147P Blind validation of an AI-based tool for predicting distant relapse from breast cancer HES stained slides von Garberis, I.J., Gaury, V., Aubert, V., Drubay, D., Saillard, C., Elgui, K., F. Bernigole, Jacquet, A., André, F., Lacroix-Triki, M.

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1760MO Impact of immune checkpoint blockade therapy according to CD274 copy number alterations: A retrospective study in the ProfiLER cohort von Hodroj, K., Heudel, P-E., Fonnesu, M., Karabajakian, A., Attignon, V.K., Tredan, O., Filleron, T., Garberis, I.J., Jimenez, M., André, F., Bachelot, T.

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1124O Prediction of distant relapse in patients with invasive breast cancer from deep learning models applied to digital pathology slides von Garberis, I.J., Saillard, C., Drubay, D., Schmauch, B., Aubert, V., Jaeger, A., Sapateiro, M., de Lavergne, A., Kamoun, A., Courtiol, P., André, F., Lacroix-Triki, M.

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138P Dissecting intra-tumoral heterogeneity in localized HR+/Her2− breast cancer using single cell DNA sequencing von Cerbone, L., Tran, D.T.N., Tran Dien, A., Verret, B., Droin, N., Scott, V., Garberis, I.J., Savaudet, A., Maella, F., Leite, B., Scoazec, J-Y., Ayadi, C., Machavoine, C., Camara-Clayette, V., André, F.

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18P Comparative genomic profiling of primary and locally recurrent luminal breast cancers (BC) von Rassy, E., Garberis, I.J., Tran Dien, A., Scott, V., Bouakka, I., Bassil, J.J., Lacroix-Triki, M., Zanconati, F., Giudici, F., Generali, D., Rouleau, E., Lacroix, L., André, F., Pistilli, B.

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LBA1 Unraveling the mechanism of action and resistance to trastuzumab deruxtecan (T-DXd): Biomarker analyses from patients from DAISY trial von Mosele, M.F., Lusque, A., Dieras, V., Deluche, E., Ducoulombier, A., Pistilli, B., Bachelot, T., Viret, F., Levy, C., Signolle, N., Tran, D., Garberis, I.J., Le-Bescond, L., Dien, A. Tran, Droin, N., Kobayashi, M., Kakegawa, T., Jimenez, M., Lacroix-Triki, M., André, F.

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161O Randomized preoperative window of opportunity (WOO) study with the CDK4/6 inhibitor abemaciclib in early breast cancer (EBC) patients and differential gene expression pathway... von Arnedos, M., Chaltiel, D., Cheaib, B., Drubay, D., Gentien, D., Vieillefon, A., Scott, V., Bouakka, I., Adam, J., Garberis, I.J., Rimareix, F., Leymarie, N., Viansone, A.A., Lacroix-Triki, M., Michiels, S., André, F.

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2O Dissecting intratumoral heterogeneity in localized HR+/HER2- breast cancer using single-cell DNA sequencing (scDNA-seq) von Tran, D.T.N., Dien, A. Tran, Cerbone, L., Verret, B., Droin, N., Scott, V., Garberis, I.J., Sauvadet, A., Francillette, M., Leite, B., Scoazec, J-Y., Ayadi, C., Machavoine, C., Camara-Clayette, V., André, F.

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