Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program von Klarin, Derek, Damrauer, Scott M., Cho, Kelly, Sun, Yan V., Teslovich, Tanya M., Honerlaw, Jacqueline, Gagnon, David R., DuVall, Scott L., Li, Jin, Peloso, Gina M., Chaffin, Mark, Small, Aeron M., Huang, Jie, Tang, Hua, Lynch, Julie A., Ho, Yuk-Lam, Liu, Dajiang J., Emdin, Connor A., Li, Alexander H., Huffman, Jennifer E., Lee, Jennifer S., Natarajan, Pradeep, Chowdhury, Rajiv, Saleheen, Danish, Vujkovic, Marijana, Baras, Aris, Pyarajan, Saiju, Di Angelantonio, Emanuele, Neale, Benjamin M., Naheed, Aliya, Khera, Amit V., Danesh, John, Chang, Kyong-Mi, Abecasis, Gonçalo, Willer, Cristen, Dewey, Frederick E., Carey, David J., Concato, John, Gaziano, J. Michael, O’Donnell, Christopher J., Tsao, Philip S., Kathiresan, Sekar, Rader, Daniel J., Wilson, Peter W. F., Assimes, Themistocles L.

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Reduced penetrance of MODY-associated HNF1A/HNF4A variants but not GCK variants in clinically unselected cohorts von Mirshahi, Uyenlinh L, Colclough, Kevin, Wright, Caroline F, Wood, Andrew R, Beaumont, Robin N, Tyrrell, Jessica, Laver, Thomas W, Stahl, Richard, Golden, Alicia, Goehringer, Jessica M, Frayling, Timothy F, Hattersley, Andrew T, Carey, David J, Weedon, Michael N, Patel, Kashyap A

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Exome sequencing and characterization of 49,960 individuals in the UK Biobank von Van Hout, Cristopher V., Tachmazidou, Ioanna, Backman, Joshua D., Hoffman, Joshua D., Liu, Daren, Pandey, Ashutosh K., Gonzaga-Jauregui, Claudia, Khalid, Shareef, Ye, Bin, Banerjee, Nilanjana, Li, Alexander H., O’Dushlaine, Colm, Marcketta, Anthony, Staples, Jeffrey, Schurmann, Claudia, Hawes, Alicia, Maxwell, Evan, Barnard, Leland, Lopez, Alexander, Penn, John, Habegger, Lukas, Blumenfeld, Andrew L., Bai, Xiaodong, O’Keeffe, Sean, Yadav, Ashish, Praveen, Kavita, Jones, Marcus, Salerno, William J., Chung, Wendy K., Surakka, Ida, Willer, Cristen J., Hveem, Kristian, Leader, Joseph B., Carey, David J., Ledbetter, David H., Cardon, Lon, Yancopoulos, George D., Economides, Aris, Coppola, Giovanni, Shuldiner, Alan R., Balasubramanian, Suganthi, Cantor, Michael, Nelson, Matthew R., Whittaker, John, Reid, Jeffrey G., Marchini, Jonathan, Overton, John D., Scott, Robert A., Abecasis, Gonçalo R., Yerges-Armstrong, Laura, Baras, Aris

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A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation von Vujkovic, Marijana, Ramdas, Shweta, Lorenz, Kim M., Guo, Xiuqing, Darlay, Rebecca, Cordell, Heather J., He, Jing, Gindin, Yevgeniy, Chung, Chuhan, Myers, Robert P., Schneider, Carolin V., Park, Joseph, Lee, Kyung Min, Serper, Marina, Carr, Rotonya M., Kaplan, David E., Haas, Mary E., MacLean, Matthew T., Witschey, Walter R., Zhu, Xiang, Tcheandjieu, Catherine, Kember, Rachel L., Kranzler, Henry R., Verma, Anurag, Giri, Ayush, Klarin, Derek M., Sun, Yan V., Huang, Jie, Huffman, Jennifer E., Creasy, Kate Townsend, Hand, Nicholas J., Liu, Ching-Ti, Long, Michelle T., Yao, Jie, Budoff, Matthew, Tan, Jingyi, Li, Xiaohui, Lin, Henry J., Chen, Yii-Der Ida, Taylor, Kent D., Chang, Ruey-Kang, Krauss, Ronald M., Vilarinho, Silvia, Brancale, Joseph, Nielsen, Jonas B., Locke, Adam E., Jones, Marcus B., Verweij, Niek, Baras, Aris, Reddy, K. Rajender, Neuschwander-Tetri, Brent A., Schwimmer, Jeffrey B., Sanyal, Arun J., Chalasani, Naga, Ryan, Kathleen A., Mitchell, Braxton D., Gill, Dipender, Wells, Andrew D., Manduchi, Elisabetta, Saiman, Yedidya, Mahmud, Nadim, Miller, Donald R., Reaven, Peter D., Phillips, Lawrence S., Muralidhar, Sumitra, DuVall, Scott L., Lee, Jennifer S., Assimes, Themistocles L., Pyarajan, Saiju, Cho, Kelly, Edwards, Todd L., Damrauer, Scott M., Wilson, Peter W., Gaziano, J. Michael, O’Donnell, Christopher J., Khera, Amit V., Grant, Struan F. A., Brown, Christopher D., Tsao, Philip S., Saleheen, Danish, Lotta, Luca A., Bastarache, Lisa, Anstee, Quentin M., Daly, Ann K., Meigs, James B., Rotter, Jerome I., Lynch, Julie A., Rader, Daniel J., Voight, Benjamin F., Chang, Kyong-Mi

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Clinical and Molecular Prevalence of Lipodystrophy in an Unascertained Large Clinical Care Cohort von Gonzaga-Jauregui, Claudia, Ge, Wenzhen, Staples, Jeffrey, Van Hout, Cristopher, Yadav, Ashish, Colonie, Ryan, Leader, Joseph B., Kirchner, H. Lester, Murray, Michael F., Reid, Jeffrey G., Carey, David J., Overton, John D., Shuldiner, Alan R., Gottesman, Omri, Gao, Steve, Gromada, Jesper, Baras, Aris, Altarejos, Judith

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Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets von Wain, Louise V, Shrine, Nick, Artigas, María Soler, Erzurumluoglu, A Mesut, Bossini-Castillo, Lara, Obeidat, Ma'en, Henry, Amanda P, Billington, Charlotte K, Rimington, Tracy L, Fenech, Anthony G, John, Catherine, Blake, Tineka, Jackson, Victoria E, Allen, Richard J, Prins, Bram P, Campbell, Archie, Porteous, David J, Jarvelin, Marjo-Riitta, Wielscher, Matthias, Hui, Jennie, Wareham, Nicholas J, Zhao, Jing Hua, Wilson, James F, Joshi, Peter K, Stubbe, Beate, Rawal, Rajesh, Schulz, Holger, Imboden, Medea, Probst-Hensch, Nicole M, Karrasch, Stefan, Gieger, Christian, Deary, Ian J, Harris, Sarah E, Marten, Jonathan, Rudan, Igor, Enroth, Stefan, Gyllensten, Ulf, Kerr, Shona M, Polasek, Ozren, Surakka, Ida, Vitart, Veronique, Hayward, Caroline, Lehtimäki, Terho, Raitakari, Olli T, Evans, David M, Henderson, A John, Pennell, Craig E, Wang, Carol A, Sly, Peter D, Wan, Emily S, Busch, Robert, Hobbs, Brian D, Litonjua, Augusto A, Sparrow, David W, Gulsvik, Amund, Bakke, Per S, Crapo, James D, Beaty, Terri H, Hansel, Nadia N, Mathias, Rasika A, Ruczinski, Ingo, Barnes, Kathleen C, Bossé, Yohan, Joubert, Philippe, van den Berge, Maarten, Brandsma, Corry-Anke, Paré, Peter D, Sin, Don D, Nickle, David C, Hao, Ke, Gottesman, Omri, Dewey, Frederick E, Bruse, Shannon E, Carey, David J, Kirchner, H Lester, Jonsson, Stefan, Thorleifsson, Gudmar, Jonsdottir, Ingileif, Gislason, Thorarinn, Stefansson, Kari, Schurmann, Claudia, Nadkarni, Girish, Bottinger, Erwin P, Loos, Ruth J F, Walters, Robin G, Chen, Zhengming, Millwood, Iona Y, Vaucher, Julien, Kurmi, Om P, Li, Liming, Hansell, Anna L, Brightling, Chris, Zeggini, Eleftheria, Cho, Michael H, Silverman, Edwin K, Sayers, Ian, Trynka, Gosia, Morris, Andrew P, Strachan, David P, Hall, Ian P

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Applying a genetic risk score model to enhance prediction of future multiple sclerosis diagnosis at first presentation with optic neuritis von Loginovic, Pavel, Wang, Feiyi, Li, Jiang, Ferrat, Lauric, Mirshahi, Uyenlinh L., Rao, H. Shanker, Petzold, Axel, Tyrrell, Jessica, Green, Harry D., Weedon, Michael N., Ganna, Andrea, Tuomi, Tiinamaija, Carey, David J., Oram, Richard A., Braithwaite, Tasanee

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GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms von Ward, Lucas D., Tu, Ho-Chou, Quenneville, Chelsea B., Tsour, Shira, Flynn-Carroll, Alexander O., Parker, Margaret M., Deaton, Aimee M., Haslett, Patrick A. J., Lotta, Luca A., Verweij, Niek, Ferreira, Manuel A. R., Baras, Aris, Hinkle, Gregory, Nioi, Paul

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Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis von Ghouse, Jonas, Sveinbjörnsson, Gardar, Vujkovic, Marijana, Seidelin, Anne-Sofie, Gellert-Kristensen, Helene, Ahlberg, Gustav, Tragante, Vinicius, Rand, Søren A., Brancale, Joseph, Vilarinho, Silvia, Lundegaard, Pia Rengtved, Sørensen, Erik, Erikstrup, Christian, Bruun, Mie Topholm, Jensen, Bitten Aagaard, Brunak, Søren, Banasik, Karina, Ullum, Henrik, Verweij, Niek, Lotta, Luca, Baras, Aris, Mirshahi, Tooraj, Carey, David J., Kaplan, David E., Lynch, Julie, Morgan, Timothy, Schwantes-An, Tae-Hwi, Dochtermann, Daniel R., Pyarajan, Saiju, Tsao, Philip S., Laisk, Triin, Mägi, Reedik, Kozlitina, Julia, Tybjærg-Hansen, Anne, Jones, David, Knowlton, Kirk U., Nadauld, Lincoln, Ferkingstad, Egil, Björnsson, Einar S., Ulfarsson, Magnus O., Sturluson, Árni, Sulem, Patrick, Pedersen, Ole B., Ostrowski, Sisse R., Gudbjartsson, Daniel F., Stefansson, Kari, Olesen, Morten Salling, Chang, Kyong-Mi, Holm, Hilma, Bundgaard, Henning, Stender, Stefan

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Genome‐wide association analysis of serum alanine and aspartate aminotransferase, and the modifying effects of BMI in 388k European individuals von Gao, Chuan, Marcketta, Anthony, Backman, Joshua D., O'Dushlaine, Colm, Staples, Jeffrey, Ferreira, Manuel Allen Revez, Lotta, Luca A., Overton, John D., Reid, Jeffrey G., Mirshahi, Tooraj, Regeneron Genetics Center, Geisinger Regeneron Discovehr Collaboration, Baras, Aris, Abecasis, Gonçalo, Shuldiner, Alan R., Van Hout, Cristopher V., McCarthy, Shane

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Genome-wide survey of parent-of-origin-specific associations across clinical traits derived from electronic health records von Kim, Hye In, Ye, Bin, Staples, Jeffrey, Marcketta, Anthony, Gao, Chuan, Shuldiner, Alan R., Van Hout, Cristopher V.

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Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program von Klarin, Derek, Damrauer, Scott M, Cho, Kelly, Sun, Yan V, Teslovich, Tanya M, Honerlaw, Jacqueline, Gagnon, David R, DuVall, Scott L, Li, Jin, Peloso, Gina M, Chaffin, Mark, Small, Aeron M, Huang, Jie, Tang, Hua, Lynch, Julie A, Ho, Yuk-Lam, Liu, Dajiang J, Emdin, Connor A, Li, Alexander H, Huffman, Jennifer E, Lee, Jennifer S, Natarajan, Pradeep, Chowdhury, Rajiv, Saleheen, Danish, Vujkovic, Marijana, Baras, Aris, Pyarajan, Saiju, Di Angelantonio, Emanuele, Neale, Benjamin M, Naheed, Aliya, Khera, Amit V, Danesh, John, Chang, Kyong-Mi, Abecasis, Gonçalo, Willer, Cristen, Dewey, Frederick E, Carey, David J, Global Lipids Genetics Consortium, Myocardial Infarction Genetics (MIGen) Consortium, Geisinger-Regeneron DiscovEHR Collaboration, VA Million Veteran Program, Concato, John, Gaziano, J Michael, O'Donnell, Christopher J, Tsao, Philip S, Kathiresan, Sekar, Rader, Daniel J, Wilson, Peter WF, Assimes, Themistocles L

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Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets von Shrine, N, Artigas, MS, Erzurumluoglu, AM, Noyvert, B, Bossini-Castillo, L, Obeidat, M, Henry, AP, Portelli, MA, Hall, RJ, Billington, CK, Rimington, TL, Fenech, AG, John, C, Blake, T, Jackson, VE, Allen, RJ, Prins, BP, Understanding Society Scientific Group, Porteous, DJ, Jarvelin, M-R, Wielscher, M, James, AL, Hui, J, Wareham, NJ, Zhao, JH, Wilson, JF, Stubbe, B, Rawal, R, Schulz, H, Imboden, M, Probst-Hensch, NM, Karrasch, S, Gieger, C, Deary, IJ, Harris, SE, Marten, J, Rudan, I, Enroth, S, Gyllensten, U, Kerr, SM, Polasek, O, Surakka, I, Vitart, V, Hayward, C, Lehtimäki, T, Raitakari, OT, Evans, DM, Henderson, AJ, Pennell, CE, Sly, PD, Wan, ES, Busch, R, Hobbs, BD, Litonjua, AA, Sparrow, DW, Gulsvik, A, Bakke, PS, Crapo, JD, Beaty, TH, Hansel, NN, Mathias, RA, Ruczinski, I, Barnes, KC, Bossé, Y, Joubert, P, van den Berge, M, Brandsma, C-A, Paré, PD, Sin, DD, Nickle, DC, Hao, K, Gottesman, O, Dewey, FE, Bruse, SE, Carey, DJ, Kirchner, HL, Geisinger-Regeneron DiscovEHR Collaboration, Jonsson, S, Thorleifsson, G, Gislason, T, Stefansson, K, Schurmann, C, Nadkarni, G, Bottinger, EP, Loos, RJF, Walters, RG, Chen, Z, Millwood, IY, Vaucher, J, Kurmi, OP, Brightling, C, Zeggini, E, Cho, MH, Silverman, EK, Sayers, I, Trynka, G, Morris, AP, Strachan, DP, Hall, IP, Tobin, MD

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Supplementary Material for: Identification of Novel Genetic Risk Variants Associated with Hidradenitis Suppurativa in an Exome Sequencing Cohort of 92,455 Individuals von R.P., Metpally, S., Vishweswaraiah, S., Krishnamurthy, N., Saiyed, R.C., Stahl, A., Golden, A., Denisenko, J., Staples, C., Gonzaga-Jauregui, D.J., Carey, F., Bechara, G.B.E., Jemec, H., Williams, U., Radhakrishna, collaboration, on behalf of the Geisinger-Regeneron DiscovEHR

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Gene-level analysis of rare variants in 379,066 whole exome sequences identifies an association of GIGYF1 loss of function with type 2 diabetes von Deaton, Aimee M., Parker, Margaret M., Ward, Lucas D., Flynn-Carroll, Alexander O., BonDurant, Lucas, Hinkle, Gregory, Akbari, Parsa, Lotta, Luca A., Baras, Aris, Nioi, Paul

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