Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities von Ahmed-Belkacem, Abdelhakim, Colliandre, Lionel, Ahnou, Nazim, Nevers, Quentin, Gelin, Muriel, Bessin, Yannick, Brillet, Rozenn, Cala, Olivier, Douguet, Dominique, Bourguet, William, Krimm, Isabelle, Pawlotsky, Jean-Michel, Guichou, Jean- François

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Small-Molecule Inhibitors of Cyclophilins Block Opening of the Mitochondrial Permeability Transition Pore and Protect Mice From Hepatic Ischemia/Reperfusion Injury von Panel, Mathieu, Ruiz, Isaac, Brillet, Rozenn, Lafdil, Fouad, Teixeira-Clerc, Fatima, Nguyen, Cong Trung, Calderaro, Julien, Gelin, Muriel, Allemand, Fred, Guichou, Jean-François, Ghaleh, Bijan, Ahmed-Belkacem, Abdelhakim, Morin, Didier, Pawlotsky, Jean-Michel

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Discovery of a cryptic site at the interface 2 of TEAD – Towards a new family of YAP/TAZ-TEAD inhibitors von Sturbaut, Manon, Bailly, Fabrice, Coevoet, Mathilde, Sileo, Pasquale, Pugniere, Martine, Liberelle, Maxime, Magnez, Romain, Thuru, Xavier, Chartier-Harlin, Marie-Christine, Melnyk, Patricia, Gelin, Muriel, Allemand, Frédéric, Guichou, Jean-François, Cotelle, Philippe

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Structural basis for chemically-induced homodimerization of a single domain antibody von Lesne, Jean, Chang, Hung-Ju, De Visch, Angelique, Paloni, Matteo, Barthe, Philippe, Guichou, Jean-François, Mayonove, Pauline, Barducci, Alessandro, Labesse, Gilles, Bonnet, Jerome, Cohen-Gonsaud, Martin

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Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings von Fnaiche, Ahmed, Mélin, Léa, Suárez, Narjara González, Paquin, Alexis, Vu, Victoria, Li, Fengling, Allali-Hassani, Abdellah, Bolotokova, Albina, Allemand, Frédéric, Gelin, Muriel, Cotelle, Philippe, Woo, Simon, LaPlante, Steven R., Barsyte-Lovejoy, Dalia, Santhakumar, Vijayaratnam, Vedadi, Masoud, Guichou, Jean-François, Annabi, Borhane, Gagnon, Alexandre

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Small-Molecule Cyclophilin Inhibitors Potently Reduce Platelet Procoagulant Activity von Van Bael, Jens, Vandenbulcke, Aline, Ahmed-Belkacem, Abdelhakim, Guichou, Jean-François, Pawlotsky, Jean-Michel, Samyn, Jelle, Barendrecht, Arjan D, Maas, Coen, De Meyer, Simon F, Vanhoorelbeke, Karen, Tersteeg, Claudia

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In-plate protein crystallization, in situ ligand soaking and X-ray diffraction von le Maire, Albane, Gelin, Muriel, Pochet, Sylvie, Hoh, François, Pirocchi, Michel, Guichou, Jean-François, Ferrer, Jean-Luc, Labesse, Gilles

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TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM von Sabatier, Laurence, Guichou, Jean-François, Kohara, Yuji, Couillault, Carole, Ewbank, Jonathan J, Reboul, Jérôme, Pujol, Nathalie

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Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography von Gelin, Muriel, Delfosse, Vanessa, Allemand, Frédéric, Hoh, François, Sallaz-Damaz, Yoann, Pirocchi, Michel, Bourguet, William, Ferrer, Jean-Luc, Labesse, Gilles, Guichou, Jean-François

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Imidazo[1,2-a]quinoxalines for melanoma treatment with original mechanism of action von Patinote, Cindy, Deleuze-Masquéfa, Carine, Kaddour, Kamel Hadj, Vincent, Laure-Anaïs, Larive, Romain, Zghaib, Zahraa, Guichou, Jean-François, Assaf, Mona Diab, Cuq, Pierre, Bonnet, Pierre-Antoine

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A Tiny Change Makes a Big Difference in the Anti-Parasitic Activities of an HDAC Inhibitor von Loeuillet, Corinne, Touquet, Bastien, Guichou, Jean François, Labesse, Gilles, Sereno, Denis

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Two crystal structures of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with rapamycin at high resolution von Bianchin, Alessandra, Allemand, Frederic, Bell, Angus, Chubb, Anthony J., Guichou, Jean-François

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Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication von Lahaye, Xavier, Satoh, Takeshi, Gentili, Matteo, Cerboni, Silvia, Silvin, Aymeric, Conrad, Cécile, Ahmed-Belkacem, Abdelhakim, Rodriguez, Elisa C., Guichou, Jean-François, Bosquet, Nathalie, Piel, Matthieu, Le Grand, Roger, King, Megan C., Pawlotsky, Jean-Michel, Manel, Nicolas

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Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis von Guca, Ewelina, Nagy, Gergely N., Hajdú, Fanni, Marton, Lívia, Izrael, Richard, Hoh, François, Yang, Yinshan, Vial, Henri, Vértessy, Beata G., Guichou, Jean-François, Cerdan, Rachel

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New imidazoquinoxaline derivatives: Synthesis, biological evaluation on melanoma, effect on tubulin polymerization and structure–activity relationships von Zghaib, Zahraa, Guichou, Jean-François, Vappiani, Johanna, Bec, Nicole, Hadj-Kaddour, Kamel, Vincent, Laure-Anaïs, Paniagua-Gayraud, Stéphanie, Larroque, Christian, Moarbess, Georges, Cuq, Pierre, Kassab, Issam, Deleuze-Masquéfa, Carine, Diab-Assaf, Mona, Bonnet, Pierre-Antoine

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Fragment Linking Strategies for Structure-Based Drug Design von Bancet, Alexandre, Raingeval, Claire, Lomberget, Thierry, Le Borgne, Marc, Guichou, Jean-François, Krimm, Isabelle

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Aminoglycoside binding and catalysis specificity of aminoglycoside 2″-phosphotransferase IVa: A thermodynamic, structural and kinetic study von Kaplan, Elise, Guichou, Jean-François, Chaloin, Laurent, Kunzelmann, Simone, Leban, Nadia, Serpersu, Engin H., Lionne, Corinne

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New IKK inhibitors: Synthesis of new imidazo[1,2-a]quinoxaline derivatives using microwave assistance and biological evaluation as IKK inhibitors von Moarbess, Georges, Guichou, Jean-François, Paniagua-Gayraud, Stéphanie, Chouchou, Adrien, Marcadet, Olivier, Leroy, Fiona, Ruédas, Rémi, Cuq, Pierre, Deleuze-Masquéfa, Carine, Bonnet, Pierre-Antoine

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Protein–ligand structure guided by backbone and side-chain proton chemical shift perturbations von Aguirre, Clémentine, ten Brink, Tim, Cala, Olivier, Guichou, Jean-François, Krimm, Isabelle

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Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric αD pocket von Bancet, Alexandre, Frem, Rita, Jeanneret, Florian, Mularoni, Angélique, Bazelle, Pauline, Roelants, Caroline, Delcros, Jean-Guy, Guichou, Jean-François, Pillet, Catherine, Coste, Isabelle, Renno, Toufic, Battail, Christophe, Cochet, Claude, Lomberget, Thierry, Filhol, Odile, Krimm, Isabelle

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