Development and validation of a high throughput SARS-CoV-2 whole genome sequencing workflow in a clinical laboratory von Rosenthal, Sun Hee, Gerasimova, Anna, Ruiz-Vega, Rolando, Livingston, Kayla, Kagan, Ron M., Liu, Yan, Anderson, Ben, Owen, Renius, Bernstein, Laurence, Smolgovsky, Alla, Xu, Dong, Chen, Rebecca, Grupe, Andrew, Tanpaiboon, Pranoot, Lacbawan, Felicitas

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Analytical validation and performance characteristics of a 48-gene next-generation sequencing panel for detecting potentially actionable genomic alterations in myeloid neoplasms von Rosenthal, Sun Hee, Gerasimova, Anna, Ma, Charles, Li, Hai-Rong, Grupe, Andrew, Chong, Hansook, Acab, Allan, Smolgovsky, Alla, Owen, Renius, Elzinga, Christopher, Chen, Rebecca, Sugganth, Daniel, Freitas, Tracey, Graham, Jennifer, Champion, Kristen, Bhattacharya, Anindya, Racke, Frederick, Lacbawan, Felicitas

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Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease: New data and meta-analysis von Fukumoto, Noriko, Fujii, Takashi, Combarros, Onofre, Kamboh, M. Ilyas, Tsai, Shin-Jen, Matsushita, Sachio, Nacmias, Benedetta, Comings, David E., Arboleda, Humberto, Ingelsson, Martin, Hyman, Bradley T., Akatsu, Hiroyasu, Grupe, Andrew, Nishimura, Agnes Lumi, Zatz, Mayana, Mattila, Kari M., Rinne, Juha, Goto, Yu-ichi, Asada, Takashi, Nakamura, Shun, Kunugi, Hiroshi

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In Silico Mapping of Complex Disease-Related Traits in Mice von Grupe, Andrew, Germer, Soren, Usuka, Jonathan, Aud, Dee, Belknap, John K., Klein, Robert F., Ahluwalia, Mandeep K., Higuchi, Russell, Peltz, Gary

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SORL1 variants and risk of late-onset Alzheimer’s disease von Li, Yonghong, Rowland, Charles, Catanese, Joseph, Morris, John, Lovestone, Simon, O’Donovan, Michael C, Goate, Alison, Owen, Michael, Williams, Julie, Grupe, Andrew

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Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma von Wills-Karp, Marsha, Karp, Christopher L, Grupe, Andrew, Schadt, Eric, Ewart, Susan L, Keane-Moore, Michelle, Cuomo, Peter J, Köhl, Jörg, Wahl, Larry, Kuperman, Douglas, Germer, Soren, Aud, Dee, Peltz, Gary

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Cutting Edge: GATA-3-Dependent Enhancer Activity in IL-4 Gene Regulation von Ranganath, Sheila, Ouyang, Wenjun, Bhattarcharya, Deepta, Sha, William C, Grupe, Andrew, Peltz, Gary, Murphy, Kenneth M

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Quantitative Trait Loci Controlling Allergen-Induced Airway Hyperresponsiveness in Inbred Mice von Ewart, Susan L, Kuperman, Douglas, Schadt, Eric, Tankersley, Clarke, Grupe, Andrew, Shubitowski, Dennis M, Peltz, Gary, Wills-Karp, Marsha

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Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease von Li, Yonghong, Rowland, Charles, Xiromerisiou, Georgia, Lagier, Robert J, Schrodi, Steven J, Dradiotis, Efthimios, Ross, David, Bui, Nam, Catanese, Joseph, Aggelakis, Konstantinos, Grupe, Andrew, Hadjigeorgiou, Georgios

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Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms von Wahrle, Suzanne E, Shah, Aarti R, Fagan, Anne M, Smemo, Scott, Kauwe, John S K, Grupe, Andrew, Hinrichs, Anthony, Mayo, Kevin, Jiang, Hong, Thal, Leon J, Goate, Alison M, Holtzman, David M

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A Polymorphism in the TCF7 Gene, C883A, Is Associated With Type 1 Diabetes von NOBLE, Janelle A, WHITE, Amy M, LAZZERONI, Laura C, VALDES, Ana M, MIREL, Daniel B, REYNOLDS, Rebecca, GRUPE, Andrew, AUD, Dee, PELTZ, Gary, ERLICH, Henry A

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Abstract 5742: Comparison of variants identified by next-generation sequencing panels: A 48-gene panel for myeloid neoplasms and a 35-gene panel for hematologic neoplasms von Rosenthal, Sun Hee, Chong, Hansook, Ma, Charles, Sugganth, Daniel, Owen, Renius, Catanese, Joseph, Elzinga, Christopher, Grupe, Andrew, Freitas, Tracey, Graham, Jennifer, Champion, Kristen, Larsen, Amanda, Racke, Frederick, Lacbawan, Felicitas

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Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants von Grupe, Andrew, Abraham, Richard, Li, Yonghong, Rowland, Charles, Hollingworth, Paul, Morgan, Angharad, Jehu, Luke, Segurado, Ricardo, Stone, David, Schadt, Eric, Karnoub, Maha, Nowotny, Petra, Tacey, Kristina, Catanese, Joseph, Sninsky, John, Brayne, Carol, Rubinsztein, David, Gill, Michael, Lawlor, Brian, Lovestone, Simon, Holmans, Peter, O'Donovan, Michael, Morris, John C., Thal, Leon, Goate, Alison, Owen, Michael J., Williams, Julie

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Abstract PS16-02: Moving in the fast lane: Test design and validation to produce up-to-date hereditary breast and gynecologic cancer tests von Angeloni, Taraneh E, Bhattacharya, Anindya, Cheng, Linda L, Chong, Hansook K, Conlan, Kelli M, Elzinga, Christopher D, Gerasimova, Anna, Grover, David, Grupe, Andrew, Hua, Michael, Hodko, Domagoj, Kazmierkiewicz, Krista, Nakles, Rebecca E, Nery, Camille R, Owen, Renius, Goos-Root, Dana M, Rowland, Charles M, Smolgovsky, Alla, Weltmer, Elaine C, Zhang, Ke, Lacbawan, Felicitas L

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Analytical validation of a 47-gene NGS panel for molecular profiling of myeloid neoplasms von Rosenthal, Sun Hee, Gerasimova, Anna, Li, Hai-Rong, Qu, Kevin, Acab, Allan J, Chong, Hansook K, Zhang, Xi, Nguyen, Quoclinh, Smolgovsky, Alla, Wolfson, David, Grupe, Andrew, Elzinga, Christopher, Chen, Rebecca, Owen, Renius, Catanese, Joseph J, Racke, Frederick KARL, Lacbawan, Felicitas L.

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Development and Validation of a 34-Gene Inherited Cancer Predisposition Panel Using Next-Generation Sequencing von Rosenthal, Sun Hee, Sun, Weimin, Zhang, Ke, Liu, Yan, Nguyen, Quoclinh, Gerasimova, Anna, Nery, Camille, Cheng, Linda, Castonguay, Carolyn, Hiller, Elaine, Li, James, Elzinga, Christopher, Wolfson, David, Smolgovsky, Alla, Chen, Rebecca, Buller-Burckle, Arlene, Catanese, Joseph, Grupe, Andrew, Lacbawan, Felicitas, Owen, Renius

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Inhibition of Insulin Receptor Phosphorylation by PC-1 Is Not Mediated by the Hydrolysis of Adenosine Triphosphate or the Generation of Adenosine (∗) von Grupe, Andrew, Alleman, Jennifer, Goldfine, Ira D., Sadick, Mike, Stewart, Timothy A.

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Abstract 5356: Validation of a clinically actionable cancer core gene test for solid tumors facilitating targeted molecular therapy and immunotherapy von Ma, Lin, Hua, Michael, Rivera, Steven, Gerasimova, Anna, Nguyen, Quoclinh, Sunkara, Sirisha, Lagier, Robert, Smolgovsky, Alla, Wolfson, David, Taylor, Jared F., Racke, Frederick, Strom, Charles, Grupe, Andrew, Catanese, Joseph, Hantash, Feras

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A Scan of Chromosome 10 Identifies a Novel Locus Showing Strong Association with Late-Onset Alzheimer Disease von Grupe, Andrew, Li, Yonghong, Rowland, Charles, Nowotny, Petra, Hinrichs, Anthony L., Smemo, Scott, Kauwe, John S.K., Maxwell, Taylor J., Cherny, Sara, Doil, Lisa, Tacey, Kristina, van Luchene, Ryan, Myers, Amanda, Wavrant-De Vrièze, Fabienne, Kaleem, Mona, Hollingworth, Paul, Jehu, Luke, Foy, Catherine, Archer, Nicola, Hamilton, Gillian, Holmans, Peter, Morris, Chris M., Catanese, Joseph, Sninsky, John, White, Thomas J., Powell, John, Hardy, John, O’Donovan, Michael, Lovestone, Simon, Jones, Lesley, Morris, John C., Thal, Leon, Owen, Michael, Williams, Julie, Goate, Alison

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Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease von Li, Yonghong, Schrodi, Steven, Rowland, Charles, Tacey, Kristina, Catanese, Joseph, Grupe, Andrew

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