Introduction to Special Issue on Bioinformatics

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A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance von Hivert, Marie-France, Scott, Robert A, Grimsby, Jonna L, Chen, Han, Amin, Najaf, Barnes, Daniel, Cadby, Gemma, Hottenga, Jouke-Jan, Ingelsson, Erik, Kanoni, Stavroula, Ladenvall, Claes, Lagou, Vasiliki, Liu, Yongmei, Martinez-Larrad, Maria Teresa, Navarro, Pau, Strawbridge, Rona J, Tanaka, Toshiko, de Andrade, Mariza, Aulchenko, Yurii, Balkau, Beverley, Beilby, John P, Blangero, John, Boban, Mladen, Boomsma, Dorret I, Böttcher, Yvonne, Bouchard, Claude, Budimir, Danijela, Clarke, Robert, Corbatón-Anchuelo, Arturo, Couper, David, Dedoussis, George V, Erdos, Michael R, Eriksson, Johan G, Franzosi, Maria Grazia, Franks, Paul W, Galan, Pilar, de Geus, Eco, Hallmans, Göran, Hansson, Ola, Harris, Tamara B, Hayward, Caroline, Hingorani, Aroon, Johnson, Paul C D, Jukema, J Wouter, Jula, Antti, Kolcic, Ivana, Kumari, Meena, Lakka, Timo, Lannfelt, Lars, Lathrop, G Mark, Lind, Lars, Lobbens, Stéphane, Loos, Ruth J F, Lyssenko, Valeriya, Magnusson, Patrik K E, Marmot, Michael, Meneton, Pierre, Mooser, Vincent, Morken, Mario A, Ong, Ken K, Oostra, Ben A, Palmer, Lyle J, Palotie, Aarno, Peden, John F, Pedersen, Nancy L, Penninx, Brenda, Perola, Markus, Peyser, Patricia A, Räikkönen, Katri, Rehnberg, Emil, Rotter, Jerome I, Rudan, Igor, Ruokonen, Aimo, Saaristo, Timo, Sabater-Lleal, Maria, Salomaa, Veikko, Saxena, Richa, Sennblad, Bengt, Shuldiner, Alan R, Sijbrands, Eric J G, Small, Kerrin S, Smith, Nicholas L, Sun, Yan V, Tuomilehto, Jaakko, Uitterlinden, Andre G, Vikström, Max, Vitart, Veronique, Vohl, Marie-Claude, Voight, Benjamin F, Waeber, Gerard, Wheeler, Eleanor, Widen, Elisabeth, Willemsen, Gonneke, Wilson, James F, Witteman, Jacqueline C M, Yaghootkar, Hanieh, Barroso, Ines, Watanabe, Richard M, Florez, Jose C, Meigs, James B

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Pendant Arm Functionalized Benzamidinate Titanium Imido Compounds:  Experimental and Computational Studies of Their Reactions with CO2 von Boyd, Catherine L, Clot, Eric, Guiducci, Aldo E, Mountford, Philip

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Anthracycline-induced cardiotoxicity: A multicenter randomised trial comparing two strategies for guiding prevention with enalapril: The International CardioOncology Society-one tr... von Cardinale, Daniela, Latini, Roberto, Franzosi, Maria Grazia, Civelli, Maurizio, Cucchi, GianFranco, Menatti, Elisabetta, Mangiavacchi, Maurizio, Cavina, Raffaele, Gori, Stefania, Colombo, Alessandro, Curigliano, Giuseppe, Salvatici, Michela, Rizzo, Antonio, Ghisoni, Francesco, Bianchi, Alessandra, Falci, Cristina, Rocca, Andrea, Monopoli, Anna, Milandri, Carlo, Bregni, Marco, Sicuro, Marco, Giordano, Monica, Staszewsky, Lidia, Nicolis, Enrico B., Masson, Serge, Cipolla, Carlo M., Cipolla, C.M., Cardinale, D., Ciceri, F., Latini, R., Sandri, M.T., Maggioni, A.P., Labianca, R., Finzi, A., Vago, T., Civelli, M., Gramenzi, S., Masson, S., Balconi, G., Bernasconi, R., Salvatici, M., Nicolis, E., Magnoli, M., Buratti, M.G., Malossi, A., Sicuro, M., Thiebat, B., Corzani, A., Colecchia, S., Pellegrini, C., Bregni, M., Appio, L., Caico, I., G.Rossetti, Mesenzani, O., Campana, C., Giordano, M., Gilardoni, M., Scognamiglio, G., Corrado, G., Battagin, D., Monopoli, A., Giannessi, P.G., Zipoli, G., Ghisoni, F., Rizzo, A., Callegari, S., Sesenna, C., Colombo, A., G.Curigliano, Fodor, C., Cavina, R., Mazza, R., Vallerio, P., Marbello, L., Sala, E., Fragasso, G., Trinca, S., Rocca, A., Farolfi, A., Gori, S., Barbieri, E., Lanzoni, L., Falci, C., Bianchi, A., Mioranza, E., Re, F., Gaibazzi, N., Turina, M.C., Giaroli, F., Nassiacos, D., Verusio, C., Barco, B., Bertolini, A., Menatti, E., Sinagra, G., Aleksova, A., Pinotti, G., Gueli, R., Mongiardi, C.

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The Lin28/let-7 Axis Regulates Glucose Metabolism von Zhu, Hao, Shyh-Chang, Ng, Segrè, Ayellet V., Shinoda, Gen, Shah, Samar P., Einhorn, William S., Takeuchi, Ayumu, Engreitz, Jesse M., Hagan, John P., Kharas, Michael G., Urbach, Achia, Thornton, James E., Triboulet, Robinson, Gregory, Richard I., Altshuler, David, Daley, George Q.

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Phenotypes Determined by Cluster Analysis and Their Survival in the Prospective European Scleroderma Trials and Research Cohort of Patients With Systemic Sclerosis von Allanore, Yannick, Riemekasten, Gabriela, Vettori, Serena, Matucci‐Cerinic, Marco, Launay, David, Walker, Ulrich, Lapadula, Giovanni, Sierakowsky, Stanislaw, Siegert, Elise, Nicoara, Ileana, Kahan, André, Carreira, Patricia E., Novak, Srdan, Varju, Cecilia, Chizzolini, Carlo, Widuchowska, Malgorzata, Rozman, Blaz, Mallia, Carmel, Wu, Chen, Hij, Darin, Dhamadi, Roza, Wollheim, Frank, Wuttge, Dirk M., Andréasson, Kristofer, Martinovic, Duska, Balbir‐Gurman, Alexandra, Braun‐Moscovici, Yolanda, Lo Monaco, Andrea, Caramaschi, Paola, Henes, Jörg, Santamaria, Vera Ortiz, Heitmann, Stefan, Krasowska, Dorota, Himsel, Andrea, Da Silva, José Antonio Pereira, Stamenkovic, Bojana, Tikly, Mohammed, Tarner, Ingo, Damgaard, Kirsten, Mendoza, Antonio Zea, Sifuentes Giraldo, WA, Midtvedt, Øyvind, Riccieri, Valeria, Ionescu, Ruxandra Maria, Opris, Daniela, Groseanu, Laura, Cornateanu, Roxana Sfrent, Ionitescu, Razvan, Gherghe, Ana Maria, Gorga, Marilena, Bojinca, Mihai, Distler, Jörg H. W., Beyer, Christian, Meroni, Pierluigi, Ingegnoli, Francesca, Mouthon, Luc, De Keyser, Filip, Smith, Vanessa, Corrado, Ada, Pozzi, Maria R., Eyerich, Kilian, Knott, Elisabeth, Wiland, Piotr, Szmyrka‐Kaczmarek, Magdalena, Morgiel, Ewa, Krummel‐Lorenz, Brigitte, Günther, Claudia, Souza Müller, Carolina, Azevedo, Valderílio F., Groppa, Liliana, Chiaburu, Lealea, Russu, Eugen, Zenone, Thierry, Stebbings, Simon, Highton, John, Stamp, Lisa, Solanki, Kamal, Doube, Alan, Loyo, Esthela, Li, Mengtao, Rosato, Edoardo, Amoroso, Antonio, Tanaseanu, Cristina‐Mihaela, Dumitrascu, Alina, Foti, Rosario, Chirieac, Rodica, Ancuta, Codrina, Villiger, Peter, Adler, Sabine, Rubio, Silvia Rodriguez, Exposito, Marta Valero, Chatelus, Emmanuel, Chifflot, Hélène, Butrimiene, Irena, Rugiene, Rita, Karpec, Diana, Montoya, Fabiana, Limonta, Massimiliano, Brucato, Antonio Luca, Spertini, François

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Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians von Cho, Yoon Shin, Chen, Chien-Hsiun, Hu, Cheng, Long, Jirong, Hee Ong, Rick Twee, Sim, Xueling, Takeuchi, Fumihiko, Wu, Ying, Go, Min Jin, Yamauchi, Toshimasa, Chang, Yi-Cheng, Kwak, Soo Heon, Ma, Ronald C W, Yamamoto, Ken, Adair, Linda S, Aung, Tin, Cai, Qiuyin, Chang, Li-Ching, Chen, Yuan-Tsong, Gao, Yutang, Hu, Frank B, Kim, Hyung-Lae, Kim, Sangsoo, Kim, Young Jin, Lee, Jeannette Jen-Mai, Lee, Nanette R, Li, Yun, Liu, Jian Jun, Lu, Wei, Nakamura, Jiro, Nakashima, Eitaro, Ng, Daniel Peng-Keat, Tay, Wan Ting, Tsai, Fuu-Jen, Wong, Tien Yin, Yokota, Mitsuhiro, Zheng, Wei, Zhang, Rong, Wang, Congrong, So, Wing Yee, Ohnaka, Keizo, Ikegami, Hiroshi, Hara, Kazuo, Cho, Young Min, Cho, Nam H, Chang, Tien-Jyun, Bao, Yuqian, Hedman, Åsa K, Morris, Andrew P, McCarthy, Mark I, Takayanagi, Ryoichi, Park, Kyong Soo, Jia, Weiping, Chuang, Lee-Ming, Chan, Juliana C N, Maeda, Shiro, Kadowaki, Takashi, Lee, Jong-Young, Wu, Jer-Yuarn, Teo, Yik Ying, Tai, E Shyong, Shu, Xiao Ou, Mohlke, Karen L, Kato, Norihiro, Han, Bok-Ghee, Seielstad, Mark

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Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma von Chambers, John C, Elliott, Paul, Kooner, Jaspal S, Sehmi, Joban, Li, Xinzhong, Wass, Mark N, Van der Harst, Pim, Holm, Hilma, Kavousi, Maryam, Deng, Guohong, Gieger, Christian, Heard-Costa, Nancy L, Hottenga, Jouke-Jan, Kühnel, Brigitte, Kumar, Vinod, Lagou, Vasiliki, Liang, Liming, Luan, Jian'an, Vidal, Pedro Marques, Leach, Irene Mateo, O'Reilly, Paul F, Peden, John F, Rahmioglu, Nilufer, Speliotes, Elizabeth K, Yuan, Xin, Alizadeh, Behrooz Z, Atwood, Larry D, Borecki, Ingrid B, Charoen, Pimphen, Cucca, Francesco, de Geus, Eco J C, Dixon, Anna L, Döring, Angela, Ehret, Georg, Forouhi, Nita G, Goessling, Wolfram, Gudbjartsson, Daniel F, Harris, Tamara B, Hartikainen, Anna-Liisa, Hirschfield, Gideon M, Homuth, Georg, Hyppönen, Elina, Janssen, Harry L A, Kangas, Antti J, Kema, Ido P, Kühn, Jens P, Lai, Sandra, Lathrop, Mark, Lerch, Markus M, Li, Yun, Liang, T Jake, Loos, Ruth J F, Martin, Nicholas G, Moffatt, Miriam F, Montgomery, Grant W, Munroe, Patricia B, Musunuru, Kiran, O'Donnell, Christopher J, Prokopenko, Inga, Ruokonen, Aimo, Savolainen, Markku J, Schlessinger, David, Seedorf, Udo, Sen-Chowdhry, Srijita, Siminovitch, Katherine A, Smit, Johannes H, Spector, Timothy D, Tan, Wenting, Teslovich, Tanya M, Tukiainen, Taru, Wallace, Chris, Wallaschofski, Henri, Wichmann, H-Erich, Willemsen, Gonneke, Würtz, Peter, Xu, Chun, Yerges-Armstrong, Laura M, Boomsma, Dorret I, Froguel, Philippe, Matsuda, Koichi, McCarthy, Mark I, Meisinger, Christa, Pietiläinen, Kirsi H, Schumann, Gunter, Snieder, Harold, Sternberg, Michael J E, Stolk, Ronald P, Thomas, Howard C, Thorsteinsdottir, Unnur, Wareham, Nicholas J, Waterworth, Dawn M, Watkins, Hugh, Whitfield, John B, Witteman, Jacqueline C M, Wolffenbuttel, Bruce H R, Fox, Caroline S, Ala-Korpela, Mika, Stefansson, Kari, Völzke, Henry, Järvelin, Marjo-Riitta

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Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis von Stahl, Eli A, Wegmann, Daniel, Trynka, Gosia, Gutierrez-Achury, Javier, Do, Ron, Voight, Benjamin F, Kraft, Peter, Chen, Robert, Kallberg, Henrik J, Kurreeman, Fina A S, Kathiresan, Sekar, Wijmenga, Cisca, Gregersen, Peter K, Alfredsson, Lars, Siminovitch, Katherine A, Worthington, Jane, de Bakker, Paul I W, Raychaudhuri, Soumya, Plenge, Robert M

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Update on the profile of the EUSTAR cohort: an analysis of the EULAR Scleroderma Trials and Research group database von Meier, Florian M P, Frommer, Klaus W, Dinser, Robert, Walker, Ulrich A, Czirjak, Laszlo, Denton, Christopher P, Allanore, Yannick, Distler, Oliver, Riemekasten, Gabriela, Valentini, Gabriele, Müller-Ladner, Ulf

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Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes von STRAWBRIDGE, Rona J, DUPUIS, Josée, NICA, Alexandra, WHEELER, Eleanor, HAN CHEN, VOIGHT, Benjamin F, TANEERA, Jalal, KANONI, Stavroula, PEDEN, John F, TURRINI, Fabiola, GUSTAFSSON, Stefan, ZABENA, Carina, PROKOPENKO, Inga, ALMGREN, Peter, BARKER, David J. P, BARNES, Daniel, DENNISON, Elaine M, ERIKSSON, Johan G, ERIKSSON, Per, EURY, Elodie, FOLKERSEN, Lasse, FOX, Caroline S, FRAYLING, Timothy M, BARKER, Adam, GOEL, Anuj, GU, Harvest F, HORIKOSHI, Momoko, ISOMAA, Bo, JACKSON, Anne U, JAMESON, Karen A, KAJANTIE, Eero, KERR-CONTE, Julie, KUULASMAA, Teemu, KUUSISTO, Johanna, AHLQVIST, Emma, LOOS, Ruth J. F, JIAN'AN LUAN, MAKRILAKIS, Konstantinos, MANNING, Alisa K, MARTINEZ-LARRAD, Maria Teresa, NARISU, Narisu, MANNILA, Maria Nastase, OHRVIK, John, OSMOND, Clive, PASCOE, Laura, RYBIN, Denis, PAYNE, Felicity, SAYER, Avan A, SENNBLAD, Bengt, SILVEIRA, Angela, STANCAKOVA, Alena, STIRRUPS, Kathy, SWIFT, Amy J, SYVÄNEN, Ann-Christine, PETRIE, John R, TRAVERS, Mary E, BOUATIA-NAJI, Nabila, DIMAS, Antigone S

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Digital ulcers predict a worse disease course in patients with systemic sclerosis von Mihai, Carina, Landewé, Robert, van der Heijde, Désirée, Walker, Ulrich A, Constantin, Paul I, Gherghe, Ana Maria, Ionescu, Ruxandra, Rednic, Simona, Allanore, Yannick, Avouac, Jérôme, Czirják, László, Hachulla, Eric, Riemekasten, Gabriela, Cozzi, Franco, Airò, Paolo, Cutolo, Maurizio, Mueller-Ladner, Ulf, Matucci-Cerinic, Marco

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Management of pregnancy in autoimmune rheumatic diseases: maternal disease course, gestational and neonatal outcomes and use of medications in the prospectiveItalian P-RHEUM.it stu... von Andreoli, Laura, Gerardi, Maria Chiara, Gerosa, Maria, Rozza, Davide, Crisafulli, Francesca, Erra, Roberta, Lini, Daniele, Trespidi, Laura, Padovan, Melissa, Ruffilli, Francesca, Serale, Francesca, Cuomo, Giovanna, Raffeiner, Bernd, Semeraro, Paolo, Tani, Chiara, Chimenti, Maria Sole, Conigliaro, Paola, Hoxha, Ariela, Nalli, Cecilia, Fredi, Micaela, Lazzaroni, Maria Grazia, Filippini, Matteo, Taglietti, Marco, Franceschini, Franco, Zatti, Sonia, Orabona, Rossana, Ramazzotto, Francesca, Zanardini, Cristina, Fontana, Giulia, Gozzoli, Giorgia, Barison, Claudia, Bizioli, Paola, Caporali, Roberto Felice, Carrea, Giulia, Ossola, Manuela Wally, Maranini, Beatrice, Silvagni, Ettore, Govoni, Marcello, Morano, Danila, Verteramo, Rosita, Doria, Andrea, Favaro, Maria, Calligaro, Antonia, Tonello, Marta, Larosa, Maddalena, Zen, Margherita, Zambon, Alessandra, Mosca, Marta, Zucchi, Dina, Elefante, Elena, Gori, Sabrina, Iannone, Florenzo, Anelli, Maria Grazia, Lavista, Marlea, Abbruzzese, Anna, Fasano, Carlo Giuseppe, D'Angelo, Salvatore, Cutro, Maria Stefania, Picerno, Valentina, Carbone, Teresa, Padula, Angela Anna, Rovere-Querini, Patrizia, Canti, Valentina, De Lorenzo, Rebecca, Cavallo, Ludovica, Ramoni, Véronique, Montecucco, Carlomaurizio, Codullo, Veronica, Milanesi, Alessandra, Pazzola, Giulia, Comitini, Giuseppina, Marvisi, Chiara, Salvarani, Carlo, Benedetti, Sara, Di Raimondo, Giuseppina, Gagliardi, Clizia, Lomater, Claudia, Crepaldi, Gloria, Bellis, Elisa, Bellisai, Francesca, Garcia Gonzalez, Estrella, Pata, Anna Paola, Zerbinati, Martina, Urban, Maria Letizia, Mattioli, Irene, Iuliano, Annamaria, Sebastiani, Giandomenico, Brucato, Antonio Luca, Bizzi, Emanuele, Cutolo, Maurizio, Santo, Leonardo, Tonetta, Sara, Landolfi, Gianpiero, Carrara, Greta, Bortoluzzi, Alessandra, Scirè, Carlo Alberto, Guiducci, Serena, Bellando-Randone, Silvia, Ditto, Maria Chiara, Chighizola, Cecilia Beatrice

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Parental origin of sequence variants associated with complex diseases von Gudjonsson, Sigurjon A, Sigurdsson, Helgi, Kristinsson, Kari Th, Sigurdsson, Asgeir, Hreidarsson, Astradur B, Masson, Gisli, Ferguson-Smith, Anne C, Frigge, Michael L, Jonsson, Thorvaldur, Stacey, Simon N, Olafsson, Jon H, Benediktsdottir, Kristrun R, Gudbjartsson, Daniel F, Besenbacher, Soren, Gylfason, Arnaldur, Sigurgeirsson, Bardur, Olason, Pall I, Sverrisson, Sverrir, Stefansson, Kari, Johannsson, Oskar Th, Thorsteinsdottir, Unnur, Benediktsson, Rafn, Thorleifsson, Gudmar, Kong, Augustine, Steinthorsdottir, Valgerdur, Sulem, Patrick, Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Sigurdsson, Gunnar

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Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes von SMALL, Kerrin S, HEDMAN, Asa K, AHMADI, Kourosh R, LINDGREN, Cecilia M, STEFANSSON, Kari, DERMITZAKIS, Emmanouilt, DELOUKAS, Panos, SPECTOR, Timothy D, MCCARTHY, Mark I, GRUNDBERG, Elin, NICA, Alexandra C, THORLEIFSSON, Gudmar, KONG, Augustine, THORSTEINDOTTIR, Unnur, SHIN, So-Youn, RICHARDS, Hannah B, SORANZO, Nicole

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ACE inhibitors in SSc patients display a risk factor for scleroderma renal crisis-a EUSTAR analysis von Butikofer, Lukas, Varisco, Pierre A., Distler, O., Kowal-Bielecka, O., Allanore, Y., Riemekasten, G., Villiger, P. M., Adler, S.

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Joint and tendon involvement predict disease progression in systemic sclerosis: a EUSTAR prospective study von Avouac, Jérôme, Walker, Ulrich A, Hachulla, Eric, Riemekasten, Gabriela, Cuomo, Giovanna, Carreira, Patricia E, Caramaschi, Paola, Ananieva, Lidia P, Matucci-Cerinic, Marco, Czirjak, Laszlo, Denton, Christopher, Ladner, Ulf Müller, Allanore, Yannick

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Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGFβR1 von Brennan, Eoin P, Nolan, Karen A, Börgeson, Emma, Gough, Oisín S, McEvoy, Caitríona M, Docherty, Neil G, Higgins, Debra F, Murphy, Madeline, Sadlier, Denise M, Ali-Shah, Syed Tasadaque, Guiry, Patrick J, Savage, David A, Maxwell, Alexander P, Martin, Finian, Godson, Catherine

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Genome-wide association study identifies three novel loci for type 2 diabetes von Hara, Kazuo, Fujita, Hayato, Johnson, Todd A, Yamauchi, Toshimasa, Yasuda, Kazuki, Horikoshi, Momoko, Peng, Chen, Hu, Cheng, Ma, Ronald C W, Imamura, Minako, Iwata, Minoru, Tsunoda, Tatsuhiko, Morizono, Takashi, Shojima, Nobuhiro, So, Wing Yee, Leung, Ting Fan, Kwan, Patrick, Zhang, Rong, Wang, Jie, Yu, Weihui, Maegawa, Hiroshi, Hirose, Hiroshi, Kaku, Kohei, Ito, Chikako, Watada, Hirotaka, Tanaka, Yasushi, Tobe, Kazuyuki, Kashiwagi, Atsunori, Kawamori, Ryuzo, Jia, Weiping, Chan, Juliana C N, Teo, Yik Ying, Shyong, Tai E, Kamatani, Naoyuki, Kubo, Michiaki, Maeda, Shiro, Kadowaki, Takashi

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A Genome-Wide Association Study Identifies GRK5 and RASGRP1 as Type 2 Diabetes Loci in Chinese Hans von HUAIXING LI, WEI GAN, MEIAN HE, LIANGDAN SUN, YIQIN WANG, JINGWEN ZHU, QIANQIAN NING, YONG TANG, RONG ZHANG, JIE WEN, DI WANG, XILIN ZHU, LING LU, KUNQUAN GUO, XIANBO ZUO, XIAOHUI GUO, HANDONG YANG, XIANGHAI ZHOU, XUEJUN ZHANG, LU QI, LOOS, Ruth J. F, HU, Frank B, TANGCHUN WU, XIAO DONG, YING LIU, LIEGANG LIU, ZE YANG, RENMING HU, WEIPING JIA, LINONG JI, YIXUE LI, XU LIN, XUEYAO HAN, CHENG HU, ZHEN YANG, LIANG SUN, WEI BAO, PENGTAO LI

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