM STRUCTURES OF TAU FILAMENTS FROM ALZHEIMER'S DISEASE BRAIN von Fitzpatrick, Anthony, Falcon, Benjamin, He, Shaoda, Murzin, Alexey, Murshudov, Garib, Garringer, Holly, Crowther, Anthony, Ghetti, Bernardino Francesco, Goedert, Michel, Scheres, Sjors

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P4‐094: OCCIPITAL TO GLOBAL PIB UPTAKE IS ASSOCIATED WITH THE PRESENCE OF MICROHEMORRHAGES AND MUTATIONS ASSOCIATED WITH CEREBRAL AMYLOID ANGIOPATHY IN THE DOMINANTLY INHERITED ALZ... von Joe, Elizabeth B., Joseph-Mathurin, Nelly, Benzinger, Tammie L.S., Bateman, Randall J., McDade, Eric, Ghetti, Bernardino Francesco, Levin, Johannes, Vöglein, Jonathan, Fox, Nick C., Sperling, Reisa A., Chhatwal, Jasmeer P., Noble, James, Salloway, Stephen, Chui, Helena C., Ringman, John M.

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ANTI-CONFORMATIONAL MONOCLONAL ANTIBODY WITH SELECTIVE PREFERENCE FOR PRP RES STRAINS FROM DIFFERENT ANIMAL SPECIES AND HUMANS von Goni, Fernando, Prelli, Frances, Drummond, Eleanor, Herline, Krystal, Marta, Mithchell, Sun, Yanjie, Ghetti, Bernardino Francesco, Wisniewski, Thomas

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P3‐009: PSEN1 M233V MUTATION CAUSES VERY EARLY ONSET ALZHEIMER DISEASE: THE IMPORTANCE OF NEUROPATHOLOGIC ARCHIVAL TISSUE von Ghetti, Bernardino Francesco, Dickson, Dennis W., Ilangovan, Saroja, Reyes, Marc G., Oblak, Adrian L., Epperson, Francine, Murrell, Jill R.

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P4‐147: PHENOTYPIC CHARACTERIZATION OF EARLY ONSET FAMILIAL AD ASSOCIATED WITH A PSEN1 L418F MUTATION von Newell, Kathy, Vonsattel, Jean Paul, Murrell, Jill, Ghetti, Bernardino Francesco, Gambetti, Pierluigi, Dubinsky, Richard, Swerdlow, Russell H.

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P3‐008: EARLY ONSET AND RAPID COURSE OF ALZHEIMER DISEASE ASSOCIATED WITH THE I143T PSEN1 MUTATION von Ghetti, Bernardino Francesco, Miller, Douglas C., Zou, Wenquan, Cohen, Yvonne, Richardson, Rose, Oblak, Adrian L., Gambetti, Pierluigi, Murrell, Jill R.

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P4‐372: ANTI‐CONFORMATIONAL MONOCLONAL ANTIBODY WITH SELECTIVE PREFERENCE FOR PRP RES STRAINS FROM DIFFERENT ANIMAL SPECIES AND HUMANS von Goni, Fernando, Prelli, Frances, Drummond, Eleanor, Herline, Krystal, Marta, Mithchell, Sun, Yanjie, Ghetti, Bernardino Francesco, Wisniewski, Thomas

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PHENOTYPIC CHARACTERIZATION OF EARLY ONSET FAMILIAL AD ASSOCIATED WITH A PSEN1 L418F MUTATION von Newell, Kathy, Vonsattel, Jean Paul, Murrell, Jill, Ghetti, Bernardino Francesco, Gambetti, Pierluigi, Dubinsky, Richard, Swerdlow, Russell H

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LONGITUDINAL BIOMARKER CHANGES IN AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE FROM THE DIAN STUDY von McDade, Eric, Wang, Guoqiao, Benzinger, Tammie L.S., Buckles, Virginia D., Fagan, Anne M., Gordon, Brian A., Hassenstab, Jason, Holtzman, David M., Cairns, Nigel J., Goate, Alison M., Marcus, Daniel S., Morris, John C., Paumier, Katrina L., Xiong, Chengjie, Ricardo, Allegri, Berman, Sarah, Mayeux, Richard, Ringman, John M., Ghetti, Bernardino Francesco, Farlow, Martin R., Chhatwal, Jasmeer P., Salloway, Stephen, Graff-Radford, Neill R., Schofield, Peter R., Masters, Colin L., Martins, Ralph N., Rossor, Martin N., Fox, Nick C., Levin, Johannes, Jucker, Mathias, Bateman, Randall J.

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