The status of Nrf2-based therapeutics： current perspectives and future prospects von Gazaryan, Irina, Thomas, Bobby

Volltext

Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy von Tapias, Victor, Jainuddin, Shari, Ahuja, Manuj, Stack, Cliona, Elipenahli, Ceyhan, Vignisse, Julie, Gerges, Meri, Starkova, Natalia, Xu, Hui, Starkov, Anatoly A, Bettendorff, Lucien, Hushpulian, Dmitry M, Smirnova, Natalya A, Gazaryan, Irina G, Kaidery, Navneet A, Wakade, Sushama, Calingasan, Noel Y, Thomas, Bobby, Gibson, Gary E, Dumont, Magali, Beal, M Flint

Volltext

Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease von Kaidery, Navneet Ammal, Banerjee, Rebecca, Yang, Lichuan, Smirnova, Natalya A, Hushpulian, Dmitry M, Liby, Karen T, Williams, Charlotte R, Yamamoto, Masayuki, Kensler, Thomas W, Ratan, Rajiv R, Sporn, Michael B, Beal, M Flint, Gazaryan, Irina G, Thomas, Bobby

Volltext

Neurotoxic lupus autoantibodies alter brain function through two distinct mechanisms von Faust, Thomas W., Chang, Eric H., Kowal, Czeslawa, Berlin, RoseAnn, Gazaryan, Irina G., Bertini, Eva, Zhang, Jie, Sanchez-Guerrero, Jorge, Fragoso-Loyo, Hilda E., Volpe, Bruce T., Diamond, Betty, Huerta, Patricio T., Scharff, Matthew D.

Volltext

Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for Neurotherapeutics: Bach1 De-Repression to the Rescue von Hushpulian, Dmitry M, Ammal Kaidery, Navneet, Ahuja, Manuj, Poloznikov, Andrey A, Sharma, Sudarshana M, Gazaryan, Irina G, Thomas, Bobby

Volltext

Zinc Irreversibly Damages Major Enzymes of Energy Production and Antioxidant Defense Prior to Mitochondrial Permeability Transition von Gazaryan, Irina G., Krasinskaya, Inna P., Kristal, Bruce S., Brown, Abraham M.

Volltext

Carotenoids from Starfish Patiria pectinifera: Therapeutic Activity in Models of Inflammatory Diseases von Popov, Aleksandr M., Kozlovskaya, Emma P., Klimovich, Anna A., Rutckova, Tatyana A., Vakhrushev, Aleksey I., Hushpulian, Dmitry M., Gazaryan, Irina G., Makhankov, Vyacheslav V., Son, Oksana M., Tekutyeva, Liudmila A.

Volltext

HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons von Poloznikov, Andrey A, Nersisyan, Stepan A, Hushpulian, Dmitry M, Kazakov, Eliot H, Tonevitsky, Alexander G, Kazakov, Sergey V, Vechorko, Valery I, Nikulin, Sergey V, Makarova, Julia A, Gazaryan, Irina G

Volltext

Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway von Haskew-Layton, Renée E., Payappilly, Jimmy B., Smirnova, Natalya A., Ma, Thong C., Chan, Kelvin K., Murphy, Timothy H., Guo, Hengchang, Langley, Brett, Sultana, Rukhsana, Butterfield, D. Allan, Santagata, Sandro, Alldred, Melissa J., Gazaryan, Irina G., Bell, George W., Ginsberg, Stephen D., Ratan, Rajiv R.

Volltext

Degradation Kinetics of Disulfide Cross-Linked Microgels: Real-Time Monitoring by Confocal Microscopy von Mercer, Iris G, Italiano, Angelina N, Gazaryan, Irina G, Steiner, Aaron B, Kazakov, Sergey V

Volltext

Zinc Switch in Pig Heart Lipoamide Dehydrogenase: Steady-State and Transient Kinetic Studies of the Diaphorase Reaction von Gazaryan, I. G., Shchedrina, V. A., Klyachko, N. L., Zakhariants, A. A., Kazakov, S. V., Brown, A. M.

Volltext

Synthesis and Anti‐Inflammatory Activity of 2‐Amino‐4,5,6,7‐tetrahydrobenzo[b]thiophene‐Derived NRF2 Activators von Mak, Kit‐Kay, Shiming, Zhang, Epemolu, Ola, Dinkova‐Kostova, Albena T., Wells, Geoffrey, Gazaryan, Irina G., Sakirolla, Raghavendra, Mohd, Zulkefeli, Pichika, Mallikarjuna Rao

Volltext

The molecular chaperone sigma 1 receptor mediates rescue of retinal cone photoreceptor cells via modulation of NRF2 von Wang, J., Zhao, J., Cui, X., Mysona, B.A., Navneet, S., Saul, A., Ahuja, M., Lambert, N., Gazaryan, I.G., Thomas, B., Bollinger, K.E., Smith, S.B.

Volltext

Zinc Is a Potent Inhibitor of Thiol Oxidoreductase Activity and Stimulates Reactive Oxygen Species Production by Lipoamide Dehydrogenase von Gazaryan, Irina G., Krasnikov, Boris F., Ashby, Gillian A., Thorneley, Roger N.F., Kristal, Bruce S., Brown, Abraham M.

Volltext

Comparison of physico-chemical characteristics of four laccases from different basidiomycetes von Shleev, S.V., Morozova, O.V., Nikitina, O.V., Gorshina, E.S., Rusinova, T.V., Serezhenkov, V.A., Burbaev, D.S., Gazaryan, I.G., Yaropolov, A.I.

Volltext

Structure-Activity Relationships and Transcriptomic Analysis of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors von Poloznikov, Andrey A, Nikulin, Sergey V, Hushpulian, Dmitry M, Khristichenko, Anna Yu, Osipyants, Andrey I, Asachenko, Andrey F, Shurupova, Olga V, Savin, Svyatoslav S, Lee, Sue H, Gaisina, Irina N, Thatcher, Gregory R J, Narciso, Anthony, Chang, Eric P, Kazakov, Sergey V, Krucher, Nancy, Tishkov, Vladimir I, Thomas, Bobby, Gazaryan, Irina G

Volltext

Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson's Disease von Smirnova, Natalya A, Kaidery, Navneet Ammal, Hushpulian, Dmitry M, Rakhman, Ilay I, Poloznikov, Andrey A, Tishkov, Vladimir I, Karuppagounder, Saravanan S, Gaisina, Irina N, Pekcec, Anton, Leyen, Klaus Van, Kazakov, Sergey V, Yang, Lichuan, Thomas, Bobby, Ratan, Rajiv R, Gazaryan, Irina G

Volltext

ACUTE CORONARY SYNDROME DUE TO CORONARY VASOSPASM – CASE REPORT von Klimovskiy, S. D., Gazaryan, G. G., Krichman, M. D., Pisetskiy, P. B., Koledinskiy, A. G., Mirilashvili, T. Sh

Volltext

Biosensors based on novel peroxidases with improved properties in direct and mediated electron transfer von Lindgren, Annika, Ruzgas, Tautgirdas, Gorton, Lo, Csöregi, Elisabeth, Bautista Ardila, Gerardo, Sakharov, Ivan Yu, Gazaryan, Irina G

Volltext

A screen for inducers of p21waf1/cip1 identifies HIF prolyl hydroxylase inhibitors as neuroprotective agents with antitumor properties von Ma, Thong C, Langley, Brett, Ko, Brian, Wei, Na, Gazaryan, Irina G, Zareen, Neela, Yamashiro, Darrell J, Willis, Dianna E, Ratan, Rajiv R

Volltext