MLH1 –93G>A Promoter Polymorphism and the Risk of Microsatellite-Unstable Colorectal Cancer von Raptis, Stavroula, Mrkonjic, Miralem, Green, Roger C., Pethe, Vaijayanti V., Monga, Neerav, Chan, Yuen Man, Daftary, Darshana, Dicks, Elizabeth, Younghusband, Banfield H., Parfrey, Patrick S., Gallinger, Steven S., McLaughlin, John R., Knight, Julia A., Bapat, Bharati

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MSH2 −118T>C and MSH6 −159C>T promoter polymorphisms and the risk of colorectal cancer von Mrkonjic, Miralem, Raptis, Stavroula, Green, Roger C., Monga, Neerav, Daftary, Darshana, Dicks, Elizabeth, Younghusband, H.Banfield, Parfrey, Patrick S., Gallinger, Steven S., McLaughlin, John R., Knight, Julia A., Bapat, Bharati

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High Frequency of Hereditary Colorectal Cancer in Newfoundland Likely Involves Novel Susceptibility Genes von WOODS, Michael O, HYDE, Angela J, CHAULK, Jason A. W, JEGATHESAN, Jegan, MCLAUGHLIN, John R, GALLINGER, Steven S, YOUNGHUSBAND, H. Banfield, BAPAT, Bharati V, PARFREY, Patrick S, CURTIS, Fiona K, STUCKLESS, Susan, GREEN, Jane S, POLLETT, Aaron F, ROBB, J. Desmond, GREEN, Roger C, CROITORU, Marina E, CAREEN, Amanda

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Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium von Goggins, Michael, Overbeek, Kasper Alexander, Brand, Randall, Syngal, Sapna, Del Chiaro, Marco, Bartsch, Detlef K, Bassi, Claudio, Carrato, Alfredo, Farrell, James, Fishman, Elliot K, Fockens, Paul, Gress, Thomas M, van Hooft, Jeanin E, Hruban, R H, Kastrinos, Fay, Klein, Allison, Lennon, Anne Marie, Lucas, Aimee, Park, Walter, Rustgi, Anil, Simeone, Diane, Stoffel, Elena, Vasen, Hans F A, Cahen, Djuna L, Canto, Marcia Irene, Bruno, Marco

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Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers von Shlien, Adam, Campbell, Brittany B, de Borja, Richard, Alexandrov, Ludmil B, Merico, Daniele, Wedge, David, Van Loo, Peter, Tarpey, Patrick S, Coupland, Paul, Behjati, Sam, Pollett, Aaron, Lipman, Tatiana, Heidari, Abolfazl, Deshmukh, Shriya, Avitzur, Na'ama, Meier, Bettina, Gerstung, Moritz, Hong, Ye, Merino, Diana M, Ramakrishna, Manasa, Remke, Marc, Arnold, Roland, Panigrahi, Gagan B, Thakkar, Neha P, Hodel, Karl P, Henninger, Erin E, Göksenin, A Yasemin, Bakry, Doua, Charames, George S, Druker, Harriet, Lerner-Ellis, Jordan, Mistry, Matthew, Dvir, Rina, Grant, Ronald, Elhasid, Ronit, Farah, Roula, Taylor, Glenn P, Nathan, Paul C, Alexander, Sarah, Ben-Shachar, Shay, Ling, Simon C, Gallinger, Steven, Constantini, Shlomi, Dirks, Peter, Huang, Annie, Scherer, Stephen W, Grundy, Richard G, Durno, Carol, Aronson, Melyssa, Gartner, Anton, Meyn, M Stephen, Taylor, Michael D, Pursell, Zachary F, Pearson, Christopher E, Malkin, David, Futreal, P Andrew, Stratton, Michael R, Bouffet, Eric, Hawkins, Cynthia, Campbell, Peter J, Tabori, Uri

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Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease von Bryois, Julien, Skene, Nathan G., Hansen, Thomas Folkmann, Kogelman, Lisette J. A., Watson, Hunna J., Liu, Zijing, Brueggeman, Leo, Breen, Gerome, Bulik, Cynthia M., Arenas, Ernest, Hjerling-Leffler, Jens, Sullivan, Patrick F.

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Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa von Yilmaz, Zeynep, Walters, Raymond, Goldstein, Jackie, Ripke, Stephan, Thornton, Laura, Hinney, Anke, Daly, Mark, Sullivan, Patrick F, Zeggini, Eleftheria, Breen, Gerome, Adan, Roger, Alfredsson, Lars, Ando, Tetsuya, Andreassen, Ole, Aschauer, Harald, Baker, Jessica, Barrett, Jeffrey, Bencko, Vladimir, Boni, Claudette, Perica, Vesna Boraska, Burghardt, Roland, Cassina, Matteo, Cichon, Sven, Crow, Scott, Davis, Oliver, de Zwaan, Martina, Dedoussis, George, Degortes, Daniela, DeSocio, Janiece, Dick, Danielle, Ding, Bo, Egberts, Karin, Escaramís, Geòrgia, Esko, Tõnu, Fichter, Manfred, Finan, Chris, Fischer, Krista, Floyd, James, Föcker, Manuel, Forzan, Monica, Gaborieau, Valerie, Gambaro, Giovanni, Giegling, Ina, Guillaume, Sébastien, Guo, Yiran, Hauser, Joanna, Helder, Sietske, Hendriks, Judith, Herpertz-Dahlmann, Beate, Herzog, Wolfgang, Hudson, James, Inoko, Hidetoshi, Jall, Sigrid, Jamain, Stephane, Johnson, Craig, Julià, Antonio, Kennedy, Martin, Kennedy, James, Keski-Rahkonen, Anna, Klareskog, Lars, Klump, Kelly, Leboyer, Marion, Levitan, Robert, Lissowska, Jolanta, Maj, Mario, Marsal, Sara, Metspalu, Andres, Micali, Nadia, Monteleone, Palmiero, Monteleone, Alessio Maria, Mortensen, Preben, Munn-Chernoff, Melissa, Müller, Timo, Ophoff, Roel, O’Toole, Julie, Pantel, Jacques, Pinto, Dalila, Rabionet, Raquel, Reichborn-Kjennerud, Ted, Ricca, Valdo, Ripatti, Samuli, Ritschel, Franziska, Roberts, Marion, Rotondo, Alessandro, Rybakowski, Filip, Santonastaso, Paolo, Scherag, André, Schork, Nicholas, Scott, Laura, Slachtova, Lenka, Sladek, Robert, Szatkiewicz, Jin, Szeszenia-Dabrowska, Neonila, Tachmazidou, Ioanna, Tortorella, Alfonso, Treasure, Janet, Tsitsika, Artemis, van Furth, Eric, Wade, Tracey, Wagner, Gudrun

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Response: Re: MLH1 −93G>A Promoter Polymorphism and the Risk of Microsatellite-Unstable Colorectal Cancer von Raptis, Stavroula, Mrkonjic, Miralem, Green, Roger C., Daftary, Darshana, Pethe, Vaijayanti, Dicks, Elizabeth, Younghusband, Banfield H., Parfrey, Patrick S., Gallinger, Steven S., McLaughlin, John R., Knight, Julia A., Bapat, Bharati

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Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study von Dowty, James G., Lee, Grant, Templeton, Allyson S., Alvarez, Karin, Ankathil, Ravindran, Austin, Rachel, Barca-Tierno, Verónica, Berthet, Pascaline, Boisjoli, Talya, Briollais, Laurent, Brunet, Joan, Bucksch, Karolin, Buettner, Reinhard, Burn, John, Caldés, Trinidad, Casey, Graham, Chew, Min H., Choi, Yun-hee, Church, James, Clendenning, Mark, Colas, Chrystelle, Coupier, Isabelle, de la Chapelle, Albert, Dębniak, Tadeusz, Della Valle, Adriana, Dominguez-Valentin, Mev, Engel, Christoph, Esperon, Patricia, Foulkes, William, Frebourg, Thierry, Gallinger, Steven, Garre, Pilar, Genuardi, Maurizio, Giraud, Sophie, Goodwin, Annabel, Green, Kate, Guindalini, Rodrigo S.C., Half, Elizabeth E., Hampel, Heather, Ho, Judy W.C., Hoogerbrugge, Nicoline, Hüneburg, Robert, Huntley, Vanessa, Jensen, Uffe B, Juhari, Wan K.W., Kloor, Matthias, Kupfer, Sonia S., Lagerstedt-Robinson, Kristina, Lalloo, Fiona, Lautrup, Charlotte K., Leggett, Barbara A., Lejeune, Sophie, Lindor, Noralane, Loeffler, Markus, Lucassen, Anneke M, Lynch, Patrick M., Møller, Pål, Navarro, Matilde, Neffa, Florencia, Neklason, Deborah, Nixon, Dawn M., Palmero, Edenir I., Pande, Mala, Parry, Susan, Pineda, Marta, Qiu, Jay, Ramesar, Raj, Rasmussen, Lene J., Redler, Silke, Ricciardiello, Luigi, Schulmann, Karsten, Schuster, Helène, Senter, Leigha, Seppälä, Toni T, Shtoyerman, Rakefet, Sijmons, Rolf H., Soto, Jose Luis, Spigelman, Allan, Steinke-Lange, Verena, Stoffel, Elena M., Strassburg, Christian P., Sunde, Lone, Therkildsen, Christina, Thibodeau, Steve, Tucker, Katherine M., Tunca, Berrin, Uhrhammer, Nancy, Vaccaro, Carlos, van Duijnhoven, Fränzel J.B., van Wanzeele, Meghan J., Vasen, Hans F.A., von Knebel Doeberitz, Magnus, von Salomé, Jenny, Ward, Robyn L., Wise, Paul E., Yamaguchi, Tatsuro, Zahary, Mohd N., Hopper, John L., Haile, Robert W., Jenkins, Mark A.

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Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study von Dimitrakopoulou, Vasiliki I, Tsilidis, Konstantinos K, Haycock, Philip C, Dimou, Niki L, Al-Dabhani, Kawthar, Martin, Richard M, Lewis, Sarah J, Gunter, Marc J, Mondul, Alison, Shui, Irene M, Theodoratou, Evropi, Nimptsch, Katharina, Lindström, Sara, Albanes, Demetrius, Kühn, Tilman, Key, Timothy J, Travis, Ruth C, Vimaleswaran, Karani Santhanakrishnan, Kraft, Peter, Pierce, Brandon L, Schildkraut, Joellen M

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Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk von Zeng, Chenjie, Matsuda, Koichi, Jia, Wei-Hua, Chang, Jiang, Kweon, Sun-Seog, Xiang, Yong-Bing, Shin, Aesun, Jee, Sun Ha, Kim, Dong-Hyun, Zhang, Ben, Cai, Qiuyin, Guo, Xingyi, Long, Jirong, Wang, Nan, Courtney, Regina, Pan, Zhi-Zhong, Wu, Chen, Takahashi, Atsushi, Shin, Min-Ho, Matsuo, Keitaro, Matsuda, Fumihiko, Gao, Yu-Tang, Oh, Jae Hwan, Kim, Soriul, Jung, Keum Ji, Ahn, Yoon-Ok, Ren, Zefang, Li, Hong-Lan, Wu, Jie, Shi, Jiajun, Wen, Wanqing, Yang, Gong, Li, Bingshan, Ji, Bu-Tian, Brenner, Hermann, Schoen, Robert E, Küry, Sébastien, Gruber, Stephen B, Schumacher, Fredrick R, Stenzel, Stephanie L, Casey, Graham, Hopper, John L, Jenkins, Mark A, Kim, Hyeong-Rok, Jeong, Jin-Young, Park, Ji Won, Tajima, Kazuo, Cho, Sang-Hee, Kubo, Michiaki, Shu, Xiao-Ou, Lin, Dongxin, Zeng, Yi-Xin, Zheng, Wei

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Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk von Zhang, Ben, Jia, Wei-Hua, Matsuda, Koichi, Kweon, Sun-Seog, Matsuo, Keitaro, Xiang, Yong-Bing, Shin, Aesun, Jee, Sun Ha, Kim, Dong-Hyun, Cai, Qiuyin, Long, Jirong, Shi, Jiajun, Wen, Wanqing, Yang, Gong, Zhang, Yanfeng, Li, Chun, Li, Bingshan, Guo, Yan, Ren, Zefang, Ji, Bu-Tian, Pan, Zhi-Zhong, Takahashi, Atsushi, Shin, Min-Ho, Matsuda, Fumihiko, Gao, Yu-Tang, Oh, Jae Hwan, Kim, Soriul, Ahn, Yoon-Ok, Chan, Andrew T, Chang-Claude, Jenny, Slattery, Martha L, Gruber, Stephen B, Schumacher, Fredrick R, Stenzel, Stephanie L, Casey, Graham, Kim, Hyeong-Rok, Jeong, Jin-Young, Park, Ji Won, Li, Hong-Lan, Hosono, Satoyo, Cho, Sang-Hee, Kubo, Michiaki, Shu, Xiao-Ou, Zeng, Yi-Xin, Zheng, Wei

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Genome-wide association analyses in east Asians identify new susceptibility loci for colorectal cancer von Jia, Wei-Hua, Zhang, Ben, Matsuo, Keitaro, Shin, Aesun, Xiang, Yong-Bing, Jee, Sun Ha, Kim, Dong-Hyun, Ren, Zefang, Cai, Qiuyin, Long, Jirong, Shi, Jiajun, Wen, Wanqing, Yang, Gong, Delahanty, Ryan J, Ji, Bu-Tian, Pan, Zhi-Zhong, Matsuda, Fumihiko, Gao, Yu-Tang, Oh, Jae Hwan, Ahn, Yoon-Ok, Park, Eun Jung, Li, Hong-Lan, Park, Ji Won, Jo, Jaeseong, Jeong, Jin-Young, Hosono, Satoyo, Casey, Graham, Peters, Ulrike, Shu, Xiao-Ou, Zeng, Yi-Xin, Zheng, Wei

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ICGC ARGO precision medicine: genomic profiling-informed prediction of immunotherapy response in two patients with metastatic head and neck squamous cell carcinoma von Nocini, Riccardo, Tondulli, Luca, D’Ambrosio, Consuelo, Luchini, Claudio, Biankin, Andrew V, Casolino, Raffaella, Scarpa, Aldo, Biankin, Andrew V, Stein, Lincoln D, Park, Keunchil, Lawlor, Rita T, Johns, Amber L, Korbel, Jan O, Zeps, Nik, Rubin, Mark A, Marra, Marco A, Elemento, Olivier, Gallinger, Steven, Tuveson, David, Trumper, Lorenz, Koch, Raphael, Scarpa, Aldo, Brennan, Paul, Pilarsky, Christian, Nikolaev, Sergey, Yoon, Sun-Soo, Lee, Eun Sook, Shibata, Tatsuhiro, Wu, Xiaojian, Wu, Jianmin, Zhan, Qimin, Poon, Wai, Yoshino, Takayuki, Al-Kuraya, Khawla S., Eeles, Rosalind, Fitzgerald, Rebecca, Caldas, Carlos, Abraham, Jean, Chang, David K, Milella, Michele, Lawlor, Rita T

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Monoallelic NTHL1 Loss-of-Function Variants and Risk of Polyposis and Colorectal Cancer von Elsayed, Fadwa A., Grolleman, Judith E., Ragunathan, Abiramy, Boot, Arnoud, Stojovska, Marija Staninova, Mahmood, Khalid, Clendenning, Mark, de Miranda, Noel, Dymerska, Dagmara, Egmond, Demi van, Gallinger, Steven, Georgeson, Peter, Hoogerbrugge, Nicoline, Hopper, John L., Jansen, Erik A.M., Jenkins, Mark A., Joo, Jihoon E., Kuiper, Roland P., Ligtenberg, Marjolijn J.L., Lubinski, Jan, Macrae, Finlay A., Morreau, Hans, Newcomb, Polly, Nielsen, Maartje, Palles, Claire, Park, Daniel J., Pope, Bernard J., Rosty, Christophe, Ruiz Ponte, Clara, Schackert, Hans K., Sijmons, Rolf H., Tomlinson, Ian P., Tops, Carli M.J., Vreede, Lilian, Walker, Romy, Win, Aung K., Buchanan, Daniel D., van Wezel, Tom, de Voer, Richarda M.

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Shared Genetic Architecture Between Schizophrenia and Anorexia Nervosa: A Cross-trait Genome-Wide Analysis von Lu, Zheng-An, Ploner, Alexander, Birgegård, Andreas, Bulik, Cynthia M, Bergen, Sarah E

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ICGC-ARGO precision medicine: familial matters in pancreatic cancer von Milella, Michele, Luchini, Claudio, Lawlor, Rita T, Johns, Amber L, Casolino, Raffaella, Yoshino, Takayuki, Biankin, Andrew V, Biankin, Andrew V, Stein, Lincoln D, Park, Keunchil, Lawlor, Rita T, Johns, Amber L, Korbel, Jan O, Zeps, Nik, Rubin, Mark A, Marra, Marco A, Elemento, Olivier, Gallinger, Steven, Tuveson, David, Trumper, Lorenz, Koch, Raphael, Scarpa, Aldo, Brennan, Paul, Pilarsky, Christian, Nikolaev, Sergey, Yoon, Sun-Soo, Lee, Eun Sook, Shibata, Tatsuhiro, Wu, Xiaojian, Wu, Jianmin, Zhan, Qimin, Poon, Wai, Yoshino, Takayuki, Al-Kuraya, Khawla S., Eeles, Rosalind, Fitzgerald, Rebecca, Caldas, Carlos, Abraham, Jean, Chang, David K

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ICGC-ARGO precision medicine: targeted therapy according to longitudinal assessment of tumour heterogeneity in colorectal cancer von Kotani, Daisuke, Nakamura, Yoshiaki, Fujisawa, Takao, Bando, Hideaki, Sakamoto, Naoya, Johns, Amber L, Park, Keunchil, Casolino, Raffaella, Yoshino, Takayuki, Biankin, Andrew V

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Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A von Wang, Hansong, Burnett, Terrilea, Kono, Suminori, Haiman, Christopher A., Iwasaki, Motoki, Wilkens, Lynne R., Loo, Lenora W. M., Van Den Berg, David, Kolonel, Laurence N., Henderson, Brian E., Keku, Temitope O., Sandler, Robert S., Signorello, Lisa B., Blot, William J., Newcomb, Polly A., Pande, Mala, Amos, Christopher I., West, Dee W., Bézieau, Stéphane, Berndt, Sonja I., Zanke, Brent W., Hsu, Li, Lindor, Noralane M., Haile, Robert W., Hopper, John L., Jenkins, Mark A., Gallinger, Steven, Casey, Graham, Stenzel, Stephanie L., Schumacher, Fredrick R., Peters, Ulrike, Gruber, Stephen B., Tsugane, Shoichiro, Stram, Daniel O., Le Marchand, Loïc

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Elucidating the Risk of Colorectal Cancer for Variants in Hereditary Colorectal Cancer Genes von Mahmood, Khalid, Thomas, Minta, Qu, Conghui, Wang, Xiaoliang, Huyghe, Jeroen R., Joo, Jihoon E., Georgeson, Peter, Arndt, Volker, Berndt, Sonja I., Bézieau, Stéphane, Bien, Stephanie A., Bishop, D. Timothy, Brenner, Hermann, Brezina, Stefanie, Burnett-Hartman, Andrea, Campbell, Peter T., Casey, Graham, Castellví-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Chen, Xuechen, Conti, David V., Cremolini, Chiara, Diergaarde, Brenda, Figueiredo, Jane C., FitzGerald, Liesel M., Gago-Dominguez, Manuela, Gallinger, Steven, Giles, Graham G., Gsu, Andrea, Gunter, Marc J., Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A., Hoffmeister, Michael, Keku, Temitope O., Kundaje, Anshul, Le Marchand, Loic, Lenz, Heinz-Josef, Li, Christopher I., Li, Li, Lin, Yi, Lindblom, Annika, Moreno, Victor, Murphy, Neil, Newcomb, Polly A., Newton, Christina C., Obón-Santacana, Mireia, Ogino, Shuji, Pai, Rish K., Palmer, Julie R., Pearlman, Rachel, Pharoah, Paul D.P., Phipps, Amanda I., Platz, Elizabeth A., Potter, John D., Rennert, Gad, Sakoda, Lori C., Schafmayer, Clemens, Schmit, Stephanie L., Schoen, Robert E., Slattery, Martha L., Stadler, Zsofia K., Steinfelder, Robert S., Thibodeau, Stephen N., Ulrich, Cornelia M., Um, Caroline Y., van Duijnhoven, Franzel J.B., Van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Weinstein, Stephanie J., White, Emily, Winship, Ingrid M., Wolk, Alicja, Gruber, Stephen B., Jenkins, Mark A., Hsu, Li, Buchanan, Daniel D., Peters, Ulrike

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