The Use of Biomarkers in Human Pharmacology (Phase I) Studies von Cohen, A.F, Burggraaf, J, van Gerven, J.M.A, Moerland, M, Groeneveld, G.J

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E.05.01 Innovative tools for ‘proof-of-pharmacological-concept’ studies von Van Gerven, J.M.A, Hay, J.L

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PK and PD of a nicotinic anticholineric challenge with mecamylamine in comparison to scopolamine von Baakman, A.C, Rissmann, R, Klaassen, E.S, van Gerven, J.M.A, Groeneveld, G.J

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Metoclopramide as pharmacological tool to assess vasopressinergic co-activation of the hypothalamus–pituitary–adrenal (HPA) axis: A study in healthy volunteers von Jacobs, G.E, Hulskotte, E.G.J, de Kam, M.L, Zha, G, Jiang, J, Hu, P, Zhao, Q, van Pelt, J, Goekoop, J.G, Zitman, F.G, van Gerven, J.M.A

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P.1.c.053 The effect of olanzapine on a tetrahydrocannabinol-induced increase on the positive and negative syndrome scale von Kleinloog, H.D, Liem-Moolenaar, M, Jacobs, G.E, de Kam, M.L, van Gerven, J.M.A

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P.3.06 Cannabis co-administration potentiates MDMA effects on temperature and heart rate von Dumont, G, Kramers, C, Sweep, F.C.G.J, van Gerven, J.M.A, van Hasselt, C, Buitelaar, J.K, Verkes, R.J

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P.1.c.037 Surinabant inhibits the effects of delta 9-tetrahydrocannabinol in a novel tetrahydrocannabinol-challenge test von Klumpers, L, Roy, C, Poitiers, F, Turpault, S, van Gerven, J.M.A

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P.1.c.049 Alertness and electrocortical activity after (co-)administration of MDMA and THC in healthy volunteers von Lansbergen, M.M, Dumont, G.J.H, Buitelaar, J.K, van Gerven, J.M.A, Verkes, R.J

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P.2.a.026 Effects of metoclopramide on 5-HTP induced activation of the hypothalamus-pituitary-adrenal (HPA) axis von Jacobs, G, Hulskotte, E.G.J, de Kam, M, Zitman, F.G, van Gerven, J.M.A

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P.1.c.023 Neuroendocrine effects and safety of intravenously administered desmopressin in healthy volunteers von Jacobs, G, Hulskotte, E.G.J, Zuurman, H.H, Burggraaf, J, Elassais-Schaap, J, Peeters, P.A.M, van Gerven, J.M.A, Ruigt, G

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P.3.d.003 Study investigating R231857 effects on scopolamine-induced CNS impairment in healthy men von Liem-Moolenaar, M, De Boer, P, Zoethout, R.W.M, Franson, K, Cohen, A.F, Van Gerven, J.M.A

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P.1.c.024 Tolerability of the 5-hydroxytryptophane challenge test with granisetron and domperidone von Jacobs, G.E, Hoeberechts-Lefrandt, L.J.C.A, de Kam, M.L, Zitman, F.G, van Gerven, J.M.A

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P.2.03 Ecstasy and ethanol interaction effects on psychomotor function von Dumont, G, Schoenmaker, R, van Gerven, J.M.A, Buitelaar, J.K, Verkes, R.J

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MK-0873, a PDE4 inhibitor, does not influence the pharmacokinetics of theophylline in healthy male volunteers von Boot, J.D, De Haas, S.L, Van Gerven, J.M.A, De Smet, M, Leathem, T, Wagner, J, Denker, A, Miller, D, Van Doorn, M.B.A, Schoemaker, R.C, Cohen, A.F, Diamant, Z

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Effect of intrapulmonary tetrahydrocannabinol administration in humans von Zuurman, L., Roy, C., Schoemaker, RC, Hazekamp, A., den Hartigh, J., Bender, JCME, Verpoorte, R., Pinquier, JL, Cohen, AF, van Gerven, JMA

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Modelling of the concentration—effect relationship of THC on central nervous system parameters and heart rate — insight into its mechanisms of action and a tool for clinical resear... von Strougo, A., Zuurman, L., Roy, C., Pinquier, JL, van Gerven, JMA, Cohen, AF, Schoemaker, RC

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The effects of the glycine reuptake inhibitor R213129 on the central nervous system and on scopolamine-induced impairments in psychomotor and cognitive function in healthy subjects von Liem-Moolenaar, M, Zoethout, RWM, de Boer, P, Schmidt, M, de Kam, ML, Cohen, AF, Franson, KL, van Gerven, JMA

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Pharmacodynamic and pharmacokinetic effects of TPA023, a GABAA α2,3 subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers von de Haas, S.L., de Visser, S.J., van der Post, J.P., de Smet, M., Schoemaker, R.C., Rijnbeek, B., Cohen, A.F., Vega, J.M., Agrawal, N.G.B., Goel, T.V., Simpson, R.C., Pearson, L.K., Li, S., Hesney, M., Murphy, M.G., van Gerven, J.M.A.

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Pharmacodynamic and pharmacokinetic effects of MK-0343, a GABAA α2,3 subtype selective agonist, compared to lorazepam and placebo in healthy male volunteers von de Haas, S.L., de Visser, S.J., van der Post, J.P., Schoemaker, R.C., van Dyck, K., Murphy, M.G., de Smet, M., Vessey, L.K., Ramakrishnan, R., Xue, L., Cohen, A.F., van Gerven, J.M.A.

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Hypothalamic glutamate levels following serotonergic stimulation: A pilot study using 7-Tesla magnetic resonance spectroscopy in healthy volunteers von Jacobs, G.E., der Grond, J. van, Teeuwisse, W.M., Langeveld, T.J.C., van Pelt, J., Verhagen, J.C.M., de Kam, M.L., Cohen, A.F., Zitman, F.G., van Gerven, J.M.A.

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