Beating tissue factor at its own game: Design and properties of a soluble tissue factor–independent coagulation factor VIIa von Sorensen, Anders B., Tuneew, Inga, Svensson, L. Anders, Persson, Egon, Østergaard, Henrik, Overgaard, Michael Toft, Olsen, Ole H., Gandhi, Prafull S.

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Crystal Structure of Thrombin Bound to the Uncleaved Extracellular Fragment of PAR1 von Gandhi, Prafull S., Chen, Zhiwei, Di Cera, Enrico

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A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa von Sorensen, Anders B., Greisen, Per Jr, Madsen, Jesper J., Lund, Jacob, Andersen, Gorm, Wulff-Larsen, Pernille G., Pedersen, Anette A., Gandhi, Prafull S., Overgaard, Michael T., Østergaard, Henrik, Olsen, Ole H.

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Tissue Distribution and Receptor Activation by Somapacitan, a Long Acting Growth Hormone Derivative von Petersen, Maj, Gandhi, Prafull S., Buchardt, Jens, Alanentalo, Tomas, Fels, Johannes Josef, Johansen, Nils Langeland, Helding-Kvist, Peter, Vad, Knud, Thygesen, Peter

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Structural identification of the pathway of long-range communication in an allosteric enzyme von Gandhi, Prafull S, Chen, Zhiwei, Mathews, F. Scott, Di Cera, Enrico

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Mutant N143P Reveals How Na+ Activates Thrombin von Niu, Weiling, Chen, Zhiwei, Bush-Pelc, Leslie A., Bah, Alaji, Gandhi, Prafull S., Di Cera, Enrico

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Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A von Gandhi, Prafull S., Page, Michael J., Chen, Zhiwei, Bush-Pelc, Leslie, Di Cera, Enrico

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Stabilization of the E Form Turns Thrombin into an Anticoagulant von Bah, Alaji, Carrell, Christopher J., Chen, Zhiwei, Gandhi, Prafull S., Di Cera, Enrico

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A factor VIIIa–mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice von Østergaard, Henrik, Lund, Jacob, Greisen, Per J., Kjellev, Stine, Henriksen, Anette, Lorenzen, Nikolai, Johansson, Eva, Røder, Gustav, Rasch, Morten G., Johnsen, Laust B., Egebjerg, Thomas, Lund, Søren, Rahbek-Nielsen, Henrik, Gandhi, Prafull S., Lamberth, Kasper, Loftager, Mette, Andersen, Lisbeth M., Bonde, Amalie C., Stavenuiter, Fabian, Madsen, Daniel E., Li, Xun, Holm, Thomas L., Ley, Carsten D., Thygesen, Peter, Zhu, Haisun, Zhou, Rong, Thorn, Karina, Yang, Zhiru, Hermit, Mette B., Bjelke, Jais R., Hansen, Bjarne G., Hilden, Ida

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Allostery in Coagulation Factor VIIa Revealed by Ensemble Refinement of Crystallographic Structures von Sorensen, Anders B., Madsen, Jesper J., Frimurer, Thomas M., Overgaard, Michael T., Gandhi, Prafull S., Persson, Egon, Olsen, Ole H.

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19F NMR reveals the conformational properties of free thrombin and its zymogen precursor prethrombin-2 von Ruben, Eliza A., Gandhi, Prafull S., Chen, Zhiwei, Koester, Sarah K., DeKoster, Gregory T., Frieden, Carl, Di Cera, Enrico

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Engineering Thrombin for Selective Specificity toward Protein C and PAR1 von Marino, Francesca, Pelc, Leslie A., Vogt, Austin, Gandhi, Prafull S., Di Cera, Enrico

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Structural insight into antibody-mediated antagonism of the Glucagon-like peptide-1 Receptor von Hennen, Stephanie, Kodra, János T., Soroka, Vladyslav, Krogh, Berit O., Wu, Xiaoai, Kaastrup, Peter, Ørskov, Cathrine, Rønn, Sif G., Schluckebier, Gerd, Barbateskovic, Silvia, Gandhi, Prafull S., Reedtz-Runge, Steffen

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Engineering of a membrane-triggered activity switch in coagulation factor VIIa von Nielsen, Anders L., Sorensen, Anders B., Holmberg, Heidi L., Gandhi, Prafull S., Karlsson, Johan, Buchardt, Jens, Lamberth, Kasper, Kjelgaard-Hansen, Mads, Ley, Carsten Dan, Sørensen, Brit B., Ruf, Wolfram, Olsen, Ole H., Østergaard, Henrik

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Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity von Sorensen, Anders B., Madsen, Jesper J., Svensson, L.Ander, Pedersen, Anette A., Østergaard, Henrik, Overgaard, Michael T., Olsen, Ole H., Gandhi, Prafull S.

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Crystallographic and Kinetic Evidence of Allostery in a Trypsin-like Protease von Niu, Weiling, Chen, Zhiwei, Gandhi, Prafull S, Vogt, Austin D, Pozzi, Nicola, Pelc, Leslie A, Zapata, Fatima, Di Cera, Enrico

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Structural basis of thrombin–protease‐activated receptor interactions von Gandhi, Prafull S., Chen, Zhiwei, Appelbaum, Eric, Zapata, Fatima, Di Cera, Enrico

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A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders von Gandhi, Prafull S, Zivkovic, Minka, Østergaard, Henrik, Bonde, Amalie C, Elm, Torben, Løvgreen, Monika N, Schluckebier, Gerd, Johansson, Eva, Olsen, Ole H, Olsen, Eva H N, de Bus, Ian-Arris, Bloem, Karien, Alskär, Oskar, Rea, Catherine J, Bjørn, Søren E, Schutgens, Roger E, Sørensen, Benny, Urbanus, Rolf T, Faber, Johan H

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A Phase 1/2, First-in-Human, Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of HMB-001 in Participants with Glanzmann Thrombastheni... von Sivapalaratnam, Suthesh, Austin, Steve, Lorch, Ulrike, York, Thomas, Want, Andrew, Gosnell, Ashley, Gandhi, Prafull S., Østergaard, Henrik, Bjornson, Erik, O'Meara, Tara, Sorensen, Benny, Schutgens, Roger E.G., Rea, Catherine

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F-19 NMR reveals the conformational properties of free thrombin and its zymogen precursor prethrombin-2 von Ruben, Eliza A., Gandhi, Prafull S., Chen, Zhiwei, Koester, Sarah K., DeKoster, Gregory T., Frieden, Carl, Di Cera, Enrico

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