Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies von Armstrong, Lee A, Lange, Sven M, Dee Cesare, Virginia, Matthews, Stephen P, Nirujogi, Raja Sekhar, Cole, Isobel, Hope, Anthony, Cunningham, Fraser, Toth, Rachel, Mukherjee, Rukmini, Bojkova, Denisa, Gruber, Franz, Gray, David, Wyatt, Paul G, Cinatl, Jindrich, Dikic, Ivan, Davies, Paul, Kulathu, Yogesh

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Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design von Zhang, Sixue, Garzan, Atefeh, Haese, Nicole, Bostwick, Robert, Martinez-Gzegozewska, Yohanka, Rasmussen, Lynn, Streblow, Daniel N, Haise, Mark T, Pathak, Ashish K, Augelli-Szafran, Corinne E, Wu, Mousheng

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Heavy water inhibits DNA double-strand break repairs and disturbs cellular transcription, presumably via quantum-level mechanisms of kinetic isotope effects on hydrolytic enzyme re... von Yasuda, Takeshi, Nakajima, Nakako, Ogi, Tomoo, Yanaka, Tomoko, Tanaka, Izumi, Gotoh, Takaya, Kagawa, Wataru, Sugasawa, Kaoru, Tajima, Katsushi

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Dual-targeting class I HDAC inhibitor and ATM activator, SP-1-303, preferentially inhibits estrogen receptor positive breast cancer cell growth von Jung, Mira, Nicholas, Nicole, Grindrod, Scott, Dritschilo, Anatoly

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Equations for estimating binary mixture toxicity: 3-methyl-2-butanone with a series of electrophiles von Dawson, Douglas A, Schultz, Terry W

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Contribution of amino acids in the active site of dipeptidyl peptidase 4 to the catalytic action of the enzyme von Gnoth, Kathrin, Bär, Joachim Wolfgang, Rosche, Fred, Rahfeld, Jens-Ulrich, Demuth, Hans-Ulrich

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Effect of the LSD1 inhibitor RN-1 on γ-globin and global gene expression during erythroid differentiation in baboons (Papio anubis) von Ibanez, Vinzon, Vaitkus, Kestis, Ruiz, Maria Armila, Lei, Zhengdeng, Maienschein-Cline, Mark, Arbieva, Zarema, Lavelle, Donald

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cis-Decalin-containing tetramic acids as inhibitors of insect steroidogenic glutathione S-transferase Noppera-bo von Kato, Naoki, Ebihara, Kana, Nogawa, Toshihiko, Futamura, Yushi, Inaba, Kazue, Okano, Akiko, Aono, Harumi, Fujikawa, Yuuta, Inoue, Hideshi, Matsuda, Kazuhiko, Osada, Hiroyuki, Niwa, Ryusuke, Takahashi, Shunji

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The exquisite specificity of human protein arginine methyltransferase 7 (PRMT7) toward Arg-X-Arg sites von Bondoc, Timothy J, Lowe, Troy L, Clarke, Steven G

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Epigenetic regulation in colorectal cancer: The susceptibility of microRNAs 145, 143 and 133b to DNA demethylation and histone deacetylase inhibitors von Omar, Aadilah, Govan, Drishna, Penny, Clement

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Exploring functional and structural features of chemically related natural prenylated hydroquinone and benzoic acid from Piper crassinervium (Piperaceae) on bacterial peroxiredoxin... von Montanhero Cabrera, Vitoria Isabela, do Nascimento Sividanes, Gabrielle, Quintiliano, Natalia Fernanda, Hikari Toyama, Marcos, Ghilardi Lago, João Henrique, de Oliveira, Marcos Antonio

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Label-free affinity screening, design and synthesis of inhibitors targeting the Mycobacterium tuberculosis L-alanine dehydrogenase von Kim, Heung-Bok, Bacik, John-Paul, Wu, Ruilian, Jha, Ramesh K, Hebron, Michaeline, Triandafillou, Catherine, McCown, Joseph E, Baek, Nam-In, Kim, Jeong Han, Kim, Young Jae, Goulding, Celia W, Strauss, Charlie E M, Schmidt, Jurgen G, Shetye, Gauri S, Ryoo, Sungweon, Jo, Eun-Kyeong, Jeon, Young Ho, Hung, Li-Wei, Terwilliger, Thomas C, Kim, Chang-Yub

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Binding of omeprazole to protein targets identified by monoclonal antibodies von Cartee, Naw May Pearl, Wang, Michael M

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The ubiquinone synthesis pathway is a promising drug target for Chagas disease von Nara, Takeshi, Nakagawa, Yukari, Tsuganezawa, Keiko, Yuki, Hitomi, Sekimata, Katsuhiko, Koyama, Hiroo, Ogawa, Naoko, Honma, Teruki, Shirouzu, Mikako, Fukami, Takehiro, Matsuo, Yuichi, Inaoka, Daniel Ken, Kita, Kiyoshi, Tanaka, Akiko

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Expression of epigenetic pathway related genes in association with PD-L1, ER/PgR and MLH1 in endometrial carcinoma von Saglam, Ozlen, Cao, Biwei, Wang, Xuefeng, Toruner, Gokce A, Conejo-Garcia, Jose R

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One-pot three component synthesis of substituted dihydropyrimidinones using fruit juices as biocatalyst and their biological studies von Gulati, Susheel, Singh, Rajvir, Prakash, Ram, Sangwan, Suman, Ganesan, A

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Piperidine scaffold as the novel P2-ligands in cyclopropyl-containing HIV-1 protease inhibitors: Structure-based design, synthesis, biological evaluation and docking study von Zhou, Huiyu, Zhu, Mei, Ma, Ling, Zhou, Jinming, Dong, Biao, Zhang, Guoning, Cen, Shan, Wang, Yucheng, Wang, Juxian

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Marine sediment-derived Streptomyces bacteria from British Columbia, Canada are a promising microbiota resource for the discovery of antimicrobial natural products von Dalisay, Doralyn S, Williams, David E, Wang, Xiao Ling, Centko, Ryan, Chen, Jessie, Andersen, Raymond J

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Practical spectrophotometric assay for the dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase, a potential antibiotic target von Heath, Tahirah K, Lutz, Jr, Marlon R, Reidl, Cory T, Guzman, Estefany R, Herbert, Claire A, Nocek, Boguslaw P, Holz, Richard C, Olsen, Kenneth W, Ballicora, Miguel A, Becker, Daniel P

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Pharmacological inhibition of polysialyltransferase ST8SiaII modulates tumour cell migration von Al-Saraireh, Yousef M J, Sutherland, Mark, Springett, Bradley R, Freiberger, Friedrich, Ribeiro Morais, Goreti, Loadman, Paul M, Errington, Rachel J, Smith, Paul J, Fukuda, Minoru, Gerardy-Schahn, Rita, Patterson, Laurence H, Shnyder, Steven D, Falconer, Robert A

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