Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors von Pu, Qinglin, Zhang, Hongjun, Guo, Liangqin, Cheng, Mangeng, Doty, Amy C, Ferguson, Heidi, Fradera, Xavier, Lesburg, Charles A, McGowan, Meredeth A, Miller, J. Richard, Geda, Prasanthi, Song, Xuelei, Otte, Karin, Sciammetta, Nunzio, Solban, Nicolas, Yu, Wensheng, Sloman, David L, Zhou, Hua, Lammens, Alfred, Neumann, Lars, Bennett, David Jonathan, Pasternak, Alexander, Han, Yongxin

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Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERα von Dykstra, Kevin D., Guo, Liangqin, Birzin, Elizabeth T., Chan, Wanda, Yang, Yi Tien, Hayes, Edward C., DaSilva, Carolyn A., Pai, Lee-Yuh, Mosley, Ralph T., Kraker, Bryan, Fitzgerald, Paula M.D., DiNinno, Frank, Rohrer, Susan P., Schaeffer, James M., Hammond, Milton L.

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Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist von Hong, Qingmei, Bakshi, Raman K., Palucki, Brenda L., Park, Min K., Ye, Zhixiong, He, Shuwen, Pollard, Patrick G., Sebhat, Iyassu K., Liu, Jian, Guo, Liangqin, Cashen, Doreen E., Martin, William J., Weinberg, David H., MacNeil, Tanya, Tang, Rui, Tamvakopoulos, Constantin, Peng, Qianping, Miller, Randy R., Stearns, Ralph A., Chen, Howard Y., Chen, Airu S., Strack, Alison M., Fong, Tung M., MacIntyre, D. Euan, Wyvratt, Matthew J., Nargund, Ravi P.

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Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist von He, Shuwen, Ye, Zhixiong, Dobbelaar, Peter H., Sebhat, Iyassu K., Guo, Liangqin, Liu, Jian, Jian, Tianying, Lai, Yingjie, Franklin, Christopher L., Bakshi, Raman K., Dellureficio, James P., Hong, Qingmei, Tsou, Nancy N., Ball, Richard G., Cashen, Doreen E., Martin, William J., Weinberg, David H., MacNeil, Tanya, Tang, Rui, Tamvakopoulos, Constantin, Peng, Qianping, Miller, Randy R., Stearns, Ralph A., Chen, Howard Y., Chen, Airu S., Strack, Alison M., Fong, Tung M., MacIntyre, D. Euan, Wyvratt, Matthew J., Nargund, Ravi P.

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α-Aminothiazole-γ-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists von Zhou, Changyou, Guo, Liangqin, Parsons, William H., Mills, Sander G., MacCoss, Malcolm, Vicario, Pasquale P., Zweerink, Hans, Cascieri, Margaret A., Springer, Martin S., Yang, Lihu

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Pictet-Spengler reaction on solid support von Lihu, Yang, Liangqin, Guo

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Development of a novel class of potent and selective FIXa inhibitors von Zhang, Ting, Andre, Patrick, Bateman, Thomas J., Chen, Yi-Heng, Desai, Kunal, Ellsworth, Kenneth, Geissler, Wayne M., Guo, Liangqin, Hruza, Alan, Jian, Tianying, Meng, Dongfang, Parker, Dann L., Qian, Xiaoxia, Reichert, Paul, Sherer, Edward C., Shu, Min, Smith, Cameron J., Sonatore, Lisa M., Tschirret-Guth, Richard, Nolting, Andrew F., Orr, Robert, Campeau, Louis-Charles, Araki, Kazuto, Nishimura, Teruyuki, Sakurada, Isao, Wood, Harold B.

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Development of a novel tricyclic class of potent and selective FIXa inhibitors von Meng, Dongfang, Andre, Patrick, Bateman, Thomas J., Berger, Richard, Chen, Yi-Heng, Desai, Kunal, Dewnani, Sunita, Ellsworth, Kenneth, Feng, Daming, Geissler, Wayne M., Guo, Liangqin, Hruza, Alan, Jian, Tianying, Li, Hong, Metzger, Joe, Parker, Dann L., Reichert, Paul, Sherer, Edward C., Smith, Cameron J., Sonatore, Lisa M., Tschirret-Guth, Richard, Wu, Jane, Xu, Jiayi, Zhang, Ting, Campeau, Louis-Charles, Orr, Robert, Poirier, Marc, McCabe-Dunn, Jamie, Araki, Kazuto, Nishimura, Teruyuki, Sakurada, Isao, Hirabayashi, Tomokazu, Wood, Harold B.

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SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists von He, Shuwen, Dobbelaar, Peter H., Guo, Liangqin, Ye, Zhixiong, Liu, Jian, Jian, Tianying, Truong, Quang, Shah, Shrenik K., Du, Wu, Qi, Hongbo, Bakshi, Raman K., Hong, Qingmei, Dellureficio, James D., Sherer, Edward, Pasternak, Alexander, Feng, Zhe, Reibarkh, Mikhail, Lin, Melissa, Samuel, Koppara, Reddy, Vijay B., Mitelman, Stan, Tong, Sharon X., Chicchi, Gary G., Tsao, Kwei-Lan, Trusca, Dorina, Wu, Margaret, Shao, Qing, Trujillo, Maria E., Fernandez, Guillermo, Nelson, Donald, Bunting, Patricia, Kerr, Janet, Fitzgerald, Patrick, Morissette, Pierre, Volksdorf, Sylvia, Eiermann, George J., Li, Cai, Zhang, Bei B., Howard, Andrew D., Zhou, Yun-Ping, Nargund, Ravi P., Hagmann, William K.

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Nipecotic and iso-nipecotic amides as potent and selective somatostatin subtype-2 receptor agonists von CHANGYOU ZHOU, LIANGQIN GUO, KANG CHENG, SCHAEFFER, James M, PATCHETT, Arthur A, LIHU YANG, MORRIELLO, Greg, PASTERNAK, Alex, PAN, Yanping, ROHRER, Susan P, BIRZIN, Elizebeth T, HUSKEY, Su-Er Wu, JACKS, Tom, SCHLEIM, Klaus D

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Preparation of 3,4-fused -spiro[furan-5(5 H),4′-piperidin]-2-one von Liu, Jian, Jian, Tianying, Guo, Liangqin, Atanasova, Tzvetomira, Nargund, Ravi P.

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Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes von Guo, Liangqin, Parker, Dann L, Zang, Yi, Sweis, Ramzi F, Liu, Weiguo, Sherer, Edward C, Buist, Nicole, Terebetski, Jenna, Kelly, Terri, Bugianesi, Randal, Priest, Birgit T, Dingley, Karen H, Li, Xiaofang, Mitelman, Stan, Salituro, Gino, Trujillo, Maria E, Pachanski, Michele, Kirkland, Melissa, Powles, Mary Ann, Eiermann, George J, Feng, Yue, Shang, Jin, Howard, Andrew D, Ujjainwalla, Feroze, Sinz, Christopher J, Debenham, John S, Edmondson, Scott D, Nargund, Ravi P, Hagmann, William K, Li, Derun

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Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes von Shah, Shrenik K, He, Shuwen, Guo, Liangqin, Truong, Quang, Qi, Hongbo, Du, Wu, Lai, Zhong, Liu, Jian, Jian, Tianying, Hong, Qingmei, Dobbelaar, Peter, Ye, Zhixiong, Sherer, Edward, Feng, Zhe, Yu, Yang, Wong, Frederick, Samuel, Koppara, Madiera, Maria, Karanam, Bindhu V, Reddy, Vijay B, Mitelman, Stan, Tong, Sharon X, Chicchi, Gary G, Tsao, Kwei-Lan, Trusca, Dorina, Feng, Yue, Wu, Margaret, Shao, Qing, Trujillo, Maria E, Eiermann, George J, Li, Cai, Pachanski, Michele, Fernandez, Guillermo, Nelson, Donald, Bunting, Patricia, Morissette, Pierre, Volksdorf, Sylvia, Kerr, Janet, Zhang, Bei B, Howard, Andrew D, Zhou, Yun-Ping, Pasternak, Alexander, Nargund, Ravi P, Hagmann, William K

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Discovery of potent, selective, and orally bioavailable 3 H-spiro[isobenzofuran-1,4′-piperidine] based melanocortin subtype-4 receptor agonists von Guo, Liangqin, Ye, Zhixiong, Liu, Jian, He, Shuwen, Bakshi, Raman K., Sebhat, Iyassu K., Dobbelaar, Peter H., Hong, Qingmei, Jian, Tianying, Dellureficio, James P., Tsou, Nancy N., Ball, Richard G., Weinberg, David H., MacNeil, Tanya, Tang, Rui, Tamvakopoulos, Constantin, Peng, Qianping, Chen, Howard Y., Chen, Airu S., Martin, William J., MacIntyre, D. Euan, Strack, Alison M., Fong, Tung M., Wyvratt, Matthew J., Nargund, Ravi P.

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Discovery and activity of (1 R,4 S,6 R)- N-[(1 R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo... von Ye, Zhixiong, Guo, Liangqin, Barakat, Khaled J., Pollard, Patrick G., Palucki, Brenda L., Sebhat, Iyassu K., Bakshi, Raman K., Tang, Rui, Kalyani, Rubana N., Vongs, Aurawan, Chen, Airu S., Chen, Howard Y., Rosenblum, Charles I., MacNeil, Tanya, Weinberg, David H., Peng, Qianping, Tamvakopoulos, Constantin, Miller, Randy R., Stearns, Ralph A., Cashen, Doreen E., Martin, William J., Metzger, Joseph M., Strack, Alison M., MacIntyre, D. Euan, Van der Ploeg, Lex H.T., Patchett, Arthur A., Wyvratt, Matthew J., Nargund, Ravi P.

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Arylalkyl pyrazole compounds as indoleamine 2,3-dioxygenase inhibitors von Han, Yongxin, Clausen, Dane, Yu, Wensheng, Lim, Jongwon, Chen, Ping, Fradera, Xavier, Xiao, Li, Guo, Liangqin, He, Shuwen, Pasternak, Alexander, Martinot, Theodore A

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Substituted pyrazole compounds as indoleamine 2,3-dioxygenase inhibitors von Li, Guoqing, Zhang, Rui, Sloman, David, Yu, Wensheng, Xiao, Li, Guo, Liangqin, He, Shuwen, Pasternak, Alexander, Martinot, Theodore A, Han, Yongxin, Clausen, Dane, Fradera, Xavier, Kozlowski, Joseph

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Substituted tricyclic compounds as indoleamine 2,3-dioxygenase inhibitors von Hopkins, Brett A, Lu, Min, Han, Yongxin, Li, Derun, Huang, Xianhai, Zhang, Hongjun, Bennett, David Jonathan, Zhou, Hua, Sloman, David L, Bharathan, Indu, Guo, Liangqin, Pasternak, Alexander

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NOVEL SUBSTITUTED [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS von GUO, Liangqin, HUANG, Xianhai, CLAUSEN, Dane, HE, Shuwen, XIAO, Li, XIAO, Dong, HAN, Yongxin, ZHANG, Hongjun, PU, Qinglin, PASTERNAK, Alexander

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Palladium-catalyzed Annulation of Oxygen-Substituted 1,3-Dienes von Larock, Richard C., Guo, Liangqin

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