The metabolism of primaquine to its active metabolite is dependent on CYP 2D6 von Pybus, Brandon S, Marcsisin, Sean R, Jin, Xiannu, Deye, Gregory, Sousa, Jason C, Li, Qigui, Caridha, Diana, Zeng, Qiang, Reichard, Gregory A, Ockenhouse, Christian, Bennett, Jason, Walker, Larry A, Ohrt, Colin, Melendez, Victor

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CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine von Pybus, Brandon S, Sousa, Jason C, Jin, Xiannu, Ferguson, James A, Christian, Robert E, Barnhart, Rebecca, Vuong, Chau, Sciotti, Richard J, Reichard, Gregory A, Kozar, Michael P, Walker, Larry A, Ohrt, Colin, Melendez, Victor

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Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes von Fasinu, Pius S, Avula, Bharathi, Tekwani, Babu L, Nanayakkara, N P Dhammika, Wang, Yan-Hong, Bandara Herath, H M T, McChesney, James D, Reichard, Gregory A, Marcsisin, Sean R, Elsohly, Mahmoud A, Khan, Shabana I, Khan, Ikhlas A, Walker, Larry A

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Enantioselective metabolism of primaquine by human CYP2D6 von Fasinu, Pius S, Tekwani, Babu L, Nanayakkara, N P Dhammika, Avula, Bharathi, Herath, H M T Bandara, Wang, Yan-Hong, Adelli, Vijender R, Elsohly, Mahmoud A, Khan, Shabana I, Khan, Ikhlas A, Pybus, Brandon S, Marcsisin, Sean R, Reichard, Gregory A, McChesney, James D, Walker, Larry A

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Scalable Preparation and Differential Pharmacologic and Toxicologic Profiles of Primaquine Enantiomers von DHAMMIKA NANAYAKKARA, N. P, TEKWANI, Babu L, FRONCZEK, Frank R, MELENDEZ, Victor, OHRT, Colin, REICHARD, Gregory A, MCCHESNEY, James D, ROCHFORD, Rosemary, WALKER, Larry A, BANDARA HERATH, H. M. T, SAHU, Rajnish, GETTAYACAMIN, Montip, TUNGTAENG, Anchalee, VAN GESSEL, Yvonne, BARESEL, Paul, WICKHAM, Kristina S, BARTLETT, Marilyn S

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Safety, Pharmacokinetics, and Activity of High-Dose Ivermectin and Chloroquine against the Liver Stage of Plasmodium cynomolgi Infection in Rhesus Macaques von Vanachayangkul, Pattaraporn, Im-erbsin, Rawiwan, Tungtaeng, Anchalee, Kodchakorn, Chanikarn, Roth, Alison, Adams, John, Chaisatit, Chaiyaporn, Saingam, Piyaporn, Sciotti, Richard J, Reichard, Gregory A, Nolan, Christina K, Pybus, Brandon S, Black, Chad C, Lugo-Roman, Luis A, Wegner, Matthew D, Smith, Philip L, Wojnarski, Mariusz, Vesely, Brian A, Kobylinski, Kevin C

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Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population von Spring, Michele D., Sousa, Jason C., Li, Qigui, Darko, Christian A., Morrison, Meshell N., Marcsisin, Sean R., Mills, Kristin T., Potter, Brittney M., Paolino, Kristopher M., Twomey, Patrick S., Moon, James E., Tosh, Donna M., Cicatelli, Susan B., Froude, Jeffrey W., Pybus, Brandon S., Oliver, Thomas G., McCarthy, William F., Waters, Norman C., Smith, Philip L., Reichard, Gregory A., Bennett, Jason W.

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Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds von Marcsisin, Sean R, Sousa, Jason C, Reichard, Gregory A, Caridha, Diana, Zeng, Qiang, Roncal, Norma, McNulty, Ronan, Careagabarja, Julio, Sciotti, Richard J, Bennett, Jason W, Zottig, Victor E, Deye, Gregory, Li, Qigui, Read, Lisa, Hickman, Mark, Dhammika Nanayakkara, N P, Walker, Larry A, Smith, Bryan, Melendez, Victor, Pybus, Brandon S

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Asymmetric Synthesis of 4,4-Disubstituted-2-Imidazoli-dinones:  Potent NK1 Antagonists von Reichard, Gregory A, Stengone, Carmine, Paliwal, Sunil, Mergelsberg, Ingrid, Majmundar, Sapna, Wang, Cheng, Tiberi, Robert, McPhail, Andrew T, Piwinski, John J, Shih, Neng-Yang

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A New Magnesium-Catalyzed Doubly Diastereoselective anti-Aldol Reaction Leads to a Highly Efficient Process for the Total Synthesis of Lactacystin in Quantity von Corey, E. J, Li, Weidong, Reichard, Gregory A

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Differential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics von Vuong, Chau, Xie, Lisa H, Potter, Brittney M J, Zhang, Jing, Zhang, Ping, Duan, Dehui, Nolan, Christina K, Sciotti, Richard J, Zottig, Victor E, Nanayakkara, N P Dhammika, Tekwani, Babu L, Walker, Larry A, Smith, Philip L, Paris, Robert M, Read, Lisa T, Li, Qigui, Pybus, Brandon S, Sousa, Jason C, Reichard, Gregory A, Smith, Bryan, Marcsisin, Sean R

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Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs von Wickham, Kristina S, Baresel, Paul C, Marcsisin, Sean R, Sousa, Jason, Vuong, Chau T, Reichard, Gregory A, Campo, Brice, Tekwani, Babu L, Walker, Larry A, Rochford, Rosemary

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Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions von Shue, Ho-Jane, Chen, Xiao, Schwerdt, John H, Paliwal, Sunil, Blythin, David J, Lin, Ling, Gu, Danlin, Wang, Cheng, Reichard, Gregory A, Wang, Hongwu, Piwinski, John J, Duffy, Ruth A, Lachowicz, Jean E, Coffin, Vicki L, Nomeir, Amin A, Morgan, Cynthia A, Varty, Geoffrey B, Shih, Neng-Yang

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SARVision Plus von Reichard, Gregory A

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SARVision Plus by ChemApps von Reichard, Gregory A

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CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever von Marcsisin, Sean R, Jin, Xiannu, Bettger, Theresa, McCulley, Nicholas, Sousa, Jason C, Shanks, G Dennis, Tekwani, Babu L, Sahu, Rajnish, Reichard, Gregory A, Sciotti, Richard J, Melendez, Victor, Pybus, Brandon S

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Cyclobutane derivatives as potent NK1 selective antagonists von WROBLESKI, Michelle Laci, REICHARD, Gregory A, PALIWAL, Sunil, SHAH, Sapna, TSUI, Hon-Chung, DUFFY, Ruth A, LACHOWICZ, Jean E, MORGAN, Cynthia A, VARTY, Geoffrey B, SHIH, Neng-Yang

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Cyclic urea derivatives as potent NK1 selective antagonists von SHUE, Ho-Jane, XIAO CHEN, PIWINSKI, John J, DUFFY, Ruth A, LACHOWICZ, Jean E, COFFIN, Vicki L, FEI LIU, NOMEIR, Amin A, MORGAN, Cynthia A, VARTY, Geoffrey B, SHIH, Neng-Yang, BLYTHIN, David J, PALIWAL, Sunil, LING LIN, DANLIN GU, SCHWERDT, John H, SHAH, Sapna, REICHARD, Gregory A

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A β-Lactone Related to Lactacystin Induces Neurite Outgrowth in a Neuroblastoma Cell Line and Inhibits Cell Cycle Progression in an Osteosarcoma Cell Line von FENTEANY, G, STANDAERT, R. F, REICHARD, G. A, COREY, E. J, SCHREIBER, S. L

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An efficient approach for the rapid assessment of oral rat exposures for new chemical entities in drug discovery von Han, Hyo-Kyung, Sadagopan, Nalini, Reichard, Gregory A., Yapa, Udeni, Zhu, Tong, Hubbel, Andrea, Johnson, Kjell, Brodfuehrer, Joanne

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