T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP von Yun, Cai-Hong, Mengwasser, Kristen E, Toms, Angela V, Woo, Michele S, Greulich, Heidi, Wong, Kwok-Kin, Meyerson, Matthew, Eck, Michael J

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Targeting mutant fibroblast growth factor receptors in cancer von Greulich, Heidi, Pollock, Pamela M

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Velcrin compounds activate the SLFN12 tRNase to induce tomoptosis von Greulich, Heidi

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Integrative Genomic Analysis of Medulloblastoma Identifies a Molecular Subgroup That Drives Poor Clinical Outcome von CHO, Yoon-Jae, TSHERNIAK, Aviad, LAU, Ching C, OLSON, James M, GILBERTSON, Richard I, GAJJAR, Amar, DELATTRE, Olivier, KOOL, Marcel, LIGON, Keith, MEYERSON, Matthew, MESIROV, Jill P, POMEROY, Scott L, TAMAYO, Pablo, SANTAGATA, Sandro, LIGON, Azra, GREULICH, Heidi, BERHOUKIM, Rameen, AMANI, Vladimir, GOUMNEROVA, Liliana, EBERHART, Charles G

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Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer von Dutt, Amit, Ramos, Alex H, Hammerman, Peter S, Mermel, Craig, Cho, Jeonghee, Sharifnia, Tanaz, Chande, Ajit, Tanaka, Kumiko Elisa, Stransky, Nicolas, Greulich, Heidi, Gray, Nathanael S, Meyerson, Matthew

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Discovering the anticancer potential of non-oncology drugs by systematic viability profiling von Corsello, Steven M., Nagari, Rohith T., Spangler, Ryan D., Rossen, Jordan, Kocak, Mustafa, Bryan, Jordan G., Humeidi, Ranad, Peck, David, Wu, Xiaoyun, Tang, Andrew A., Wang, Vickie M., Bender, Samantha A., Lemire, Evan, Narayan, Rajiv, Montgomery, Philip, Ben-David, Uri, Garvie, Colin W., Chen, Yejia, Rees, Matthew G., Lyons, Nicholas J., McFarland, James M., Wong, Bang T., Wang, Li, Dumont, Nancy, O’Hearn, Patrick J., Stefan, Eric, Doench, John G., Harrington, Caitlin N., Greulich, Heidi, Meyerson, Matthew, Vazquez, Francisca, Subramanian, Aravind, Roth, Jennifer A., Bittker, Joshua A., Boehm, Jesse S., Mader, Christopher C., Tsherniak, Aviad, Golub, Todd R.

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A complex puzzle: Regulation of SLFN12 RNase activity by phosphorylation von Greulich, Heidi

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Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase von Garvie, Colin W., Wu, Xiaoyun, Papanastasiou, Malvina, Lee, Sooncheol, Fuller, James, Schnitzler, Gavin R., Horner, Steven W., Baker, Andrew, Zhang, Terry, Mullahoo, James P., Westlake, Lindsay, Hoyt, Stephanie H., Toetzl, Marcus, Ranaghan, Matthew J., de Waal, Luc, McGaunn, Joseph, Kaplan, Bethany, Piccioni, Federica, Yang, Xiaoping, Lange, Martin, Tersteegen, Adrian, Raymond, Donald, Lewis, Timothy A., Carr, Steven A., Cherniack, Andrew D., Lemke, Christopher T., Meyerson, Matthew, Greulich, Heidi

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Colorectal adenocarcinoma‐derived EGFR mutants are oncogenic and sensitive to EGFR‐targeted monoclonal antibodies, cetuximab and panitumumab von Kim, Nayoung, Cho, Daseul, Kim, Hyunjin, Kim, Sujin, Cha, Young‐je, Greulich, Heidi, Bass, Adam, Cho, Hyun‐Soo, Cho, Jeonghee

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Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy von Barretina, Jordi, Taylor, Barry S, Banerji, Shantanu, Ramos, Alexis H, Lagos-Quintana, Mariana, DeCarolis, Penelope L, Shah, Kinjal, Socci, Nicholas D, Weir, Barbara A, Ho, Alan, Chiang, Derek Y, Reva, Boris, Mermel, Craig H, Getz, Gad, Antipin, Yevgenyi, Beroukhim, Rameen, Major, John E, Hatton, Charles, Nicoletti, Richard, Hanna, Megan, Sharpe, Ted, Fennell, Tim J, Cibulskis, Kristian, Onofrio, Robert C, Saito, Tsuyoshi, Shukla, Neerav, Lau, Christopher, Nelander, Sven, Silver, Serena J, Sougnez, Carrie, Viale, Agnes, Winckler, Wendy, Maki, Robert G, Garraway, Levi A, Lash, Alex, Greulich, Heidi, Root, David E, Sellers, William R, Schwartz, Gary K, Antonescu, Cristina R, Lander, Eric S, Varmus, Harold E, Ladanyi, Marc, Sander, Chris, Meyerson, Matthew, Singer, Samuel

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Activating mutations in ALK provide a therapeutic target in neuroblastoma von George, Rani E., Sanda, Takaomi, Hanna, Megan, Fröhling, Stefan, II, William Luther, Zhang, Jianming, Ahn, Yebin, Zhou, Wenjun, London, Wendy B., McGrady, Patrick, Xue, Liquan, Zozulya, Sergey, Gregor, Vlad E., Webb, Thomas R., Gray, Nathanael S., Gilliland, D. Gary, Diller, Lisa, Greulich, Heidi, Morris, Stephan W., Meyerson, Matthew, Look, A. Thomas

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Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2 von Greulich, Heidi, Kaplan, Bethany, Mertins, Philipp, Chen, Tzu-Hsiu, Tanaka, Kumiko E, Yun, Cai-Hong, Zhang, Xiaohong, Lee, Se-Hoon, Cho, Jeonghee, Ambrogio, Lauren, Liao, Rachel, Imielinski, Marcin, Banerji, Shantanu, Berger, Alice H, Lawrence, Michael S, Zhang, Jinghui, Pho, Nam H, Walker, Sarah R, Winckler, Wendy, Getz, Gad, Frank, David, Hahn, William C, Eck, Michael J, Mani, D. R, Jaffe, Jacob D, Carr, Steven A, Wong, Kwok-Kin, Meyerson, Matthew

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Cetuximab Response of Lung Cancer―Derived EGF Receptor Mutants Is Associated with Asymmetric Dimerization von JEONGHEE CHO, LIANG CHEN, GREULICH, Heidi, JOHNSON, Bruce E, ECK, Michael J, JÄNNE, Pasi A, WONG, Kwok-Kin, MEYERSON, Matthew, SANGJI, Naveen, OKABE, Takafumi, YONESAKA, Kimio, FRANCIS, Joshua M, FLAVIN, Richard J, JOHNSON, William, JIHYUN KWON, SOYOUNG YU

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An Activated ErbB3/NRG1 Autocrine Loop Supports In Vivo Proliferation in Ovarian Cancer Cells von Sheng, Qing, Liu, Xinggang, Fleming, Eleanor, Yuan, Karen, Piao, Huiying, Chen, Jinyun, Moustafa, Zeinab, Thomas, Roman K., Greulich, Heidi, Schinzel, Anna, Zaghlul, Sara, Batt, David, Ettenberg, Seth, Meyerson, Matthew, Schoeberl, Birgit, Kung, Andrew L., Hahn, William C., Drapkin, Ronny, Livingston, David M., Liu, Joyce F.

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Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants von Greulich, Heidi, Chen, Tzu-Hsiu, Feng, Whei, Jänne, Pasi A, Alvarez, James V, Zappaterra, Mauro, Bulmer, Sara E, Frank, David A, Hahn, William C, Sellers, William R, Meyerson, Matthew

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Drug-Sensitive FGFR2 Mutations in Endometrial Carcinoma von Dutt, Amit, Salvesen, Helga B., Chen, Tzu-Hsiu, Ramos, Alex H., Onofrio, Robert C., Hatton, Charlie, Nicoletti, Richard, Winckler, Wendy, Grewal, Rupinder, Hanna, Megan, Wyhs, Nicolas, Ziaugra, Liuda, Richter, Daniel J., Trovik, Jone, Engelsen, Ingeborg B., Stefansson, Ingunn M., Fennell, Tim, Cibulskis, Kristian, Zody, Michael C., Akslen, Lars A., Gabriel, Stacey, Wong, Kwok-Kin, Sellers, William R., Meyerson, Matthew, Greulich, Heidi

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Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions von Sos, Martin L, Michel, Kathrin, Zander, Thomas, Weiss, Jonathan, Frommolt, Peter, Peifer, Martin, Li, Danan, Ullrich, Roland, Koker, Mirjam, Fischer, Florian, Shimamura, Takeshi, Rauh, Daniel, Mermel, Craig, Fischer, Stefanie, Stückrath, Isabel, Heynck, Stefanie, Beroukhim, Rameen, Lin, William, Winckler, Wendy, Shah, Kinjal, LaFramboise, Thomas, Moriarty, Whei F, Hanna, Megan, Tolosi, Laura, Rahnenführer, Jörg, Verhaak, Roel, Chiang, Derek, Getz, Gad, Hellmich, Martin, Wolf, Jürgen, Girard, Luc, Peyton, Michael, Weir, Barbara A, Chen, Tzu-Hsiu, Greulich, Heidi, Barretina, Jordi, Shapiro, Geoffrey I, Garraway, Levi A, Gazdar, Adi F, Minna, John D, Meyerson, Matthew, Wong, Kwok-Kin, Thomas, Roman K

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Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor von ALVAREZ, James V, GREULICH, Heidi, SELLERS, William R, MEYERSON, Matthew, FRANK, David A

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Inhibition of Hsp90 Down-regulates Mutant Epidermal Growth Factor Receptor (EGFR) Expression and Sensitizes EGFR Mutant Tumors to Paclitaxel von SAWAI, Ayana, CHANDARLAPATY, Sarat, GREULICH, Heidi, GONEN, Mithat, QING YE, ARTEAGA, Carlos L, SELLERS, William, ROSEN, Neal, SOLIT, David B

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Modeling Genomic Diversity and Tumor Dependency in Malignant Melanoma von LIN, William M, BAKER, Alissa C, HODI, F. Stephen, DRANOFF, Glenn, SELLERS, William R, THOMAS, Roman K, MEYERSON, Matthew, GOLUB, Todd R, DUMMER, Reinhard, HERLYN, Meenhard, GETZ, Gad, GARRAWAY, Levi A, BEROUKHIM, Rameen, WINCKLER, Wendy, WHEI FENG, MARMION, Jennifer M, LAINE, Elisabeth, GREULICH, Heidi, TSENG, Hsiuyi, GATES, Casey

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