Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity von Karger, David R, Fraenkel, Ernest, Su, Linhui Julie, Geddie, Melissa L, King, Oliver D, Riva, Laura, Yeger-Lotem, Esti, Cashikar, Anil G, Lindquist, Susan, Auluck, Pavan K, Gitler, Aaron D, Valastyan, Julie S

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Novel HPLC-Based Screening Method to Assess Developability of Antibody-Like Molecules von Kohli, Neeraj, Geddie, Melissa L.

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Polyamine pathway contributes to the pathogenesis of Parkinson disease von Lewandowski, Nicole M., Ju, Shulin, Verbitsky, Miguel, Ross, Barbara, Geddie, Melissa L., Rockenstein, Edward, Adame, Anthony, Muhammad, Alim, Vonsattel, Jean Paul, Ringe, Dagmar, Cote, Lucien, Lindquist, Susan, Masliah, Eliezer, Petsko, Gregory A., Marder, Karen, Clark, Lorraine N., Small, Scott A.

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Development of disulfide-stabilized Fabs for targeting of antibody-directed nanotherapeutics von Geddie, Melissa L, Kirpotin, Dmitri B, Kohli, Neeraj, Kornaga, Tad, Boll, Bjoern, Razlog, Maja, Drummond, Daryl C, Lugovskoy, Alexey A

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Antitumour activity and tolerability of an EphA2-targeted nanotherapeutic in multiple mouse models von Kamoun, Walid S., Kirpotin, Dmitri B., Huang, Zhaohua Richard, Tipparaju, Suresh K., Noble, Charles O., Hayes, Mark E., Luus, Lia, Koshkaryev, Alexander, Kim, Jaeyeon, Olivier, Ken, Kornaga, Tad, Oyama, Shinji, Askoxylakis, Vasileios, Pien, Christine, Kuesters, Geoffrey, Dumont, Nancy, Lugovskoy, Alexey A., Schihl, Sarah A., Wilton, John H., Geddie, Melissa L., Suchy, James, Grabow, Stephanie, Kohli, Neeraj, Reynolds, C. Patrick, Blaydes, Rachel, Zhou, Yu, Sawyer, Andrew J., Marks, James D., Drummond, Daryl C.

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Comprehensive optimization of a single-chain variable domain antibody fragment as a targeting ligand for a cytotoxic nanoparticle von Zhang, Kathy, Geddie, Melissa L, Kohli, Neeraj, Kornaga, Tad, Kirpotin, Dmitri B, Jiao, Yang, Rennard, Rachel, Drummond, Daryl C, Nielsen, Ulrik B, Xu, Lihui, Lugovskoy, Alexey A

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Improving the developability of an anti-EphA2 single-chain variable fragment for nanoparticle targeting von Geddie, Melissa L, Kohli, Neeraj, Kirpotin, Dmitri B, Razlog, Maja, Jiao, Yang, Kornaga, Tad, Rennard, Rachel, Xu, Lihui, Schoerberl, Birgit, Marks, James D, Drummond, Daryl C, Lugovskoy, Alexey A

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A Comparison of Directed Evolution Approaches Using the β-Glucuronidase Model System von Rowe, Lori A., Geddie, Melissa L., Alexander, Omar B., Matsumura, Ichiro

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Rational Design of p53, an Intrinsically Unstructured Protein, for the Fabrication of Novel Molecular Sensors von Geddie, Melissa L., O'Loughlin, Taryn L., Woods, Kristen K., Matsumura, Ichiro

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High Throughput Microplate Screens for Directed Protein Evolution von Geddie, Melissa L, Rowe, Lori A, Alexander, Omar B, Matsumura, Ichiro

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Abstract 22: MM-161, a first-in-class pan-FGFR antibody von Dake, Tamara, Finn, Greg, Geddie, Melissa, Kohli, Neeraj, Razlog, Maja, Xu, Lihui, Paragas, Violette, Yuzugullu, Haluk, Ghassemifar, Sara, Hashambhoy-Ramsay, Yasmin, McDonagh, Charlotte, Muda, Marco, Schoeberl, Birgit

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Abstract 1690: Mechanistic characterization of MM-131, a bispecific antibody that blocks c-Met signaling through concurrent targeting of EpCAM von Abu-Yousif, Adnan O., Casaletto, Jessica B., Masson, Kristina, Fulgham, Aaron, Geddie, Melissa, Schoeberl, Birgit, Nielsen, Ulrik, MacBeath, Gavin

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Abstract 871: Nanoliposomal targeting of ephrin receptor A2 (EphA2): Preclinical in vitro and in vivo rationale von Kamoun, Walid S., Luus, Lia, Pien, Christine, Kornaga, Tad, Oyama, Shinji, Huang, Zhaohua Richard, Tipparaju, Suresh, Kirpotin, Dmitri B., Marks, James D., Koshkaryev, Alexander, Geddie, Melissa, Xu, Lihui, Lugovosky, Alexey, Drummond, Daryl C.

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HINGE-MODIFIED BISPECIFIC ANTIBODIES von Lugovskoy, Alexey Alexandrovich, Hus, Jean-Christophe, Geddie, Melissa

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Bridging high-throughput genetic and transcriptional data reveals cellular responses to alphα-synuclein toxicity von Yeger-Lotem, Esti, Riva, Laura, Su, Linhui Julie, Gitler, Aaron D, Cashikar, Anil G, King, Oliver D, Auluck, Pavan K, Geddie, Melissa L, Valastyan, Julie S, Karger, David R, Lindquist, Susan, Fraenkel, Ernest

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Bridging the gap between high-throughput genetic and transcriptional data reveals cellular pathways responding to alpha-synuclein toxicity von Yeger-Lotem, Esti, Riva, Laura, Su, Linhui Julie, Gitler, Aaron D., Cashikar, Anil, King, Oliver D., Auluck, Pavan K., Geddie, Melissa L., Valastyan, Julie S., Karger, David R., Lindquist, Susan, Fraenkel, Ernest

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BISPECIFIC AGONISTIC ANTIBODIES TO ACTIVIN A RECEPTOR LIKE TYPE 1 (ALK1) von HUS, Jean-Christophe, LUGOVSKOY, Alexey Alexandrovich, GEDDIE, Melissa

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HETEROMERIC AGONISTIC ANTIBODIES TO IL-18 RECEPTOR von Lugovskoy, Alexey Alexandrovich, Hus, Jean-Christophe, Geddie, Melissa

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Rapid Evolution of β-Glucuronidase Specificity by Saturation Mutagenesis of an Active Site Loop von Melissa L. Geddie, Ichiro Matsumura

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Development of disulfide-stabilized Fabs for targeting of antibody-directed nanotherapeutics von Geddie, Melissa L., Kirpotin, Dmitri B., Kohli, Neeraj, Kornaga, Tad, Boll, Bjoern, Razlog, Maja, Drummond, Daryl C., Lugovskoy, Alexey A.

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