Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers von Peng, Sheng-Bin, Henry, James R., Kaufman, Michael D., Lu, Wei-Ping, Smith, Bryan D., Vogeti, Subha, Rutkoski, Thomas J., Wise, Scott, Chun, Lawrence, Zhang, Youyan, Van Horn, Robert D., Yin, Tinggui, Zhang, Xiaoyi, Yadav, Vipin, Chen, Shih-Hsun, Gong, Xueqian, Ma, Xiwen, Webster, Yue, Buchanan, Sean, Mochalkin, Igor, Huber, Lysiane, Kays, Lisa, Donoho, Gregory P., Walgren, Jennie, McCann, Denis, Patel, Phenil, Conti, Ilaria, Plowman, Gregory D., Starling, James J., Flynn, Daniel L.

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Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen von Poole, Andrew, Karuppiah, Vijaykumar, Hartt, Annabelle, Haidar, Jaafar N., Moureau, Sylvie, Dobrzycki, Tomasz, Hayes, Conor, Rowley, Christopher, Dias, Jorge, Harper, Stephen, Barnbrook, Keir, Hock, Miriam, Coles, Charlotte, Yang, Wei, Aleksic, Milos, Lin, Aimee Bence, Robinson, Ross, Dukes, Joe D., Liddy, Nathaniel, Van der Kamp, Marc, Plowman, Gregory D., Vuidepot, Annelise, Cole, David K., Whale, Andrew D., Chillakuri, Chandramouli

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Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combinat... von Holmgaard, Rikke B, Schaer, David A, Li, Yanxia, Castaneda, Stephen P, Murphy, Mary Y, Xu, Xiaohong, Inigo, Ivan, Dobkin, Julie, Manro, Jason R, Iversen, Philip W, Surguladze, David, Hall, Gerald E, Novosiadly, Ruslan D, Benhadji, Karim A, Plowman, Gregory D, Kalos, Michael, Driscoll, Kyla E

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Evolution of protein kinase signaling from yeast to man von Manning, Gerard, Plowman, Gregory D, Hunter, Tony, Sudarsanam, Sucha

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Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models von Hamilton, Patricia, Devasthali, Vidusha, Bou Reslan, Hani, Nannini, Michelle A, Cheng, Jason H, Johnson, Leisa, Ho, Calvin C K, Lee, Chingwei V, Fuh, Germaine, Forrest, William F, Molina, Rafael, Clermont, Anne C, Cao, Timothy C, Carano, Richard A D, Yu, Ron X, Koeppen, Hartmut, Plowman, Gregory D, Singh, Mallika, Lima, Anthony, Thompson, Jennifer D

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Tumor cell expression of vascular endothelial growth factor receptor 2 is an adverse prognostic factor in patients with squamous cell carcinoma of the lung von Holzer, Timothy R, Fulford, Angie D, Nedderman, Drew M, Umberger, Tara S, Hozak, Rebecca R, Joshi, Adarsh, Melemed, Symantha A, Benjamin, Laura E, Plowman, Gregory D, Schade, Andrew E, Ackermann, Bradley L, Konrad, Robert J, Nasir, Aejaz

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The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis von Bischoff, James R, Plowman, Gregory D

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The Protein Kinases of Caenorhabditis elegans: A Model for Signal Transduction in Multicellular Organisms von Plowman, Gregory D., Sudarsanam, Sucha, Bingham, Jonathan, Whyte, David, Hunter, Tony

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Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene von Gong, Xueqian, Du, Jian, Parsons, Stephen H, Merzoug, Farhana F, Webster, Yue, Iversen, Philip W, Chio, Li-Chun, Van Horn, Robert D, Lin, Xi, Blosser, Wayne, Han, Bomie, Jin, Shaoling, Yao, Sufang, Bian, Huimin, Ficklin, Chris, Fan, Li, Kapoor, Avnish, Antonysamy, Stephen, Mc Nulty, Ann M, Froning, Karen, Manglicmot, Danalyn, Pustilnik, Anna, Weichert, Kenneth, Wasserman, Stephen R, Dowless, Michele, Marugán, Carlos, Baquero, Carmen, Lallena, María José, Eastman, Scott W, Hui, Yu-Hua, Dieter, Matthew Z, Doman, Thompson, Chu, Shaoyou, Qian, Hui-Rong, Ye, Xiang S, Barda, David A, Plowman, Gregory D, Reinhard, Christoph, Campbell, Robert M, Henry, James R, Buchanan, Sean G

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Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120 von Chen, Shih-Hsun, Zhang, Youyan, Van Horn, Robert D, Yin, Tinggui, Buchanan, Sean, Yadav, Vipin, Mochalkin, Igor, Wong, Swee Seong, Yue, Yong Gang, Huber, Lysiane, Conti, Ilaria, Henry, James R, Starling, James J, Plowman, Gregory D, Peng, Sheng-Bin

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ERK Inhibitor LY3214996 Targets ERK Pathway-Driven Cancers: A Therapeutic Approach Toward Precision Medicine von Bhagwat, Shripad V., McMillen, William T., Cai, Shufen, Zhao, Baohui, Whitesell, Matthew, Shen, Weihua, Kindler, Lisa, Flack, Robert S., Wu, Wenjuan, Anderson, Bryan, Zhai, Yan, Yuan, Xiu-Juan, Pogue, Meghann, Van Horn, Robert D., Rao, Xi, McCann, Denis, Dropsey, Andrew J., Manro, Jason, Walgren, Jennie, Yuen, Eunice, Rodriguez, Michael J., Plowman, Gregory D., Tiu, Ramon V., Joseph, Sajan, Peng, Sheng-Bin

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Mouse PDX Trial Suggests Synergy of Concurrent Inhibition of RAF and EGFR in Colorectal Cancer with BRAF or KRAS Mutations von Yao, Yung-Mae M, Donoho, Gregory P, Iversen, Philip W, Zhang, Youyan, Van Horn, Robert D, Forest, Amelie, Novosiadly, Ruslan D, Webster, Yue Wang, Ebert, Philip, Bray, Steven, Ting, Jason C, Aggarwal, Amit, Henry, James R, Tiu, Ramon V, Plowman, Gregory D, Peng, Sheng-Bin

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Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy von Du, Jian, Yan, Lei, Torres, Raquel, Gong, Xueqian, Bian, Huimin, Marugán, Carlos, Boehnke, Karsten, Baquero, Carmen, Hui, Yu-Hua, Chapman, Sonya C, Yang, Yanzhu, Zeng, Yi, Bogner, Sarah M, Foreman, Robert T, Capen, Andrew, Donoho, Gregory P, Van Horn, Robert D, Barnard, Darlene S, Dempsey, Jack A, Beckmann, Richard P, Marshall, Mark S, Chio, Li-Chun, Qian, Yuewei, Webster, Yue W, Aggarwal, Amit, Chu, Shaoyou, Bhattachar, Shobha, Stancato, Louis F, Dowless, Michele S, Iversen, Phillip W, Manro, Jason R, Walgren, Jennie L, Halstead, Bartley W, Dieter, Matthew Z, Martinez, Ricardo, Bhagwat, Shripad V, Kreklau, Emiko L, Lallena, Maria Jose, Ye, Xiang S, Patel, Bharvin K R, Reinhard, Christoph, Plowman, Gregory D, Barda, David A, Henry, James R, Buchanan, Sean G, Campbell, Robert M

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Characterization of 7A5: A Human CD137 (4-1BB) Receptor Binding Monoclonal Antibody with Differential Agonist Properties That Promotes Antitumor Immunity von Kotanides, Helen, Sattler, Rose Marie, Lebron, Maria B., Carpenito, Carmine, Shen, Juqun, Li, Jingxing, Surguladze, David, Haidar, Jaafar N., Burns, Colleen, Shen, Leyi, Inigo, Ivan, Pennello, Anthony L., Forest, Amelie, Chen, Xinlei, Chin, Darin, Sonyi, Andreas, Topper, Michael, Boucher, Lauren, Sharma, Prachi, Zhang, Yiwei, Burtrum, Douglas, Novosiadly, Ruslan D., Ludwig, Dale L., Plowman, Gregory D., Kalos, Michael

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Bispecific Targeting of PD-1 and PD-L1 Enhances T-cell Activation and Antitumor Immunity von Kotanides, Helen, Li, Yiwen, Malabunga, Maria, Carpenito, Carmine, Eastman, Scott W., Shen, Yang, Wang, George, Inigo, Ivan, Surguladze, David, Pennello, Anthony L., Persaud, Krishnadatt, Hindi, Sagit, Topper, Michael, Chen, Xinlei, Zhang, Yiwei, Bulaon, Danielle K., Bailey, Tim, Lao, Yanbin, Han, Bing, Torgerson, Stacy, Chin, Darin, Sonyi, Andreas, Haidar, Jaafar N., Novosiadly, Ruslan D., Moxham, Christopher M., Plowman, Gregory D., Ludwig, Dale L., Kalos, Michael

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Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome von Friedman, Lori, Deal, Jennifer E, Howie, Elizabeth, Tan, Lory R, Edgar, Kyle A, Plowman, Gregory D, Marcinko, Marie, Winter, Christopher G, Milash, Brett, Winner, Millicent A, Cook, Kevin R, Parks, Annette L, Belvin, Marcia, Fawcett, Robert, Andrade, Rachel S, Kopczynski, Casey, Killpack, Keith, Duyk, Geoffrey, Grant, Deanna, Shaw, Kenneth J, Huppert, Kari, Miyazaki, Wesley Y, Margolis, Jonathan, Tabios, Mariano, Thao, Doua, Vysotskaia, Valentina, Kaufman, Thomas C, Zhao, Lora, Francis-Lang, Helen L, Robertson, Stephanie, Dompe, Nicholas A, Curtis, Daniel, Whittaker, Kellie, Deal-Herr, Megan E, Norton, Amanda, Bogart, Kevin P, Singer, Matthew A

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The protein kinases of budding yeast: six score and more von Hunter, Tony, Plowman, Gregory D.

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Structure and Function of Human Amphiregulin: A Member of the Epidermal Growth Factor Family von Shoyab, Mohammed, Plowman, Gregory D., McDonald, Vicki L., Bradley, J. Garrett, Todaro, George J.

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Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions von Peles, Elior, Nativ, Moshe, Lustig, Marc, Grumet, Martin, Schilling, James, Martinez, Ricardo, Plowman, Gregory D., Schlessinger, Joseph

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The carbonic anhydrase domain of receptor tyrosine phosphatase β is a functional ligand for the axonal cell recognition molecule contactin von Peles, Elior, Nativ, Moshe, Campbell, Phillip L, Sakurai, Takeshi, Martinez, Ricardo, Levt, Sima, Clary, Douglas O, Schilling, James, Barnea, Gilad, Plowman, Gregory D, Grumet, Martin, Schlessinger, Joseph

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