Malignant precursor cells pre-exist in human breast DCIS and require autophagy for survival von Espina, Virginia, Mariani, Brian D, Gallagher, Rosa I, Tran, Khoa, Banks, Stacey, Wiedemann, Joy, Huryk, Heather, Mueller, Claudius, Adamo, Luana, Deng, Jianghong, Petricoin, Emanuel F, Pastore, Lucia, Zaman, Syed, Menezes, Geetha, Mize, James, Johal, Jasbir, Edmiston, Kirsten, Liotta, Lance A

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An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models von Xia, Wenle, Petricoin, 3rd, Emanual F, Zhao, Sumin, Liu, Leihua, Osada, Takuya, Cheng, Qing, Wulfkuhle, Julia D, Gwin, William R, Yang, Xiaoyi, Gallagher, Rosa I, Bacus, Sarah, Lyerly, H Kim, Spector, Neil L

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Reverse Phase Protein Arrays: Mapping the Path Towards Personalized Medicine von Gallagher, Rosa I., Espina, Virginia

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Establishment and characterization of patient-derived xenograft of a rare pediatric anaplastic pleomorphic xanthoastrocytoma (PXA) bearing a CDC42SE2-BRAF fusion von Damayanti, Nur P., Saadatzadeh, M. Reza, Dobrota, Erika, Ordaz, Josue D., Bailey, Barbara J., Pandya, Pankita H., Bijangi-Vishehsaraei, Khadijeh, Shannon, Harlan E., Alfonso, Anthony, Coy, Kathy, Trowbridge, Melissa, Sinn, Anthony L., Zhang, Zhong-Yin, Gallagher, Rosa I., Wulfkuhle, Julia, Petricoin, Emanuel, Richardson, Angela M., Marshall, Mark S., Lion, Alex, Ferguson, Michael J., Balsara, Karl E., Pollok, Karen E.

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Multi‐omic molecular profiling guide’s efficacious treatment selection in refractory metastatic breast cancer: a prospective phase II clinical trial von Pierobon, Mariaelena, Robert, Nicholas J., Northfelt, Donald W., Jahanzeb, Mohammad, Wong, Shukmei, Hodge, Kimberly A., Baldelli, Elisa, Aldrich, Jessica, Craig, David W., Liotta, Lance A., Avramovic, Sanja, Wojtusiak, Janusz, Alemi, Farrokh, Wulfkuhle, Julia D., Bellos, Angela, Gallagher, Rosa I., Arguello, David, Conrad, Amber, Kemkes, Ariane, Loesch, David M., Vocila, Linda, Dunetz, Bryant, Carpten, John D., Petricoin, Emanuel F., Anthony, Stephen P.

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Microenvironmental agonists generate de novo phenotypic resistance to combined ibrutinib plus venetoclax in CLL and MCL von Jayappa, Kallesh D., Portell, Craig A., Gordon, Vicki L., Capaldo, Brian J., Bekiranov, Stefan, Axelrod, Mark J., Brett, L. Kyle, Wulfkuhle, Julia D., Gallagher, Rosa I., Petricoin, Emanuel F., Bender, Timothy P., Williams, Michael E., Weber, Michael J.

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Integrative Multi-OMICs Identifies Therapeutic Response Biomarkers and Confirms Fidelity of Clinically Annotated, Serially Passaged Patient-Derived Xenografts Established from Prim... von Pandya, Pankita H, Jannu, Asha Jacob, Bijangi-Vishehsaraei, Khadijeh, Dobrota, Erika, Bailey, Barbara J, Barghi, Farinaz, Shannon, Harlan E, Riyahi, Niknam, Damayanti, Nur P, Young, Courtney, Malko, Rada, Justice, Ryli, Albright, Eric, Sandusky, George E, Wurtz, L Daniel, Collier, Christopher D, Marshall, Mark S, Gallagher, Rosa I, Wulfkuhle, Julia D, Petricoin, Emanuel F, Coy, Kathy, Trowbridge, Melissa, Sinn, Anthony L, Renbarger, Jamie L, Ferguson, Michael J, Huang, Kun, Zhang, Jie, Saadatzadeh, M Reza, Pollok, Karen E

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Redefining breast cancer subtypes to guide treatment prioritization and maximize response: Predictive biomarkers across 10 cancer therapies von Wolf, Denise M., Yau, Christina, Wulfkuhle, Julia, Brown-Swigart, Lamorna, Gallagher, Rosa I., Lee, Pei Rong Evelyn, Zhu, Zelos, Magbanua, Mark J., Sayaman, Rosalyn, O’Grady, Nicholas, Basu, Amrita, Delson, Amy, Coppé, Jean Philippe, Lu, Ruixiao, Braun, Jerome, Asare, Smita M., Sit, Laura, Matthews, Jeffrey B., Perlmutter, Jane, Hylton, Nola, Liu, Minetta C., Pohlmann, Paula, Symmans, W. Fraser, Rugo, Hope S., Isaacs, Claudine, DeMichele, Angela M., Yee, Douglas, Berry, Donald A., Pusztai, Lajos, Petricoin, Emanuel F., Hirst, Gillian L., Esserman, Laura J., van 't Veer, Laura J.

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Clinical and immune responses to neoadjuvant fulvestrant with or without enzalutamide in ER+/Her2− breast cancer von Elias, Anthony D., Staley, Alyse W., Fornier, Monica, Vidal, Gregory A., Alami, Vida, Sams, Sharon, Spoelstra, Nicole S., Goodspeed, Andrew, Kabos, Peter, Diamond, Jennifer R., Shagisultanova, Elena, Gallagher, Rosa I., Wulfkuhle, Julia D., Petricoin, Emanuel F., Zolman, Kathryn L., McSpadden, Tessa, Jordan, Kimberly R., Slansky, Jill E., Borges, Virginia F., Gao, Dexiang, Richer, Jennifer K.

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PD-L1 quantification across tumor types using the reverse phase protein microarray: implications for precision medicine von Baldelli, Elisa, Hodge, K Alex, Bellezza, Guido, Shah, Neil J, Gambara, Guido, Sidoni, Angelo, Mandarano, Martina, Ruhunusiri, Chamodya, Dunetz, Bryant, Abu-Khalaf, Maysa, Wulfkuhle, Julia, Gallagher, Rosa I, Liotta, Lance, de Bono, Johann, Mehra, Niven, Riisnaes, Ruth, Ravaggi, Antonella, Odicino, Franco, Sereni, Maria Isabella, Blackburn, Matthew, Zupa, Angela, Improta, Giuseppina, Demsko, Perry, Crino', Lucio, Ludovini, Vienna, Giaccone, Giuseppe, Petricoin, Emanuel F, Pierobon, Mariaelena

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Tumor-Specific Major Histocompatibility-II Expression Predicts Benefit to Anti-PD-1/L1 Therapy in Patients With HER2-Negative Primary Breast Cancer von Gonzalez-Ericsson, Paula I, Wulfkhule, Julia D, Gallagher, Rosa I, Sun, Xiaopeng, Axelrod, Margaret L, Sheng, Quanhu, Luo, Na, Gomez, Henry, Sanchez, Violeta, Sanders, Melinda, Pusztai, Lajos, Petricoin, Emanuel, Blenman, Kim R M, Balko, Justin M

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Functional Mapping of AKT Signaling and Biomarkers of Response from the FAIRLANE Trial of Neoadjuvant Ipatasertib plus Paclitaxel for Triple-Negative Breast Cancer von Shi, Zhen, Wulfkuhle, Julia, Nowicka, Malgorzata, Gallagher, Rosa I, Saura, Cristina, Nuciforo, Paolo G, Calvo, Isabel, Andersen, Jay, Passos-Coelho, José Luis, Gil-Gil, Miguel J, Bermejo, Begoña, Pratt, Debra A, Ciruelos, Eva M, Villagrasa, Patricia, Wongchenko, Matthew J, Petricoin, Emanuel F, Oliveira, Mafalda, Isakoff, Steven J

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Neoadjuvant T-DM1/pertuzumab and paclitaxel/trastuzumab/pertuzumab for HER2+ breast cancer in the adaptively randomized I-SPY2 trial von Clark, Amy S., Yau, Christina, Wolf, Denise M., Petricoin, Emanuel F., van ‘t Veer, Laura J., Yee, Douglas, Moulder, Stacy L., Wallace, Anne M., Chien, A. Jo, Isaacs, Claudine, Boughey, Judy C., Albain, Kathy S., Kemmer, Kathleen, Haley, Barbara B., Han, Hyo S., Forero-Torres, Andres, Elias, Anthony, Lang, Julie E., Ellis, Erin D., Yung, Rachel, Tripathy, Debu, Nanda, Rita, Wulfkuhle, Julia D., Brown-Swigart, Lamorna, Gallagher, Rosa I., Helsten, Teresa, Roesch, Erin, Ewing, Cheryl A., Alvarado, Michael, Crane, Erin P., Buxton, Meredith, Clennell, Julia L., Paoloni, Melissa, Asare, Smita M., Wilson, Amy, Hirst, Gillian L., Singhrao, Ruby, Steeg, Katherine, Asare, Adam, Matthews, Jeffrey B., Berry, Scott, Sanil, Ashish, Melisko, Michelle, Perlmutter, Jane, Rugo, Hope S., Schwab, Richard B., Symmans, W. Fraser, Hylton, Nola M., Berry, Donald A., Esserman, Laura J., DeMichele, Angela M.

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Enrichment of PI3K-AKT-mTOR Pathway Activation in Hepatic Metastases from Breast Cancer von Pierobon, Mariaelena, Ramos, Corinne, Wong, Shukmei, Hodge, K Alex, Aldrich, Jessica, Byron, Sara, Anthony, Stephen P, Robert, Nicholas J, Northfelt, Donald W, Jahanzeb, Mohammad, Vocila, Linda, Wulfkuhle, Julia, Gambara, Guido, Gallagher, Rosa I, Dunetz, Bryant, Hoke, Nicholas, Dong, Ting, Craig, David W, Cristofanilli, Massimo, Leyland-Jones, Brian, Liotta, Lance A, O'Shaughnessy, Joyce A, Carpten, John D, Petricoin, Emanuel F

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A pilot study utilizing multi-omic molecular profiling to find potential targets and select individualized treatments for patients with previously treated metastatic breast cancer von Jameson, Gayle S., Petricoin, Emanuel F., Sachdev, Jasgit, Liotta, Lance A., Loesch, David M., Anthony, Stephen P., Chadha, Manpreet K., Wulfkuhle, Julia D., Gallagher, Rosa I., Reeder, Kimberley A., Pierobon, Mariaelena, Fulk, Monica R., Cantafio, Nina A., Dunetz, Bryant, Mikrut, William D., Von Hoff, Daniel D., Robert, Nicholas J.

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Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria von Guo, Zhijun, Sevrioukova, Irina F., Denisov, Ilia G., Zhang, Xia, Chiu, Ting-Lan, Thomas, Dafydd G., Hanse, Eric A., Cuellar, Rebecca A.D., Grinkova, Yelena V., Langenfeld, Vanessa Wankhede, Swedien, Daniel S., Stamschror, Justin D., Alvarez, Juan, Luna, Fernando, Galván, Adela, Bae, Young Kyung, Wulfkuhle, Julia D., Gallagher, Rosa I., Petricoin, Emanuel F., Norris, Beverly, Flory, Craig M., Schumacher, Robert J., O'Sullivan, M. Gerard, Cao, Qing, Chu, Haitao, Lipscomb, John D., Atkins, William M., Gupta, Kalpna, Kelekar, Ameeta, Blair, Ian A., Capdevila, Jorge H., Falck, John R., Sligar, Stephen G., Poulos, Thomas L., Georg, Gunda I., Ambrose, Elizabeth, Potter, David A.

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Mechanism of action biomarkers predicting response to AKT inhibition in the I-SPY 2 breast cancer trial von Wolf, Denise M., Yau, Christina, Wulfkuhle, Julia, Brown-Swigart, Lamorna, Gallagher, Rosa I., Jesus M. Magbanua, Mark, O’Grady, Nick, Hirst, Gillian, Asare, Smita, Tripathy, Debu, Berry, Don, Esserman, Laura, Chien, A. Jo, Petricoin, Emanuel F., van ‘t Veer, Laura

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Phase II trial of fulvestrant plus enzalutamide in ER+/HER2− advanced breast cancer von Elias, Anthony D., Spoelstra, Nicole S., Staley, Alyse W., Sams, Sharon, Crump, Lyndsey S., Vidal, Gregory A., Borges, Virginia F., Kabos, Peter, Diamond, Jennifer R., Shagisultanova, Elena, Afghahi, Anosheh, Mayordomo, Jose, McSpadden, Tessa, Crawford, Gloria, D’Alessandro, Angelo, Zolman, Kathryn L., van Bokhoven, Adrie, Zhuang, Yonghua, Gallagher, Rosa I., Wulfkuhle, Julia D., Petricoin III, Emanuel F., Gao, Dexiang, Richer, Jennifer K.

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Protein signaling and drug target activation signatures to guide therapy prioritization: Therapeutic resistance and sensitivity in the I-SPY 2 Trial von Gallagher, Rosa I, Wulfkuhle, Julia, Wolf, Denise M, Brown-Swigart, Lamorna, Yau, Christina, O'Grady, Nicholas, Basu, Amrita, Lu, Ruixiao, Campbell, Michael J, Magbanua, Mark J, Coppé, Jean-Philippe, Asare, Smita M, Sit, Laura, Matthews, Jeffrey B, Perlmutter, Jane, Hylton, Nola, Liu, Minetta C, Symmans, W Fraser, Rugo, Hope S, Isaacs, Claudine, DeMichele, Angela M, Yee, Douglas, Pohlmann, Paula R, Hirst, Gillian L, Esserman, Laura J, van 't Veer, Laura J, Petricoin, Emanuel F

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Epithelial Expressed B7-H4 Drives Differential Immunotherapy Response in Murine and Human Breast Cancer von Wescott, Elizabeth C, Sun, Xiaopeng, Gonzalez-Ericsson, Paula, Hanna, Ann, Taylor, Brandie C, Sanchez, Violeta, Bronzini, Juliana, Opalenik, Susan R, Sanders, Melinda E, Wulfkuhle, Julia, Gallagher, Rosa I, Gomez, Henry, Isaacs, Claudine, Bharti, Vijaya, Wilson, John T, Ballinger, Tarah J, Santa-Maria, Cesar A, Shah, Payal D, Dees, Elizabeth C, Lehmann, Brian D, Abramson, Vandana G, Hirst, Gillian L, Brown Swigart, Lamorna, van ˈt Veer, Laura J, Esserman, Laura J, Petricoin, Emanuel F, Pietenpol, Jennifer A, Balko, Justin M

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