Pathophysiology of aortic aneurysm: insights from human genetics and mouse models von Wilson, Nicole K, Gould, Russell A, Gallo MacFarlane, Elena, Consortium, MIBAVA Leducq

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Insights on the Pathogenesis of Aneurysm through the Study of Hereditary Aortopathies von Creamer, Tyler J, Bramel, Emily E, MacFarlane, Elena Gallo

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Targetable cellular signaling events mediate vascular pathology in vascular Ehlers-Danlos syndrome von Bowen, Caitlin J, Calderón Giadrosic, Juan Francisco, Burger, Zachary, Rykiel, Graham, Davis, Elaine C, Helmers, Mark R, Benke, Kelly, Gallo MacFarlane, Elena, Dietz, Harry C

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Postnatal Smad3 Inactivation in Murine Smooth Muscle Cells Elicits a Temporally and Regionally Distinct Transcriptional Response von Bramel, Emily E, Creamer, Tyler J, Saqib, Muzna, Camejo Nunez, Wendy A, Bagirzadeh, Rustam, Roker, LaToya Ann, Goff, Loyal A, MacFarlane, Elena Gallo

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Distinct Contribution of Global and Regional Angiotensin II Type 1a Receptor Inactivation to Amelioration of Aortopathy in Tgfbr1M318R/+ Mice von Bramel, Emily E., Bagirzadeh, Rustam, Saqib, Muzna, Creamer, Tyler J., Espinoza Camejo, Wendy A., Roker, LaToya Ann, Pardo Habashi, Jennifer, Dietz, Harry C., Gallo MacFarlane, Elena

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Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice von Rouf, Rosanne, MacFarlane, Elena Gallo, Takimoto, Eiki, Chaudhary, Rahul, Nagpal, Varun, Rainer, Peter P, Bindman, Julia G, Gerber, Elizabeth E, Bedja, Djahida, Schiefer, Christopher, Miller, Karen L, Zhu, Guangshuo, Myers, Loretha, Amat-Alarcon, Nuria, Lee, Dong I, Koitabashi, Norimichi, Judge, Daniel P, Kass, David A, Dietz, Harry C

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TGF-β Family Signaling in Connective Tissue and Skeletal Diseases von MacFarlane, Elena Gallo, Haupt, Julia, Dietz, Harry C, Shore, Eileen M

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Abstract 131: Gata4 Ablation In Smooth Muscle Cells Reduces Aortic Root Dilation In A Murine Model Of Loeys-Dietz Syndrome von Bramel, Emily E, Saqib, Muzna, Creamer, Tyler J, Gallo MacFarlane, Elena

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Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome von MacFarlane, Elena Gallo, Parker, Sarah J, Shin, Joseph Y, Kang, Benjamin E, Ziegler, Shira G, Creamer, Tyler J, Bagirzadeh, Rustam, Bedja, Djahida, Chen, Yichun, Calderon, Juan F, Weissler, Katherine, Frischmeyer-Guerrerio, Pamela A, Lindsay, Mark E, Habashi, Jennifer P, Dietz, Harry C

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Abstract 11068: Smad3-Deficiency in Murine Smooth Muscle Cells Causes Global Defects in Expression of Focal Adhesion Components, but Drives Subset-Specific Compensatory Mechanisms... von Bramel, Emily E, Creamer, Tyler J, Saqib, Muzna, Camejo Nunez, Wendy A, Goff, Loyal A, Gallo MacFarlane, Elena

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Early clinical outcomes and molecular smooth muscle cell phenotyping using a prophylactic aortic arch replacement strategy in Loeys-Dietz syndrome von Pedroza, Albert J., Cheng, Paul, Dalal, Alex R., Baeumler, Kathrin, Kino, Aya, Tognozzi, Emily, Shad, Rohan, Yokoyama, Nobu, Nakamura, Ken, Mitchel, Olivia, Hiesinger, William, MacFarlane, Elena Gallo, Fleischmann, Dominik, Woo, Y. Joseph, Quertermous, Thomas, Fischbein, Michael P.

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Intrinsic GATA4 expression sensitizes the aortic root to dilation in a Loeys–Dietz syndrome mouse model von Bramel, Emily E., Espinoza Camejo, Wendy A., Creamer, Tyler J., Restrepo, Leda, Saqib, Muzna, Bagirzadeh, Rustam, Zeng, Anthony, Mitchell, Jacob T., Stein-O’Brien, Genevieve L., Pedroza, Albert J., Fischbein, Michael P., Dietz, Harry C., Gallo MacFarlane, Elena

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Distinct Contribution of Global and Regional Angiotensin II Type 1a Receptor Inactivation to Amelioration of Aortopathy in Tgfbr1 M318R /+ Mice von Bramel, Emily E, Bagirzadeh, Rustam, Saqib, Muzna, Creamer, Tyler J, Espinoza Camejo, Wendy A, Roker, LaToya Ann, Pardo Habashi, Jennifer, Dietz, Harry C, Gallo MacFarlane, Elena

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