Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification von Guilinger, John P, Thompson, David B, Liu, David R

Volltext

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity von Pattanayak, Vikram, Lin, Steven, Guilinger, John P, Ma, Enbo, Doudna, Jennifer A, Liu, David R

Volltext

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo von Zuris, John A, Thompson, David B, Shu, Yilai, Guilinger, John P, Bessen, Jeffrey L, Hu, Johnny H, Maeder, Morgan L, Joung, J Keith, Chen, Zheng-Yi, Liu, David R

Volltext

Concentration Depth Profiles of Microplastic Particles in River Flow and Implications for Surface Sampling von Cowger, Win, Gray, Andrew B, Guilinger, James J, Fong, Brandon, Waldschläger, Kryss

Volltext

Predicting Postfire Sediment Yields of Small Steep Catchments Using Airborne Lidar Differencing von Guilinger, James J., Foufoula‐Georgiou, Efi, Gray, Andrew B., Randerson, James T., Smyth, Padhraic, Barth, Nicolas C., Goulden, Michael L.

Volltext

Determining the specificities of TALENs, Cas9, and other genome-editing enzymes von Pattanayak, Vikram, Guilinger, John P, Liu, David R

Volltext

Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity von Guilinger, John P, Pattanayak, Vikram, Reyon, Deepak, Tsai, Shengdar Q, Sander, Jeffry D, Joung, J Keith, Liu, David R

Volltext

Continuous directed evolution of DNA-binding proteins to improve TALEN specificity von Hubbard, Basil P, Badran, Ahmed H, Zuris, John A, Guilinger, John P, Davis, Kevin M, Chen, Liwei, Tsai, Shengdar Q, Sander, Jeffry D, Joung, J Keith, Liu, David R

Volltext

Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding von McCloskey, Kevin, Sigel, Eric A, Kearnes, Steven, Xue, Ling, Tian, Xia, Moccia, Dennis, Gikunju, Diana, Bazzaz, Sana, Chan, Betty, Clark, Matthew A, Cuozzo, John W, Guié, Marie-Aude, Guilinger, John P, Huguet, Christelle, Hupp, Christopher D, Keefe, Anthony D, Mulhern, Christopher J, Zhang, Ying, Riley, Patrick

Volltext

Computational screening of metal-organic frameworks for large-molecule chemical sensing von GREATHOUSE, Jeffery A, OCKWIG, Nathan W, CRISCENTI, Louise J, GUILINGER, T. R, POHL, Phil, ALLENDORF, Mark D

Volltext

Discovery of Nanomolar DCAF1 Small Molecule Ligands von Li, Alice Shi Ming, Kimani, Serah, Wilson, Brian, Noureldin, Mahmoud, González-Álvarez, Héctor, Mamai, Ahmed, Hoffer, Laurent, Guilinger, John P., Zhang, Ying, von Rechenberg, Moritz, Disch, Jeremy S., Mulhern, Christopher J., Slakman, Belinda L., Cuozzo, John W., Dong, Aiping, Poda, Gennady, Mohammed, Mohammed, Saraon, Punit, Mittal, Manish, Modh, Pratik, Rathod, Vaibhavi, Patel, Bhashant, Ackloo, Suzanne, Santhakumar, Vijayaratnam, Szewczyk, Magdalena M, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Marcellus, Richard, Guié, Marie-Aude, Keefe, Anthony D., Brown, Peter J., Halabelian, Levon, Al-awar, Rima, Vedadi, Masoud

Volltext

Wildfire impacts on the persistent suspended sediment dynamics of the Ventura River, California von Jumps, Nathan, Gray, Andrew B., Guilinger, James J., Cowger, Win C.

Volltext

Turbidity Structures the Controls of Ecosystem Metabolism and Associated Metabolic Process Domains Along a 75-km Segment of a Semiarid Stream von Honious, Sarah A. S., Hale, Rebecca L., Guilinger, James J., Crosby, Benjamin T., Baxter, Colden V.

Volltext

Electrophilic activity-based RNA probes reveal a self-alkylating RNA for RNA labeling von McDonald, Richard I, Guilinger, John P, Mukherji, Shankar, Curtis, Edward A, Lee, Won I, Liu, David R

Volltext

Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV‑2 Mpro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition against Pan-Coronaviru... von Wang, Xu, Gotchev, Dimitar, Fan, Kristi Yi, Vega, Marvin M., Mani, Nagraj, McGovern-Gooch, Kayleigh, Cuconati, Andrea, Tercero, Breanna, Wang, Xiaohe, Carpino, Philip, Maskos, Klaus, Centrella, Paolo A., Schmitt, Andreas, Preuss, Franziska, Prasad, Archna, Chen, Chia-yi, Clark, Matthew A., Guilinger, John P., Johnstone, Shawn, von König, Konstanze, Keefe, Anthony D., Liu, Jenny, Turcotte, Stéphane, Zhang, Ying, Konz Makino, Debora L., Lam, Angela M., Cole, Andrew G., Sofia, Michael J.

Volltext

Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV-2 M pro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition against Pan-Coronavir... von Wang, Xu, Gotchev, Dimitar, Fan, Kristi Yi, Vega, Marvin M, Mani, Nagraj, McGovern-Gooch, Kayleigh, Cuconati, Andrea, Tercero, Breanna, Wang, Xiaohe, Carpino, Philip, Maskos, Klaus, Centrella, Paolo A, Schmitt, Andreas, Preuss, Franziska, Prasad, Archna, Chen, Chia-Yi, Clark, Matthew A, Guilinger, John P, Johnstone, Shawn, von König, Konstanze, Keefe, Anthony D, Liu, Jenny, Turcotte, Stéphane, Zhang, Ying, Konz Makino, Debora L, Lam, Angela M, Cole, Andrew G, Sofia, Michael J

Volltext

Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning von Ahmad, Shabbir, Xu, Jin, Feng, Jianwen A., Hutchinson, Ashley, Zeng, Hong, Ghiabi, Pegah, Dong, Aiping, Centrella, Paolo A., Clark, Matthew A., Guié, Marie-Aude, Guilinger, John P., Keefe, Anthony D., Zhang, Ying, Cerruti, Thomas, Cuozzo, John W., von Rechenberg, Moritz, Bolotokova, Albina, Li, Yanjun, Loppnau, Peter, Seitova, Alma, Li, Yen-Yen, Santhakumar, Vijayaratnam, Brown, Peter J., Ackloo, Suzanne, Halabelian, Levon

Volltext

Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry von Guilinger, John P., Archna, Archna, Augustin, Martin, Bergmann, Andreas, Centrella, Paolo A., Clark, Matthew A., Cuozzo, John W., Däther, Maike, Guié, Marie-Aude, Habeshian, Sevan, Kiefersauer, Reiner, Krapp, Stephan, Lammens, Alfred, Lercher, Lukas, Liu, Julie, Liu, Yanbin, Maskos, Klaus, Mrosek, Michael, Pflügler, Klaus, Siegert, Markus, Thomson, Heather A., Tian, Xia, Zhang, Ying, Konz Makino, Debora L., Keefe, Anthony D.

Volltext

Generating Selective Leads for Mer Kinase InhibitorsExample of a Comprehensive Lead-Generation Strategy von Nissink, J. Willem M, Bazzaz, Sana, Blackett, Carolyn, Clark, Matthew A, Collingwood, Olga, Disch, Jeremy S, Gikunju, Diana, Goldberg, Kristin, Guilinger, John P, Hardaker, Elizabeth, Hennessy, Edward J, Jetson, Rachael, Keefe, Anthony D, McCoull, William, McMurray, Lindsay, Olszewski, Allison, Overman, Ross, Pflug, Alexander, Preston, Marian, Rawlins, Philip B, Rivers, Emma, Schimpl, Marianne, Smith, Paul, Truman, Caroline, Underwood, Elizabeth, Warwicker, Juli, Winter-Holt, Jon, Woodcock, Simon, Zhang, Ying

Volltext

The Evolution of Sediment Sources Over a Sequence of Postfire Sediment‐Laden Flows Revealed Through Repeat High‐Resolution Change Detection von Guilinger, James J., Gray, Andrew B., Barth, Nicolas C., Fong, Brandon T.

Volltext