Escape to Ferality: The Endoferal Origin of Weedy Rice from Crop Rice through De-Domestication von Kanapeckas, Kimberly L, Vigueira, Cynthia C, Ortiz, Aida, Gettler, Kyle A, Burgos, Nilda R, Fischer, Albert J, Lawton-Rauh, Amy L

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Serum Analyte Profiles Associated With Crohn’s Disease and Disease Location von Boucher, Gabrielle, Paradis, Alexandre, Chabot-Roy, Geneviève, Coderre, Lise, Hillhouse, Erin E, Bitton, Alain, Des Rosiers, Christine, Levings, Megan K, Schumm, L Philip, Lazarev, Mark, Brant, Steve R, Duerr, Richard, McGovern, Dermot, Silverberg, Mark S, Cho, Judy, Lesage, Sylvie, Rioux, John D

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A myeloid–stromal niche and gp130 rescue in NOD2-driven Crohn’s disease von Nayar, Shikha, Morrison, Joshua K., Giri, Mamta, Gettler, Kyle, Chuang, Ling-shiang, Walker, Laura A., Ko, Huaibin M., Kenigsberg, Ephraim, Kugathasan, Subra, Merad, Miriam, Chu, Jaime, Cho, Judy H.

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Utility of polygenic embryo screening for disease depends on the selection strategy von Lencz, Todd, Backenroth, Daniel, Granot-Hershkovitz, Einat, Green, Adam, Gettler, Kyle, Cho, Judy H, Weissbrod, Omer, Zuk, Or, Carmi, Shai

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369 IBD PREDICTION AND TREATMENT: MULTI-POPULATION RISK SCORES AND RARE VEO-IBD VARIANTS von Gettler, Kyle, Levantovsky, Rachel, Cho, Judy H.

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Su1801 MULTI-RACIAL RISK SCORE INTEGRATION TO PREDICT IBD ACROSS BIOBANK POPULATIONS von Gettler, Kyle, giri, mamt, Cho, Judy H.

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341 PHEWAS OF MONOGENIC, VEO-IBD GENES IN DIVERSE COHORTS REVEALS IBD RISK-ASSOCIATED VARIANTS AND DEFINES REPLICATED GI AND NON-GI ASSOCIATIONS von Bao, Michelle, Kars, Meltem Ece, Gettler, Kyle, Itan, Yuval, Cho, Judy H.

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Mo1792 THERAPEUTIC TARGETS FOR INFLAMMATORY BOWEL DISEASE: A PHEWAS APPROACH von Kars, Meltem Ece, Bao, Michelle, Gettler, Kyle, Stein, David, Cho, Judy H., Itan, Yuval

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Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs von Cummings, Ryan J., Barbet, Gaetan, Bongers, Gerold, Hartmann, Boris M., Gettler, Kyle, Muniz, Luciana, Furtado, Glaucia C., Cho, Judy, Lira, Sergio A., Blander, J. Magarian

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Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy von Martin, Jerome C., Chang, Christie, Boschetti, Gilles, Ungaro, Ryan, Giri, Mamta, Grout, John A., Gettler, Kyle, Chuang, Ling-shiang, Nayar, Shikha, Greenstein, Alexander J., Dubinsky, Marla, Walker, Laura, Leader, Andrew, Fine, Jay S., Whitehurst, Charles E., Mbow, M Lamine, Kugathasan, Subra, Denson, Lee A., Hyams, Jeffrey S., Friedman, Joshua R., Desai, Prerak T., Ko, Huaibin M., Laface, Ilaria, Akturk, Guray, Schadt, Eric E., Salmon, Helene, Gnjatic, Sacha, Rahman, Adeeb H., Merad, Miriam, Cho, Judy H., Kenigsberg, Ephraim

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Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients von Wu, Yiming, Gettler, Kyle, Kars, Meltem Ece, Giri, Mamta, Li, Dalin, Bayrak, Cigdem Sevim, Zhang, Peng, Jain, Aayushee, Maffucci, Patrick, Sabic, Ksenija, Van Vleck, Tielman, Nadkarni, Girish, Denson, Lee A., Ostrer, Harry, Levine, Adam P., Schiff, Elena R., Segal, Anthony W., Kugathasan, Subra, Stenson, Peter D., Cooper, David N., Philip Schumm, L., Snapper, Scott, Daly, Mark J., Haritunians, Talin, Duerr, Richard H., Silverberg, Mark S., Rioux, John D., Brant, Steven R., McGovern, Dermot P. B., Cho, Judy H., Itan, Yuval

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NOX1 is essential for TNFα-induced intestinal epithelial ROS secretion and inhibits M cell signatures von Hsu, Nai-Yun, Nayar, Shikha, Gettler, Kyle, Talware, Sayali, Giri, Mamta, Alter, Isaac, Argmann, Carmen, Sabic, Ksenija, Thin, Tin Htwe, Ko, Huai-Bin Mabel, Werner, Robert, Tastad, Christopher, Stappenbeck, Thaddeus, Azabdaftari, Aline, Uhlig, Holm H, Chuang, Ling-Shiang, Cho, Judy H

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Prioritizing Crohn’s disease genes by integrating association signals with gene expression implicates monocyte subsets von Gettler, Kyle, Giri, Mamta, Kenigsberg, Ephraim, Martin, Jerome, Chuang, Ling-Shiang, Hsu, Nai-Yun, Denson, Lee A., Hyams, Jeffrey S., Griffiths, Anne, Noe, Joshua D., Crandall, Wallace V., Mack, David R., Kellermayer, Richard, Abraham, Clara, Hoffman, Gabriel, Kugathasan, Subra, Cho, Judy H.

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Inflamed Ulcerative Colitis Regions Associated With MRGPRX2-Mediated Mast Cell Degranulation and Cell Activation Modules, Defining a New Therapeutic Target von Chen, Ernie, Chuang, Ling-shiang, Giri, Mamta, Villaverde, Nicole, Hsu, Nai-yun, Sabic, Ksenija, Joshowitz, Sari, Gettler, Kyle, Nayar, Shikha, Chai, Zhi, Alter, Isaac L., Chasteau, Colleen C., Korie, Ujunwa M., Dzedzik, Siarhei, Thin, Tin Htwe, Jain, Aayushee, Moscati, Arden, Bongers, Gerardus, Duerr, Richard H., Silverberg, Mark S., Brant, Steven R., Rioux, John D., Peter, Inga, Schumm, L. Philip, Haritunians, Talin, McGovern, Dermot P., Itan, Yuval, Cho, Judy H.

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Common and Rare Variant Prediction and Penetrance of IBD in a Large, Multi-ethnic, Health System-based Biobank Cohort von Gettler, Kyle, Levantovsky, Rachel, Moscati, Arden, Giri, Mamta, Wu, Yiming, Hsu, Nai-Yun, Chuang, Ling-Shiang, Sazonovs, Aleksejs, Venkateswaran, Suresh, Korie, Ujunwa, Chasteau, Colleen, Duerr, Richard H., Silverberg, Mark S., Snapper, Scott B., Daly, Mark J., McGovern, Dermot P., Brant, Steven R., Rioux, John D., Kugathasan, Subra, Anderson, Carl A., Itan, Yuval, Cho, Judy H.

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03 TOWARDS DISEASE INTERCEPTION: CONTRIBUTION OF POLYGENIC RISK SCORES TOWARDS AGE-DEPENDENT RISK OF IBD IN A HIGH-RISK POPULATION von Spencer, Elizabeth A., Gettler, Kyle, Helmus, Drew, Telesco, Shannon, Hart, Amy, Dubinsky, Marla, Cho, Judy

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Su1563: GWAS OF INFLAMMATORY BOWEL DISEASE IN A SRI LANKAN POPULATION REVEALED DISTINCT AND SHARED IBD ALLELE ARCHITECTURE von Niriella, Madunil A., Venkateswaran, Suresh, Rajindrajith, Shaman, Kodisinghe, Kuleesha, Silva, Arjuna P. De, Silva, Hithanadura J. De, Yasara, Nirmani, Mettananda, Sachith, Pelia, Ranjit S., Gettler, Kyle, Cutler, David J., Cho, Judy H., Kugathasan, Subra

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03 TOWARDS DISEASE INTERCEPTION: CONTRIBUTION OF POLYGENIC RISK SCORES TOWARDS AGE-DEPENDENT RISK OF IBD IN A HIGH-RISK POPULATION von Spencer, Elizabeth A, Gettler, Kyle, Helmus, Drew, Telesco, Shannon, Hart, Amy, Dubinsky, Marla, Cho, Judy

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Mo1112 IDENTIFYING NOVEL HIGH-IMPACT RARE DISEASE-CAUSING MUTATIONS, GENES AND PATHWAYS IN EXOMES OF ASHKENAZI JEWISH INFLAMMATORY BOWEL DISEASE PATIENTS von wu, yiming, Jain, Aayushee, Sevim, Cigdem, Li, Dalin, giri, mamta, Gettler, Kyle, Mengesha, Emebet, Schumm, L. Philip, Haritunians, Talin, McGovern, Dermot P.B., Cho, Judy H., Itan, Yuval

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168 GENE EXPRESSION ANALYSES IN THE PERIOPERATIVE ILEAL RESECTION PERIOD ILLUMINATE PATHOGENIC AND PROTECTIVE CROHN'S DISEASE CELL SUBSETS von Gettler, Kyle, Sabic, Ksenija, Giri, Mamta, Schumm, L. Philip, Haritunians, Talin, Lazarev, Mark, Mcgovern, Dermot P.B., Duerr, Richard H., Rioux, John D., Brant, Steven R., Silverberg, Mark S., Cho, Judy H.

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