Abstract 3003: OMX-4.80P, a novel H-NOX oxygen carrier that oxygenates hypoxic tumors in multiple tumor models and canine cancer patients, downregulates HIF-1 pathway and increases... von Krtolica, Ana, Le Moan, Natacha, Getz, Jen, Davis, Tina, Ng, Sarah, Bedard, Catherine, Davis, Andrew, Leung, Philberta, Serwer, Laura, Tanaka, Kevin, Keating, Tim, Yan, Feng, Guerrero, Teri, Kent, Michael, Dickinson, Peter, Winger, Jonathan, Cary, Stephen P. L.

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ATPS-49RESULTS OF A PHASE 0 CLINICAL TRIAL IN CANINE BRAIN CANCER EVALUATING SAFETY AND ACTIVITY OF OMX-4.80P, A PROTEIN OXYGEN CARRIER IND CANDIDATE FOR TREATMENT OF GLIOBLASTOMA von Leung, Philberta, Le Moan, Natacha, Getz, Jen, Ng, Sarah, Bedard, Catherine, Davis, Tina, Liang, Carol, Davis, Andrew, Serwer, Laura, Tanaka, Kevin, Keating, Tim, Yan, Feng, Winger, Jonathan, Sturges, Beverly, Guerrero, Teri, Dickinson, Peter, Kent, Michael, Cary, Stephen, Krtolica, Ana

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ET-31 RADIOSENSITIZATION BY OMX-4.80P, A PEGylated H-NOX OXYGEN CARRIER THAT PENETRATES AND OXYGENATES HYPOXIC TUMORS, IN PRECLINICAL MODELS OF GLIOBLASTOMA AND OTHER HYPOXIC CANCE... von Krtolica, A., Le Moan, N., Getz, J., Davis, T., Ng, S., Bedard, C., Davis, A., Leung, P., Serwer, L., Tanaka, K., Keating, T., Yan, F., Winger, J., Cary, S.

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ET-32 HYPOXIA REDUCTION IN INTRACRANIAL GLIOBLASTOMA MODELS BY OMX-4.80P, A PEGylated ENGINEERED H-NOX OXYGEN CARRIER THAT IS LONG-LASTING IN CIRCULATION AND SAFE von Le Moan, N., Getz, J., Ng, S., Davis, T., Bedard, C., Davis, A., Leung, P., Serwer, L., Tanaka, K., Keating, T., Yan, F., Winger, J., Cary, S., Krtolica, A.

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ET-31RADIOSENSITIZATION BY OMX-4.80P, A PEGylated H-NOX OXYGEN CARRIER THAT PENETRATES AND OXYGENATES HYPOXIC TUMORS, IN PRECLINICAL MODELS OF GLIOBLASTOMA AND OTHER HYPOXIC CANCER... von Krtolica, Ana, Le Moan, Natacha, Getz, Jen, Davis, Tina, Ng, Sarah, Bedard, Catherine, Davis, Andrew, Leung, Philberta, Serwer, Laura, Tanaka, Kevin, Keating, Tim, Yan, Feng, Winger, Jonathan, Cary, Stephen

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ET-32HYPOXIA REDUCTION IN INTRACRANIAL GLIOBLASTOMA MODELS BY OMX-4.80P, A PEGylated ENGINEERED H-NOX OXYGEN CARRIER THAT IS LONG-LASTING IN CIRCULATION AND SAFE von Le Moan, Natacha, Getz, Jen, Ng, Sarah, Davis, Tina, Bedard, Catherine, Davis, Andrew, Leung, Philberta, Serwer, Laura, Tanaka, Kevin, Keating, Tim, Yan, Feng, Winger, Jonathan, Cary, Stephen, Krtolica, Ana

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Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant von Mouhieddine, Tarek H., Sperling, Adam S., Redd, Robert, Park, Jihye, Leventhal, Matthew, Gibson, Christopher J., Manier, Salomon, Nassar, Amin H., Capelletti, Marzia, Huynh, Daisy, Bustoros, Mark, Sklavenitis-Pistofidis, Romanos, Tahri, Sabrin, Hornburg, Kalvis, Dumke, Henry, Itani, Muhieddine M., Boehner, Cody J., Liu, Chia-Jen, AlDubayan, Saud H., Reardon, Brendan, Van Allen, Eliezer M., Keats, Jonathan J., Stewart, Chip, Mehr, Shaadi, Auclair, Daniel, Schlossman, Robert L., Munshi, Nikhil C., Anderson, Kenneth C., Steensma, David P., Laubach, Jacob P., Richardson, Paul G., Ritz, Jerome, Ebert, Benjamin L., Soiffer, Robert J., Trippa, Lorenzo, Getz, Gad, Neuberg, Donna S., Ghobrial, Irene M.

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Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma von Zavidij, Oksana, Haradhvala, Nicholas J, Mouhieddine, Tarek H, Sklavenitis-Pistofidis, Romanos, Cai, Songjie, Reidy, Mairead, Rahmat, Mahshid, Flaifel, Abdallah, Ferland, Benjamin, Su, Nang K, Agius, Michael P, Park, Jihye, Manier, Salomon, Bustoros, Mark, Huynh, Daisy, Capelletti, Marzia, Berrios, Brianna, Liu, Chia-Jen, He, Meng Xiao, Braggio, Esteban, Fonseca, Rafael, Maruvka, Yosef E, Guerriero, Jennifer L, Goldman, Melissa, Van Allen, Eliezer M, McCarroll, Steven A, Azzi, Jamil, Getz, Gad, Ghobrial, Irene M

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The Global Cardiovascular Risk Transition: Associations of Four Metabolic Risk Factors with National Income, Urbanization, and Western Diet in 1980 and 2008 von DANAEI, Goodarz, SINGH, Gitanjali M, RAO, Mayuree, EZZATI, Majid, PACIOREK, Christopher J, LIN, John K, COWAN, Melanie J, FINUCANE, Mariel M, FARZADFAR, Farshad, STEVENS, Gretchen A, RILEY, Leanne M, YUAN LU

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Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma von Dewal, Ninad, Knijnenburg, Theo A., Shih, Juliann, Hoadley, Katherine A., Meyerson, Matthew, Demeure, Michael J., Beuschlein, Felix, Fragoso, Maria C.B.V., Kebebew, Electron, Habra, Mouhammed A., Rainey, William E., Asa, Sylvia L., Bertherat, Jérôme, Wheeler, David A., Giordano, Thomas J., Hammer, Gary D., Dewal, Ninad, Moffitt, Richard A., Murray, Bradley A., Kim, Seungchan, Morozova, Olena, Hoadley, Katherine A., Mete, Ozgur, Robertson, A. Gordon, Demeure, Michael J., Sidhu, Stan B., Asa, Sylvia L., Wheeler, David A., Ally, Adrian, Balasundaram, Miruna, Brooks, Denise, Butterfield, Yaron S.N., Carlsen, Rebecca, Li, Haiyan I., Lim, Lynette, Mungall, Andrew J., Mungall, Karen, Sadeghi, Sara, Kroiss, Matthias, Sander, Chris, Parker, Joel S., Veluvolu, Umadevi, Wilkerson, Matthew D., Auman, J. Todd, Sanborn, Zack, Dahdouli, Mahmoud, Drummond, Jennifer, Gibbs, Richard, Han, Yi, Kovar, Christine, Morgan, Margaret, Morton, Donna, Muzny, Donna, Groussin, Lionel, Libé, Rossella, Chin, Lynda, Reynolds, Sheila, Chudamani, Sudha, Liu, Jia, Lolla, Laxmi, Wu, Ye, Hoyle, Alan P., Jefferys, Stuart R., Shi, Yan, Soloway, Matthew G., Mills Shaw, Kenna R., Demchok, John A., Felau, Ina, Tarnuzzer, Roy, Wang, Zhining, Zenklusen, Jean C., Crawford, Catherine, Roach, Jeffrey, Bshara, Wiam, Alonso, Shelley, Baboud, Julien, Wan, Yunhu, Naresh, Rashi, Arachchi, Harindra, Beroukhim, Rameen, Gabriel, Stacey B., Getz, Gad, Lawrence, Michael S., Noble, Michael S., Sougnez, Carrie, Zhang, Hailei, Leraas, Kristen M., Lichtenberg, Tara M., Ramirez, Nilsa C., Allolio, Bruno, Deutschbein, Timo, Vinco, Michelle, Van Den Berg, David J., Robinson, Bruce, Liu, Wenbin, Wang, Wenyi, Reincke, Martin, Defreitas, Timothy, Hammer, Gary D., Giordano, Thomas J.

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National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years an... von Danaei, Goodarz, Finucane, Mariel M, Lin, John K, Singh, Gitanjali M, Paciorek, Christopher J, Cowan, Melanie J, Farzadfar, Farshad, Stevens, Gretchen A, Lim, Stephen S, Riley, Leanne M, Ezzati, Majid

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National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years an... von Danaei, Goodarz, MD, Finucane, Mariel M, AM, Lin, John K, AB, Singh, Gitanjali M, PhD, Paciorek, Christopher J, PhD, Cowan, Melanie J, MPH, Farzadfar, Farshad, MD, Stevens, Gretchen A, DSc, Lim, Stephen S, PhD, Riley, Leanne M, MSc, Ezzati, Majid, Prof

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Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment von Danaei, Goodarz, Lu, Yuan, Singh, Gitanjali M, Carnahan, Emily, Eggertsen, Robert, Björkelund, Cecilia, Lissner, Lauren, Sundh, Valter

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Using administrative laboratory result data to describe adverse events von Miller, Tamara P., Getz, Kelly D., Jen, Emily, Huang, Yuan-Shung, Przepiorka, Donna, Li, Yimei, Bagatell, Rochelle, Seif, Alix Eden, Fisher, Brian, Aplenc, Richard

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Abstract 139: Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma von Haradhvala, Nicholas J., Zavidij, Oksana, Mouhieddine, Tarek H., Sklavenitis-Pistofidis, Romanos, Park, Jihye, Reidy, Mairead, Flaifel, Abdallah, Ferland, Benjamin, Manier, Salomon, Bustoros, Mark, Huynh, Daisy, Capelletti, Marzia, Berrios, Brianna, Rahmat, Mahshid, Liu, Chia-Jen, He, Meng Xiao, Braggio, Esteban, Fonseca, Rafael, Maruvka, Yosef, Guerriero, Jennifer, Goldman, Melissa, Allen, Eliezer Van, McCarroll, Steven, Azzi, Jamil, Getz, Gad, Ghobrial, Irene M.

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Single-Cell RNA Sequencing Reveals Compromised Immune Microenvironment in Precursor Stages of Multiple Myeloma von Zavidij, Oksana, Haradhvala, Nicholas, Mouhieddine, Tarek H, Park, Jihye, Pistofidis, Romanos, Reidy, Mairead, Huynh, Daisy, Capelletti, Marzia, Berrios, Brianna, Rahmat, Mahshid, Bustoros, Mark, Liu, Chia-Jen, He, Meng Xiao, Maruvka, Yosef, Rivotto, Bradley, Hornburg, Kalvis, Goldman, Melissa, Van Allen, Eliezer, McCarroll, Steven A, Azzi, Jamil, Getz, Gad, Ghobrial, Irene M.

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Next Generation Sequencing Identifies Smoldering Multiple Myeloma Patients with a High Risk of Disease Progression von Bustoros, Mark, Park, Jihye, Salem, Karma Ziad, Liu, Chia-Jen, Capelletti, Marzia, Huynh, Daisy, Tai, Yu-Tzu, Mouhieddine, Tarek H, Freeman, Samuel, Ha, Gavin, Rhoades, Justin, Reed, Sarah, Gydush, Gregory, Rotem, Denisse, Perilla Glen, Adriana, Henrick, Patrick, Caola, Aaron, Rivotto, Bradley, Savell, Alexandra, Noonan, Kimberly, Reyes, Kaitlen, Sacco, Antonio, Boehner, Cody J, Leblebjian, Houry, Liu, David, Morgan, Elizabeth A, Roccaro, Aldo M., Paba-Prada, Claudia, Van Allen, Eliezer, Love, Christopher, Adalsteinsson, Viktor, Laubach, Jacob, Schlossman, Robert, Munshi, Nikhil, Richardson, Paul G, Anderson, Kenneth C, Kumar, Shaji K, Getz, Gad, Ghobrial, Irene M, Manier, Salomon

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Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma von Zavidij, Oksana, Haradhvala, Nicholas J., Mouhieddine, Tarek, Sklavenitis-Pistofidis, Romanos, Agius, Michael P., Cai, Songjie, Reidy, Mairead, Rahmat, Mahshid, Flaifel, Abdallah, Ferland, Benjamin, Park, Jihye, Manier, Salomon, Bustoros, Mark, Huynh, Daisy, Capelletti, Marzia, Berrios, Brianna, Liu, Chia-Jen, He, Meng Xiao, Braggio, Esteban, Fonseca, Rafael, Maruvka, Yosef, Guerriero, Jennifer L., Goldman, Melissa, Van Allen, Eliezer, McCarroll, Steven A., Azzi, Jamil, Getz, Gad, Ghobrial, Irene

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Immunomodulatory therapy improves outcome in multiple myeloma patients with clonal hematopoiesis von Mouhieddine, Tarek, Tahri, Sabrin, Park, Jihye, Redd, Robert, Leventhal, Matthew, Gibson, Christopher, Sperling, Adam S., Manier, Salomon, Nassar, Amin, Capelletti, Marzia, Huynh, Daisy, Bustoros, Mark, Sklavenitis-Pistofidis, Romanos, Hornburg, Kalvis, Dumke, Henry, Itani, Muhieddine, Boehner, Cody, Liu, Chia-Jen, AlDubayan, Saud, Reardon, Brendan, Van Allen, Eliezer, Keats, Jonathan, Stewart, Chip, Mehr, Shaadi, Auclair, Daniel, Schlossman, Robert, Munshi, Nikhil, Anderson, Kenneth C., Steensma, David, Laubach, Jacob, Richardson, Paul G., Ritz, Jerome, Ebert, Benjamin, Soiffer, Robert, Getz, Gad, Neuberg, Donna, Ghobrial, Irene

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Nonhistone chromatin protein phosphorylation during azo-dye carcinogenesis von Chiu, Jen-Fu, Craddock, Catherine, Getz, Susan, Hnilica, Lubomir S.

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