Factor XI as a Therapeutic Target von Gailani, David, Gruber, Andras

Volltext

Factor XII inhibition reduces thrombus formation in a primate thrombosis model von Matafonov, Anton, Leung, Philberta Y., Gailani, Adam E., Grach, Stephanie L., Puy, Cristina, Cheng, Qiufang, Sun, Mao-fu, McCarty, Owen J.T., Tucker, Erik I., Kataoka, Hiroaki, Renné, Thomas, Morrissey, James H., Gruber, Andras, Gailani, David

Volltext

Antithrombotic Effect of Antisense Factor XI Oligonucleotide Treatment in Primates von Crosby, Jeffrey R, Marzec, Ulla, Revenko, Alexey S, Zhao, Chenguang, Gao, Dacao, Matafonov, Anton, Gailani, David, MacLeod, A Robert, Tucker, Erik I, Gruber, Andras, Hanson, Stephen R, Monia, Brett P

Volltext

The role of coagulation and platelets in colon cancer-associated thrombosis von Mitrugno, Annachiara, Tassi Yunga, Samuel, Sylman, Joanna L, Zilberman-Rudenko, Jevgenia, Shirai, Toshiaki, Hebert, Jessica F, Kayton, Robert, Zhang, Ying, Nan, Xiaolin, Shatzel, Joseph J, Esener, Sadik, Duvernay, Matthew T, Hamm, Heidi E, Gruber, András, Williams, Craig D, Takata, Yumie, Armstrong, Randall, Morgan, Terry K, McCarty, Owen J T

Volltext

Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways von Popescu, Narcis I., Silasi, Robert, Keshari, Ravi S., Girton, Alanson, Burgett, Tarea, Zeerleder, Sacha S., Gailani, David, Gruber, Andras, Lupu, Florea, Coggeshall, K. Mark

Volltext

Excess of heme induces tissue factor-dependent activation of coagulation in mice von Sparkenbaugh, Erica M, Chantrathammachart, Pichika, Wang, Shaobin, Jonas, Will, Kirchhofer, Daniel, Gailani, David, Gruber, Andras, Kasthuri, Raj, Key, Nigel S, Mackman, Nigel, Pawlinski, Rafal

Volltext

Nucleic acids as cofactors for factor XI and prekallikrein activation: Different roles for high-molecular-weight kininogen von Ivanov, Ivan, Shakhawat, Ruhama, Sun, Mao-fu, Dickeson, S. Kent, Puy, Cristina, McCarty, Owen J.T, Gruber, Andras, Matafonov, Anton, Gailani, David

Volltext

Role of platelets in regulating activated coagulation factor XI activity von Reitsma, Stéphanie E, Pang, Jiaqing, Raghunathan, Vikram, Shatzel, Joseph J, Lorentz, Christina U, Tucker, Erik I, Gruber, András, Gailani, David, McCarty, Owen J T, Puy, Cristina

Volltext

Factor XI contributes to thrombin generation in the absence of factor XII von Kravtsov, Dmitri V., Matafonov, Anton, Tucker, Erik I., Sun, Mao-fu, Walsh, Peter N., Gruber, Andras, Gailani, David

Volltext

Factor XI Deficiency Alters the Cytokine Response and Activation of Contact Proteases during Polymicrobial Sepsis in Mice von Bane, Jr, Charles E, Ivanov, Ivan, Matafonov, Anton, Boyd, Kelli L, Cheng, Qiufang, Sherwood, Edward R, Tucker, Erik I, Smiley, Stephen T, McCarty, Owen J T, Gruber, Andras, Gailani, David

Volltext

The contact activation system as a potential therapeutic target in patients with COVID‐19 von Shatzel, Joseph J., DeLoughery, Emma P., Lorentz, Christina U., Tucker, Erik I., Aslan, Joseph E., Hinds, Monica T., Gailani, David, Weitz, Jeffrey I., McCarty, Owen J.T., Gruber, Andras

Volltext

The Role of the Contact Pathway in Thrombus Propagation von Gruber, Andras

Volltext

Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial von Lorentz, Christina U, Verbout, Norah G, Wallisch, Michael, Hagen, Matthew W, Shatzel, Joseph J, Olson, Sven R, Puy, Cristina, Hinds, Monica T, McCarty, Owen J.T, Gailani, David, Gruber, András, Tucker, Erik I

Volltext

Factor XI-Deficient Mice Display Reduced Inflammation, Coagulopathy, and Bacterial Growth during Listeriosis von Luo, Deyan, Szaba, Frank M, Kummer, Lawrence W, Johnson, Lawrence L, Tucker, Erik I, Gruber, Andras, Gailani, David, Smiley, Stephen T

Volltext

Differential Roles for the Coagulation Factors XI and XII in Regulating the Physical Biology of Fibrin von Sylman, Joanna L., Daalkhaijav, Uranbileg, Zhang, Ying, Gray, Elliot M., Farhang, Parsa A., Chu, Tiffany T., Zilberman-Rudenko, Jevgenia, Puy, Cristina, Tucker, Erik I., Smith, Stephanie A., Morrissey, James H., Walker, Travis W., Nan, Xiaolin L., Gruber, András, McCarty, Owen J. T.

Volltext

Cross-Talk between the Complement Pathway and the Contact Activation System of Coagulation: Activated Factor XI Neutralizes Complement Factor H von Puy, Cristina, Pang, Jiaqing, Reitsma, Stéphanie E, Lorentz, Christina U, Tucker, Erik I, Gailani, David, Gruber, András, Lupu, Florea, McCarty, Owen J T

Volltext

P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice von Furlan-Freguia, Christian, Marchese, Patrizia, Gruber, András, Ruggeri, Zaverio M, Ruf, Wolfram

Volltext

The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial von Lorentz, Christina U., Tucker, Erik I., Verbout, Norah G., Shatzel, Joseph J., Olson, Sven R., Markway, Brandon D., Wallisch, Michael, Ralle, Martina, Hinds, Monica T., McCarty, Owen J.T., Gailani, David, Weitz, Jeffrey I., Gruber, András

Volltext

Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo von Healy, Laura D., Puy, Cristina, Fernández, José A., Mitrugno, Annachiara, Keshari, Ravi S., Taku, Nyiawung A., Chu, Tiffany T., Xu, Xiao, Gruber, András, Lupu, Florea, Griffin, John H., McCarty, Owen J.T.

Volltext

Selective factor VIII activation by the tissue factor–factor VIIa–factor Xa complex von Kamikubo, Yuichi, Mendolicchio, G. Loredana, Zampolli, Antonella, Marchese, Patrizia, Rothmeier, Andrea S., Orje, Jennifer Nagrampa, Gale, Andrew J., Krishnaswamy, Sriram, Gruber, András, Østergaard, Henrik, Petersen, Lars C., Ruf, Wolfram, Ruggeri, Zaverio M.

Volltext