A novel method to enable SNAr reaction of aminopyrrolopyrazoles von CHUANGXING GUO, LIMING DONG, MARAKOVITS, Joseph, KEPHART, Susan

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Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth von Murray, Brion W, Guo, Chuangxing, Piraino, Joseph, Westwick, John K, Zhang, Cathy, Lamerdin, Jane, Dagostino, Eleanor, Knighton, Daniel, Loi, Cho-Ming, Zager, Michael, Kraynov, Eugenia, Popoff, Ian, Christensen, James G, Martinez, Ricardo, Kephart, Susan E, Marakovits, Joseph, Karlicek, Shannon, Bergqvist, Simon, Smeal, Tod

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Systematic Structure Modifications of Imidazo[1,2-a]pyrimidine to Reduce Metabolism Mediated by Aldehyde Oxidase (AO) von Linton, Angelica, Kang, Ping, Ornelas, Martha, Kephart, Susan, Hu, Qiyue, Pairish, Mason, Jiang, Ying, Guo, Chuangxing

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Structure-based design of novel human Pin1 inhibitors (III): Optimizing affinity beyond the phosphate recognition pocket von Guo, Chuangxing, Hou, Xinjun, Dong, Liming, Marakovits, Joseph, Greasley, Samantha, Dagostino, Eleanor, Ferre, RoseAnn, Catherine Johnson, M., Humphries, Paul S., Li, Haitao, Paderes, Genevieve D., Piraino, Joseph, Kraynov, Eugenia, Murray, Brion W.

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Structure-based design of novel human Pin1 inhibitors (II) von Dong, Liming, Marakovits, Joseph, Hou, Xinjun, Guo, Chuangxing, Greasley, Samantha, Dagostino, Eleanor, Ferre, RoseAnn, Johnson, M. Catherine, Kraynov, Eugenia, Thomson, James, Pathak, Ved, Murray, Brion W.

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Structure-based design of novel human Pin1 inhibitors (I) von Guo, Chuangxing, Hou, Xinjun, Dong, Liming, Dagostino, Eleanor, Greasley, Samantha, Ferre, RoseAnn, Marakovits, Joseph, Johnson, M. Catherine, Matthews, David, Mroczkowski, Barbara, Parge, Hans, VanArsdale, Todd, Popoff, Ian, Piraino, Joseph, Margosiak, Stephen, Thomson, James, Los, Gerrit, Murray, Brion W.

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The first synthesis of the aglycone of the potent anti-tumor steroidal saponin OSW-1 von Guo, Chuangxing, Fuchs, P.L.

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A first-in-human phase 1 study of proxalutamide (GT0918), a dual MOA androgen receptor blocker in patients with advanced CRPC von Zhou, Tie, Xu, Wei-Dong, Xu, Chuang-Liang, Gao, Xu, Hou, Jian-Guo, Ren, Shancheng, Yang, Bo, Wei, Guolan, Sun, Ye, Chen, Chunyun, Guo, Chuangxing, Tong, Youzhi, Zhou, Karl, Sun, Ying-Hao

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Discovery of Pyrroloaminopyrazoles as Novel PAK Inhibitors von Guo, Chuangxing, McAlpine, Indrawan, Zhang, Junhu, Knighton, Daniel D, Kephart, Susan, Johnson, M. Catherine, Li, Haitao, Bouzida, Djamal, Yang, Anle, Dong, Liming, Marakovits, Joseph, Tikhe, Jayashree, Richardson, Paul, Guo, Lisa C, Kania, Robert, Edwards, Martin P, Kraynov, Eugenia, Christensen, James, Piraino, Joseph, Lee, Joseph, Dagostino, Eleanor, Del-Carmen, Christine, Deng, Ya-Li, Smeal, Tod, Murray, Brion W

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Design of oxobenzimidazoles and oxindoles as novel androgen receptor antagonists von Guo, Chuangxing, Pairish, Mason, Linton, Angelica, Kephart, Susan, Ornelas, Martha, Nagata, Asako, Burke, Benjamin, Dong, Liming, Engebretsen, Jon, Fanjul, Andrea N.

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Discovery of Aryloxy Tetramethylcyclobutanes as Novel Androgen Receptor Antagonists von Guo, Chuangxing, Linton, Angelica, Kephart, Susan, Ornelas, Martha, Pairish, Mason, Gonzalez, Javier, Greasley, Samantha, Nagata, Asako, Burke, Benjamin J, Edwards, Martin, Hosea, Natilie, Kang, Ping, Hu, Wenyue, Engebretsen, Jon, Briere, David, Shi, Manli, Gukasyan, Hovik, Richardson, Paul, Dack, Kevin, Underwood, Toby, Johnson, Patrick, Morell, Andrew, Felstead, Robert, Kuruma, Hidetoshi, Matsimoto, Hiroaki, Zoubeidi, Amina, Gleave, Martin, Los, Gerrit, Fanjul, Andrea N

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An efficient synthesis of highly functionalized chiral lactams von Ornelas, Martha A., Gonzalez, Javier, Sach, Neal W., Richardson, Paul F., Bunker, Kevin D., Linton, Angelica, Kephart, Susan E., Pairish, Mason, Guo, Chuangxing

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Structural modifications of a 3-methoxy-2-aminopyridine compound to reduce potential for mutagenicity and time-dependent drug–drug interaction von Palmer, Cynthia, Pairish, Mason, Kephart, Susan, Bouzida, Djamal, Cui, Jingrong, Deal, Judith, Dong, Liming, Gu, Danlin, Linton, Angelica, McAlpine, Indrawan, Yamazaki, Shinji, Smith, Evan, John-Baptiste, Annette, Bagrodia, Shubha, Kania, Robert, Guo, Chuangxing

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Discovery of 3-aryloxy-lactam analogs as potent androgen receptor full antagonists for treating castration resistant prostate cancer von Guo, Chuangxing, Kephart, Susan, Ornelas, Martha, Gonzalez, Javier, Linton, Angelica, Pairish, Mason, Nagata, Asako, Greasley, Samantha, Elleraas, Jeff, Hosea, Natilie, Engebretsen, Jon, Fanjul, Andrea N.

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Outer-ring stereochemical modulation of cytotoxicity in cephalostatins von LaCour, T G, Guo, C, Boyd, M R, Fuchs, P L

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Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators von Guo, Chuangxing, Linton, Angelica, Jalaie, Mehran, Kephart, Susan, Ornelas, Martha, Pairish, Mason, Greasley, Samantha, Richardson, Paul, Maegley, Karen, Hickey, Michael, Li, John, Wu, Xin, Ji, Xiaodong, Xie, Zhi

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An efficient synthesis of sulfamides von Guo, Chuangxing, Dong, Liming, Kephart, Susan, Hou, Xinjun

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Abstract 614: Proxalutamide (GT0918), a potent androgen receptor pathway inhibitor von Tong, Youzhi, Chen, Chunyun, Wu, Juan, Yang, Jiangtao, Zhang, Huihui, Wu, Xiaojun, Duan, Yanmei, Gao, Wei, Qian, Weidong, Niu, Xiaoxia, Mi, Lili, Guo, Chuangxing

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Abstract 2460: Discovery of potent androgen receptor antagonists for treating CRPC and AR+ breast cancer von Tong, Youzhi, Chen, Chunyun, Wu, Juan, Zhang, Huihui, Wu, Xiaojun, Duan, Yanmei, Gao, Wei, Niu, Xiaoxia, Ma, Linglan, Guo, Chuangxing

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Design, Synthesis, and Biological Activity of Novel Polycyclic Aza-Amide FKBP12 Ligands von Hudack, Raymond A, Barta, Nancy S, Guo, Chuangxing, Deal, Judith, Dong, Liming, Fay, Lorraine K, Caprathe, Bradley, Chatterjee, Arindam, Vanderpool, Darin, Bigge, Christopher, Showalter, Richard, Bender, Steve, Augelli-Szafran, Corinne E, Lunney, Elizabeth, Hou, Xinjun

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