Precision medicine in type 2 diabetes von Prasad, R. B., Groop, L.

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Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood von Rönn, Tina, Volkov, Petr, Gillberg, Linn, Kokosar, Milana, Perfilyev, Alexander, Jacobsen, Anna Louisa, Jørgensen, Sine W, Brøns, Charlotte, Jansson, Per-Anders, Eriksson, Karl-Fredrik, Pedersen, Oluf, Hansen, Torben, Groop, Leif, Stener-Victorin, Elisabet, Vaag, Allan, Nilsson, Emma, Ling, Charlotte

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Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study von Almgren, P., Lehtovirta, M., Isomaa, B., Sarelin, L., Taskinen, M. R., Lyssenko, V., Tuomi, T., Groop, L.

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Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes von Ahluwalia, T. S., Lindholm, E., Groop, L. C.

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Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion von Ling, C, Del Guerra, S, Lupi, R, Rönn, T, Granhall, C, Luthman, H, Masiello, P, Marchetti, P, Groop, L, Del Prato, S

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The link between family history and risk of type 2 diabetes is not explained by anthropometric, lifestyle or genetic risk factors: the EPIC-InterAct study von Scott, R A, Langenberg, C, Sharp, S J, Franks, P W, Rolandsson, O, Drogan, D, van der Schouw, Y T, Ekelund, U, Kerrison, N D, Ardanaz, E, Arriola, L, Balkau, B, Barricarte, A, Barroso, I, Bendinelli, B, Beulens, J W J, Boeing, H, de Lauzon-Guillain, B, Deloukas, P, Fagherazzi, G, Gonzalez, C, Griffin, S J, Groop, L C, Halkjaer, J, Huerta, J M, Kaaks, R, Khaw, K T, Krogh, V, Nilsson, P M, Norat, T, Overvad, K, Panico, S, Rodriguez-Suarez, L, Romaguera, D, Romieu, I, Sacerdote, C, Sánchez, M J, Spijkerman, A M W, Teucher, B, Tjonneland, A, Tumino, R, van der A, D L, Wark, P A, McCarthy, M I, Riboli, E, Wareham, N J

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Ghrelin suppresses insulin secretion in human islets and type 2 diabetes patients have diminished islet ghrelin cell number and lower plasma ghrelin levels von Lindqvist, A., Shcherbina, L., Prasad, R.B., Miskelly, M.G., Abels, M., Martínez-Lopéz, J.A., Fred, R.G., Nergård, B.J., Hedenbro, J., Groop, L., Hjerling-Leffler, J., Wierup, N.

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Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene von Mulder, H, Nagorny, C. L. F, Lyssenko, V, Groop, L

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Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA₁c levels in human pancreatic islets von Yang, B. T, Dayeh, T. A, Kirkpatrick, C. L, Taneera, J, Kumar, R, Groop, L, Wollheim, C. B, Nitert, M. D, Ling, C

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common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans von Kotronen, A, Johansson, L. E, Johansson, L. M, Roos, C, Westerbacka, J, Hamsten, A, Bergholm, R, Arkkila, P, Arola, J, Kiviluoto, T, Fisher, R. M, Ehrenborg, E, Orho-Melander, M, Ridderstråle, M, Groop, L, Yki-Järvinen, H

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Prediction of postpartum diabetes in women with gestational diabetes mellitus von Ekelund, M., Shaat, N., Almgren, P., Groop, L., Berntorp, K.

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Reduced expression of OXPHOS and DNA damage genes is linked to protection from microvascular complications in long-term type 1 diabetes: the PROLONG study von Özgümüş, Türküler, Sulaieva, Oksana, Jessen, Leon Eyrich, Jain, Ruchi, Falhammar, Henrik, Nyström, Thomas, Catrina, Sergiu-Bogdan, Jörneskog, Gun, Groop, Leif, Eliasson, Mats, Eliasson, Björn, Brismar, Kerstin, Stokowy, Tomasz, Nilsson, Peter M., Lyssenko, Valeriya

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Insulin secretion and insulin sensitivity in relation to glucose tolerance: lessons from the Botnia Study von TRIPATHY, D, CARLSSON, M, ALMGREN, P, ISOMAA, B, TASKINEN, M.-R, TUOMI, T, GROOP, L. C

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γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes von Taneera, J., Jin, Z., Jin, Y., Muhammed, S. J., Zhang, E., Lang, S., Salehi, A., Korsgren, O., Renström, E., Groop, L., Birnir, B.

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empirical index of insulin sensitivity from short IVGTT: validation against the minimal model and glucose clamp indices in patients with different clinical characteristics von Tura, A, Sbrignadello, S, Succurro, E, Groop, L, Sesti, G, Pacini, G

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family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia study von Isomaa, B, Forsén, B, Lahti, K, Holmström, N, Wadén, J, Matintupa, O, Almgren, P, Eriksson, J. G, Lyssenko, V, Taskinen, M.-R, Tuomi, T, Groop, L. C

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Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study von Langenberg, C, Sharp, S, Forouhi, N G, Franks, P W, Schulze, M B, Kerrison, N, Ekelund, U, Barroso, I, Panico, S, Tormo, M J, Spranger, J, Griffin, S, van der Schouw, Y T, Amiano, P, Ardanaz, E, Arriola, L, Balkau, B, Barricarte, A, Beulens, J W J, Boeing, H, Bueno-de-Mesquita, H B, Buijsse, B, Chirlaque Lopez, M D, Clavel-Chapelon, F, Crowe, F L, de Lauzon-Guillan, B, Deloukas, P, Dorronsoro, M, Drogan, D, Froguel, P, Gonzalez, C, Grioni, S, Groop, L, Groves, C, Hainaut, P, Halkjaer, J, Hallmans, G, Hansen, T, Huerta Castaño, J M, Kaaks, R, Key, T J, Khaw, K T, Koulman, A, Mattiello, A, Navarro, C, Nilsson, P, Norat, T, Overvad, K, Palla, L, Palli, D, Pedersen, O, Peeters, P H, Quirós, J R, Ramachandran, A, Rodriguez-Suarez, L, Rolandsson, O, Romaguera, D, Romieu, I, Sacerdote, C, Sánchez, M J, Sandbaek, A, Slimani, N, Sluijs, I, Spijkerman, A M W, Teucher, B, Tjonneland, A, Tumino, R, van der A, D L, Verschuren, W M M, Tuomilehto, J, Feskens, E, McCarthy, M, Riboli, E, Wareham, N J

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Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle von Rönn, T, Poulsen, P, Hansson, O, Holmkvist, J, Almgren, P, Nilsson, P, Tuomi, T, Isomaa, B, Groop, L, Vaag, A, Ling, C

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A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes von Thanabalasingham, G., Shah, N., Vaxillaire, M., Hansen, T., Tuomi, T., Gašperíková, D., Szopa, M., Tjora, E., James, T. J., Kokko, P., Loiseleur, F., Andersson, E., Gaget, S., Isomaa, B., Nowak, N., Raeder, H., Stanik, J., Njolstad, P. R., Malecki, M. T., Klimes, I., Groop, L., Pedersen, O., Froguel, P., McCarthy, M. I., Gloyn, A. L., Owen, K. R.

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Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults von Jonsson, A., Renström, F., Lyssenko, V., Brito, E. C., Isomaa, B., Berglund, G., Nilsson, P. M., Groop, L., Franks, P. W.

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