Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase von Ersching, Jonatan, Efeyan, Alejo, Mesin, Luka, Jacobsen, Johanne T., Pasqual, Giulia, Grabiner, Brian C., Dominguez-Sola, David, Sabatini, David M., Victora, Gabriel D.

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E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation von Yang, Wei-Lei, Wang, Jing, Chan, Chia-Hsin, Lee, Szu-Wei, Campos, Alejandro D, Lamothe, Betty, Hur, Lana, Grabiner, Brian C, Lin, Xin, Darnay, Bryant G, Lin, Hui-Kuan

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A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity von Grabiner, Brian C, Nardi, Valentina, Birsoy, Kıvanc, Possemato, Richard, Shen, Kuang, Sinha, Sumi, Jordan, Alexander, Beck, Andrew H, Sabatini, David M

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A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1 von Bar-Peled, Liron, Chantranupong, Lynne, Cherniack, Andrew D., Chen, Walter W., Ottina, Kathleen A., Grabiner, Brian C., Spear, Eric D., Carter, Scott L, Meyerson, Matthew, Sabatini, David M.

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Response and Acquired Resistance to Everolimus in Anaplastic Thyroid Cancer von Wagle, Nikhil, Grabiner, Brian C, Van Allen, Eliezer M, Amin-Mansour, Ali, Taylor-Weiner, Amaro, Rosenberg, Mara, Gray, Nathanael, Barletta, Justine A, Guo, Yanan, Swanson, Scott J, Ruan, Daniel T, Hanna, Glenn J, Haddad, Robert I, Getz, Gad, Kwiatkowski, David J, Carter, Scott L, Sabatini, David M, Jänne, Pasi A, Garraway, Levi A, Lorch, Jochen H

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Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib von Wagle, Nikhil, Grabiner, Brian C, Van Allen, Eliezer M, Hodis, Eran, Jacobus, Susanna, Supko, Jeffrey G, Stewart, Michelle, Choueiri, Toni K, Gandhi, Leena, Cleary, James M, Elfiky, Aymen A, Taplin, Mary Ellen, Stack, Edward C, Signoretti, Sabina, Loda, Massimo, Shapiro, Geoffrey I, Sabatini, David M, Lander, Eric S, Gabriel, Stacey B, Kantoff, Philip W, Garraway, Levi A, Rosenberg, Jonathan E

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Specificity of ABCA7-mediated cell lipid efflux von Picataggi, Antonino, Rodrigues, Amrith, Cromley, Debra A., Wang, Hu, Wiener, Joel P., Garliyev, Viktor, Billheimer, Jeffrey T., Grabiner, Brian C., Hurt, Jessica A., Chen, Allen C., Han, Xianlin, Rader, Daniel J., Praticò, Domenico, Lyssenko, Nicholas N.

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Constitutively Active Type I Insulin-Like Growth Factor Receptor Causes Transformation and Xenograft Growth of Immortalized Mammary Epithelial Cells and Is Accompanied by an Epithe... von Kim, Hyun-Jung, Litzenburger, Beate C., Cui, Xiaojiang, Delgado, David A., Grabiner, Brian C., Lin, Xin, Lewis, Michael T., Gottardis, Marco M., Wong, Tai W., Attar, Ricardo M., Carboni, Joan M., Lee, Adrian V.

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CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-κB activation von Grabiner, Brian C., Blonska, Marzenna, Lin, Pei-Chun, You, Yun, Wang, Donghai, Sun, Jiyuan, Darnay, Bryant G., Dong, Chen, Lin, Xin

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Abstract A163: A diverse array of mutations in MTOR are hyperactivating and correlate with rapamycin sensitivity von Grabiner, Brian, Sabatini, David

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The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming von Phan, Liem, Chou, Ping-Chieh, Velazquez-Torres, Guermarie, Samudio, Ismael, Parreno, Kenneth, Huang, Yaling, Tseng, Chieh, Vu, Thuy, Gully, Chris, Su, Chun-Hui, Wang, Edward, Chen, Jian, Choi, Hyun-Ho, Fuentes-Mattei, Enrique, Shin, Ji-Hyun, Shiang, Christine, Grabiner, Brian, Blonska, Marzenna, Skerl, Stephen, Shao, Yiping, Cody, Dianna, Delacerda, Jorge, Kingsley, Charles, Webb, Douglas, Carlock, Colin, Zhou, Zhongguo, Hsieh, Yun-Chih, Lee, Jaehyuk, Elliott, Andrew, Ramirez, Marc, Bankson, Jim, Hazle, John, Wang, Yongxing, Li, Lei, Weng, Shaofan, Rizk, Nibal, Wen, Yu Ye, Lin, Xin, Wang, Hua, Wang, Huamin, Zhang, Aijun, Xia, Xuefeng, Wu, Yun, Habra, Mouhammed, Yang, Wei, Pusztai, Lajos, Yeung, Sai-Ching, Lee, Mong-Hong

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CARMA3 is Crucial for EGFR-Induced Activation of NF-κB and Tumor Progression von TANG JIANG, GRABINER, Brian, YIFAN ZHU, CHANGYING JIANG, HONGXIU LI, YUN YOU, JINGYU LANG, HUNG, Mien-Chie, XIN LIN

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Abstract PR04: mTOR mutations in cancer von Grabiner, Brian, Wagle, Nikhil, Allen, Eliezer Van, Garraway, Levi, Lorch, Jochen, Sabatini, David

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A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1 von Bar‐Peled, Liron, Chantranupong, Lynne, Cherniack, Andrew, Chen, Walter, Ottina, Kathleen, Grabiner, Brian, Spear, Eric, Carter, Scott, Meyerson, Matthew, Sabatini, David M

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MEKK3 is required for lysophosphatidic acid-induced NF-κB activation von Sun, Wenjing, Li, Hongxiu, Yu, Yang, Fan, Yihui, Grabiner, Brian C., Mao, Renfang, Ge, Ningling, Zhang, Hong, Fu, Songbin, Lin, Xin, Yang, Jianhua

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Abstract 1724: Genomic mechanisms of exquisite sensitivity and acquired resistance to everolimus in a patient with anaplastic thyroid carcinoma von Wagle, Nikhil, Grabiner, Brian C., Allen, Eliezer M. Van, Amin-Mansour, Ali, Carter, Scott C., Gray, Nathanael, Barletta, Justine A., Swanson, Scott J., Ruan, Daniel, Kwiatkowski, David J., Hanna, Glenn J., Haddad, Robert I., Sabatini, David, Janne, Pasi A., Garraway, Levi A., Lorch, Jochen H.

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CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-{kappa}B activation von Grabiner, Brian C, Blonska, Marzenna, Lin, Pei-Chun, You, Yun, Wang, Donghai, Sun, Jiyuan, Darnay, Bryant G, Dong, Chen, Lin, Xin

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Spi-1 and Spi-B control the expression of the Grap2 gene in B cells von Garrett-Sinha, Lee Ann, Hou, Ping, Wang, Duncheng, Grabiner, Brian, Araujo, Elizabeth, Rao, Sridhar, Yun, Theodore J., Clark, Edward A., Simon, M. Celeste, Clark, Marcus R.

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The cell cycle regulator 14-3-3[sigma] opposes and reverses cancer metabolic reprogramming von Phan, Liem, Chou, Ping-chieh, Velazquez-torres, Guermarie, Samudio, Ismael, Parreno, Kenneth, Huang, Yaling, Tseng, Chieh, Vu, Thuy, Gully, Chris, Su, Chun-hui, Wang, Edward, Chen, Jian, Choi, Hyun-ho, Fuentes-mattei, Enrique, Shin, Ji-hyun, Shiang, Christine, Grabiner, Brian, Blonska, Marzenna, Skerl, Stephen, Shao, Yiping, Cody, Dianna, Delacerda, Jorge, Kingsley, Charles, Webb, Douglas, Carlock, Colin, Zhou, Zhongguo, Hsieh, Yun-chih, Lee, Jaehyuk, Elliott, Andrew, Ramirez, Marc, Bankson, Jim, Hazle, John, Wang, Yongxing, Li, Lei, Weng, Shaofan, Rizk, Nibal, Wen, Yu Ye, Lin, Xin, Wang, Hua, Wang, Huamin, Zhang, Aijun, Xia, Xuefeng, Wu, Yun, Habra, Mouhammed, Yang, Wei, Pusztai, Lajos, Yeung, Sai-ching, Lee, Mong-hong

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Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithe... von Kim, Hyun-Jung, Litzenburger, Beate C, Cui, Xiaojiang, Delgado, David A, Grabiner, Brian C, Lin, Xin, Lewis, Michael T, Gottardis, Marco M, Wong, Tai W, Attar, Ricardo M, Carboni, Joan M, Lee, Adrian V

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