Adaptation of a multiple myeloma minimal residual disease multicolor flow cytometry assay for real‐world practice von McMillan, Annabel, Tran, Thien‐An, Galas‐Filipowicz, Daria, Camilleri, Marquita, Lecat, Catherine, Ainley, Louise, Guo, Yanping, Yong, Kwee, Sive, Jonathan

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Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease von Leng, Houfu, Zhang, Hanlin, Li, Linsen, Zhang, Shuhao, Wang, Yanping, Chavda, Selina J., Galas-Filipowicz, Daria, Lou, Hantao, Ersek, Adel, Morris, Emma V., Sezgin, Erdinc, Lee, Yi-Hsuan, Li, Yunsen, Lechuga-Vieco, Ana Victoria, Tian, Mei, Mi, Jian-Qing, Yong, Kwee, Zhong, Qing, Edwards, Claire M., Simon, Anna Katharina, Horwood, Nicole J.

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Co-operation of MCL-1 and BCL-XL anti-apoptotic proteins in stromal protection of MM cells from carfilzomib mediated cytotoxicity von Galas-Filipowicz, Daria, Chavda, Selina J., Gong, Jia-Nan, Huang, David C. S., Khwaja, Asim, Yong, Kwee

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Increased Immune-Regulatory Receptor Expression on Effector T Cells as Early Indicators of Relapse Following Autologous Stem Cell Transplantation for Multiple Myeloma von Lee, Lydia, Alrasheed, Nouf, Khandelwal, Garima, Fitzsimons, Evelyn, Richards, Huw, Wilson, William, Chavda, Selina J, Henry, Jake, Conde, Lucia, De Massy, Marc Robert, Chin, Melody, Galas-Filipowicz, Daria, Herrero, Javier, Chain, Benny, Quezada, Sergio A, Yong, Kwee

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Limited efficacy of APRIL CAR in patients with multiple myeloma indicate challenges in the use of natural ligands for CAR T-cell therapy von Lee, Lydia, Lim, Wen Chean, Galas-Filipowicz, Daria, Fung, Kent, Taylor, Julia, Patel, Dominic, Akbar, Zulaikha, Alvarez Mediavilla, Elena, Wawrzyniecka, Patrycja, Shome, Debarati, Reijmers, Rogier M, Gregg, Trillian, Wood, Leigh, Day, William, Cerec, Virginie, Ferrari, Mathieu, Thomas, Simon, Cordoba, Shaun, Onuoha, Shimobi, Khokhar, Nushmia, Peddareddigari, Vijay, Al-Hajj, Muhammad, Cavet, Jim, Zweegman, Sonja, Rodriguez-Justo, Manuel, Yong, Kwee, Pule, Martin, Popat, Rakesh

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Genetic variants in BRIP1 (BACH1) contribute to risk of nonsyndromic cleft lip with or without cleft palate von Mostowska, Adrianna, Hozyasz, Kamil K., Wójcicki, Piotr, Galas-Filipowicz, Daria, Lasota, Agnieszka, Dunin-Wilczyńska, Izabella, Lianeri, Margarita, Jagodziński, Paweł P.

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An APRIL-based chimeric antigen receptor for dual targeting of BCMA and TACI in multiple myeloma von Lee, Lydia, Draper, Benjamin, Chaplin, Neil, Philip, Brian, Chin, Melody, Galas-Filipowicz, Daria, Onuoha, Shimobi, Thomas, Simon, Baldan, Vania, Bughda, Reyisa, Maciocia, Paul, Kokalaki, Eva, Neves, Margarida P., Patel, Dominic, Rodriguez-Justo, Manuel, Francis, James, Yong, Kwee, Pule, Martin

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Co-Operation of MCL-1 and BCL-X L Anti-Apoptotic Proteins in Stromal Protection of MM Cells from Carfilzomib Mediated Cytotoxicity von Galas-Filipowicz, Daria, Chavda, Selina J, Gong, Jianan, Huang, David C.S., Khwaja, Asim, Yong, Kwee

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Marrow-Infiltrating Regulatory T Cells Correlate with the Presence of Dysfunctional CD4 + PD-1 + Cells and Inferior Survival in Patients with Newly Diagnosed Multiple Myeloma von Alrasheed, Nouf, Lee, Lydia, Ghorani, Ehsan, Henry, Jake Y, Conde, Lucia, Chin, Melody, Galas-Filipowicz, Daria, Furness, Andrew J S, Chavda, Selina J, Richards, Huw, De-Silva, Dunnya, Cohen, Oliver C, Patel, Dominic, Brooks, Anthony, Rodriguez-Justo, Manuel, Pule, Martin, Herrero, Javier, Quezada, Sergio A, Yong, Kwee L

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Co-operation of MCL-1 and BCL-X L anti-apoptotic proteins in stromal protection of MM cells from carfilzomib mediated cytotoxicity von Galas-Filipowicz, Daria, Chavda, Selina J, Gong, Jia-Nan, Huang, David C S, Khwaja, Asim, Yong, Kwee

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Autophagy Blockade Disrupts Myeloma Cell Recovery from Proteasome Inhibition and Enhances Apoptosis von Chavda, Selina J, Galas-Filipowicz, Daria, Fitzsimons, Evelyn, Mikolajczak, Anna, Tooze, Sharon, Auner, Holger W, Simon, Katja, Khwaja, Asim, Yong, Kwee

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High Neoantigen Load Confers a Major Benefit from Autologous Stem Cell Transplantation Compared to Consolidation in Newly Diagnosed Multiple Myeloma von Walker, Ieuan, D'Arcy, Venetia, Foster, Kane, Khandelwal, Garima, Anderson, Georgina S.F., Wilson, William, Fitzsimons, Evie, Galas-Filipowicz, Daria, Popat, Rakesh, Ramasamy, Karthik, Streetly, Matthew, Bygrave, Ceri, Benjamin, Reuben, de Tute, Ruth M, Camilleri, Marquita, Chavda, Selina J, Pang, Gavin, Kamora, Sumaiya, Cavenagh, James D., Phillips, Elizabeth, Clifton-Hadley, Laura, Tyson, Charlotte, Fananapazir, Fuad, Parikh, Krupali, Owen, Roger, Herrero, Javier, Yong, Kwee, Chapman, Michael A.

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Tumor Reactive T Cells Reside in the Bone Marrow and Are Associated with Clinical Response to Hematological Malignancies von Wagner, Tim Robin, Kehl, Niklas, Steiger, Simon, Kilian, Michael, Foster, Kane, Boschert, Tamara, Hernandez, Gabrielle M., Abelin, Jennifer, Lindner, Katharina, Sester, Lilli Sophie, Frenking, Jan, Schönfelder, Bruno, Galas-Filipowicz, Daria, Fitzsimons, Evie, Green, Edward W., Schmidt, Patrick, Uhrig, Sebastian, Bunse, Lukas, Chain, Benny, Goldschmidt, Hartmut, Weinhold, Niels, Fröhling, Stefan, Müller-Tidow, Carsten, Carr, Steven A., Yong, Kwee, Rippe, Karsten, Raab, Marc S., Platten, Michael, Eichmüller, Stefan B, Friedrich, Mirco Julian

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Developing a Flow Cytometric Signature of Carfilzomib Responsiveness in Myeloma von Walker, Ieuan, D'arcy, Venetia, Rodriguez Romera, Antonio, Anderson, Georgina, Aubareda, Anna, Roy, James, Khandelwal, Garima, Wilson, William, Fitzsimons, Evelyn, Galas-Filipowicz, Daria, Foster, Kane, Popat, Rakesh, Ramasamy, Karthik, Streetly, Matthew, Bygrave, Ceri, Benjamin, Reuben, de Tute, Ruth M., Camilleri, Marquita, Chavda, Selina J, Pang, Gavin, Dadaga, Tushhar, Kamora, Sumaiya, Cavenagh, James, Phillips, Elizabeth H., Clifton-Hadley, Laura, Owen, Roger G, Herrero, Javier, Yong, Kwee, Chapman, Michael A

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P-389 Progression to myeloma reflects accelerating immunosenescence, loss of tumour MHC class I, and tumour growth-associated inflammation von Foster, Kane, Rees, Elise, Ainley, Louise, Lee, Lydia, Ward, Gwennan, Galas-Filipowicz, Daria, Mikolajczak, Anna, Lyon, Emma, Uddin, Imran, Beattie, Gordon, Turakhia, Mahima, Hoade, Yvette, Zhu, Catherine, Reading, James, Ramasamy, Karthik, Herrero, Javier, Chain, Benny, Quezada, Sergio, Yong, Kwee

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Frequency of Marrow Infiltrating PD-1 Expressing CD4 Effectors Following Autologous Stem Cell Transplant (ASCT) for Multiple Myeloma Is Prognostic for Clinical Outcome von Alrasheed, Nouf, Lee, Lydia, Richards, Huw, Wilson, William, Cohen, Oliver C, Chavda, Selina J, Henry, Jake, Furness, Andrew, Chin, Melody, Galas-Filipowicz, Daria, Kyriakou, Charalampia, Rabin, Neil K, Quezada, Sergio A, Yong, Kwee

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P-226 Study of T Cell Receptor (TCR) Dynamics in Smouldering Myeloma (SMM) Using TCR Sequence Clustering To Infer Contribution of the Immune Microenvironment to Progression to Mult... von Laidler, Annabel, Foster, Kane, Scobie, David, Hughes, Daniel, Byrne, Suzanne, Nageswaran, Gayathri, Rees, Elise, Lyon, Emma, Jankovic, Dylan, Hudson-Lund, Bethan, Galas-Filipowicz, Daria, Rashid, Ambreen, Ainley, Louise, Lecat, Catherine, Rahman, Jasmin, Vallance, Grant, Bygrave, Ceri, Smith, Dean, Al-Kaisi, Firas, Willis, Fenella, Ramasamy, Karthik, Boyle, Eileen, Yong, Kwee, Chain, Benny, Lee, Lydia

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P-235 Isatuximab as Post-ASCT Therapy in MRDpositive Patients Augments CD8 Effector T Cell Differentiation: Insights from the UKMRA Phase 3 RADAR Study von Mehta, Dipal, Rahman, Jasmin, Lyon, Emma, Rees, Elise, Foster, Kane, Mikolajczak, Anna, Galas-Filipowicz, Daria, Olivier, Catherine, Barnard, Lorna, Royle, Kara-Louise, Cicero, Robert, Kennaway, Charlotte, Levinte, Doina, Clemmens, Jonathan, Parrish, Christopher, Drayson, Mark, Bygrave, Ceri, Smith, Dean, Pratt, Guy, Sive, Jonathan, Jenner, Matthew, Quezada, Sergio, Ramasamy, Karthik, Yong, Kwee

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P-219 Longitudinal Analysis of t(11; 14) and t(4; 14) Genomes Reveals Distinct Evolutionary Trajectories in Multiple Myeloma von Hudson-Lund, Bethan, Hughes, Daniel, Sodi, Isabella, Foster, Kane, Lyon, Emma, Laidler, Annabel, Rees, Elise, Galas-Filipowicz, Daria, Fitzsimons, Evie, Chavda, Selina, Rashid, Ambreen, Lecat, Catherine, Mehta, Dipal, Rahman, Jasmin, Yoon, Jong Won, Lee, Lydia, Quezada, Sergio, Srinivasan, Anandagopal, Kazeroun, Mohammad, Ansari-Pour, Naser, Thakurta, Anjan, Yong, Kwee, Cribbs, Adam, Gooding, Sarah, Boyle, Eileen

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P-241 Progression From Smouldering Myeloma to Myeloma Is Accompanied by an Increase in CD56bright Bone Marrow Resident NK Cells With Reduced NK Cell Cytotoxic Capacity von Rees, Elise, Sodi, Isabella, Foster, Kane, Ainley, Louise, Hughes, Daniel, Rashid, Ambreen, Lyon, Emma, Galas-Filipowicz, Daria, Rahman, Jasmin, Lecat, Catherine, Vallace, Grant, Bygrave, Ceri, Smith, Dean, Al-Kaisi, Firas, Willis, Fenella, Parrish, Christopher, Lee, Lydia, Ramasamy, Karthik, Colucci, Francesco, Boyle, Eileen, Yong, Kwee

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