Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1 von Geier, Ethan G., Schlessinger, Avner, Fan, Hao, Gable, Jonathan E., Irwin, John J., Sali, Andrej, Giacomini, Kathleen M.

Volltext

Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study von Steele, Natasha Z R, Carr, Jessie S, Bonham, Luke W, Geier, Ethan G, Damotte, Vincent, Miller, Zachary A, Desikan, Rahul S, Boehme, Kevin L, Mukherjee, Shubhabrata, Crane, Paul K, Kauwe, John S K, Kramer, Joel H, Miller, Bruce L, Coppola, Giovanni, Hollenbach, Jill A, Huang, Yadong, Yokoyama, Jennifer S

Volltext

Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin von Chen, Eugene C, Liang, Xiaomin, Yee, Sook Wah, Geier, Ethan G, Stocker, Sophie L, Chen, Ligong, Giacomini, Kathleen M

Volltext

SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan von Johnson, Alyssa E., Orr, Brian O., Fetter, Richard D., Moughamian, Armen J., Primeaux, Logan A., Geier, Ethan G., Yokoyama, Jennifer S., Miller, Bruce L., Davis, Graeme W.

Volltext

Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases von Cochran, J. Nicholas, Geier, Ethan G., Bonham, Luke W., Newberry, J. Scott, Amaral, Michelle D., Thompson, Michelle L., Lasseigne, Brittany N., Karydas, Anna M., Roberson, Erik D., Cooper, Gregory M., Rabinovici, Gil D., Miller, Bruce L., Myers, Richard M., Yokoyama, Jennifer S.

Volltext

Role of the copper transporter, CTR1, in platinum-induced ototoxicity von More, Swati S, Akil, Omar, Ianculescu, Alexandra G, Geier, Ethan G, Lustig, Lawrence R, Giacomini, Kathleen M

Volltext

Expression and splicing of ABC and SLC transporters in the human blood-brain barrier measured with RNAseq von Suhy, Adam M., Webb, Amy, Papp, Audrey C., Geier, Ethan G., Sadee, Wolfgang

Volltext

Expansion of highly interferon‐responsive T cells in early‐onset Alzheimer's disease von Sirkis, Daniel W., Warly Solsberg, Caroline, Johnson, Taylor P., Bonham, Luke W., Oddi, Alexis P., Geier, Ethan G., Miller, Bruce L., Rabinovici, Gil D., Yokoyama, Jennifer S.

Volltext

Insulin-Like Growth Factor Binding Protein 2 Is Associated With Biomarkers of Alzheimer's Disease Pathology and Shows Differential Expression in Transgenic Mice von Bonham, Luke W, Geier, Ethan G, Steele, Natasha Z R, Holland, Dominic, Miller, Bruce L, Dale, Anders M, Desikan, Rahul S, Yokoyama, Jennifer S

Volltext

Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy von Sirkis, Daniel W, Warly Solsberg, Caroline, Johnson, Taylor P, Bonham, Luke W, Sturm, Virginia E, Lee, Suzee E, Rankin, Katherine P, Rosen, Howard J, Boxer, Adam L, Seeley, William W, Miller, Bruce L, Geier, Ethan G, Yokoyama, Jennifer S

Volltext

Exchange of Apolipoprotein A-I between Lipid-associated and Lipid-free States: A POTENTIAL TARGET FOR OXIDATIVE GENERATION OF DYSFUNCTIONAL HIGH DENSITY LIPOPROTEINS von Cavigiolio, Giorgio, Geier, Ethan G, Shao, Baohai, Heinecke, Jay W, Oda, Michael N

Volltext

Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET von Schlessinger, Avner, Geier, Ethan, Fan, Hao, Irwin, John J, Shoichet, Brian K, Giacomini, Kathleen M, Sali, Andrej

Volltext

Radiogenomics of C9orf72 Expansion Carriers Reveals Global Transposable Element Derepression and Enables Prediction of Thalamic Atrophy and Clinical Impairment von Bonham, Luke W, Geier, Ethan G, Sirkis, Daniel W, Leong, Josiah K, Ramos, Eliana Marisa, Wang, Qing, Karydas, Anna, Lee, Suzee E, Sturm, Virginia E, Sawyer, Russell P, Friedberg, Adit, Ichida, Justin K, Gitler, Aaron D, Sugrue, Leo, Cordingley, Michael, Bee, Walter, Weber, Eckard, Kramer, Joel H, Rankin, Katherine P, Rosen, Howard J, Boxer, Adam L, Seeley, William W, Ravits, John, Miller, Bruce L, Yokoyama, Jennifer S

Volltext

The Interplay between Size, Morphology, Stability, and Functionality of High-Density Lipoprotein Subclasses von Cavigiolio, Giorgio, Shao, Baohai, Geier, Ethan G, Ren, Gang, Heinecke, Jay W, Oda, Michael N

Volltext

Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins von Salphati, Laurent, Chu, Xiaoyan, Chen, Liangfu, Prasad, Bhagwat, Dallas, Shannon, Evers, Raymond, Mamaril-Fishman, Donna, Geier, Ethan G, Kehler, Jonathan, Kunta, Jeevan, Mezler, Mario, Laplanche, Loic, Pang, Jodie, Rode, Anja, Soars, Matthew G, Unadkat, Jashvant D, van Waterschoot, Robert A B, Yabut, Jocelyn, Schinkel, Alfred H, Scheer, Nico

Volltext

Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia von Geier, Ethan G., Bourdenx, Mathieu, Storm, Nadia J., Cochran, J. Nicholas, Sirkis, Daniel W., Hwang, Ji-Hye, Bonham, Luke W., Ramos, Eliana Marisa, Diaz, Antonio, Van Berlo, Victoria, Dokuru, Deepika, Nana, Alissa L., Karydas, Anna, Balestra, Maureen E., Huang, Yadong, Russo, Silvia P., Spina, Salvatore, Grinberg, Lea T., Seeley, William W., Myers, Richard M., Miller, Bruce L., Coppola, Giovanni, Lee, Suzee E., Cuervo, Ana Maria, Yokoyama, Jennifer S.

Volltext

Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr) von Ramirez Aguilar, Laura, Acosta-Uribe, Juliana, Giraldo, Margarita M., Moreno, Sonia, Baena, Ana, Alzate, Diana, Cuastumal, Rosario, Aguillón, David, Madrigal, Lucía, Saldarriaga, Amanda, Navarro, Alexander, Garcia, Gloria P., Aguirre-Acevedo, Daniel C., Geier, Ethan G., Cochran, J. Nicholas, Quiroz, Yakeel T., Myers, Richard M., Yokoyama, Jennifer S., Kosik, Kenneth S., Lopera, Francisco

Volltext

Recent Advances in the Genetics of Frontotemporal Dementia von Sirkis, Daniel W., Geier, Ethan G., Bonham, Luke W., Karch, Celeste M., Yokoyama, Jennifer S.

Volltext

Genetic Variation in the Androgen Receptor and Measures of Plasma Testosterone Levels Suggest Androgen Dysfunction in Alzheimer's Disease von Carr, Jessie S, Bonham, Luke W, Morgans, Alicia K, Ryan, Charles J, Yokoyama, Jennifer S, Geier, Ethan G

Volltext

TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy von Alquezar, Carolina, Schoch, Kathleen M., Geier, Ethan G., Ramos, Eliana Marisa, Scrivo, Aurora, Li, Kathy H., Argouarch, Andrea R., Mlynarski, Elisabeth E., Dombroski, Beth, DeTure, Michael, Dickson, Dennis W., Yokoyama, Jennifer S., Cuervo, Ana M., Burlingame, Alma L., Schellenberg, Gerard D., Miller, Timothy M., Miller, Bruce L., Kao, Aimee W.

Volltext