Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation von Wu, Fangzhou, Mayer, John P, Gelfanov, Vasily M, Liu, Fa, DiMarchi, Richard D

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Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems von Yang, Bin, Gelfanov, Vasily M, El, Kimberley, Chen, Alex, Rohlfs, Rebecca, DuBois, Barent, Kruse Hansen, Ann Maria, Perez-Tilve, Diego, Knerr, Patrick J, D'Alessio, David, Campbell, Jonathan E, Douros, Jonathan D, Finan, Brian

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Chemical Synthesis of Insulin Analogs through a Novel Precursor von Zaykov, Alexander N, Mayer, John P, Gelfanov, Vasily M, DiMarchi, Richard D

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Synthesis of relaxin‐2 and insulin‐like peptide 5 enabled by novel tethering and traceless chemical excision von Thalluri, Kishore, Kou, Binbin, Yang, Xu, Zaykov, Alexander N., Mayer, John P., Gelfanov, Vasily M., Liu, Fa, DiMarchi, Richard D.

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A Novel Human-Based Receptor Antagonist of Sustained Action Reveals Body Weight Control by Endogenous GLP-1 von Patterson, James T, Ottaway, Nickki, Gelfanov, Vasily M, Smiley, David L, Perez-Tilve, Diego, Pfluger, Paul T, Tschöp, Matthias H, DiMarchi, Richard D

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Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists von Yang, Bin, Gelfanov, Vasily M, Perez-Tilve, Diego, DuBois, Barent, Rohlfs, Rebecca, Levy, Jay, Douros, Jonathan D, Finan, Brian, Mayer, John P, DiMarchi, Richard D

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Insulin Prodrugs with Programmed Chemical Release of an Intramolecular Cross-Link von Zaykov, Alexander N., Gelfanov, Vasily M., DiMarchi, Richard D.

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High-Yield Synthesis of Human Insulin-Like Peptide 5 Employing a Nonconventional Strategy von Zaykov, Alexander N, Gelfanov, Vasily M, Liu, Fa, DiMarchi, Richard D

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Insulin-like peptide 5 fails to improve metabolism or body weight in obese mice von Zaykov, Alexander N., Gelfanov, Vasily M., Perez-Tilve, Diego, Finan, Brian, DiMarchi, Richard D.

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Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence von Kabotso, Daniel E K, Smiley, David, Mayer, John P, Gelfanov, Vasily M, Perez-Tilve, Diego, DiMarchi, Richard D, Pohl, Nicola L B, Liu, Fa

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A Disulfide Scan of Insulin by [3 + 1] Methodology Exhibits Site-Specific Influence on Bioactivity von Brunel, Florence M, Mayer, John P, Gelfanov, Vasily M, Zaykov, Alexander N, Finan, Brian, Perez-Tilve, Diego, DiMarchi, Richard D

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Synthesis and Characterization of the R27S Genetic Variant of Insulin‐like Peptide 5 von Zaykov, Alexander N., Gelfanov, Vasily M., Liu, Fa, DiMarchi, Richard D.

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Controlled intramolecular antagonism as a regulator of insulin receptor maximal activity von Brandt, Sara J., Mayer, John P., Ford, James, Gelfanov, Vasily M., DiMarchi, Richard D.

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Peptide lipidation stabilizes structure to enhance biological function von Ward, Brian P, Ottaway, Nickki L, Perez-Tilve, Diego, Ma, Dejian, Gelfanov, Vasily M, Tschöp, Matthias H, DiMarchi, Richard D

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Toward once-monthly insulin therapy via synergy in two pharmacokinetic protractors: Fc-conjugation and fatty acid acylation von Zaykov, Alexander N, Gelfanov, Vasily M, Tagmose, Tina M, Demozay, Damien, Manfè, Valentina, Rohlfs, Rebecca, Rivir, Marita, Perez-Tilve, Diego, Finan, Brian, DiMarchi, Richard D

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Max Bergmann award lecture:Macromolecular medicinal chemistry as applied to metabolic diseases von DiMarchi, Richard D., Mayer, John P., Gelfanov, Vasily M., Tschöp, Matthias

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Optimization of the native glucagon sequence for medicinal purposes von Chabenne, Joseph R, DiMarchi, Maria A, Gelfanov, Vasily M, DiMarchi, Richard D

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Three-chain insulin analogs demonstrate the importance of insulin secondary structure to bioactivity von Wu, Fangzhou, Chabenne, Joseph R., Gelfanov, Vasily M., Mayer, John P., DiMarchi, Richard D.

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Discovery of High Potency, Single-Chain Insulin Analogs with a Shortened B‑Chain and Nonpeptide Linker von Kaur, Zachary P, Ochman, Alexander R, Mayer, John P, Gelfanov, Vasily M, DiMarchi, Richard D

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Functional association of the N-terminal residues with the central region in glucagon-related peptides von Patterson, James T., Day, Jonathan W., Gelfanov, Vasily M., DiMarchi, Richard D.

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