Charting a course through the acute promyelocytic leukemia (APL)-like nebula: the enigmatic cousins of APL von Ghiaur, Alexandra, Ghiaur, Gabriel

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Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations von Deng, Kai, Pertea, Mihaela, Rongvaux, Anthony, Wang, Leyao, Durand, Christine M., Ghiaur, Gabriel, Lai, Jun, McHugh, Holly L., Hao, Haiping, Zhang, Hao, Margolick, Joseph B., Gurer, Cagan, Murphy, Andrew J., Valenzuela, David M., Yancopoulos, George D., Deeks, Steven G., Strowig, Till, Kumar, Priti, Siliciano, Janet D., Salzberg, Steven L., Flavell, Richard A., Shan, Liang, Siliciano, Robert F.

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The Coming of Age of Preclinical Models of MDS von Liu, Wei, Teodorescu, Patric, Halene, Stephanie, Ghiaur, Gabriel

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Regulation of human hematopoietic stem cell self-renewal by the microenvironment’s control of retinoic acid signaling von Ghiaur, Gabriel, Yegnasubramanian, Srinivasan, Perkins, Brandy, Gucwa, Jessica L., Gerber, Jonathan M., Jones, Richard J.

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Taking the STING out of acute myeloid leukemia through macrophage-mediated phagocytosis von Dalton, William Brian, Ghiaur, Gabriel, Resar, Linda Ms

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Retinoic acid, CYP26, and drug resistance in the stem cell niche von Alonso, Salvador, Jones, Richard J., Ghiaur, Gabriel

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Targeting the Microenvironment in MDS: The Final Frontier von Teodorescu, Patric, Pasca, Sergiu, Dima, Delia, Tomuleasa, Ciprian, Ghiaur, Gabriel

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Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity von Li, Ling, Knutsdottir, Hildur, Hui, Ken, Weiss, Matthew J, He, Jin, Philosophe, Benjamin, Cameron, Andrew M, Wolfgang, Christopher L, Pawlik, Timothy M, Ghiaur, Gabriel, Ewald, Andrew J, Mezey, Esteban, Bader, Joel S, Selaru, Florin M

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Knockout of Cyp26a1 and Cyp26b1 during postnatal life causes reduced lifespan, dermatitis, splenomegaly, and systemic inflammation in mice von Snyder, Jessica M., Zhong, Guo, Hogarth, Cathryn, Huang, Weize, Topping, Traci, LaFrance, Jeffrey, Palau, Laura, Czuba, Lindsay C., Griswold, Michael, Ghiaur, Gabriel, Isoherranen, Nina

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An accessible patient-derived xenograft model of low-risk myelodysplastic syndromes von Teodorescu, Patric, Pasca, Sergiu, Choi, InYoung, Shams, Cynthia, Dalton, W Brian, Gondek, Lukasz P, DeZern, Amy E, Ghiaur, Gabriel

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Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells von Ishikawa, Eri Taniguchi, Gonzalez-Nieto, Daniel, Ghiaur, Gabriel, Dunn, Susan K., Ficker, Ashley M., Murali, Bhuvana, Madhu, Malav, Gutstein, David E., Fishman, Glenn I., Barrio, Luis C., Cancelas, Jose A.

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Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3 von Kim, Dongwon, Chen, Ruosi, Sheu, Mary, Kim, Noori, Kim, Sooah, Islam, Nasif, Wier, Eric M., Wang, Gaofeng, Li, Ang, Park, Angela, Son, Wooyang, Evans, Benjamin, Yu, Victoria, Prizmic, Vicky P., Oh, Eugene, Wang, Zixiao, Yu, Jianshi, Huang, Weiliang, Archer, Nathan K., Hu, Zhiqi, Clemetson, Nashay, Nelson, Amanda M., Chien, Anna, Okoye, Ginette A., Miller, Lloyd S., Ghiaur, Gabriel, Kang, Sewon, Jones, Jace W., Kane, Maureen A., Garza, Luis A.

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Coagulopathy in Acute Promyelocytic Leukemia: Can We Go Beyond Supportive Care? von Hambley, Bryan C., Tomuleasa, Ciprian, Ghiaur, Gabriel

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Overcoming microenvironment-mediated protection from ATRA using CYP26-resistant retinoids von Hernandez, Daniela, Palau, Laura, Norsworthy, Kelly, Anders, Nicole M., Alonso, Salvador, Su, Meng, Petkovich, Martin, Chandraratna, Rosh, Rudek, Michelle A., Smith, B. Douglas, Jones, Richard J., Ghiaur, Gabriel

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Outcome heterogeneity of TP53 -mutated myeloid neoplasms and the role of allogeneic hematopoietic cell transplantation von Pasca, Sergiu, Haldar, Saurav D, Ambinder, Alexander, Webster, Jonathan A, Jain, Tania, Dalton, W Brian, Prince, Gabrielle T, Ghiaur, Gabriel, DeZern, Amy E, Gojo, Ivana, Smith, B Douglas, Karantanos, Theodoros, Schulz, Cory, Stokvis, Kristin, Levis, Mark J, Jones, Richard J, Gondek, Lukasz P

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All-Trans Retinoic Acid Activity in Acute Myeloid Leukemia: Role of Cytochrome P450 Enzyme Expression by the Microenvironment von Su, Meng, Alonso, Salvador, Jones, Jace W, Yu, Jianshi, Kane, Maureen A, Jones, Richard J, Ghiaur, Gabriel

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Outcome of older (≥70 years) APL patients frontline treated with or without arsenic trioxide—an International Collaborative Study von Kayser, Sabine, Rahmé, Ramy, Martínez-Cuadrón, David, Ghiaur, Gabriel, Thomas, Xavier, Sobas, Marta, Guerci-Bresler, Agnes, Garrido, Ana, Pigneux, Arnaud, Gil, Cristina, Raffoux, Emmanuel, Tormo, Mar, Vey, Norbert, de la Serna, Javier, Salamero, Olga, Lengfelder, Eva, Levis, Mark J., Fenaux, Pierre, Sanz, Miguel A., Platzbecker, Uwe, Schlenk, Richard F., Adès, Lionel, Montesinos, Pau

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CCRL2 affects the sensitivity of myelodysplastic syndrome and secondary acute myeloid leukemia cells to azacitidine von Karantanos, Theodoros, Teodorescu, Patric, Arvanitis, Marios, Perkins, Brandy, Jain, Tania, DeZern, Amy E, Dalton, W Brian, Christodoulou, Ilias, Paun, Bogdan C, Varadhan, Ravi, Esteb, Christopher, Rajkhowa, Trivikram, Bonifant, Challice, Gondek, Lukasz P, Levis, Mark J, Yegnasubramanian, Srinivasan, Ghiaur, Gabriel, Jones, Richard J

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Immunomodulation with pomalidomide at early lymphocyte recovery after induction chemotherapy in newly diagnosed AML and high-risk MDS von Zeidner, Joshua F., Knaus, Hanna A., Zeidan, Amer M., Blackford, Amanda L., Montiel-Esparza, Raul, Hackl, Hubert, Prince, Gabrielle T., Gondek, Lukasz P., Ghiaur, Gabriel, Showel, Margaret M., DeZern, Amy E., Pratz, Keith W., Douglas Smith, B., Levis, Mark J., Gore, Steven, Coombs, Catherine C., Foster, Matthew C., Streicher, Howard, Karp, Judith E., Luznik, Leo, Gojo, Ivana

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Granulopoiesis requires increased C/EBPα compared to monopoiesis, correlated with elevated Cebpa in immature G-CSF receptor versus M-CSF receptor expressing cells von Ma, Ou, Hong, SunHwa, Guo, Hong, Ghiaur, Gabriel, Friedman, Alan D

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