Fab'-bearing siRNA TNFα-loaded nanoparticles targeted to colonic macrophages offer an effective therapy for experimental colitis von Laroui, Hamed, Viennois, Emilie, Xiao, Bo, Canup, Brandon S.B., Geem, Duke, Denning, Timothy L., Merlin, Didier

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Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage von Medina-Contreras, Oscar, Harusato, Akihito, Nishio, Hikaru, Flannigan, Kyle L, Ngo, Vu, Leoni, Giovanna, Neumann, Philipp-Alexander, Geem, Duke, Lili, Loukia N, Ramadas, Ravisankar A, Chassaing, Benoit, Gewirtz, Andrew T, Kohlmeier, Jacob E, Parkos, Charles A, Towne, Jennifer E, Nusrat, Asma, Denning, Timothy L

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Macrophage Isolation from the Mouse Small and Large Intestine von Harusato, Akihito, Geem, Duke, Denning, Timothy L.

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Combined IL-2 Immunocomplex and Anti-IL-5 mAb Treatment Expands Foxp3 + Treg Cells in the Absence of Eosinophilia and Ameliorates Experimental Colitis von Abo, Hirohito, Flannigan, Kyle L, Geem, Duke, Ngo, Vu L, Harusato, Akihito, Denning, Timothy L

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Resolution of recurrent pediatric acute liver failure with liver transplantation in a patient with NBAS mutation von Geem, Duke, Jiang, Wenxiao, Rytting, Heather B., Chandrakasan, Shanmuganathan, Salem, Anand, Stevens, James P., Karpen, Saul J., Magliocca, Joseph F., Romero, Rene, Rodriguez, Dellys Soler

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Small intestinal intraepithelial TCRγδ+ T lymphocytes are present in the premature intestine but selectively reduced in surgical necrotizing enterocolitis von Weitkamp, Jörn-Hendrik, Rosen, Michael J, Zhao, Zhiguo, Koyama, Tatsuki, Geem, Duke, Denning, Timothy L, Rock, Michael T, Moore, Daniel J, Halpern, Melissa D, Matta, Pranathi, Denning, Patricia W

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Persistent Inflammation of the Rectum in Perianal Fistulizing Crohn's Disease Is Associated With Goblet Cell Function von Washburn, Savannah, Maddipatla, Sushma C, Murthy, Shanta, Dodd, Anne, Pelia, Ranjit S, Kolachala, Vasantha L, Geem, Duke, Matthews, Jason D, Gibson, Greg, Kugathasan, Subra

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Phenotypic and functional profiling of mouse intestinal antigen presenting cells von Harusato, Akihito, Flannigan, Kyle L., Geem, Duke, Denning, Timothy L.

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Targeting Intestinal Inflammation With CD98 siRNA/PEI–loaded Nanoparticles von Laroui, Hamed, Geem, Duke, Xiao, Bo, Viennois, Emilie, Rakhya, Poonam, Denning, Timothy, Merlin, Didier

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A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage von Ngo, Vu L., Abo, Hirohito, Maxim, Estera, Harusato, Akihito, Geem, Duke, Medina-Contreras, Oscar, Merlin, Didier, Gewirtz, Andrew T., Nusrat, Asma, Denning, Timothy L.

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866 PRO-INFLAMMATORY SIRPα-EXPRESSING MONOCYTES AND MACROPHAGES MEDIATE ANTI-TNF REFRACTORY CROHN'S DISEASE IN CHILDREN von Geem, Duke, Maddipatia, Sushma C., Pelia, Ranjit S., Matthews, Jason, Anbazhagan, Murugadas, Kolachala, Vasantha, Dodd, Ann, Kugathasan, Subra

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Su1735 PTGER4-PGE2 SIGNALING DRIVES EXPRESSION OF THE GOBLET CELL MARKER SPINK4 IN PATIENT-DERIVED INTESTINAL ORGANOIDS von Anbazhagan, Murugadas, Murthy, Shanta, Maddipatia, Sushma C., Geem, Duke, Kolachala, Vasantha, Dodd, Ann, Cutler, David J., Matthews, Jason, Kugathasan, Subra

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Intestinal Antigen-Presenting Cells: Key Regulators of Immune Homeostasis and Inflammation von Flannigan, Kyle L, Geem, Duke, Harusato, Akihito, Denning, Timothy L

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PRO-INFLAMMATORY SIRPα-EXPRESSING MONOCYTES AND MACROPHAGES MEDIATE ANTI-TNF REFRACTORY CROHN'S DISEASE IN CHILDREN von Geem, Duke, Maddipatla, Sushma, Pelia, Ranjit, Venkateswaran, Suresh, Matthews, Jason, Anbazhagan, Murugadas, Kolachala, Vasantha, Dodd, Anne, Kugathasan, Subra

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IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria von Flannigan, K L, Ngo, V L, Geem, D, Harusato, A, Hirota, S A, Parkos, C A, Lukacs, N W, Nusrat, A, Gaboriau-Routhiau, V, Cerf-Bensussan, N, Gewirtz, A T, Denning, T L

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Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mo... von Denning, Timothy L, Norris, Brian A, Medina-Contreras, Oscar, Manicassamy, Santhakumar, Geem, Duke, Madan, Rajat, Karp, Christopher L, Pulendran, Bali

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CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice von Medina-Contreras, Oscar, Geem, Duke, Laur, Oskar, Williams, Ifor R, Lira, Sergio A, Nusrat, Asma, Parkos, Charles A, Denning, Timothy L

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12: MUCOSAL BIOPSY DERIVED MESENCHYMAL STROMAL CELLS DISPLAY FITNESS AND FUNCTIONALITY TO USE AS AUTOLOGOUS CELLULAR PHARMACEUTICALS FOR INFLAMMATORY BOWEL DISEASE von Anbazhagan, Murugadas, Geem, Duke, Venkateswaran, Suresh, Pelia, Ranjit S., Kolachala, Vasantha, Dodd, Ann, Matthews, Jason, Chinnadurai, Raghavan, Kugathasan, Subra

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Su1816 COMPARATIVE SINGLE-CELL RNA-SEQ ANALYSIS BETWEEN PATIENT-DERIVED MUCOSAL EPITHELIUM AND THEIR INTESTINAL ORGANOIDS von Murthy, Shanta, Maddipatia, Sushma C., Anbazhagan, Murugadas, Pelia, Ranjit S., Dodd, Ann, Kolachala, Vasantha, Geem, Duke, Cutler, David J., Matthews, Jason, Kugathasan, Subra

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Harnessing regulatory T cells for the treatment of inflammatory bowel disease von Geem, Duke, Harusato, Akihito, Flannigan, Kyle, Denning, Timothy L

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