The c-myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells von Zhao, Huiwu, Kalota, Anna, Jin, Shenghao, Gewirtz, Alan M.

Volltext

Embryonic and adult stem cell therapy von Brignier, Anne C., MD, Gewirtz, Alan M., MD

Volltext

c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis von Jin, Shenghao, Zhao, Huiwu, Yi, Yan, Nakata, Yuji, Kalota, Anna, Gewirtz, Alan M

Volltext

Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells von Ptasznik, Andrzej, Gewirtz, Alan M, Nakata, Yuji, Kalota, Anna, Emerson, Stephen G

Volltext

Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing von Deleavey, Glen F, Watts, Jonathan K, Alain, Tommy, Robert, Francis, Kalota, Anna, Aishwarya, Veenu, Pelletier, Jerry, Gewirtz, Alan M, Sonenberg, Nahum, Damha, Masad J

Volltext

Numerous growth factors, cytokines, and chemokines are secreted by human CD34+ cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocr... von Majka, Marcin, Janowska-Wieczorek, Anna, Ratajczak, Janina, Ehrenman, Karen, Pietrzkowski, Zbigniew, Kowalska, M. Anna, Gewirtz, Alan M., Emerson, Stephen G., Ratajczak, Mariusz Z.

Volltext

Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells von Drabsch, Yvette, Hugo, Honor, Zhang, Rui, Dowhan, Dennis H, Miao, Yu Rebecca, Gewirtz, Alan M, Barry, Simon C, Ramsay, Robert G, Gonda, Thomas J

Volltext

c-Myb and GATA-3 cooperatively regulate IL-13 expression via conserved GATA-3 response element and recruit mixed lineage leukemia (MLL) for histone modification of the IL-13 locus von Kozuka, Teruhiko, Sugita, Mayumi, Shetzline, Susan, Gewirtz, Alan M, Nakata, Yuji

Volltext

A Phase I Study of the Mammalian Target of Rapamycin Inhibitor Sirolimus and MEC Chemotherapy in Relapsed and Refractory Acute Myelogenous Leukemia von Perl, Alexander E, Kasner, Margaret T, Tsai, Donald E, Vogl, Dan T, Loren, Alison W, Schuster, Stephen J, Porter, David L, Stadtmauer, Edward A, Goldstein, Steven C, Frey, Noelle V, Nasta, Sunita D, Hexner, Elizabeth O, Dierov, Jamil K, Swider, Cezary R, Bagg, Adam, Gewirtz, Alan M, Carroll, Martin, Luger, Selina M

Volltext

A prototype nonpeptidyl, hydrazone class, thrombopoietin receptor agonist, SB-559457, is toxic to primary human myeloid leukemia cells von Kalota, Anna, Gewirtz, Alan M.

Volltext

c-Myb Contributes to G2/M Cell Cycle Transition in Human Hematopoietic Cells by Direct Regulation of Cyclin B1 Expression von Nakata, Yuji, Shetzline, Susan, Sakashita, Chizuko, Kalota, Anna, Rallapalli, Ravikumar, Rudnick, Stephen I., Zhang, Yi, Emerson, Stephen G., Gewirtz, Alan M.

Volltext

Phenylpyrrolocytosine as an Unobtrusive Base Modification for Monitoring Activity and Cellular Trafficking of siRNA von Wahba, Alexander S, Azizi, Fereshteh, Deleavey, Glen F, Brown, Claire, Robert, Francis, Carrier, Marilyn, Kalota, Anna, Gewirtz, Alan M, Pelletier, Jerry, Hudson, Robert H. E, Damha, Masad J

Volltext

Real time detection of DNA⋅RNA hybridization in living cells von Sokol, Deborah L., Zhang, Xiaolin, Lu, Ponzy, Gewirtz, Alan M.

Volltext

On future's doorstep: RNA interference and the pharmacopeia of tomorrow von Gewirtz, Alan M

Volltext

The Histone Acetyltransferase TIP60 Interacts with c-Myb and Inactivates Its Transcriptional Activity in Human Leukemia von Zhao, Huiwu, Jin, Shenghao, Gewirtz, Alan M.

Volltext

Nucleic-acid therapeutics: basic principles and recent applications von Gewirtz, Alan M, Opalinska, Joanna B

Volltext

Integrin inhibition through Lyn-dependent cross talk from CXCR4 chemokine receptors in normal human CD34+ marrow cells von Nakata, Yuji, Tomkowicz, Brian, Gewirtz, Alan M., Ptasznik, Andrzej

Volltext

Effects of local mRNA structure on posttranscriptional gene silencing von Rudnick, Stephen I, Swaminathan, Jyothishmathi, Sumaroka, Marina, Liebhaber, Stephen, Gewirtz, Alan M

Volltext

Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells von Ptasznik, Andrzej, Urbanowska, Elzbieta, Chinta, Suneetha, Costa, Melinda A, Katz, Benjamin A, Stanislaus, Marisha A, Demir, Gokhan, Linnekin, Diana, Pan, Zhixing K, Gewirtz, Alan M

Volltext

Antitumor Efficacy of the Cytotoxic RNase, Ranpirnase, on A549 Human Lung Cancer Xenografts of Nude Mice von LEE, Intae, KALOTA, Anna, GEWIRTZ, Alan M, SHOGEN, Kuslima

Volltext