Safety and immunogenicity of the rVSV∆G-ZEBOV-GP Ebola virus vaccine candidate in healthy adults: a phase 1b randomised, multicentre, double-blind, placebo-controlled, dose-respons... von Heppner, D Gray, Dr, Kemp, Tracy L, MPH, Martin, Brian K, PhD, Ramsey, William J, MD, Nichols, Richard, MA, Dasen, Emily J, BA, Link, Charles J, MD, Das, Rituparna, MD, Xu, Zhi Jin, PhD, Sheldon, Eric A, MD, Nowak, Teresa A, BSE, Monath, Thomas P, MD

Volltext

A Field Trial to Assess a Blood-Stage Malaria Vaccine von Thera, Mahamadou A, Doumbo, Ogobara K, Coulibaly, Drissa, Laurens, Matthew B, Ouattara, Amed, Kone, Abdoulaye K, Guindo, Ando B, Traore, Karim, Traore, Idrissa, Kouriba, Bourema, Diallo, Dapa A, Diarra, Issa, Daou, Modibo, Dolo, Amagana, Tolo, Youssouf, Sissoko, Mady, Sissoko, Mahamadou S, Niangaly, Amadou, Takala-Harrison, Shannon, Lyke, Kirsten E, Wu, Yukun, Blackwelder, William C, Godeaux, Olivier, Vekemans, Johan, Dubois, Marie-Claude, Ballou, W. Ripley, Cohen, Joe, Thompson, Darby, Dube, Tina, Soisson, Lorraine, Diggs, Carter L, House, Brent, Lanar, David E, Dutta, Sheetij, Heppner, D. Gray, Plowe, Christopher V

Volltext

Randomized, Double-Blind, Phase 2a Trial of Falciparum Malaria Vaccines RTS,S/AS01B and RTS,S/AS02A in Malaria-Naive Adults: Safety, Efficacy, and Immunologic Associates of Protect... von Kester, Kent E., Cummings, James F., Ofori-Anyinam, Opokua, Ockenhouse, Christian F., Krzych, Urszula, Moris, Philippe, Schwenk, Robert, Nielsen, Robin A., Debebe, Zufan, Pinelis, Evgeny, Juompan, Laure, Williams, Jack, Dowler, Megan, Stewart, V. Ann, Wirtz, Robert A., Dubois, Marie-Claude, Lievens, Marc, Cohen, Joe, Ballou, W. Ripley, Heppner, D. Gray

Volltext

Assessing the safety and immunogenicity of recombinant vesicular stomatitis virus Ebola vaccine in healthy adults: a randomized clinical trial von ElSherif, May S, Brown, Catherine, MacKinnon-Cameron, Donna, Li, Li, Racine, Trina, Alimonti, Judie, Rudge, Thomas L, Sabourin, Carol, Silvera, Peter, Hooper, Jay W, Kwilas, Steven A, Kilgore, Nicole, Badorrek, Christopher, Ramsey, W Jay, Heppner, D Gray, Kemp, Tracy, Monath, Thomas P, Nowak, Teresa, McNeil, Shelly A, Langley, Joanne M, Halperin, Scott A

Volltext

Clinical development of a recombinant Ebola vaccine in the midst of an unprecedented epidemic von Coller, Beth-Ann G, Blue, Jeffrey, Das, Rituparna, Dubey, Sheri, Finelli, Lynn, Gupta, Swati, Helmond, Frans, Grant-Klein, Rebecca J, Liu, Kenneth, Simon, Jakub, Troth, Sean, VanRheenen, Susan, Waterbury, Julie, Wivel, Ashley, Wolf, Jayanthi, Heppner, D. Gray, Kemp, Tracy, Nichols, Rick, Monath, Thomas P

Volltext

Evaluation of RTS,S/AS02A and RTS,S/AS01B in adults in a high malaria transmission area von Polhemus, Mark E, Remich, Shon A, Ogutu, Bernhards R, Waitumbi, John N, Otieno, Lucas, Apollo, Stella, Cummings, James F, Kester, Kent E, Ockenhouse, Christian F, Stewart, Ann, Ofori-Anyinam, Opokua, Ramboer, Isabelle, Cahill, Conor P, Lievens, Marc, Dubois, Marie-Claude, Demoitie, Marie-Ange, Leach, Amanda, Cohen, Joe, Ballou, W Ripley, Heppner, Jr, D Gray

Volltext

Molecular Basis of Allele-Specific Efficacy of a Blood-Stage Malaria Vaccine: Vaccine Development Implications von Ouattara, Amed, Takala-Harrison, Shannon, Thera, Mahamadou A., Coulibaly, Drissa, Niangaly, Amadou, Saye, Renion, Tolo, Youssouf, Dutta, Sheetij, Heppner, D. Gray, Soisson, Lorraine, Diggs, Carter L., Vekemans, Johan, Cohen, Joe, Blackwelder, William C., Dube, Tina, Laurens, Matthew B., Doumbo, Ogobara K., Plowe, Christopher V.

Volltext

First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers von Spring, Michele, Murphy, Jittawadee, Nielsen, Robin, Dowler, Megan, Bennett, Jason W, Zarling, Stasya, Williams, Jack, de la Vega, Patricia, Ware, Lisa, Komisar, Jack, Polhemus, Mark, Richie, Thomas L, Epstein, Judy, Tamminga, Cindy, Chuang, Ilin, Richie, Nancy, O’Neil, Michael, Heppner, D. Gray, Healer, Julie, O’Neill, Matthew, Smithers, Hannah, Finney, Olivia C, Mikolajczak, Sebastian A, Wang, Ruobing, Cowman, Alan, Ockenhouse, Christian, Krzych, Urszula, Kappe, Stefan H.I

Volltext

Sequential Phase 1 and Phase 2 randomized, controlled trials of the safety, immunogenicity and efficacy of combined pre-erythrocytic vaccine antigens RTS,S and TRAP formulated with... von Kester, Kent E, Gray Heppner, D, Moris, Philippe, Ofori-Anyinam, Opokua, Krzych, Urszula, Tornieporth, Nadia, McKinney, Denise, Delchambre, Martine, Ockenhouse, Christian F, Voss, Gerald, Holland, Carolyn, Beckey, Jolie Palensky, Ballou, W. Ripley, Cohen, Joe

Volltext

Expression of genes associated with immunoproteasome processing of major histocompatibility complex peptides is indicative of protection with adjuvanted RTS,S malaria vaccine von Vahey, Maryanne T., Wang, Zhining, Kester, Kent E., Cummings, James, Heppner, D. Gray, Nau, Martin E., Ofori-Anyinam, Opokua, Cohen, Joe, Coche, Thierry, Ballou, W. Ripley, Ockenhouse, Christian F.

Volltext

Protection of Humans against Malaria by Immunization with Radiation-Attenuated Plasmodium falciparum Sporozoites von Hoffman, Stephen L., Goh, Lucy M. L., Luke, Thomas C., Schneider, Imogene, Le, Thong P., Doolan, Denise L., Sacci, John, de la Vega, Patricia, Dowler, Megan, Paul, Chris, Gordon, Daniel M., Stoute, Jose A., Church, L. W. Preston, Sedegah, Martha, Heppner, D. Gray, Ballou, W. Ripley, Richie, Thomas L.

Volltext

rVSVΔG-ZEBOV-GP (also designated V920) recombinant vesicular stomatitis virus pseudotyped with Ebola Zaire Glycoprotein: Standardized template with key considerations for a risk/be... von Monath, Thomas P, Fast, Patricia E, Modjarrad, Kayvon, Clarke, David K, Martin, Brian K, Fusco, Joan, Nichols, Richard, Heppner, D Gray, Simon, Jakub K, Dubey, Sheri, Troth, Sean P, Wolf, Jayanthi, Singh, Vidisha, Coller, Beth-Ann, Robertson, James S

Volltext

Priming with an Adenovirus 35-Circumsporozoite Protein (CS) Vaccine followed by RTS,S/AS01B Boosting Significantly Improves Immunogenicity to Plasmodium falciparum CS Compared to T... von STEWART, V. Ann, MCGRATH, Shannon M, DEMOITIE, Marie-Ange, JAN WEVERLING, Gerrit, BAYAT, Babak, CUSTERS, Jerome H. H. V, DUBOIS, Marie-Claude, COHEN, Joe, GOUDSMIT, Jaap, GRAY HEPPNER, D, DUBOIS, Patrice M, PAU, Maria G, METTENS, Pascal, SHOTT, Joseph, COBB, Michelle, BURGE, J. Robert, LARSON, David, WARE, Lisa A

Volltext

High antibody titer against apical membrane antigen-1 is required to protect against malaria in the Aotus model von Dutta, Sheetij, Sullivan, JoAnn S, Grady, Katharine K, Haynes, J David, Komisar, Jack, Batchelor, Adrian H, Soisson, Lorraine, Diggs, Carter L, Heppner, D Gray, Lanar, David E, Collins, William E, Barnwell, John W

Volltext

Recombinant Liver Stage Antigen-1 (LSA-1) formulated with AS01 or AS02 is safe, elicits high titer antibody and induces IFN-γ/IL-2 CD4+ T cells but does not protect against experim... von Cummings, James F, Spring, Michele D, Schwenk, Robert J, Ockenhouse, Christian F, Kester, Kent E, Polhemus, Mark E, Walsh, Douglas S, Yoon, In-Kyu, Prosperi, Christine, Juompan, Laure Y, Lanar, David E, Krzych, Urszula, Hall, B. Ted, Ware, Lisa A, Stewart, V. Ann, Williams, Jack, Dowler, Megan, Nielsen, Robin K, Hillier, Collette J, Giersing, Birgitte K, Dubovsky, Filip, Malkin, Elissa, Tucker, Kathryn, Dubois, Marie-Claude, Cohen, Joe D, Ballou, W. Ripley, Jr, D. Gray Heppner

Volltext

Extended safety, immunogenicity and efficacy of a blood-stage malaria vaccine in malian children: 24-month follow-up of a randomized, double-blinded phase 2 trial von Laurens, Matthew B, Thera, Mahamadou A, Coulibaly, Drissa, Ouattara, Amed, Kone, Abdoulaye K, Guindo, Ando B, Traore, Karim, Traore, Idrissa, Kouriba, Bourema, Diallo, Dapa A, Diarra, Issa, Daou, Modibo, Dolo, Amagana, Tolo, Youssouf, Sissoko, Mahamadou S, Niangaly, Amadou, Sissoko, Mady, Takala-Harrison, Shannon, Lyke, Kirsten E, Wu, Yukun, Blackwelder, William C, Godeaux, Olivier, Vekemans, Johan, Dubois, Marie-Claude, Ballou, W Ripley, Cohen, Joe, Dube, Tina, Soisson, Lorraine, Diggs, Carter L, House, Brent, Bennett, Jason W, Lanar, David E, Dutta, Sheetij, Heppner, D Gray, Plowe, Christopher V, Doumbo, Ogobara K

Volltext

Protective immunity induced with the RTS,S/AS vaccine is associated with IL-2 and TNF-α producing effector and central memory CD4 T cells von Lumsden, Joanne M, Schwenk, Robert J, Rein, Lisa E, Moris, Philippe, Janssens, Michel, Ofori-Anyinam, Opokua, Cohen, Joe, Kester, Kent E, Heppner, D Gray, Krzych, Urszula

Volltext

Malaria Blood Stage Parasites Activate Human Plasmacytoid Dendritic Cells and Murine Dendritic Cells through a Toll-Like Receptor 9-Dependent Pathway von Pichyangkul, Sathit, Yongvanitchit, Kosol, Kum-arb, Utaiwan, Hemmi, Hiroaki, Akira, Shizuo, Krieg, Arthur M, Heppner, D. Gray, Stewart, V. Ann, Hasegawa, Hitoshi, Looareesuwan, Sornchai, Shanks, G. Dennis, Miller, R. Scott

Volltext

A novel RBD-protein/peptide vaccine elicits broadly neutralizing antibodies and protects mice and macaques against SARS-CoV-2 von Wang, Shixia, Wang, Chang Yi, Kuo, Hui-Kai, Peng, Wen-Jiun, Huang, Juin-Hua, Kuo, Be-Shen, Lin, Feng, Liu, Yaw-Jen, Liu, Zhi, Wu, Huang-Ting, Ding, Shuang, Hou, Kou-Liang, Cheng, Jennifer, Yang, Ya-Ting, Jiang, Ming-Han, Wang, Min-Sheng, Chen, Tony, Xia, Wei Guo, Lin, Ed, Hung, Chung Ho, Chen, Hui-Jung, Shih, Zhonghao, Lin, Yi Ling, Ryan, Valorie, Hu, Mei Mei, Heppner, D. Gray, Malherbe, Delphine C., Periasamy, Sivakumar, Kuzmina, Natalia, Subramani, Chandru, Hellerstein, Michael, Monath, Thomas P., Rumyantsev, Alexander, Bukreyev, Alexander, Guirakhoo, Farshad

Volltext

Phase 1 randomized double-blind safety and immunogenicity trial of Plasmodium falciparum malaria merozoite surface protein FMP1 vaccine, adjuvanted with AS02A, in adults in western... von Stoute, José A, Gombe, Joash, Withers, Mark R, Siangla, Joram, McKinney, Denise, Onyango, Melanie, Cummings, James F, Milman, Jessica, Tucker, Kathryn, Soisson, Lorraine, Stewart, V. Ann, Lyon, Jeffrey A, Angov, Evelina, Leach, Amanda, Cohen, Joe, Kester, Kent E, Ockenhouse, Christian F, Holland, Carolyn A, Diggs, Carter L, Wittes, Janet, Gray Heppner, D

Volltext