Trends in industrialization of biotherapeutics: a survey of product characteristics of 89 antibody-based biotherapeutics von Martin, Kyle P., Grimaldi, Christine, Grempler, Rolf, Hansel, Steven, Kumar, Sandeep

Volltext

Short- and Longterm Glycemic Control of Streptozotocin-Induced Diabetic Rats Using Different Insulin Preparations von Luippold, Gerd, Bedenik, Jessica, Voigt, Anke, Grempler, Rolf

Volltext

Characterization of Micro-RNA Changes during the Progression of Type 2 Diabetes in Zucker Diabetic Fatty Rats von Delic, Denis, Eisele, Claudia, Schmid, Ramona, Luippold, Gerd, Mayoux, Eric, Grempler, Rolf

Volltext

Discovery and translation of a target engagement marker for AMP-activated protein kinase (AMPK) von Grempler, Rolf, Wolff, Michael, Simon, Eric, Schmid, Ramona, Eisele, Claudia, Rieber, Kathrin, Fischer, Elke, Mettel, Sonja, Gabrielyan, Ogsen, Delic, Denis, Luippold, Gerd, Redeman, Norbert

Volltext

Design and rationale of the EMPA‐VISION trial: investigating the metabolic effects of empagliflozin in patients with heart failure von Hundertmark, Moritz J., Agbaje, Olorunsola F., Coleman, Ruth, George, Jyothis T., Grempler, Rolf, Holman, Rury R., Lamlum, Hanan, Lee, Jisoo, Milton, Joanne E., Niessen, Heiko G., Rider, Oliver, Rodgers, Christopher T., Valkovič, Ladislav, Wicks, Eleanor, Mahmod, Masliza, Neubauer, Stefan

Volltext

A reference map of potential determinants for the human serum metabolome von Bar, Noam, Korem, Tal, Weissbrod, Omer, Zeevi, David, Rothschild, Daphna, Leviatan, Sigal, Kosower, Noa, Lotan-Pompan, Maya, Weinberger, Adina, Le Roy, Caroline I., Menni, Cristina, Visconti, Alessia, Falchi, Mario, Spector, Tim D., Adamski, Jerzy, Franks, Paul W., Pedersen, Oluf, Segal, Eran

Volltext

Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models von Allesøe, Rosa Lundbye, Lundgaard, Agnete Troen, Hernández Medina, Ricardo, Aguayo-Orozco, Alejandro, Johansen, Joachim, Nissen, Jakob Nybo, Brorsson, Caroline, Mazzoni, Gianluca, Niu, Lili, Biel, Jorge Hernansanz, Leal Rodríguez, Cristina, Brasas, Valentas, Webel, Henry, Benros, Michael Eriksen, Pedersen, Anders Gorm, Chmura, Piotr Jaroslaw, Jacobsen, Ulrik Plesner, Mari, Andrea, Koivula, Robert, Mahajan, Anubha, Vinuela, Ana, Tajes, Juan Fernandez, Sharma, Sapna, Haid, Mark, Hong, Mun-Gwan, Musholt, Petra B., De Masi, Federico, Vogt, Josef, Pedersen, Helle Krogh, Gudmundsdottir, Valborg, Jones, Angus, Kennedy, Gwen, Bell, Jimmy, Thomas, E. Louise, Frost, Gary, Thomsen, Henrik, Hansen, Elizaveta, Hansen, Tue Haldor, Vestergaard, Henrik, Muilwijk, Mirthe, Blom, Marieke T., ‘t Hart, Leen M., Pattou, Francois, Raverdy, Violeta, Brage, Soren, Kokkola, Tarja, Heggie, Alison, McEvoy, Donna, Mourby, Miranda, Kaye, Jane, Hattersley, Andrew, McDonald, Timothy, Ridderstråle, Martin, Walker, Mark, Forgie, Ian, Giordano, Giuseppe N., Pavo, Imre, Ruetten, Hartmut, Pedersen, Oluf, Hansen, Torben, Dermitzakis, Emmanouil, Franks, Paul W., Schwenk, Jochen M., Adamski, Jerzy, McCarthy, Mark I., Pearson, Ewan, Banasik, Karina, Rasmussen, Simon, Brunak, Søren

Volltext

A phase Ia/Ib, dose-escalation/expansion study of the MDM2–p53 antagonist BI 907828 in patients with solid tumors, including advanced/metastatic liposarcoma (LPS) von Gounder, Mrinal M., Yamamoto, Noboru, Patel, Manish R., Bauer, Todd Michael, Schöffski, Patrick, Grempler, Rolf, Durland-Busbice, Sara, Geng, Junxian, Maerten, Angela, LoRusso, Patricia

Volltext

Human Dose and Pharmacokinetic Predictions for Biologics at Boehringer Ingelheim: A Retrospective Analysis von Grempler, Rolf, Ahlberg, Jennifer, Germovsek, Eva, Gupta, Priyanka, Li, Hua, Pilvankar, Minu, Sharma, Ashish, Stopfer, Peter, Hansel, Steven

Volltext

The effect of carbamazepine, a strong CYP3A inducer, on the pharmacokinetics of zongertinib in healthy male volunteers von Tian, Xiaofan, Esmaeili, Habib, Minich, David, Seitz, Friedeborg, Roessner, Philipp M, Wind, Sven, Grempler, Rolf, Gan, Guanfa, Chan, Tom S, Mahmoudi, Mazyar, Sadrolhefazi, Behbood, Müller, Fabian

Volltext

Functional characterisation of human SGLT-5 as a novel kidney-specific sodium-dependent sugar transporter von Grempler, Rolf, Augustin, Robert, Froehner, Stefanie, Hildebrandt, Tobias, Simon, Eric, Mark, Michael, Eickelmann, Peter

Volltext

A phase I dose-escalation study of the MDM2-p53 antagonist BI 907828 in patients (pts) with advanced solid tumors von LoRusso, Patricia, Gounder, Mrinal M., Patel, Manish R., Yamamoto, Noboru, Bauer, Todd Michael, Laurie, Scott, Grempler, Rolf, Davenport, Teffany, Geng, Junxian, Rohrbacher, Maren, Lahmar, Mehdi

Volltext

Abstract C047: A phase Ia/Ib, dose-escalation/expansion study of BI 907828, an MDM2-p53 antagonist, in combination with BI 754091, an anti-PD-1 antibody, and BI 754111, an anti-LAG... von Tolcher, Anthony, Hafez, Navid, Yamamoto, Noboru, Park, Jaehong, Grempler, Rolf, Lucarelli, Anthony, Vallaster, Markus P, Wang, Bushi, Hyman, David

Volltext

A phase Ia/Ib, dose-escalation/expansion study of BI 907828 in combination with BI 754091 and BI 754111 in patients (pts) with advanced solid tumors von Tolcher, Anthony W., Hafez, Navid, Yamamoto, Noboru, Park, Jaehong, Grempler, Rolf, Lucarelli, Anthony G., Lahmar, Mehdi, Wang, Bushi, Gounder, Mrinal M.

Volltext

Normalization of Prandial Blood Glucose and Improvement of Glucose Tolerance by Liver-Specific Inhibition of SH2 Domain–Containing Inositol Phosphatase 2 (SHIP2) in Diabetic KKAy M... von Grempler, Rolf, Zibrova, Darya, Schoelch, Corinna, van Marle, André, Rippmann, Joerg F., Redemann, Norbert

Volltext

Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits von Brown, Andrew A., Fernandez-Tajes, Juan J., Hong, Mun-gwan, Brorsson, Caroline A., Koivula, Robert W., Davtian, David, Dupuis, Théo, Sartori, Ambra, Michalettou, Theodora-Dafni, Forgie, Ian M., Adam, Jonathan, Allin, Kristine H., Caiazzo, Robert, Cederberg, Henna, De Masi, Federico, Elders, Petra J. M., Giordano, Giuseppe N., Haid, Mark, Hansen, Torben, Hansen, Tue H., Hattersley, Andrew T., Heggie, Alison J., Howald, Cédric, Jones, Angus G., Kokkola, Tarja, Laakso, Markku, Mahajan, Anubha, Mari, Andrea, McDonald, Timothy J., McEvoy, Donna, Mourby, Miranda, Musholt, Petra B., Nilsson, Birgitte, Pattou, Francois, Penet, Deborah, Raverdy, Violeta, Ridderstråle, Martin, Romano, Luciana, Rutters, Femke, Sharma, Sapna, Teare, Harriet, ‘t Hart, Leen, Tsirigos, Konstantinos D., Vangipurapu, Jagadish, Vestergaard, Henrik, Brunak, Søren, Franks, Paul W., Frost, Gary, Grallert, Harald, Jablonka, Bernd, McCarthy, Mark I., Pavo, Imre, Pedersen, Oluf, Ruetten, Hartmut, Walker, Mark, Adamski, Jerzy, Schwenk, Jochen M., Pearson, Ewan R., Dermitzakis, Emmanouil T., Viñuela, Ana

Volltext

Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study von Bizzotto, Roberto, Jennison, Christopher, Jones, Angus G, Kurbasic, Azra, Tura, Andrea, Kennedy, Gwen, Bell, Jimmy D, Thomas, E Louise, Frost, Gary, Eriksen, Rebeca, Koivula, Robert W, Brage, Soren, Kaye, Jane, Hattersley, Andrew T, Heggie, Alison, McEvoy, Donna, 't Hart, Leen M, Beulens, Joline W, Elders, Petra, Musholt, Petra B, Ridderstråle, Martin, Hansen, Tue H, Allin, Kristine H, Hansen, Torben, Vestergaard, Henrik, Lundgaard, Agnete T, Thomsen, Henrik S, De Masi, Federico, Tsirigos, Konstantinos D, Brunak, Søren, Viñuela, Ana, Mahajan, Anubha, McDonald, Timothy J, Kokkola, Tarja, Forgie, Ian M, Giordano, Giuseppe N, Pavo, Imre, Ruetten, Hartmut, Dermitzakis, Emmanouil, McCarthy, Mark I, Pedersen, Oluf, Schwenk, Jochen M, Adamski, Jerzy, Franks, Paul W, Walker, Mark, Pearson, Ewan R, Mari, Andrea

Volltext

Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models von Allesøe, Rosa Lundbye, Lundgaard, Agnete Troen, Hernández Medina, Ricardo, Aguayo-Orozco, Alejandro, Johansen, Joachim, Nissen, Jakob Nybo, Brorsson, Caroline, Mazzoni, Gianluca, Niu, Lili, Biel, Jorge Hernansanz, Leal Rodríguez, Cristina, Brasas, Valentas, Webel, Henry, Benros, Michael Eriksen, Pedersen, Anders Gorm, Chmura, Piotr Jaroslaw, Jacobsen, Ulrik Plesner, Mari, Andrea, Koivula, Robert, Mahajan, Anubha, Vinuela, Ana, Tajes, Juan Fernandez, Sharma, Sapna, Haid, Mark, Hong, Mun-Gwan, Musholt, Petra B., De Masi, Federico, Vogt, Josef, Pedersen, Helle Krogh, Gudmundsdottir, Valborg, Jones, Angus, Kennedy, Gwen, Bell, Jimmy, Thomas, E. Louise, Frost, Gary, Thomsen, Henrik, Hansen, Elizaveta, Hansen, Tue Haldor, Vestergaard, Henrik, Muilwijk, Mirthe, Blom, Marieke T., ‘t Hart, Leen M., Pattou, Francois, Raverdy, Violeta, Brage, Soren, Kokkola, Tarja, Heggie, Alison, McEvoy, Donna, Mourby, Miranda, Kaye, Jane, Hattersley, Andrew, McDonald, Timothy, Ridderstråle, Martin, Walker, Mark, Forgie, Ian, Giordano, Giuseppe N., Pavo, Imre, Ruetten, Hartmut, Pedersen, Oluf, Hansen, Torben, Dermitzakis, Emmanouil, Franks, Paul W., Schwenk, Jochen M., Adamski, Jerzy, McCarthy, Mark I., Pearson, Ewan, Banasik, Karina, Rasmussen, Simon, Brunak, Søren

Volltext

89Zr-immuno-PET using the anti-LAG-3 tracer [89Zr]Zr-BI 754111: demonstrating target specific binding in NSCLC and HNSCC von Miedema, Iris H.C., Huisman, Marc C., Zwezerijnen, Gerben J.C., Grempler, Rolf, Pitarch, Alejandro Perez, Thiele, Andrea, Hesse, Raphael, Elgadi, Mabrouk, Peltzer, Alexander, Vugts, Danielle J., van Dongen, Guus A.M.S., de Gruijl, Tanja D., Menke-van der Houven van Oordt, C. Willemien, Bahce, Idris

Volltext

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration von Parisinos, Constantinos A., Kelly, Matt, Neubauer, Stefan, Jennison, Christopher, Baum, Patrick, Freijer, Jan, Grempler, Rolf, Graefe-Mody, Ulrike, Dings, Christiane, Lehr, Thorsten, Scherer, Nina, Pattou, Francois, Raverdi, Violeta, Torres, Fanelly, Verkindt, Helene, Mari, Andrea, Tura, Andrea, Bizzotto, Roberto, Bonneford, Amelie, Dhennin, Veronique, De Masi, Federico, Pedersen, Helle, Banasik, Karina, Thomas, Cecilia, Sackett, Peter, Staerfeldt, Hans-Henrik, Lundgaard, Agnete, Nilsson, Birgitte, Nielsen, Agnes, Rasmussen, Simon, Johansen, Joachim, Allesøe, Rosa, Fritsche, Andreas, Thorand, Barbara, Adamski, Jurek, Haid, Mark, Sharma, Sapna, Troll, Martina, Adam, Jonathan, Frost, Gary, Haussler, Ragna, Schwenk, Jochen, Uhlen, Mathias, Nicolay, Claudia, Thomas, Melissa, Wu, Han, Hart, Leen't, Dekkers, Koen, Gassenhuber, Johann, Jablonka, Bernd, Musholt, Petra, Ruetten, Hartmut, Tillner, Joachim, Baltauss, Tania, Rodriquez, Marianne, Engelbrechtsen, Line, Hansen, Torben, Hansen, Tue, Vestergaard, Henrik, Kokkola, Tarja, Kuulasmaa, Teemu, Fitipaldi, Hugo, Mutie, Pascal, Klintenberg, Maria, Bergstrom, Margit, Groop, Leif, Atabaki Pasdar, Naeimeh, Wake, Dianne, McEvoy, Donna, Hattersley, Andrew, Hill, Anita, McDonald, Timothy, Perry, Mandy, Nice, Rachel, Hudson, Michelle, Dermitzakis, Emmanouil, Viñuela, Ana, Cabrelli, Louise, Loftus, Heather, Dawed, Adem, Donnelly, Louise, Forgie, Ian, Pearson, Ewan, Brown, Andrew, McRobert, Nicky, Jiao, Yunlong, Mahajan, Anubha, McCarthy, Mark, Shah, Nisha, Teare, Harriet, Beulens, Joline, Bell, Jimmy, Thomas, Louise, Whitcher, Brandon, Mahajan, Anubha, Patel, Riyaz S., Hemingway, Harry, Franks, Paul W., Bell, Jimmy D., Yaghootkar, Hanieh

Volltext