In Vivo Quantification of Calcitonin Gene-Related Peptide Receptor Occupancy by Telcagepant in Rhesus Monkey and Human Brain Using the Positron Emission Tomography Tracer [11C]MK-4... von Hostetler, Eric D., Joshi, Aniket D., Sanabria-Bohórquez, Sandra, Fan, Hong, Zeng, Zhizhen, Purcell, Mona, Gantert, Liza, Riffel, Kerry, Williams, Mangay, O’Malley, Stacey, Miller, Patricia, Selnick, Harold G., Gallicchio, Steven N., Bell, Ian M., Salvatore, Christopher A., Kane, Stefanie A., Li, Chi-Chung, Hargreaves, Richard J., de Groot, Tjibbe, Bormans, Guy, Van Hecken, Anne, Derdelinckx, Inge, de Hoon, Jan, Reynders, Tom, Declercq, Ruben, De Lepeleire, Inge, Kennedy, W.P., Blanchard, Rebecca, Marcantonio, Eugene E., Sur, Cyrille, Cook, Jacquelynn J., Van Laere, Koen, Evelhoch, Jeffrey L.

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Invention of novel 3-aminopiperidin-2-ones as calcitonin gene-related peptide receptor antagonists von Staas, Donnette D., Bell, Ian M., Burgey, Christopher S., Deng, James Z., Gallicchio, Steven N., Lim, John J., Paone, Daniel V., Potteiger, Craig M., Shaw, Anthony W., Stevenson, Heather, Stump, Craig A., Blair Zartman, C., Moore, Eric L., Bruno, Joseph G., Mosser, Scott D., White, Rebecca B., Kane, Stefanie A., Salvatore, Christopher A., Graham, Samuel L., Williams, Theresa M., Selnick, Harold G., Fraley, Mark E.

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Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction von Beshore, Douglas C., Adam, Gregory C., Barnard, Richard J. O., Burlein, Christine, Gallicchio, Steven N., Holloway, M. Katharine, Krosky, Daniel, Lemaire, Wei, Myers, Robert W., Patel, Sangita, Plotkin, Michael A., Powell, David A., Rada, Vanessa, Cox, Christopher D., Coleman, Paul J., Klein, Daniel J., Wolkenberg, Scott E.

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Pharmacological Properties of MK-3207, a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist von Salvatore, Christopher A., Moore, Eric L., Calamari, Amy, Cook, Jacquelynn J., Michener, Maria S., O'Malley, Stacey, Miller, Patricia J., Sur, Cyrille, Williams, David L., Zeng, Zhizhen, Danziger, Andrew, Lynch, Joseph J., Regan, Christopher P., Fay, John F., Tang, Yui S., Li, Chi-Chung, Pudvah, Nicole T., White, Rebecca B., Bell, Ian M., Gallicchio, Steven N., Graham, Samuel L., Selnick, Harold G., Vacca, Joseph P., Kane, Stefanie A.

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MK-8825: A potent and selective CGRP receptor antagonist with good oral activity in rats von Bell, Ian M., Stump, Craig A., Gallicchio, Steven N., Staas, Donnette D., Zartman, C. Blair, Moore, Eric L., Sain, Nova, Urban, Mark, Bruno, Joseph G., Calamari, Amy, Kemmerer, Amanda L., Mosser, Scott D., Fandozzi, Christine, White, Rebecca B., Zrada, Matthew M., Selnick, Harold G., Graham, Samuel L., Vacca, Joseph P., Kane, Stefanie A., Salvatore, Christopher A.

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Discovery of MK-3207: A Highly Potent, Orally Bioavailable CGRP Receptor Antagonist von Bell, Ian M, Gallicchio, Steven N, Wood, Michael R, Quigley, Amy G, Stump, Craig A, Zartman, C. Blair, Fay, John F, Li, Chi-Chung, Lynch, Joseph J, Moore, Eric L, Mosser, Scott D, Prueksaritanont, Thomayant, Regan, Christopher P, Roller, Shane, Salvatore, Christopher A, Kane, Stefanie A, Vacca, Joseph P, Selnick, Harold G

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Identification of a novel RAMP-independent CGRP receptor antagonist von Zartman, C. Blair, Bell, Ian M., Gallicchio, Steven N., Graham, Samuel L., Kane, Stefanie A., Mallee, John J., Rutledge, Ruth Z., Salvatore, Christopher A., Vacca, Joseph P., Williams, Theresa M.

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The discovery of highly potent CGRP receptor antagonists von Stump, Craig A., Bell, Ian M., Bednar, Rodney A., Bruno, Joseph G., Fay, John F., Gallicchio, Steven N., Johnston, Victor K., Moore, Eric L., Mosser, Scott D., Quigley, Amy G., Salvatore, Christopher A., Theberge, Cory R., Blair Zartman, C., Zhang, Xu-Fang, Kane, Stefanie A., Graham, Samuel L., Vacca, Joseph P., Williams, Theresa M.

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[11C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor von Bell, Ian M, Gallicchio, Steven N, Stump, Craig A, Bruno, Joseph G, Fan, Hong, Gantert, Liza T, Hostetler, Eric D, Kemmerer, Amanda L, McWherter, Melody, Moore, Eric L, Mosser, Scott D, Purcell, Mona L, Riffel, Kerry, Salvatore, Christopher A, Sanabria-Bohórquez, Sandra, Staas, Donnette D, White, Rebecca B, Williams, Mangay, Zartman, C. Blair, Cook, Jacquelynn J, Hargreaves, Richard J, Kane, Stefanie A, Graham, Samuel L, Selnick, Harold G

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Non-peptide calcitonin gene-related peptide receptor antagonists from a benzodiazepinone lead von Williams, Theresa M., Stump, Craig A., Nguyen, Diem N., Quigley, Amy G., Bell, Ian M., Gallicchio, Steven N., Zartman, C. Blair, Wan, Bang-Lin, Penna, Kimberly Della, Kunapuli, Priya, Kane, Stefanie A., Koblan, Ken S., Mosser, Scott D., Rutledge, Ruth Z., Salvatore, Christopher, Fay, John F., Vacca, Joseph P., Graham, Samuel L.

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Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists von Bell, Ian M., Bednar, Rodney A., Fay, John F., Gallicchio, Steven N., Hochman, Jerome H., McMasters, Daniel R., Miller-Stein, Cynthia, Moore, Eric L., Mosser, Scott D., Pudvah, Nicole T., Quigley, Amy G., Salvatore, Christopher A., Stump, Craig A., Theberge, Cory R., Wong, Bradley K., Zartman, C. Blair, Zhang, Xu-Fang, Kane, Stefanie A., Graham, Samuel L., Vacca, Joseph P., Williams, Theresa M.

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Identification of potent, highly constrained CGRP receptor antagonists von Stump, Craig A., Bell, Ian M., Bednar, Rodney A., Fay, John F., Gallicchio, Steven N., Hershey, James C., Jelley, Richard, Kreatsoulas, Constantine, Moore, Eric L., Mosser, Scott D., Quigley, Amy G., Roller, Shane A., Salvatore, Christopher A., Sharik, Steven S., Theberge, Cory R., Zartman, C. Blair, Kane, Stefanie A., Graham, Samuel L., Selnick, Harold G., Vacca, Joseph P., Williams, Theresa M.

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Biochemical and Structural Characterization of a Novel Class of Inhibitors of the Type 1 Insulin-like Growth Factor and Insulin Receptor Kinases von Bell, Ian M, Stirdivant, Steven M, Ahern, Janet, Culberson, J. Christopher, Darke, Paul L, Dinsmore, Christopher J, Drakas, Robert A, Gallicchio, Steven N, Graham, Samuel L, Heimbrook, David C, Hall, Dawn L, Hua, Jin, Kett, Nathan R, Kim, Annette S, Kornienko, Maria, Kuo, Lawrence C, Munshi, Sanjeev K, Quigley, Amy G, Reid, John C, Trotter, B. Wesley, Waxman, Lloyd H, Williams, Theresa M, Zartman, C. Blair

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The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists von Bell, Ian M., Bednar, Rodney A., Corcoran, Halea A., Fay, John F., Gallicchio, Steven N., Johnston, Victor K., Hershey, James C., Miller-Stein, Cynthia M., Moore, Eric L., Mosser, Scott D., Roller, Shane A., Salvatore, Christopher A., Theberge, Cory R., Wong, Bradley K., Blair Zartman, C., Kane, Stefanie A., Williams, Theresa M., Graham, Samuel L., Vacca, Joseph P.

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Efficient synthesis of 1-heterocyclic-3-aminopyrrolidinones von Bell, Ian M, Beshore, Douglas C, Gallicchio, Steven N, Williams, Theresa M

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Convenient synthesis of 1,3-substituted-6-phenylpiperazin-2-ones von Gallicchio, Steven N., Bell, Ian M.

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Development of Orally Active Oxytocin Antagonists:  Studies on 1-(1-{4-[1-(2-Methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl}piperidin-4-yl)-1,4-dihydrobenz[d... von Bell, Ian M, Erb, Jill M, Freidinger, Roger M, Gallicchio, Steven N, Guare, James P, Guidotti, Maribeth T, Halpin, Rita A, Hobbs, Doug W, Homnick, Carl F, Kuo, Michelle S, Lis, Edward V, Mathre, David J, Michelson, Stuart R, Pawluczyk, Joseph M, Pettibone, Douglas J, Reiss, Duane R, Vickers, Stanley, Williams, Peter D, Woyden, Carla J

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In vivo quantification of calcitonin gene-related peptide (CGRP) receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography (PET) tra... von Hostetler, Eric D, Joshi, Aniket D, Sanabria-Bohorquez, Sandra, Fan, Hong, Zeng, Zhizhen, Purcell, Mona, Gantert, Liza, Riffel, Kerry, Williams, Mangay, O'Malley, Stacey, Miller, Patricia, Selnick, Harold G, Gallicchio, Steven N, Bell, Ian M, Salvatore, Christopher, Kane, Stefanie A, Li, Chi-Chung, Hargreaves, Richard, de Groot, Tjibbe, Bormans, Guy, Van Hecken, Anne, Derdelinckx, Inge, de Hoon, Jan, Reynders, Tom, Declercq, Ruben, De Lepeleire, Inge, Kennedy, W. Dexter, Blanchard, Rebecca, Marcantonio, Eugene E, Sur, Cyrille, Cook, Jacquelynn J, Van Laere, Koen, Evelhoch, Jeffrey L

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3-Aminopyrrolidinone Farnesyltransferase Inhibitors:  Design of Macrocyclic Compounds with Improved Pharmacokinetics and Excellent Cell Potency von Bell, Ian M, Gallicchio, Steven N, Abrams, Marc, Beese, Lorena S, Beshore, Douglas C, Bhimnathwala, Hema, Bogusky, Michael J, Buser, Carolyn A, Culberson, J. Christopher, Davide, Joseph, Ellis-Hutchings, Michelle, Fernandes, Christine, Gibbs, Jackson B, Graham, Samuel L, Hamilton, Kelly A, Hartman, George D, Heimbrook, David C, Homnick, Carl F, Huber, Hans E, Huff, Joel R, Kassahun, Kelem, Koblan, Kenneth S, Kohl, Nancy E, Lobell, Robert B, Lynch, Joseph J, Robinson, Ronald, Rodrigues, A. David, Taylor, Jeffrey S, Walsh, Eileen S, Williams, Theresa M, Zartman, C. Blair

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Design and Biological Activity of (S)-4-(5-{[1-(3-Chlorobenzyl)-2- oxopyrrolidin-3-ylamino]methyl}imidazol-1-ylmethyl)benzonitrile, a 3-Aminopyrrolidinone Farnesyltransferase Inhib... von Bell, Ian M, Gallicchio, Steven N, Abrams, Marc, Beshore, Douglas C, Buser, Carolyn A, Culberson, J. Christopher, Davide, Joseph, Ellis-Hutchings, Michelle, Fernandes, Christine, Gibbs, Jackson B, Graham, Samuel L, Hartman, George D, Heimbrook, David C, Homnick, Carl F, Huff, Joel R, Kassahun, Kelem, Koblan, Kenneth S, Kohl, Nancy E, Lobell, Robert B, Lynch, Joseph J, Miller, Patricia A, Omer, Charles A, Rodrigues, A. David, Walsh, Eileen S, Williams, Theresa M

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