Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms von Riley, Brigit E, Gardai, Shyra J, Emig-Agius, Dorothea, Bessarabova, Marina, Ivliev, Alexander E, Schüle, Birgitt, Schüle, Birgit, Alexander, Jeff, Wallace, William, Halliday, Glenda M, Langston, J William, Braxton, Scott, Yednock, Ted, Shaler, Thomas, Johnston, Jennifer A

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Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease von Gardai, Shyra J, Mao, Wenxian, Schüle, Birgitt, Babcock, Michael, Schoebel, Sue, Lorenzana, Carlos, Alexander, Jeff, Kim, Sam, Glick, Heather, Hilton, Kathryn, Fitzgerald, J Kent, Buttini, Manuel, Chiou, San-San, McConlogue, Lisa, Anderson, John P, Schenk, Dale B, Bard, Frederique, Langston, J William, Yednock, Ted, Johnston, Jennifer A

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Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte von Gardai, Shyra J., McPhillips, Kathleen A., Frasch, S. Courtney, Janssen, William J., Starefeldt, Anna, Murphy-Ullrich, Joanne E., Bratton, Donna L., Oldenborg, Per-Arne, Michalak, Marek, Henson, Peter M.

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Recognition ligands on apoptotic cells: a perspective von Gardai, Shyra J., Bratton, Donna L., Ogden, Carole Anne, Henson, Peter M.

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Brentuximab Vedotin-Driven Microtubule Disruption Results in Endoplasmic Reticulum Stress Leading to Immunogenic Cell Death and Antitumor Immunity von Heiser, Ryan A, Cao, Anthony T, Zeng, Weiping, Ulrich, Michelle, Younan, Patrick, Anderson, Martha E, Trueblood, Esther S, Jonas, Mechthild, Thurman, Robert, Law, Che-Leung, Gardai, Shyra J

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Nonfucosylation of an anti-TIGIT antibody enhances FcγR engagement, driving innate immune activation and antitumor activity von Smith, Alyson J, Thurman, Robert E, Zeng, Weiping, Grogan, Bryan, Lucas, Sasha, Gutierrez, Guadalupe, Heiser, Ryan A, Wo, Serena W, Blackmarr, Amber, Peterson, Scott, Gardai, Shyra J

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Targeting the Intrinsically Disordered Structural Ensemble of [alpha]-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson's Disease von Tóth, Gergely, Gardai, Shyra J, Zago, Wagner, Bertoncini, Carlos W, Cremades, Nunilo, Roy, Susan L, Tambe, Mitali A, Rochet, Jean-Christophe, Galvagnion, Celine, Skibinski, Gaia, Finkbeiner, Steven, Bova, Michael, Regnstrom, Karin, Chiou, San-San, Johnston, Jennifer, Callaway, Kari, Anderson, John P, Jobling, Michael F, Buell, Alexander K, Yednock, Ted A, Knowles, Tuomas P. J, Vendruscolo, Michele, Christodoulou, John, Dobson, Christopher M, Schenk, Dale, McConlogue, Lisa

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Apoptotic Cells, through Transforming Growth Factor-β, Coordinately Induce Anti-inflammatory and Suppress Pro-inflammatory Eicosanoid and NO Synthesis in Murine Macrophages von Freire-de-Lima, Celio G., Xiao, Yi Qun, Gardai, Shyra J., Bratton, Donna L., Schiemann, William P., Henson, Peter M.

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Reversible Chemical Modification of Antibody Effector Function Mitigates Unwanted Systemic Immune Activation von Moquist, Philip N., Zhang, Xinqun, Leiske, Chris I., Eng-Duncan, Nicole M.-L., Zeng, Weiping, Bindman, Noah A., Wo, Serena W., Wong, Abbie, Henderson, Clark M., Crowder, Karalyne, Lyon, Robert, Doronina, Svetlana O., Senter, Peter D., Neff-LaFord, Haley D., Sussman, Django, Gardai, Shyra J., Levengood, Matthew R.

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Therapeutic and Prophylactic Antitumor Activity of an Oral Inhibitor of Fucosylation in Spontaneous Mammary Cancers von Disis, Mary L, Corulli, Lauren R, Gad, Ekram A, Koehnlein, Marlese R, Cecil, Denise L, Senter, Peter D, Gardai, Shyra J, Okeley, Nicole M

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Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease von Tóth, Gergely, Gardai, Shyra J, Zago, Wagner, Bertoncini, Carlos W, Cremades, Nunilo, Roy, Susan L, Tambe, Mitali A, Rochet, Jean-Christophe, Galvagnion, Celine, Skibinski, Gaia, Finkbeiner, Steven, Bova, Michael, Regnstrom, Karin, Chiou, San-San, Johnston, Jennifer, Callaway, Kari, Anderson, John P, Jobling, Michael F, Buell, Alexander K, Yednock, Ted A, Knowles, Tuomas P J, Vendruscolo, Michele, Christodoulou, John, Dobson, Christopher M, Schenk, Dale, McConlogue, Lisa

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Leucine-rich repeat kinase 2 (LRRK2)-deficient rats exhibit renal tubule injury and perturbations in metabolic and immunological homeostasis von Ness, Daniel, Ren, Zhao, Gardai, Shyra, Sharpnack, Douglas, Johnson, Victor J, Brennan, Richard J, Brigham, Elizabeth F, Olaharski, Andrew J

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Abstract 4914: Auristatin-based antibody drug conjugates activate multiple ER stress response pathways resulting in immunogenic cell death and amplified T-cell responses von Cao, Anthony, Heiser, Ryan, Law, Che-Leung, Gardai, Shyra J.

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Surfactant Proteins A and D Suppress Alveolar Macrophage Phagocytosis via Interaction with SIRPα von JANSSEN, William J, MCPHILLIPS, Kathleen A, DICKINSON, Matthew G, LINDERMAN, Derek J, MORIMOTO, Konosuke, YI QUN XIAO, OLDHAM, Kelly M, VANDIVIER, R. William, HENSON, Peter M, GARDAI, Shyra J

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ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages von Jehle, Andreas W, Gardai, Shyra J, Li, Suzhao, Linsel-Nitschke, Patrick, Morimoto, Konosuke, Janssen, William J, Vandivier, R. William, Wang, Nan, Greenberg, Steven, Dale, Benjamin M, Qin, Chunbo, Henson, Peter M, Tall, Alan R

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Neutralization of soluble, synaptotoxic amyloid β species by antibodies is epitope specific von Zago, Wagner, Buttini, Manuel, Comery, Thomas A, Nishioka, Christopher, Gardai, Shyra J, Seubert, Peter, Games, Dora, Bard, Frédérique, Schenk, Dale, Kinney, Gene G

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Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS von Flanagan, Ken, Fitzgerald, Kent, Baker, Jeanne, Regnstrom, Karin, Gardai, Shyra, Bard, Frederique, Mocci, Simonetta, Seto, Pui, You, Monica, Larochelle, Catherine, Prat, Alexandre, Chow, Samuel, Li, Lauri, Vandevert, Chris, Zago, Wagner, Lorenzana, Carlos, Nishioka, Christopher, Hoffman, Jennifer, Botelho, Raquel, Willits, Christopher, Tanaka, Kevin, Johnston, Jennifer, Yednock, Ted

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Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions von Tóth, Gergely, Neumann, Thomas, Berthet, Amandine, Masliah, Eliezer, Spencer, Brian, Tao, Jiahui, Jobling, Michael F., Gardai, Shyra J., Bertoncini, Carlos W., Cremades, Nunilo, Bova, Michael, Ballaron, Stephen, Chen, Xiao-Hua, Mao, Wenxian, Nguyen, Phuong, Tabios, Mariano C., Tambe, Mitali A., Rochet, Jean-Christophe, Junker, Hans-Dieter, Schwizer, Daniel, Sekul, Renate, Ott, Inge, Anderson, John P., Szoke, Balazs, Hoffman, Wherly, Christodoulou, John, Yednock, Ted, Agard, David A., Schenk, Dale, McConlogue, Lisa

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SGN-B7H4V, an investigational vedotin ADC directed to the immune checkpoint ligand B7-H4, shows promising activity in preclinical models von Gray, Elizabeth, Ulrich, Michelle, Epp, Angela, Younan, Patrick, Sahetya, Disha, Hensley, Kelly, Allred, Sean, Huang, Li-Ya, Hahn, Julie, Gahnberg, Kristen, Treuting, Piper M, Trueblood, Esther S, Gosink, John J, Thurman, Robert, Wo, Serena, Spahr, Kellie, Haass, Evgenia Jane, Snead, Katie, Miller, Dannah, Padilla, Mary, Smith, Alyson J, Frantz, Chris, Schrum, Jason P, Nazarenko, Natalya, Gardai, Shyra J

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Abstract 4994: SEA-CD40: from bench to bedside von Gardai, Shyra J., Neff-LaFord, Haley, Epp, Angela, Yang, Jing, Manley, Thomas, Law, Che-Leung

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