Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo von Pusch, Stefan, Krausert, Sonja, Fischer, Viktoria, Balss, Jörg, Ott, Martina, Schrimpf, Daniel, Capper, David, Sahm, Felix, Eisel, Jessica, Beck, Ann-Christin, Jugold, Manfred, Eichwald, Viktoria, Kaulfuss, Stefan, Panknin, Olaf, Rehwinkel, Hartmut, Zimmermann, Katja, Hillig, Roman C., Guenther, Judith, Toschi, Luisella, Neuhaus, Roland, Haegebart, Andrea, Hess-Stumpp, Holger, Bauser, Markus, Wick, Wolfgang, Unterberg, Andreas, Herold-Mende, Christel, Platten, Michael, von Deimling, Andreas

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Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target von Ellermann, Manuel, Eheim, Ashley, Rahm, Fredrik, Viklund, Jenny, Guenther, Judith, Andersson, Martin, Ericsson, Ulrika, Forsblom, Rickard, Ginman, Tobias, Lindström, Johan, Silvander, Camilla, Trésaugues, Lionel, Giese, Anja, Bunse, Stefanie, Neuhaus, Roland, Weiske, Jörg, Quanz, Maria, Glasauer, Andrea, Nowak-Reppel, Katrin, Bader, Benjamin, Irlbacher, Horst, Meyer, Hanna, Queisser, Nina, Bauser, Marcus, Haegebarth, Andrea, Gorjánácz, Mátyás

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Discovery of a hidden transient state in all bromodomain families von Raich, Lluís, Meier, Katharina, Günther, Judith, Christ, Clara D., Noé, Frank, Olsson, Simon

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Pelargonium sidoides extract for treating acute respiratory tract infections von Timmer, Antje, Günther, Judith, Motschall, Edith, Rücker, Gerta, Antes, Gerd, Kern, Winfried V, Timmer, Antje

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Discovery of BAY-405: An Azaindole-Based MAP4K1 Inhibitor for the Enhancement of T‑Cell Immunity against Cancer von Mowat, Jeffrey, Carretero, Rafael, Leder, Gabriele, Aiguabella Font, Nuria, Neuhaus, Roland, Berndt, Sandra, Günther, Judith, Friberg, Anders, Schäfer, Martina, Briem, Hans, Raschke, Marian, Miyatake Ondozabal, Hideki, Buchmann, Bernd, Boemer, Ulf, Kreft, Bertolt, Hartung, Ingo V., Offringa, Rienk

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Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839 von Bothe, Ulrich, Günther, Judith, Nubbemeyer, Reinhard, Siebeneicher, Holger, Ring, Sven, Bömer, Ulf, Peters, Michaele, Rausch, Alexandra, Denner, Karsten, Himmel, Herbert, Sutter, Andreas, Terebesi, Ildiko, Lange, Martin, Wengner, Antje M., Guimond, Nicolas, Thaler, Tobias, Platzek, Johannes, Eberspächer, Uwe, Schäfer, Martina, Steuber, Holger, Zollner, Thomas M., Steinmeyer, Andreas, Schmidt, Nicole

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A Novel NAMPT Inhibitor-Based Antibody–Drug Conjugate Payload Class for Cancer Therapy von Böhnke, Niels, Berger, Markus, Griebenow, Nils, Rottmann, Antje, Erkelenz, Michael, Hammer, Stefanie, Berndt, Sandra, Günther, Judith, Wengner, Antje M., Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Jörißen, Hannah, Barak, Naomi, Bömer, Ulf, Hillig, Roman C., Eberspaecher, Uwe, Weiske, Jörg, Giese, Anja, Mumberg, Dominik, Nising, Carl Friedrich, Weinmann, Hilmar, Sommer, Anette

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Best of both worlds: An expansion of the state of the art pKa model with data from three industrial partners von Fraczkiewicz, Robert, Quoc Nguyen, Huy, Wu, Newton, Kausch‐Busies, Nina, Grimbs, Sergio, Sommer, Kai, ter Laak, Antonius, Günther, Judith, Wagner, Björn, Reutlinger, Michael

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A data science roadmap for open science organizations engaged in early-stage drug discovery von Edfeldt, Kristina, Edwards, Aled M., Engkvist, Ola, Günther, Judith, Hartley, Matthew, Hulcoop, David G., Leach, Andrew R., Marsden, Brian D., Menge, Amelie, Misquitta, Leonie, Müller, Susanne, Owen, Dafydd R., Schütt, Kristof T., Skelton, Nicholas, Steffen, Andreas, Tropsha, Alexander, Vernet, Erik, Wang, Yanli, Wellnitz, James, Willson, Timothy M., Clevert, Djork-Arné, Haibe-Kains, Benjamin, Schiavone, Lovisa Holmberg, Schapira, Matthieu

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Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo von Wortmann, Lars, Lindenthal, Bernhard, Muhn, Peter, Walter, Alexander, Nubbemeyer, Reinhard, Heldmann, Dieter, Sobek, Lothar, Morandi, Federica, Schrey, Anna K, Moosmayer, Dieter, Günther, Judith, Kuhnke, Joachim, Koppitz, Marcus, Lücking, Ulrich, Röhn, Ulrike, Schäfer, Martina, Nowak-Reppel, Katrin, Kühne, Ronald, Weinmann, Hilmar, Langer, Gernot

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Assuring the quality of continuous professional development: An analysis of accreditation documents of the chambers of pharmacists in Germany von Hinneburg, Iris, Günther, Judith, Fleer, Daniel, Schwalbe, Oliver

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Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design von Rahm, Fredrik, Viklund, Jenny, Trésaugues, Lionel, Ellermann, Manuel, Giese, Anja, Ericsson, Ulrika, Forsblom, Rickard, Ginman, Tobias, Günther, Judith, Hallberg, Kenth, Lindström, Johan, Persson, Lars Boukharta, Silvander, Camilla, Talagas, Antoine, Díaz-Sáez, Laura, Fedorov, Oleg, Huber, Kilian V. M, Panagakou, Ioanna, Siejka, Paulina, Gorjánácz, Mátyás, Bauser, Marcus, Andersson, Martin

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CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson’s Disease Associated Protein von Li, Fengling, Ackloo, Suzanne, Arrowsmith, Cheryl H., Ban, Fuqiang, Barden, Christopher J., Beck, Hartmut, Beránek, Jan, Berenger, Francois, Bolotokova, Albina, Bret, Guillaume, Breznik, Marko, Carosati, Emanuele, Chau, Irene, Chen, Yu, Cherkasov, Artem, Corte, Dennis Della, Denzinger, Katrin, Dong, Aiping, Draga, Sorin, Dunn, Ian, Edfeldt, Kristina, Edwards, Aled, Eguida, Merveille, Eisenhuth, Paul, Friedrich, Lukas, Fuerll, Alexander, Gardiner, Spencer S, Gentile, Francesco, Ghiabi, Pegah, Gibson, Elisa, Glavatskikh, Marta, Gorgulla, Christoph, Guenther, Judith, Gunnarsson, Anders, Gusev, Filipp, Gutkin, Evgeny, Halabelian, Levon, Harding, Rachel J., Hillisch, Alexander, Hoffer, Laurent, Hogner, Anders, Houliston, Scott, Irwin, John J, Isayev, Olexandr, Ivanova, Aleksandra, Jacquemard, Celien, Jarrett, Austin J, Jensen, Jan H., Kireev, Dmitri, Kleber, Julian, Koby, S. Benjamin, Koes, David, Kumar, Ashutosh, Kurnikova, Maria G., Kutlushina, Alina, Lessel, Uta, Liessmann, Fabian, Liu, Sijie, Lu, Wei, Meiler, Jens, Mettu, Akhila, Minibaeva, Guzel, Moretti, Rocco, Morris, Connor J, Narangoda, Chamali, Noonan, Theresa, Obendorf, Leon, Pach, Szymon, Pandit, Amit, Perveen, Sumera, Poda, Gennady, Polishchuk, Pavel, Puls, Kristina, Pütter, Vera, Rognan, Didier, Roskams-Edris, Dylan, Schindler, Christina, Sindt, François, Spiwok, Vojtěch, Steinmann, Casper, Stevens, Rick L., Talagayev, Valerij, Tingey, Damon, Vu, Oanh, Walters, W. Patrick, Wang, Xiaowen, Wang, Zhenyu, Wolber, Gerhard, Wolf, Clemens Alexander, Wortmann, Lars, Zeng, Hong, Zepeda, Carlos A., Zhang, Kam Y. J., Zhang, Jixian, Zheng, Shuangjia, Schapira, Matthieu

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Abstract 1722: Enhancement of anti-tumor T-cell immunity by means of an oral small molecule targeting the intracellular immune checkpoint MAP4K1 von Leder, Gabriele, Carretero, Rafael, Mowat, Jeffrey, Berndt, Sandra, Neuhaus, Roland, Font, Nuria Aiguabella, Boemer, Ulf, von Ahsen, Oliver, Eberspaecher, Uwe, Guenther, Judith, Grees, Mareike, Link, Corinna, Nicke, Barbara, Baumann, Daniel, Schaefer, Martina, Oezcan-Wahlbrink, Mine, Werbeck, Nicolas D., Hartung, Ingo, Kreft, Bertolt, Offringa, Rienk

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Abstract 3248: Identification and optimization of a highly active, cross reactive Complex-1 inhibitor von Mowat, Jeffrey, Christian, Sven, Sperl, Carolyn, Ehrmann, Alexander, Menz, Stephan, Guenther, Judith, Hillig, Roman, Bauser, Marcus, Haegebarth, Andrea, Schwede, Wolfgang

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Identification of the Highly Active, Species Cross-Reactive Complex I Inhibitor BAY-179 von Mowat, Jeffrey, Ehrmann, Alexander H. M, Christian, Sven, Sperl, Carolyn, Menz, Stephan, Günther, Judith, Hillig, Roman C, Bauser, Marcus, Schwede, Wolfgang

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Abstract 2: Discovery of BAY 2402234 by phenotypic screening: A human Dihydroorotate Dehydrogenase (DHODH) inhibitor in clinical trials for the treatment of myeloid malignancies von Gradl, Stefan N., Mueller, Thomas, Ferrara, Steven, Sheikh, Sherif El, Janzer, Andreas, Zhou, Han-Jie, Friberg, Anders, Guenther, Judith, Schaefer, Martina, Stellfeld, Timo, Eis, Knut, Kroeber, Michael, Nguyen, Duy, Merz, Claudia, Niehues, Michael, Stoeckigt, Detlef, Christian, Sven, Zimmermann, Katja, Lejeune, Pascal, Bruening, Michael, Meyer, Hanna, Puetter, Vera, Scadden, David T., Sykes, David B., Seidel, Henrik, Eheim, Ashley, Michels, Martin, Haegebarth, Andrea, Bauser, Marcus

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Abstract ND04: BAY 2965501: A highly selective DGK- ζ inhibitor for cancer immuno-therapy with first-in-class potential von Offringa, Rienk, Olesch, Catherine, Cichon, Frederik, Grees, Mareike, Schmees, Norbert, Roehn, Ulrike, Prinz, Florian, Guenther, Judith, Stoeckigt, Detlef, Erkelenz, Michael, Nguyen, Thi Thanh Uyen, Boemer, Ulf, Werbeck, Nicolas, Kunze, Marc, Petersen, Kirstin, Kirchhoff, Dennis

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Abstract 1887: Preclinical evaluation of a novel interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor in combination with PI3K inhibitor copanlisib or BTK inhibitors in ABC... von Lange, Martin, Wengner, Antje Margret, Bothe, Ulrich, Boemer, Ulf, Nubbemeyer, Reinhard, Siebeneicher, Holger, Steuber, Holger, Guenther, Judith, Potze, Lisette, Schmidt, Nicole, Politz, Oliver, Doecke, Wolf-Dietrich, Lagkadinou, Eleni, Zollner, Thomas M., Nussbaum, Franz von, Mumberg, Dominik, Steinmeyer, Andreas, Brands, Michael, Ziegelbauer, Karl

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Abstract 689: Identification and optimization of novel chemical matter via a structure-based approach resulting in a probe for MTH1 von Bauser, Marcus, Giese, Anja, Ellermann, Manuel, Guenther, Judith, Eheim, Ashley, Bunse, Stefanie, Neuhaus, Roland, Weiske, Joerg, Quanz, Maria, Glasauer, Andrea, Nowak-Reppel, Katrin, Bader, Benjamin, Irlbacher, Horst, Meyer, Hanna, Queisser, Nina, Haegebarth, Andrea, Gorjanacz, Matyas, Tresaugues, Lionel, Ginman, Tobias, Rahm, Fredrik, Andersson, Martin, Ericsson, Ulrica, Forsblom, Rickard, Lindstroem, Johan, Silvander, Camilla, Vicklund, Jenny

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