Comparison of in vitro and computational experiments on the relation of inter-beat interval and duration of repolarization in a specific type of human induced pluripotent stem cell... von Kügler, Philipp, Rast, Georg, Guth, Brian D

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Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystem... von Ribeiro, Alexandre J. S., Guth, Brian D., Engwall, Michael, Eldridge, Sandy, Foley, C. Michael, Guo, Liang, Gintant, Gary, Koerner, John, Parish, Stanley T., Pierson, Jennifer B., Brock, Mathew, Chaudhary, Khuram W., Kanda, Yasunari, Berridge, Brian

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Comparison of Physiological Parameters and Anaesthesia Specific Observations during Isoflurane, Ketamine-Xylazine or Medetomidine-Midazolam-Fentanyl Anaesthesia in Male Guinea Pigs von Schmitz, Sabrina, Tacke, Sabine, Guth, Brian, Henke, Julia

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Preclinical Cardiovascular Risk Assessment in Modern Drug Development von Guth, Brian D.

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Effects of isoflurane, ketamine-xylazine and a combination of medetomidine, midazolam and fentanyl on physiological variables continuously measured by telemetry in Wistar rats von Albrecht, Maike, Henke, Julia, Tacke, Sabine, Markert, Michael, Guth, Brian

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Repeated anaesthesia with isoflurane and medetomidine-midazolam-fentanyl in guinea pigs and its influence on physiological parameters von Schmitz, Sabrina, Tacke, Sabine, Guth, Brian, Henke, Julia

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The impact of environmental and biological factors on the resting heart rate of dogs as assessed using 20 years of data from safety pharmacology studies von Alizadeh, Elham Ataei, Trautmann, Thomas, Krause, Florian, Knoeferl, Benjamin, Guns, Pieter-Jan, De Meyer, Guido, Guth, Brian D., Markert, Michael

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Safety pharmacology in and for Africa: Establishment of the pre-clinical drug development platform von Guth, Brian D., Grobler, Anne

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Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization von Alizadeh, Elham Ataei, Graf, Karin, Schiwon, Jessica, Trautmann, Thomas, Krause, Florian, Mayer, Werner, Christ, Katrin, Martel, Eric, Guth, Brian D., Markert, Michael

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Optimization of bioanalysis of dried blood samples von Alizadeh, Elham Ataei, Rast, Georg, Cantow, Chris, Schiwon, Jessica, Krause, Florian, De Meyer, Guido R.Y., Guns, Pieter-Jan, Guth, Brian D., Markert, Michael

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A new telemetry-based system for assessing cardiovascular function in group-housed large animals. Taking the 3Rs to a new level with the evaluation of remote measurement via cloud... von Markert, Michael, Trautmann, Thomas, Krause, Florian, Cioaga, Marius, Mouriot, Sebastien, Wetzel, Miriam, Guth, Brian D.

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Influence of field potential duration on spontaneous beating rate of human induced pluripotent stem cell-derived cardiomyocytes: Implications for data analysis and test system sele... von Rast, Georg, Kraushaar, Udo, Buckenmaier, Sandra, Ittrich, Carina, Guth, Brian D.

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Considerations for an In Vitro , Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for D... von Guth, Brian D, Engwall, Michael, Eldridge, Sandy, Foley, C Michael, Guo, Liang, Gintant, Gary, Koerner, John, Parish, Stanley T, Pierson, Jennifer B, Ribeiro, Alexandre J S, Zabka, Tanja, Chaudhary, Khuram W, Kanda, Yasunari, Berridge, Brian

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The evaluation of drug-induced changes in cardiac inotropy in dogs: Results from a HESI-sponsored consortium von Guth, Brian D., Chiang, Alan Y., Doyle, Jennifer, Engwall, Michael J., Guillon, Jean-Michel, Hoffmann, Peter, Koerner, John, Mittelstadt, Scott, Ottinger, Sean, Pierson, Jennifer Beck, Pugsley, Michael K., Rossman, Eric I., Walisser, Jacqueline, Sarazan, R. Dustan

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An integrated platform for simultaneous multi-well field potential recording and Fura-2-based calcium transient ratiometry in human induced pluripotent stem cell (hiPSC)-derived ca... von Rast, Georg, Weber, Jürgen, Disch, Christoph, Schuck, Elmar, Ittrich, Carina, Guth, Brian D.

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GLP in safety pharmacology studies: Report card after 15years von Guth, Brian D., Pugsley, Michael K.

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Solubility assessment and on-line exposure confirmation in a patch-clamp assay for hERG (human ether-a-go-go-related gene) potassium channel inhibition von Rast, Georg, Guth, Brian D.

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Considerations for assessing the potential effects of antidiabetes drugs on cardiac ventricular repolarization: A report from the Cardiac Safety Research Consortium von Heller, Simon, FRCP, Darpö, Börje, MD, PhD, Mitchell, Malcolm I., MBBS, MFPM, Linnebjerg, Helle, PhD, Leishman, Derek J., PhD, DSP, Mehrotra, Nitin, PhD, Zhu, Hao, PhD, Koerner, John, PhD, Fiszman, Mónica L., MD, PhD, Balakrishnan, Suchitra, MD, PhD, Xiao, Shen, MD, PhD, Todaro, Thomas G., MD, JD, Hensley, Ingrid, PhD, Guth, Brian D., PhD, Michelson, Eric L., MD, FACC, Sager, Philip, MD, FACC, FAHA, FHRS

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INSPIRE: A European training network to foster research and training in cardiovascular safety pharmacology von Guns, Pieter-Jan D., Guth, Brian D., Braam, Stefan, Kosmidis, Georgios, Matsa, Elena, Delaunois, Annie, Gryshkova, Vitalina, Bernasconi, Sylvain, Knot, Harm J., Shemesh, Yair, Chen, Alon, Markert, Michael, Fernández, Miguel A., Lombardi, Damiano, Grandmont, Céline, Cillero-Pastor, Berta, Heeren, Ron M.A., Martinet, Wim, Woolard, Jeanette, Skinner, Matt, Segers, Vincent F.M., Franssen, Constantijn, Van Craenenbroeck, Emeline M., Volders, Paul G.A., Pauwelyn, Thomas, Braeken, Dries, Yanez, Paz, Correll, Krystle, Yang, Xi, Prior, Helen, Kismihók, Gábor, De Meyer, Guido R.Y., Valentin, Jean-Pierre

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Drug safety Africa: An overview of safety pharmacology & toxicology in South Africa von Guth, Brian D., Grobler, Anne F., Frazier, Kendall S., Greiter-Wilke, Andrea, Herzyk, Danuta, Hough, Tertius A., Khan, Asrar Ali, Markert, Michael, Smith, James D., Svenson, Karen L., Wells, Sara, Pugsley, Michael K.

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