Vaccine-linked chemotherapy induces IL-17 production and reduces cardiac pathology during acute Trypanosoma cruzi infection von Cruz-Chan, Julio V., Villanueva-Lizama, Liliana E., Versteeg, Leroy, Damania, Ashish, Villar, Maria José, González-López, Cristina, Keegan, Brian, Pollet, Jeroen, Gusovsky, Fabian, Hotez, Peter J., Bottazzi, Maria Elena, Jones, Kathryn M.

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The TLR4 antagonist Eritoran protects mice from lethal influenza infection von Shirey, Kari Ann, Lai, Wendy, Scott, Alison J., Lipsky, Michael, Mistry, Pragnesh, Pletneva, Lioubov M., Karp, Christopher L., McAlees, Jaclyn, Gioannini, Theresa L., Weiss, Jerrold, Chen, Wilbur H., Ernst, Robert K., Rossignol, Daniel P., Gusovsky, Fabian, Blanco, Jorge C. G., Vogel, Stefanie N.

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Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase von Michalska, Karolina, Chang, Changsoo, Maltseva, Natalia I., Jedrzejczak, Robert, Robertson, Gregory T., Gusovsky, Fabian, McCarren, Patrick, Schreiber, Stuart L., Nag, Partha P., Joachimiak, Andrzej

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A therapeutic vaccine prototype induces protective immunity and reduces cardiac fibrosis in a mouse model of chronic Trypanosoma cruzi infection von Barry, Meagan A, Versteeg, Leroy, Wang, Qian, Pollet, Jeroen, Zhan, Bin, Gusovsky, Fabian, Bottazzi, Maria Elena, Hotez, Peter J, Jones, Kathryn M

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The Tuberculosis Drug Accelerator at year 10: what have we learned? von Aldridge, Bree B., Barros-Aguirre, David, Barry, Clifton E., Bates, Robert H., Berthel, Steven J., Boshoff, Helena I., Chibale, Kelly, Chu, Xin-Jie, Cooper, Christopher B., Dartois, Véronique, Duncan, Ken, Fotouhi, Nader, Gusovsky, Fabian, Hipskind, Philip A., Kempf, Dale J., Lelièvre, Joël, Lenaerts, Anne J., McNamara, Case W., Mizrahi, Valerie, Nathan, Carl, Olsen, David B., Parish, Tanya, Petrassi, H. Michael, Pym, Alexander, Rhee, Kyu Y., Robertson, Gregory T., Rock, Jeremy Michael, Rubin, Eric J., Russell, Betsy, Russell, David G., Sacchettini, James C., Schnappinger, Dirk, Schrimpf, Michael, Upton, Anna M., Warner, Peter, Wyatt, Paul Graham, Yuan, Ying

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The Toll-Like Receptor 4 Antagonist Eritoran Protects Mice from Lethal Filovirus Challenge von Younan, Patrick, Ramanathan, Palaniappan, Graber, Jessica, Gusovsky, Fabian, Bukreyev, Alexander

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Novel Small Molecule Inhibitors of TLR7 and TLR9: Mechanism of Action and Efficacy In Vivo von Lamphier, Marc, Zheng, Wanjun, Latz, Eicke, Spyvee, Mark, Hansen, Hans, Rose, Jeffrey, Genest, Melinda, Yang, Hua, Shaffer, Christina, Zhao, Yan, Shen, Yongchun, Liu, Carrie, Liu, Diana, Mempel, Thorsten R., Rowbottom, Christopher, Chow, Jesse, Twine, Natalie C., Yu, Melvin, Gusovsky, Fabian, Ishizaka, Sally T.

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The impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection von Nguyen, Duc Minh, Poveda, Cristina, Pollet, Jeroen, Gusovsky, Fabian, Bottazzi, Maria Elena, Hotez, Peter J, Jones, Kathryn Marie

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Influenza "Trains" the Host for Enhanced Susceptibility to Secondary Bacterial Infection von Shirey, Kari Ann, Perkins, Darren J, Lai, Wendy, Zhang, Wei, Fernando, Lurds R, Gusovsky, Fabian, Blanco, Jorge C G, Vogel, Stefanie N

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Vaccine-linked chemotherapy with a low dose of benznidazole plus a bivalent recombinant protein vaccine prevents the development of cardiac fibrosis caused by Trypanosoma cruzi in... von Dzul-Huchim, Victor Manuel, Ramirez-Sierra, Maria Jesus, Martinez-Vega, Pedro Pablo, Rosado-Vallado, Miguel Enrique, Arana-Argaez, Victor Ermilo, Ortega-Lopez, Jaime, Gusovsky, Fabian, Dumonteil, Eric, Cruz-Chan, Julio Vladimir, Hotez, Peter, Bottazzi, María Elena, Villanueva-Lizama, Liliana Estefania

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Vaccine-linked chemotherapy improves cardiac structure and function in a mouse model of chronic Chagas disease von Jones, Kathryn M, Mangin, Elise N, Reynolds, Corey L, Villanueva, Liliana E, Cruz, Julio Vladimir, Versteeg, Leroy, Keegan, Brian, Kendricks, April, Pollet, Jeroen, Gusovsky, Fabian, Bottazzi, Maria Elena, Hotez, Peter J

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Combinations of the azaquinazoline anti- Wolbachia agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in exper... von Hegde, Shrilakshmi, Marriott, Amy E, Pionnier, Nicolas, Steven, Andrew, Bulman, Christina, Gunderson, Emma, Vogel, Ian, Koschel, Marianne, Ehrens, Alexandra, Lustigman, Sara, Voronin, Denis, Tricoche, Nancy, Hoerauf, Achim, Hübner, Marc P, Sakanari, Judy, Aljayyoussi, Ghaith, Gusovsky, Fabian, Dagley, Jessica, Hong, David W, O'Neill, Paul, Ward, Steven A, Taylor, Mark J, Turner, Joseph D

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Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria von Franklin, Bernardo S, Ishizaka, Sally T, Lamphier, Marc, Gusovsky, Fabian, Hansen, Hans, Rose, Jeffrey, Zheng, Wanjun, Ataíde, Marco Antônio, de Oliveira, Rosane B, Golenbock, Douglas T, Gazzinelli, Ricardo T

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Combining SJ733, an oral ATP4 inhibitor of Plasmodium falciparum, with the pharmacokinetic enhancer cobicistat: An innovative approach in antimalarial drug development von Gaur, Aditya H., Panetta, John C., Smith, Amber M., Dallas, Ronald H., Freeman, Burgess B., Stewart, Tracy B., Tang, Li, John, Elizabeth, Branum, Kristen C., Patel, Nehali D., Ost, Shelley, Heine, Ryan N., Richardson, Julie L., Hammill, Jared T., Bebrevska, Lidiya, Gusovsky, Fabian, Maki, Noritsugu, Yanagi, Toshiharu, Flynn, Patricia M., McCarthy, James S., Chalon, Stephan, Guy, R. Kiplin

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E6201 [(3S,4R,5Z,8S,9S,11E)-14-(Ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a Novel Kinase Inhibitor of Mitogen-Act... von Goto, Masaki, Chow, Jesse, Muramoto, Kenzo, Chiba, Ken-ichi, Yamamoto, Satoshi, Fujita, Masanori, Obaishi, Hiroshi, Tai, Kenji, Mizui, Yoshiharu, Tanaka, Isao, Young, Donna, Yang, Hua, Wang, Yuan J, Shirota, Hiroshi, Gusovsky, Fabian

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Discovery of anti-inflammatory clinical candidate E6201, inspired from resorcylic lactone LL-Z1640-2, III von Shen, Yongchun, Boivin, Roch, Yoneda, Naoki, Du, Hong, Schiller, Shawn, Matsushima, Tomohiro, Goto, Masaki, Shirota, Hiroshi, Gusovsky, Fabian, Lemelin, Charles, Jiang, Yimin, Zhang, Zhiyi, Pelletier, Robert, Ikemori-Kawada, Megumi, Kawakami, Yoshiyuki, Inoue, Atsushi, Schnaderbeck, Matthew, Wang, Yuan

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Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction von Chow, J C, Young, D W, Golenbock, D T, Christ, W J, Gusovsky, F

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Discovery of an in vitro and in vivo potent resorcylic lactone analog of LL-Z1640-2 as anti-inflammatory lead, II von Shen, Yongchun, Du, Hong, Kotake, Makoto, Matsushima, Tomohiro, Goto, Masaki, Shirota, Hiroshi, Gusovsky, Fabian, Li, Xiangyi, Jiang, Yimin, Schiller, Shawn, Spyvee, Mark, Davis, Heather, Zhang, Zhiyi, Pelletier, Robert, Ikemori-Kawada, Megumi, Kawakami, Yoshiyuki, Inoue, Atsushi, Wang, Yuan

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A Novel Synthetic Acyclic Lipid A-like Agonist Activates Cells via the Lipopolysaccharide/Toll-like Receptor 4 Signaling Pathway von Lien, Egil, Chow, Jesse C., Hawkins, Lynn D., McGuinness, Pamela D., Miyake, Kensuke, Espevik, Terje, Gusovsky, Fabian, Golenbock, Douglas T.

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Diversity-oriented synthesis yields novel multistage antimalarial inhibitors von Kato, Nobutaka, Comer, Eamon, Sakata-Kato, Tomoyo, Sharma, Arvind, Sharma, Manmohan, Maetani, Micah, Bastien, Jessica, Brancucci, Nicolas M., Bittker, Joshua A., Corey, Victoria, Clarke, David, Derbyshire, Emily R., Dornan, Gillian L., Duffy, Sandra, Eckley, Sean, Itoe, Maurice A., Koolen, Karin M. J., Lewis, Timothy A., Lui, Ping S., Lukens, Amanda K., Lund, Emily, March, Sandra, Meibalan, Elamaran, Meier, Bennett C., McPhail, Jacob A., Mitasev, Branko, Moss, Eli L., Sayes, Morgane, Van Gessel, Yvonne, Wawer, Mathias J., Yoshinaga, Takashi, Zeeman, Anne-Marie, Avery, Vicky M., Bhatia, Sangeeta N., Burke, John E., Catteruccia, Flaminia, Clardy, Jon C., Clemons, Paul A., Dechering, Koen J., Duvall, Jeremy R., Foley, Michael A., Gusovsky, Fabian, Kocken, Clemens H. M., Marti, Matthias, Morningstar, Marshall L., Munoz, Benito, Neafsey, Daniel E., Sharma, Amit, Winzeler, Elizabeth A., Wirth, Dyann F., Scherer, Christina A., Schreiber, Stuart L.

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