Abstract 1020: BRD9 defines a novel mammalian SWI/SNF (BAF) complex configuration which supports proliferation in AML von Michel, Brittany C., Pan, Joshua, Meyers, Robin M., Grandi, Paola, Humphreys, Phillip G., Garton, Neil G., Prinja, Rab K., Kadoch, Cigall

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Interrogating the Druggability of the 2‑Oxoglutarate-Dependent Dioxygenase Target Class by Chemical Proteomics von Joberty, Gérard, Boesche, Markus, Brown, Jack A, Eberhard, Dirk, Garton, Neil S, Humphreys, Philip G, Mathieson, Toby, Muelbaier, Marcel, Ramsden, Nigel G, Reader, Valérie, Rueger, Anne, Sheppard, Robert J, Westaway, Susan M, Bantscheff, Marcus, Lee, Kevin, Wilson, David M, Prinjha, Rab K, Drewes, Gerard

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Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor von Liddle, John, Atkinson, Francis L., Barker, Michael D., Carter, Paul S., Curtis, Neil R., Davis, Rob P., Douault, Clement, Dickson, Marion C., Elwes, Dorothy, Garton, Neil S., Gray, Matthew, Hayhow, Thomas G., Hobbs, Clare I., Jones, Emma, Leach, Stuart, Leavens, Karen, Lewis, Huw D., McCleary, Scott, Neu, Margarete, Patel, Vipulkumar K., Preston, Alex G.S., Ramirez-Molina, Cesar, Shipley, Tracy J., Skone, Philip A., Smithers, Nick, Somers, Donald O., Walker, Ann L., Watson, Robert J., Weingarten, Gordon G.

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Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4‑d]pyrimidin-4(3H)‑one Derivatives von Westaway, Susan M, Preston, Alex G. S, Barker, Michael D, Brown, Fiona, Brown, Jack A, Campbell, Matthew, Chung, Chun-wa, Drewes, Gerard, Eagle, Robert, Garton, Neil, Gordon, Laurie, Haslam, Carl, Hayhow, Thomas G, Humphreys, Philip G, Joberty, Gerard, Katso, Roy, Kruidenier, Laurens, Leveridge, Melanie, Pemberton, Michelle, Rioja, Inma, Seal, Gail A, Shipley, Tracy, Singh, Onkar, Suckling, Colin J, Taylor, Joanna, Thomas, Pamela, Wilson, David M, Lee, Kevin, Prinjha, Rab K

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Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors von Garton, Neil S., Barker, Michael D., Davis, Rob P., Douault, Clement, Hooper-Greenhill, Edward, Jones, Emma, Lewis, Huw D., Liddle, John, Lugo, Dave, McCleary, Scott, Preston, Alex G.S., Ramirez-Molina, Cesar, Neu, Margarete, Shipley, Tracy J., Somers, Don O., Watson, Robert J., Wilson, David M.

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6-Aryl-pyrazolo[3,4- b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3) von Witherington, Jason, Bordas, Vincent, Gaiba, Alessandra, Garton, Neil S., Naylor, Antoinette, Rawlings, Anthony D., Slingsby, Brian P., Smith, David G., Takle, Andrew K., Ward, Robert W.

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OSI-930 : A novel selective inhibitor of kit and kinase insert domain receptor tyrosine kinases with antitumor activity in mouse xenograft models von GARTON, Andrew J, CREW, Andrew P. A, BITTNER, Mark A, KEILY, John F, BRINER, Paul, HIDDEN, Chris, SREBERNAK, Mary C, PIRRIT, Carrie, O'CONNOR, Matthew, ANNA CHAN, VULEVIC, Bojana, HENNINGER, Dwight, FRANKLIN, Maryland, HART, Karen, SENNELLO, Regina, LI, An-Hu, TAO ZHANG, RICHARDSON, Frank, EMERSON, David L, CASTELHANO, Arlindo L, ARNOLD, Lee D, GIBSON, Neil W, COOKE, Andrew R, WYNNE, Graham M, CASTALDO, Linda, KAHLER, Jennifer, WINSKI, Shannon L, FRANKS, April, BROWN, Eric N

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Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists von Witherington, Jason, Blaney, Emma L., Bordas, Vincent, Elliott, Richard L., Gaiba, Alessandra, Garton, Neil, Green, Philip M., Naylor, Antoinette, Smith, David G., Spalding, David J., Takle, Andrew K., Ward, Robert W.

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6-Aryl-pyrazolo[3,4-b]pyridines: Potent inhibitors of glycogen synthase kinase-3 (GSK-3): Recent advances in the design of kinase inhibitors as novel therapeutic agents von WITHERINGTON, Jason, BORDAS, Vincent, GAIBA, Alessandra, GARTON, Neil S, NAYLOR, Antoinette, RAWLINGS, Anthony D, SLINGSBY, Brian P, SMITH, David G, TAKLE, Andrew K, WARD, Robert W

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PYRIDO[3,4-B]PYRAZINE DERIVATIVES AS SYK INHIBITORS von WILSON, DAVID MATTHEW, ATKINSON, STEPHEN JOHN, GARTON, NEIL STUART, LIDDLE, JOHN, DOUAULT, CLEMENT, WATSON, ROBERT J, PATEL, VIPULKUMAR KANTIBHAI, ATKINSON, FRANCIS LOUIS, SHIPLEY, TRACY JANE, BARKER, MICHAEL DAVID, PRESTON, ALEXANDER G

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PYRIDO[3,4-B]PYRAZINE DERIVATIVES AS SYK INHIBITORS von WILSON DAVID MATTHEW, ATKINSON FRANCIS LOUIS, PRESTON ALEXANDER G, LIDDLE JOHN, PATEL VIPULKUMAR KANTIBHAI, WATSON ROBERT J, ATKINSON STEPHEN JOHN, GARTON NEIL STUART, DOUAULT CLEMENT, BARKER MICHAEL DAVID, SHIPLEY TRACY JANE

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PYRIDO[3,4-B]PYRAZINE DERIVATIVES AS SYK INHIBITORS von WILSON, DAVID MATTHEW, ATKINSON, STEPHEN JOHN, GARTON, NEIL STUART, LIDDLE, JOHN, DOUAULT, CLEMENT, WATSON, ROBERT J, PATEL, VIPULKUMAR KANTIBHAI, ATKINSON, FRANCIS LOUIS, SHIPLEY, TRACY JANE, BARKER, MICHAEL DAVID, PRESTON, ALEXANDER G

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6-Aryl-pyrazolo[3,4-b]pyridines: Potent Inhibitors of Glycogen Synthase Kinase-3 (GSK-3) von Witherington, Jason, Bordas, Vincent, Gaiba, Alessandra, Garton, Neil S., Naylor, Antoinette, Rawlings, Anthony D., Slingsby, Brian P., Smith, David G., Takle, Andrew K., Ward, Robert W.

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