Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade von Sanders, Matthew J, Grondin, Pascal O, Hegarty, Bronwyn D, Snowden, Michael A, Carling, David

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Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection von Karoyan, Philippe, Vieillard, Vincent, Gómez-Morales, Luis, Odile, Estelle, Guihot, Amélie, Luyt, Charles-Edouard, Denis, Alexis, Grondin, Pascal, Lequin, Olivier

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Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine von Brusq, Jean-Marie, Ancellin, Nicolas, Grondin, Pascal, Guillard, Raphaelle, Martin, Sandrine, Saintillan, Yannick, Issandou, Marc

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Short-Term Overexpression of a Constitutively Active Form of AMP-Activated Protein Kinase in the Liver Leads to Mild Hypoglycemia and Fatty Liver von FORETZ, Marc, ANCELLIN, Nicolas, ANDREELLI, Fabrizio, SAINTILLAN, Yannick, GRONDIN, Pascal, KAHN, Axel, THORENS, Bernard, VAULONT, Sophie, VIOLLET, Benoit

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A new AMPK activator, GSK773, corrects fatty acid oxidation and differentiation defect in CPT2-deficient myotubes von Boufroura, Fatima-Zohra, Le Bachelier, Carole, Tomkiewicz-Raulet, Céline, Schlemmer, Dimitri, Benoist, Jean-François, Grondin, Pascal, Lamotte, Yann, Mirguet, Olivier, Mouillet-Richard, Sophie, Bastin, Jean, Djouadi, Fatima

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Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase von Harris, Philip A, Faucher, Nicolas, George, Nicolas, Eidam, Patrick M, King, Bryan W, White, Gemma V, Anderson, Niall A, Bandyopadhyay, Deepak, Beal, Allison M, Beneton, Veronique, Berger, Scott B, Campobasso, Nino, Campos, Sebastien, Capriotti, Carol A, Cox, Julie A, Daugan, Alain, Donche, Frederic, Fouchet, Marie-Hélène, Finger, Joshua N, Geddes, Brad, Gough, Peter J, Grondin, Pascal, Hoffman, Bonnie L, Hoffman, Sandra J, Hutchinson, Susan E, Jeong, Jae U, Jigorel, Emilie, Lamoureux, Pauline, Leister, Lara K, Lich, John D, Mahajan, Mukesh K, Meslamani, Jamel, Mosley, Julie E, Nagilla, Rakesh, Nassau, Pamela M, Ng, Sze-Ling, Ouellette, Michael T, Pasikanti, Kishore K, Potvain, Florent, Reilly, Michael A, Rivera, Elizabeth J, Sautet, Stéphane, Schaeffer, Michelle C, Sehon, Clark A, Sun, Helen, Thorpe, James H, Totoritis, Rachel D, Ward, Paris, Wellaway, Natalie, Wisnoski, David D, Woolven, James M, Bertin, John, Marquis, Robert W

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Abstract 4115: ADCs optimization lead to a significant anti-tumoral activity in lymphoma and breast tumor xenograft mouse models von Mirjolet, Jean-Francois, Bertaux, Audrey, Benhamouche-Trouillet, Samira, Grondin, Pascal, Sahal, Ambrine, Serin, Guillaume, Juen, Ludovic, Baltus, Christine, Gély, Camille, Feuillâtre, Ofelia, Desgranges, Audrey, Viaud-Massuard, Marie-Claude, Martin, Camille

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Characterization of a novel potent and specific inhibitor of type v phosphodiesterase von Coste, Hervé, Grondin, Pascal

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The Discovery of Tadalafil:  A Novel and Highly Selective PDE5 Inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1‘,2‘:1,6]pyrido[3,4-b]indole-1,4-dione Analogues von Daugan, Alain, Grondin, Pascal, Ruault, Cécile, Le Monnier de Gouville, Anne-Charlotte, Coste, Hervé, Linget, Jean Michel, Kirilovsky, Jorge, Hyafil, François, Labaudinière, Richard

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Homotrimerization Approach in the Design of Thrombospondin‑1 Mimetic Peptides with Improved Potency in Triggering Regulated Cell Death of Cancer Cells von Denèfle, Thomas, Pramil, Elodie, Gómez-Morales, Luis, Levasseur, Mikail D, Lardé, Eva, Newton, Clara, Herry, Kenny, Herbi, Linda, Lamotte, Yann, Odile, Estelle, Ancellin, Nicolas, Grondin, Pascal, Martinez-Torres, Ana-Carolina, Viviani, Fabrice, Merle-Beral, Hélène, Lequin, Olivier, Susin, Santos A, Karoyan, Philippe

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The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies von Karoyan, Philippe, Vieillard, Vincent, Gómez-Morales, Luis, Odile, Estelle, Guihot, Amélie, Luyt, Charles-Edouard, Denis, Alexis, Grondin, Pascal, Lequin, Olivier

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Supporting Information Homotrimerization Approach in the Design of Thrombospondin-1 Mimetic Peptides with Improved Potency in Triggering Regulated Cell Death of Cancer Cells von Denèfle, Thomas, Pramil, Elodie, Gómez-Morales, Luis, Levasseur, Mikail D, Lardé, Eva, Newton, Clara, Herry, Kenny, Herbi, Linda, Lamotte, Yann, Odile, Estelle, Ancellin, Nicolas, Grondin, Pascal, Martinez-Torres, Ana-Carolina, Viviani, Fabrice, Merle-Béral, Hélène, Lequin, Olivier, Susin, Santos A, Karoyan, Philippe

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Thrombospondin‑1 Mimetic Agonist Peptides Induce Selective Death in Tumor Cells: Design, Synthesis, and Structure–Activity Relationship Studies von Denèfle, Thomas, Boullet, Héloise, Herbi, Linda, Newton, Clara, Martinez-Torres, Ana-Carolina, Guez, Alexandre, Pramil, Elodie, Quiney, Claire, Pourcelot, Marilyne, Levasseur, Mikail D, Lardé, Eva, Moumné, Roba, Ogi, François-Xavier, Grondin, Pascal, Merle-Beral, Hélène, Lequin, Olivier, Susin, Santos A, Karoyan, Philippe

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Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection von Karoyan, Philippe, Vieillard, Vincent, Gómez-Morales, Luis, Odile, Estelle, Guihot, Amélie, Luyt, Charles-Edouard, Denis, Alexis, Grondin, Pascal, Lequin, Olivier

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Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) von Woolford, Alison J.-A, Day, Philip J, Bénéton, Véronique, Berdini, Valerio, Coyle, Joseph E, Dudit, Yann, Grondin, Pascal, Huet, Pascal, Lee, Lydia Y. W, Manas, Eric S, McMenamin, Rachel L, Murray, Christopher W, Page, Lee W, Patel, Vipulkumar K, Potvain, Florent, Rich, Sharna J, Sang, Yingxia, Somers, Don O, Trottet, Lionel, Wan, Zehong, Zhang, Xiaomin

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The Discovery of Tadalafil:  A Novel and Highly Selective PDE5 Inhibitor. 1: 5,6,11,11a-Tetrahydro-1H-imidazo[1‘,5‘:1,6]pyrido[3,4-b]indole-1,3(2H)-dione Analogues von Daugan, Alain, Grondin, Pascal, Ruault, Cécile, Le Monnier de Gouville, Anne-Charlotte, Coste, Hervé, Kirilovsky, Jorge, Hyafil, François, Labaudinière, Richard

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Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X‑ray Fragment Screening von Woolford, Alison J.-A, Pero, Joseph E, Aravapalli, Sridhar, Berdini, Valerio, Coyle, Joseph E, Day, Philip J, Dodson, Andrew M, Grondin, Pascal, Holding, Finn P, Lee, Lydia Y. W, Li, Peng, Manas, Eric S, Marino, Joseph, Martin, Agnes C. L, McCleland, Brent W, McMenamin, Rachel L, Murray, Christopher W, Neipp, Christopher E, Page, Lee W, Patel, Vipulkumar K, Potvain, Florent, Rich, Sharna, Rivero, Ralph A, Smith, Kirsten, Somers, Donald O, Trottet, Lionel, Velagaleti, Ranganadh, Williams, Glyn, Xie, Ren

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Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress von Costell, Melissa H, Ancellin, Nicolas, Bernard, Roberta E, Zhao, Shufang, Upson, John J, Morgan, Lisa A, Maniscalco, Kristeen, Olzinski, Alan R, Ballard, Victoria L T, Herry, Kenny, Grondin, Pascal, Dodic, Nerina, Mirguet, Olivier, Bouillot, Anne, Gellibert, Francoise, Coatney, Robert W, Lepore, John J, Jucker, Beat M, Jolivette, Larry J, Willette, Robert N, Schnackenberg, Christine G, Behm, David J

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Discovery of Pyridones As Oral AMPK Direct Activators von Mirguet, Olivier, Sautet, Stéphane, Clément, Catherine-Anne, Toum, Jérôme, Donche, Frédéric, Marques, Celine, Rondet, Emilie, Pizzonero, Mathieu, Beaufils, Benjamin, Dudit, Yann, Huet, Pascal, Trottet, Lionel, Grondin, Pascal, Brusq, Jean-Marie, Boursier, Eric, Saintillan, Yannick, Nicodeme, Edwige

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Activation of nitric oxide (NO)‐insensitive soluble guanylate cyclase does not provide greater benefit than NO‐sensitive stimulation in acute and chronic models of cardiovascular d... von Costell, Melissa H., Bernard, Roberta E., Alsaid, Hasan, Upson, John J., Olzinski, Alan R., Morgan, Lisa A., Grondin, Pascal O., Ancellin, Nicolas, Dodic, Nerina, Gellibert, Francoise, Jucker, Beat M., Jolivette, Larry J., Willette, Robert N., Schnackenberg, Christine G., Behm, David J.

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