New approach methodologies in human regulatory toxicology – Not if, but how and when von Schmeisser, Sebastian, Miccoli, Andrea, von Bergen, Martin, Berggren, Elisabet, Braeuning, Albert, Busch, Wibke, Desaintes, Christian, Gourmelon, Anne, Grafström, Roland, Harrill, Joshua, Hartung, Thomas, Herzler, Matthias, Kass, George E.N., Kleinstreuer, Nicole, Leist, Marcel, Luijten, Mirjam, Marx-Stoelting, Philip, Poetz, Oliver, van Ravenzwaay, Bennard, Roggeband, Rob, Rogiers, Vera, Roth, Adrian, Sanders, Pascal, Thomas, Russell S., Marie Vinggaard, Anne, Vinken, Mathieu, van de Water, Bob, Luch, Andreas, Tralau, Tewes

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The mitochondrial death pathway: a promising therapeutic target in diseases von Gupta, Sanjeev, Kass, George E.N., Szegezdi, Eva, Joseph, Bertrand

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[Corrigendum] What is considered cardiotoxicity of anthracyclines in animal studies von Georgiadis, Nikolaos, Tsarouhas, Konstantinos, Rezaee, Ramin, Nepka, Haritini, Kass, George E N, Dorne, Jean-Lou C M, Stagos, Dimitrios, Toutouzas, Konstantinos, Spandidos, Demetrios A, Kouretas, Dimitrios, Tsitsimpikou, Christina

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The ionic liquid 1-octyl-3-methylimidazolium (M8OI) is an activator of the human estrogen receptor alpha von Leitch, Alistair C., Lakey, Anne F., Hotham, William E., Agius, Loranne, Kass, George E.N., Blain, Peter G., Wright, Matthew C.

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In vitro anti-inflammatory activity of Malus × domestica var. Mela Rosa Marchigiana pulp callus extract contrasting high glucose conditions von Benayada, Leila, Gubitosa, Federica, Fraternale, Daniele, Carloni, Silvia, Cerioni, Liana, Matacchione, Giulia, Olivieri, Fabiola, Potenza, Lucia, De Bellis, Roberta, Chiarantini, Laura, Roselli, Carla, Valentini, Laura, Gobbi, Pietro, Balduini, Walter, Pappagallo, Noemi, Ventura, Natascia, Kass, George E.N., Colomba, Mariastella, Albertini, Maria Cristina

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Long-lasting bioactive compounds production from Malus x domestica Borkh var. Mela Rosa Marchigiana pulp callus culture with antioxidant activity: In vitro, ex vivo and in vivo val... von Gubitosa, Federica, Benayada, Leila, Fraternale, Daniele, De Bellis, Roberta, Carloni, Silvia, Potenza, Lucia, Chiarantini, Laura, Gorassini, Andrea, Verardo, Giancarlo, Roselli, Carla, Valentini, Laura, Gobbi, Pietro, Balduini, Walter, Ventura, Natascia, Giannaccini, Francesca, Kass, George E.N., Colomba, Mariastella, Albertini, Maria Cristina

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B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals von Leitch, Alistair C, Probert, Philip M.E, Shayman, James A, Meyer, Stephanie K, Kass, George E.N, Wright, Matthew C

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Advancing human health risk assessment von Lanzoni, Anna, Castoldi, Anna F, Kass, George EN, Terron, Andrea, De Seze, Guilhem, Bal‐Price, Anna, Bois, Frédéric Y, Delclos, K Barry, Doerge, Daniel R, Fritsche, Ellen, Halldorsson, Thorhallur, Kolossa‐Gehring, Marike, Hougaard Bennekou, Susanne, Koning, Frits, Lampen, Alfonso, Leist, Marcel, Mantus, Ellen, Rousselle, Christophe, Siegrist, Michael, Steinberg, Pablo, Tritscher, Angelika, Van de Water, Bob, Vineis, Paolo, Walker, Nigel, Wallace, Heather, Whelan, Maurice, Younes, Maged

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TKPlate 1.0: An Open‐access platform for toxicokinetic and toxicodynamic modelling of chemicals to implement new approach methodologies in chemical risk assessment von Dorne, Jean Lou C. M., Cortiñas‐Abrahantes, José, Spyropoulos, Fotis, Darney, Keyvin, Lautz, Leonie, Louisse, Jochem, Kass, George E. N., Carnesecchi, Edoardo, Liem, A. K. Djien, Tarazona, José V., Billat, Pierre‐André, Beaudoin, Rémy, Zeman, Florence, Bodin, Cléo, Smith, Anthony, Nathanail, Alexis, Di Nicola, Matteo R., Kleiner, Juliane, Terron, Andrea, Parra‐Morte, Juan Manuel, Verloo, Didier, Robinson, Tobin

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Effect of the histone deacetylase inhibitor trichostatin A on spontaneous apoptosis in various types of adult rat hepatocyte cultures von Vanhaecke, Tamara, Henkens, Tom, Kass, George E.N, Rogiers, Vera

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Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury: Roles of cytochrome c, Bax, Bid, and caspases von El-Hassan, Hasan, Anwar, Khurshid, Macanas-Pirard, Patricia, Crabtree, Mark, Chow, Sek C, Johnson, Victoria L, Lee, Pauline C, Hinton, Richard H, Price, Shirley C, Kass, George E.N

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Vipers of Major clinical relevance in Europe: Taxonomy, venom composition, toxicology and clinical management of human bites von Di Nicola, Matteo R., Pontara, Andrea, Kass, George E.N., Kramer, Nynke I., Avella, Ignazio, Pampena, Riccardo, Mercuri, Santo Raffaele, Dorne, Jean Lou C.M., Paolino, Giovanni

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Use of New Approach Methodologies (NAMs) in regulatory decisions for chemical safety: Report from an EPAA Deep Dive Workshop von Westmoreland, Carl, Bender, Hans J., Doe, John E., Jacobs, Miriam N., Kass, George E.N., Madia, Federica, Mahony, Catherine, Manou, Irene, Maxwell, Gavin, Prieto, Pilar, Roggeband, Rob, Sobanski, Tomasz, Schütte, Katrin, Worth, Andrew P., Zvonar, Zvonimir, Cronin, Mark T.D.

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Guidance on harmonised methodologies for human health, animal health and ecological risk assessment of combined exposure to multiple chemicals von More, Simon John, Bampidis, Vasileios, Benford, Diane, Bennekou, Susanne Hougaard, Bragard, Claude, Halldorsson, Thorhallur Ingi, Hernández‐Jerez, Antonio F, Koutsoumanis, Konstantinos, Naegeli, Hanspeter, Schlatter, Josef R, Silano, Vittorio, Nielsen, Søren Saxmose, Schrenk, Dieter, Turck, Dominique, Younes, Maged, Benfenati, Emilio, Castle, Laurence, Cedergreen, Nina, Hardy, Anthony, Laskowski, Ryszard, Leblanc, Jean Charles, Kortenkamp, Andreas, Ragas, Ad, Posthuma, Leo, Svendsen, Claus, Solecki, Roland, Testai, Emanuela, Dujardin, Bruno, Kass, George EN, Manini, Paola, Jeddi, Maryam Zare, Dorne, Jean‐Lou CM, Hogstrand, Christer

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Implementing New Approach Methodologies (NAMs) in food safety assessments: Strategic objectives and actions taken by the European Food Safety Authority von Cattaneo, Irene, Astuto, Maria Chiara, Binaglia, Marco, Devos, Yann, Dorne, Jean Lou C.M., Fernandez Agudo, Ana, Fernandez Dumont, Antonio, Garcia-Vello, Pilar, Kass, George E.N., Lanzoni, Anna, Liem, A.K. Djien, Panzarea, Martina, Paraskevopulos, Konstantinos, Parra Morte, Juan Manuel, Tarazona, Jose V., Terron, Andrea

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Addressing the need for safe, nutritious and sustainable food: Outcomes of the “ONE – Health, Environment & Society – Conference 2022 von Devos, Yann, Arena, Maria, Ashe, Sean, Blanck, Max, Bray, Edward, Broglia, Alessandro, Bronzwaer, Stef, Cafaro, Angelo, Corsini, Elisa, Dujardin, Bruno, Dumont, Antonio Fernandez, Garcia, Matilde Gomez, Gardi, Ciro, Guerra, Beatriz, Kass, George E.N., Maggiore, Angelo, Martino, Laura, Merten, Caroline, Percivaldi, Cinzia, Szoradi, Andras, Martinez, Silvia Valtueña, Ververis, Ermolaos, Vrbos, Domagoj, Hugas, Marta

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Guidance on the use of the Threshold of Toxicological Concern approach in food safety assessment von More, Simon J, Bampidis, Vasileios, Benford, Diane, Bragard, Claude, Halldorsson, Thorhallur I, Hernández‐Jerez, Antonio F, Hougaard Bennekou, Susanne, Koutsoumanis, Kostas P, Machera, Kyriaki, Naegeli, Hanspeter, Nielsen, Søren S, Schlatter, Josef R, Schrenk, Dieter, Silano, Vittorio, Turck, Dominique, Younes, Maged, Gundert‐Remy, Ursula, Kass, George E N, Kleiner, Juliane, Rossi, Anna Maria, Serafimova, Rositsa, Reilly, Linda, Wallace, Heather M

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Emerging technologies and their impact on regulatory science von Anklam, Elke, Bahl, Martin Iain, Ball, Robert, Beger, Richard D, Cohen, Jonathan, Fitzpatrick, Suzanne, Girard, Philippe, Halamoda-Kenzaoui, Blanka, Hinton, Denise, Hirose, Akihiko, Hoeveler, Arnd, Honma, Masamitsu, Hugas, Marta, Ishida, Seichi, Kass, George EN, Kojima, Hajime, Krefting, Ira, Liachenko, Serguei, Liu, Yan, Masters, Shane, Marx, Uwe, McCarthy, Timothy, Mercer, Tim, Patri, Anil, Pelaez, Carmen, Pirmohamed, Munir, Platz, Stefan, Ribeiro, Alexandre JS, Rodricks, Joseph V, Rusyn, Ivan, Salek, Reza M, Schoonjans, Reinhilde, Silva, Primal, Svendsen, Clive N, Sumner, Susan, Sung, Kyung, Tagle, Danilo, Tong, Li, Tong, Weida, Eijnden-van-Raaij, Janny van den, Vary, Neil, Wang, Tao, Waterton, John, Wang, May, Wen, Hairuo, Wishart, David, Yuan, Yinyin, Slikker Jr, William

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What is considered cardiotoxicity of anthracyclines in animal studies von Georgiadis, Nikolaos, Tsarouhas, Konstantinos, Rezaee, Ramin, Nepka, Haritini, Kass, George E.N., Dorne, Jean-Lou C.M., Stagos, Dimitrios, Toutouzas, Konstantinos, Spandidos, Demetrios A., Kouretas, Dimitrios, Tsitsimpikou, Christina

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Testing the thresholds of toxicological concern values using a new database for food-related substances von Reilly, Linda, Serafimova, Rositsa, Partosch, Falko, Gundert-Remy, Ursula, Cortiñas Abrahantes, José, Dorne, Jean-Lou M.C., Kass, George E.N.

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