Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles von Kirschke, Elaine, Goswami, Devrishi, Southworth, Daniel, Griffin, Patrick R., Agard, David A.

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Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d von Zhang, Cheng, Konermann, Silvana, Brideau, Nicholas J., Lotfy, Peter, Wu, Xuebing, Novick, Scott J., Strutzenberg, Timothy, Griffin, Patrick R., Hsu, Patrick D., Lyumkis, Dmitry

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Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors von Zhou, X. Edward, He, Yuanzheng, de Waal, Parker W., Gao, Xiang, Kang, Yanyong, Van Eps, Ned, Yin, Yanting, Pal, Kuntal, Goswami, Devrishi, White, Thomas A., Barty, Anton, Latorraca, Naomi R., Chapman, Henry N., Hubbell, Wayne L., Dror, Ron O., Stevens, Raymond C., Cherezov, Vadim, Gurevich, Vsevolod V., Griffin, Patrick R., Ernst, Oliver P., Melcher, Karsten, Xu, H. Eric

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Structural and mechanistic bases for a potent HIV-1 capsid inhibitor von Bester, Stephanie M, Wei, Guochao, Zhao, Haiyan, Adu-Ampratwum, Daniel, Iqbal, Naseer, Courouble, Valentine V, Francis, Ashwanth C, Annamalai, Arun S, Singh, Parmit K, Shkriabai, Nikoloz, Van Blerkom, Peter, Morrison, James, Poeschla, Eric M, Engelman, Alan N, Melikyan, Gregory B, Griffin, Patrick R, Fuchs, James R, Asturias, Francisco J, Kvaratskhelia, Mamuka

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TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis von Ye, Li, Kleiner, Sandra, Wu, Jun, Sah, Rajan, Gupta, Rana K, Banks, Alexander S, Cohen, Paul, Khandekar, Melin J, Boström, Pontus, Mepani, Rina J, Laznik, Dina, Kamenecka, Theodore M, Song, Xinyi, Liedtke, Wolfgang, Mootha, Vamsi K, Puigserver, Pere, Griffin, Patrick R, Clapham, David E, Spiegelman, Bruce M

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The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria von Long, Jonathan Z., Svensson, Katrin J., Bateman, Leslie A., Lin, Hua, Kamenecka, Theodore, Lokurkar, Isha A., Lou, Jesse, Rao, Rajesh R., Chang, Mi Ra, Jedrychowski, Mark P., Paulo, Joao A., Gygi, Steven P., Griffin, Patrick R., Nomura, Daniel K., Spiegelman, Bruce M.

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Hydrogen–Deuterium Exchange Epitope Mapping of Glycosylated Epitopes Enabled by Online Immobilized Glycosidase von O’Leary, Timothy R., Balasubramaniam, Deepa, Hughes, Kristin, Foster, Denisa, Boyles, Jeffrey, Coleman, Kristina, Griffin, Patrick R.

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A molecular switch regulating transcriptional repression and activation of PPARγ von Shang, Jinsai, Mosure, Sarah A., Zheng, Jie, Brust, Richard, Bass, Jared, Nichols, Ashley, Solt, Laura A., Griffin, Patrick R., Kojetin, Douglas J.

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SPA70 is a potent antagonist of human pregnane X receptor von Lin, Wenwei, Wang, Yue-Ming, Chai, Sergio C., Lv, Lili, Zheng, Jie, Wu, Jing, Zhang, Qijun, Wang, Yong-Dong, Griffin, Patrick R., Chen, Taosheng

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Structures of the human LONP1 protease reveal regulatory steps involved in protease activation von Shin, Mia, Watson, Edmond R., Song, Albert S., Mindrebo, Jeffrey T., Novick, Scott J., Griffin, Patrick R., Wiseman, R. Luke, Lander, Gabriel C.

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One-step construction of circularized nanodiscs using SpyCatcher-SpyTag von Zhang, Shanwen, Ren, Qian, Novick, Scott J., Strutzenberg, Timothy S., Griffin, Patrick R., Bao, Huan

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Structure of the full-length glucagon class B G-protein-coupled receptor von Zhang, Haonan, Qiao, Anna, Yang, Dehua, Yang, Linlin, Dai, Antao, de Graaf, Chris, Reedtz-Runge, Steffen, Dharmarajan, Venkatasubramanian, Zhang, Hui, Han, Gye Won, Grant, Thomas D., Sierra, Raymond G., Weierstall, Uwe, Nelson, Garrett, Liu, Wei, Wu, Yanhong, Ma, Limin, Cai, Xiaoqing, Lin, Guangyao, Wu, Xiaoai, Geng, Zhi, Dong, Yuhui, Song, Gaojie, Griffin, Patrick R., Lau, Jesper, Cherezov, Vadim, Yang, Huaiyu, Hanson, Michael A., Stevens, Raymond C., Zhao, Qiang, Jiang, Hualiang, Wang, Ming-Wei, Wu, Beili

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Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases von Soon, Fen-Fen, Ng, Ley-Moy, Zhou, X. Edward, West, Graham M., Kovach, Amanda, Tan, M. H. Eileen, Suino-Powell, Kelly M., He, Yuanzheng, Xu, Yong, Chalmers, Michael J., Brunzelle, Joseph S., Zhang, Huiming, Yang, Huaiyu, Jiang, Hualiang, Li, Jun, Yong, Eu-Leong, Cutler, Sean, Zhu, Jian-Kang, Griffin, Patrick R., Melcher, Karsten, Xu, H. Eric

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CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase von He, Weiwei, Bai, Ge, Zhou, Huihao, Wei, Na, White, Nicholas M., Lauer, Janelle, Liu, Huaqing, Shi, Yi, Dumitru, Calin Dan, Lettieri, Karen, Shubayev, Veronica, Jordanova, Albena, Guergueltcheva, Velina, Griffin, Patrick R., Burgess, Robert W., Pfaff, Samuel L., Yang, Xiang-Lei

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Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation von Fanning, Sean W, Mayne, Christopher G, Dharmarajan, Venkatasubramanian, Carlson, Kathryn E, Martin, Teresa A, Novick, Scott J, Toy, Weiyi, Green, Bradley, Panchamukhi, Srinivas, Katzenellenbogen, Benita S, Tajkhorshid, Emad, Griffin, Patrick R, Shen, Yang, Chandarlapaty, Sarat, Katzenellenbogen, John A, Greene, Geoffrey L

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Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6 von Liu, Wallace H., Zheng, Jie, Feldman, Jessica L., Klein, Mark A., Kuznetsov, Vyacheslav I., Peterson, Craig L., Griffin, Patrick R., Denu, John M.

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Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3) von Li, Kuohan, Zheng, Jie, Wirawan, Melissa, Trinh, Nguyen Mai, Fedorova, Olga, Griffin, Patrick R, Pyle, Anna M, Luo, Dahai

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Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3 von Zhao, Li-Hua, Zhou, X Edward, Yi, Wei, Wu, Zhongshan, Liu, Yue, Kang, Yanyong, Hou, Li, de Waal, Parker W, Li, Suling, Jiang, Yi, Scaffidi, Adrian, Flematti, Gavin R, Smith, Steven M, Lam, Vinh Q, Griffin, Patrick R, Wang, Yonghong, Li, Jiayang, Melcher, Karsten, Xu, H Eric

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Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand von Zhang, Xianjun, Zhao, Fei, Wu, Yiran, Yang, Jun, Han, Gye Won, Zhao, Suwen, Ishchenko, Andrii, Ye, Lintao, Lin, Xi, Ding, Kang, Dharmarajan, Venkatasubramanian, Griffin, Patrick R., Gati, Cornelius, Nelson, Garrett, Hunter, Mark S., Hanson, Michael A., Cherezov, Vadim, Stevens, Raymond C., Tan, Wenfu, Tao, Houchao, Xu, Fei

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The Therapeutic Potential of Nuclear Receptor Modulators for Treatment of Metabolic Disorders: PPARγ, RORs, and Rev-erbs von Marciano, David P., Chang, Mi Ra, Corzo, Cesar A., Goswami, Devrishi, Lam, Vinh Q., Pascal, Bruce D., Griffin, Patrick R.

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