CD34 + acute myeloid leukemia cells with low levels of reactive oxygen species show increased expression of stemness genes and can be targeted by the BCL2 inhibitor venetoclax von Mattes, Katharina, Gerritsen, Mylène, Folkerts, Hendrik, Geugien, Marjan, van den Heuvel, Fiona A, Svendsen, Arthur Flohr, Yi, Guoqiang, Martens, Joost H A, Vellenga, Edo

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Acute myeloid leukemia associated RUNX1 variants induce aberrant expression of transcription factor TCF4 von Gerritsen, Mylène, In 't Hout, Florentien E M, Knops, Ruth, Mandos, Bas L R, Decker, Melanie, Ripperger, Tim, van der Reijden, Bert A, Martens, Joost H A, Jansen, Joop H

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Presence of mutant p53 increases stem cell frequency and is associated with reduced binding to classic TP53 binding sites in cell lines and primary AMLs von Gerritsen, Mylène, Hilgendorf, Susan, Yi, Guoqiang, Wierenga, Albertus T.J., Schuringa, Jan-Jacob, Martens, Joost H.A., Vellenga, Edo

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Transcription factor 4 (TCF4) expression predicts clinical outcome in RUNX1 mutated and translocated acute myeloid leukemia von In 't Hout, Florentien E M, Gerritsen, Mylène, Bullinger, Lars, van der Reijden, Bert A, Huls, Gerwin, Vellenga, Edo, Jansen, Joop H

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Transcription factor 4 ( TCF4 ) expression predicts clinical outcome in RUNX1 mutated and translocated acute myeloid leukemia von In't Hout, Florentien E M, Gerritsen, Mylène, Bullinger, Lars, Van der Reijden, Bert A, Huls, Gerwin, Vellenga, Edo, Jansen, Joop H

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RUNX1 Mutations Cause a Myeloid Differentiation Block Leading to the Formation of a Long Term Expanding CD34+/CD33+/CD45RA+/CD123+ Cell Population von Gerritsen, Myléne, Tijchon, Esther, Mandoli, Amit, Martens, Joost H.A., Schuringa, Jan Jacob, Vellenga, Edo

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Tumor suppressor BTG1 limits activation of BCL6 expression downstream of ETV6-RUNX1 von Tijchon, Esther, van Emst, Liesbeth, Yuniati, Laurensia, van Ingen Schenau, Dorette, Gerritsen, Mylène, van der Meer, Laurens T., Williams, Owen, Hoogerbrugge, Peter M., Scheijen, Blanca, van Leeuwen, Frank N.

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P455: RUNX1 DIRECTLY BINDS AND REGULATES THE TCF4 PROMOTER von Gerritsen, Mylene, In‘t Hout, Florentien E.M., G.H.J.N. Knops, Ruth, Van Der Reijden, Bert A., Martens, Joost H.A., H Jansen, Joop

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Ring sideroblasts in AML are associated with adverse risk characteristics and have a distinct gene expression pattern von Berger, Gerbrig, Gerritsen, Mylene, Yi, Guoqiang, Koorenhof-Scheele, Theresia N., Kroeze, Leonie I., Stevens-Kroef, Marian, Yoshida, Kenichi, Shiraishi, Yuichi, van den Berg, Eva, Schepers, Hein, Huls, Geert, Mulder, André B., Ogawa, Seishi, Martens, Joost H.A., Jansen, Joop H., Vellenga, Edo

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RUNX1 Mutations Lead to a Myeloid Differentiation Block in Association with Enhanced Proliferation By Altering the RUNX1 Transcriptional Program von Gerritsen, Mylène, Tijchon, Esther, Yi, Guoqiang, Kuster, Jorren, Schuringa, Jan Jacob, Martens, Joost H.A., Vellenga, Edo

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RUNX1 mutations enhance self-renewal and block granulocytic differentiation in human in vitro models and primary AMLs von Gerritsen, Mylène, Yi, Guoqiang, Tijchon, Esther, Kuster, Jorren, Schuringa, Jan Jacob, Martens, Joost H.A., Vellenga, Edo

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