Phenotypic Optimization of Urea–Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss von Chowdhury, Sarwat, Owens, Kelly N, Herr, R. Jason, Jiang, Qin, Chen, Xinchao, Johnson, Graham, Groppi, Vincent E, Raible, David W, Rubel, Edwin W, Simon, Julian A

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Soluble CD13 induces inflammatory arthritis by activating the bradykinin receptor B1 von Tsou, Pei-Suen, Lu, Chenyang, Gurrea-Rubio, Mikel, Muraoka, Sei, Campbell, Phillip L, Wu, Qi, Model, Ellen N, Lind, Matthew E, Vichaikul, Sirapa, Mattichak, Megan N, Brodie, William D, Hervoso, Jonatan L, Ory, Sarah, Amarista, Camila I, Pervez, Rida, Junginger, Lucas, Ali, Mustafa, Hodish, Gal, O'Mara, Morgan M, Ruth, Jeffrey H, Robida, Aaron M, Alt, Andrew J, Zhang, Chengxin, Urquhart, Andrew G, Lawton, Jeffrey N, Chung, Kevin C, Maerz, Tristan, Saunders, Thomas L, Groppi, Vincent E, Fox, David A, Amin, M Asif

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Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders von Gurney, Mark E, Nugent, Richard A, Mo, Xuesheng, Sindac, Janice A, Hagen, Timothy J, Fox, David, O’Donnell, James M, Zhang, Chong, Xu, Ying, Zhang, Han-Ting, Groppi, Vincent E, Bailie, Marc, White, Ronald E, Romero, Donna L, Vellekoop, A. Samuel, Walker, Joel R, Surman, Matthew D, Zhu, Lei, Campbell, Robert F

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Positive Allosteric Modulators of the α7 Nicotinic Acetylcholine Receptor: SAR Investigation Around PNU-120596 von Acker, Brad A, Badescu, Valentina O, Berkenpas, Mitchell B, Groppi, Vincent E, Hajós, Mihaly, Higdon, Nicole R, Hurst, Raymond S, Jon Jacobsen, E, Margolis, Brandon J, McWhorter, William W, Myers, Jason K, Piotrowski, David W, Rogers, Bruce N, Sarapa, Dusan, Vetman, Tatiana N, Walker, Daniel P, Wall, Theron M, Wilhite, David M, Wishka, Donn G, Xu, Wenjian, Yates, Karen M

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High-Throughput Screening for Drugs that Modulate Intermediate Filament Proteins von Sun, Jingyuan, Groppi, Vincent E, Gui, Honglian, Chen, Lu, Xie, Qing, Liu, Li, Omary, M Bishr

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Discovery and Structure−Activity Relationship of Quinuclidine Benzamides as Agonists of α7 Nicotinic Acetylcholine Receptors von Bodnar, Alice L, Cortes-Burgos, Luz A, Cook, Karen K, Dinh, Dac M, Groppi, Vincent E, Hajos, Mihaly, Higdon, Nicole R, Hoffmann, William E, Hurst, Raymond S, Myers, Jason K, Rogers, Bruce N, Wall, Theron M, Wolfe, Mark L, Wong, Erik

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Pharmacologic Characterization of a Kinetic In Vitro Human Co-Culture Angiogenesis Model Using Clinically Relevant Compounds von Wolfe, Ashley, O’Clair, Belinda, Groppi, Vincent E., McEwen, Dyke P.

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Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive... von Wishka, Donn G, Walker, Daniel P, Yates, Karen M, Reitz, Steven C, Jia, Shaojuan, Myers, Jason K, Olson, Kirk L, Jacobsen, E. Jon, Wolfe, Mark L, Groppi, Vincent E, Hanchar, Alexander J, Thornburgh, Bruce A, Cortes-Burgos, Luz A, Wong, Erik H. F, Staton, Brian A, Raub, Thomas J, Higdon, Nicole R, Wall, Theron M, Hurst, Raymond S, Walters, Rodney R, Hoffmann, William E, Hajos, Mihaly, Franklin, Stanley, Carey, Galen, Gold, Lisa H, Cook, Karen K, Sands, Steven B, Zhao, Sabrina X, Soglia, John R, Kalgutkar, Amit S, Arneric, Stephen P, Rogers, Bruce N

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The DBA/2J strain and prepulse inhibition of startle: a model system to test antipsychotics? von Olivier, B, Leahy, C, Mullen, T, Paylor, R, Groppi, V E, Sarnyai, Z, Brunner, D

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Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3- c]pyridine-5-carboxamide as an agonist of the alpha 7 nicotinic acetylcholine receptor: In vitro and in vivo activity von Acker, Brad A, Jacobsen, EJon, Rogers, Bruce N, Wishka, Donn G, Reitz, Steven C, Piotrowski, David W, Myers, Jason K, Wolfe, Mark L, Groppi, Vincent E, Thornburgh, Bruce A, Tinholt, Paula M, Walters, Rodney R, Olson, Barbara A, Fitzgerald, Laura, Staton, Brian A, Raub, Thomas J, Krause, Michael, Li, Kai S, Hoffmann, William E, Hajos, Mihaly, Hurst, Raymond S, Walker, Daniel P

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Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha 7 nicotinic acetylcholine receptor agonists von Walker, Daniel P, Wishka, Donn G, Piotrowski, David W, Jia, Shaojuan, Reitz, Steven C, Yates, Karen M, Myers, Jason K, Vetman, Tatiana N, Margolis, Brandon J, Jacobsen, EJon, Acker, Brad A, Groppi, Vincent E, Wolfe, Mark L, Thornburgh, Bruce A, Tinholt, Paula M, Cortes-Burgos, Luz A, Walters, Rodney R, Hester, Matthew R, Seest, Eric P, Dolak, Lester A, Han, Fusen, Olson, Barbara A, Fitzgerald, Laura, Staton, Brian A, Raub, Thomas J, Hajos, Mihaly, Hoffmann, William E, Li, Kai S, Higdon, Nicole R, Wall, Theron M, Hurst, Raymond S, Wong, Erik HF, Rogers, Bruce N

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Design, synthesis, structure–activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists von Walker, Daniel P., Wishka, Donn G., Piotrowski, David W., Jia, Shaojuan, Reitz, Steven C., Yates, Karen M., Myers, Jason K., Vetman, Tatiana N., Margolis, Brandon J., Jacobsen, E. Jon, Acker, Brad A., Groppi, Vincent E., Wolfe, Mark L., Thornburgh, Bruce A., Tinholt, Paula M., Cortes-Burgos, Luz A., Walters, Rodney R., Hester, Matthew R., Seest, Eric P., Dolak, Lester A., Han, Fusen, Olson, Barbara A., Fitzgerald, Laura, Staton, Brian A., Raub, Thomas J., Hajos, Mihaly, Hoffmann, William E., Li, Kai S., Higdon, Nicole R., Wall, Theron M., Hurst, Raymond S., Wong, Erik H.F., Rogers, Bruce N.

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A Novel Positive Allosteric Modulator of the alpha 7 Neuronal Nicotinic Acetylcholine Receptor: In Vitro and In Vivo Characterization von Hurst, Raymond S, Hajos, Mihaly, Raggenbass, Mario, Wall, Theron M, Higdon, Nicole R, Lawson, Judy A, Rutherford-Root, Karen L, Berkenpas, Mitchell B, Hoffmann, W E, Piotrowski, David W, Groppi, Vincent E, Allaman, Geraldine, Ogier, Roch, Bertrand, Sonia, Bertrand, Daniel, Arneric, Stephen P

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A Novel Positive Allosteric Modulator of the α7 Neuronal Nicotinic Acetylcholine Receptor: In Vitro and In Vivo Characterization von Hurst, Raymond S., Hajós, Mihaly, Raggenbass, Mario, Wall, Theron M., Higdon, Nicole R., Lawson, Judy A., Rutherford-Root, Karen L., Berkenpas, Mitchell B., Hoffmann, W. E., Piotrowski, David W., Groppi, Vincent E., Allaman, Geraldine, Ogier, Roch, Bertrand, Sonia, Bertrand, Daniel, Arneric, Stephen P.

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Anthelmintic paraherquamides are cholinergic antagonists in gastrointestinal nematodes and mammals von Zinser, Erich W, Wolf, Mark L, Alexander-Bowman, Susan J, Thomas, Eileen M, Davis, John P, Groppi, Vincent E, Lee, Byung H, Thompson, David P, Geary, Timothy G

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Synthesis and biological activity of spirocyclic benzopyran imidazolone potassium channel openers von Gadwood, Robert C, Kamdar, Bharat V, Dubray, Loretta A. Cipkus, Wolfe, Mark L, Smith, Michael P, Watt, William, Mizsak, Stephen A, Groppi, Vincent E

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6-Alkoxyisoindolin-1-one based dopamine D 2 partial agonists as potential antipsychotics von Favor, David A., Powers, James J., White, Andrew D., Fitzgerald, Lawrence W., Groppi, Vincent, Serpa, Kevin A.

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Discovery of N-[(3 R,5 R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3- c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: In vitro and in vivo activity von Acker, Brad A., Jacobsen, E. Jon, Rogers, Bruce N., Wishka, Donn G., Reitz, Steven C., Piotrowski, David W., Myers, Jason K., Wolfe, Mark L., Groppi, Vincent E., Thornburgh, Bruce A., Tinholt, Paula M., Walters, Rodney R., Olson, Barbara A., Fitzgerald, Laura, Staton, Brian A., Raub, Thomas J., Krause, Michael, Li, Kai S., Hoffmann, William E., Hajos, Mihaly, Hurst, Raymond S., Walker, Daniel P.

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6-Alkoxyisoindolin-1-one based dopamine D2 partial agonists as potential antipsychotics von FAVOR, David A, POWERS, James J, WHITE, Andrew D, FITZGERALD, Lawrence W, GROPPI, Vincent, SERPA, Kevin A

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Localization of TIMP in cycling mouse hair von KAWABE, T. T, REA, T. J, FLENNIKEN, A. M, WILLIAMS, B. R. G, GROPPI, V. E, BUHL, A. E

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